Clinical trials: in India
Pancreatic Ductal Adenocarcinoma
A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)
The purpose of this study is to assess the safety and efficacy of Navlimetostat (BMS-986504), a selective, MTA-cooperative PRMT5 inhibitor, in combination with Nab-paclitaxel/Gemcitabine (nab-p/gem) versus placebo in combination…
- Trial name
- NCT07076121
- Testing
- Navlimetostat, Gemcitabine, Nab-paclitaxel
- Where
- 269 sites in United States, Argentina and 34 more
- Volunteers
- 470 people
- Sponsor
- Bristol-Myers Squibb
Retention, Relapse
Comparative 3-dimensional Superimposition Analysis of Dentition in Horizontal and Vertical Grower During the Retention Phase -A Prospective Clinical Trial''
This study aims to investigate the relationship between facial type and relapse of dentition post-orthodontically during the retention phase.
- Trial name
- NCT07622277
- Testing
- 3 planes of space
- Where
- India
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Multivessel Coronary Artery Disease, Ischemia
COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events
The COMBINE-INTERVENE Trial will investigate whether a PCI revascularization strategy based on combined FFR and OCT assessment is superior to a PCI revascularization strategy based on FFR-alone in patients with MVD with any…
- Conditions
- Multivessel Coronary Artery Disease, Ischemia, Vulnerable Plaque, Coronary Artery Disease
- Trial name
- NCT05333068
- Testing
- PCI revascularization strategy based on combined FFR and OCT assessment, PCI revascularization strategy based FFR assessment
- Where
- 49 sites in Australia, Canada and 16 more
- Volunteers
- 1,223 people
- Sponsor
- Diagram B.V.
Motivational Interviewing, Periodontitis
Motivational Interviewing and Subgingival Instrumentation Outcomes in Periodontitis
Motivational Interviewing (MI) represents a patient centered counselling approach designed to facilitate behaviour change by guiding patients through the exploration and resolution of ambivalence toward positive health actions.
- Conditions
- Motivational Interviewing, Periodontitis, Oral Hygiene
- Trial name
- NCT07618533
- Testing
- Motivational Interviewing, Oral hygiene instructions
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
COVID-19
Study of Monovalent and Bivalent Recombinant Protein Vaccines Against COVID-19 in Adults 18 Years of Age and Older
The purpose of this Phase III study is to assess the efficacy, safety, and immunogenicity of two CoV2 preS dTM-AS03 vaccines (monovalent and bivalent) as part of primary series vaccinations in a multi-stage approach, as well as a…
- Trial name
- VAT00008 (NCT04904549)
- Testing
- SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent D614) (primary series), SARS-CoV-2 adjuvanted recombinant protein vaccine (bivalent D614 + B.1.351) (primary series), SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent B.1.351) (booster dose) >= 4 months after last vaccination
- Where
- 86 sites in United States, Colombia and 9 more
- Volunteers
- 23,670 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Periodontitis, Dental Health Utility Value
Dental Health State Utilities and Oral Health Beliefs in Periodontitis
This observational, cross-sectional study addresses gaps in periodontal health economics by measuring dental health state utility values (HSUVs) for periodontitis treatment.
- Conditions
- Periodontitis, Dental Health Utility Value, Health Belief Model
- Trial name
- NCT07615127
- Testing
- Health Utility State Assessment
- Where
- India
- Volunteers
- 112 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Tuberculous Meningitis
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC)…
- Trial name
- NCT05383742
- Testing
- Rifampicin (RIF), Isoniazid (INH), Linezolid (LZD)
- Where
- 18 sites in Brazil, India and 10 more
- Volunteers
- 330 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Periodontitis, Bruxism
Psychological Resilience, Perceived Stress and Periodontal Status Among Bruxers
The present study aims to evaluate psychological resilience as a modifier of the relationship between perceived stress and periodontal status among bruxers.
- Conditions
- Periodontitis, Bruxism, Perceived Stress
- Trial name
- NCT07615140
- Testing
- Resilience assessment
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Achalasia Cardia, GERD (Gastroesophageal Reflux Disease)
Biological Optimization Versus Standard Care in Post-POEM Achalasia Patients (BIO-POEM)
This study aims to evaluate whether a structured biological optimization program can improve reflux symptoms and overall recovery in patients with achalasia cardia who previously underwent Peroral Endoscopic Myotomy (POEM).
- Trial name
- BIO-POEM 1 (NCT07620899)
- Testing
- Structured Biological Optimization
- Where
- India
- Volunteers
- 166 people
- Sponsor
- Asian Institute of Gastroenterology, India
Overweight (BMI > 25), Weight Loss
The Impact of Salmon Protein Hydrolysate (SPH / ProGo®) Supplementation on Hematologic and Metabolic Health
Healthy, overweight males and females randomised to receive 8-weeks of salmon protein hydrolysate SPH (12g daily) or whey protein isolate (12g daily) to assess the impact on red blood cell and ferritin levels, blood glucose…
- Trial name
- NCT07616752
- Testing
- Nutritional supplementation, Nutritional Supplement
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hofseth Biocare ASA
Hypertension, Overweight or Obesity
A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1
GZL1 is an independent study conducted under the GZPL master protocol. GZL1 will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.
- Trial name
- NCT06948435
- Testing
- Orforglipron
- Where
- 99 sites in United States, Argentina and 9 more
- Volunteers
- 487 people
- Sponsor
- Eli Lilly and Company
Healthy Volunteers
A Study of Dengue Vaccine in Healthy Children, Teenagers and Adults in India
The main aims of the study are to learn about side effects and a participant's immune response to Takeda's Dengue Vaccine when given twice within 3 months.
- Trial name
- NCT06060067
- Testing
- TDV
- Where
- 10 sites in India
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Takeda
Stage IIIC
Stereotactic Body Radiotherapy Boost Versus Simultaneous Integrated Boost to Pelvic Nodes Among Patients Receiving Radical Chemoradiation in Carcinoma Cervix
Cervical cancer is a significant cause of morbidity and mortality among women worldwide. Radiotherapy, in combination with chemotherapy or as a standalone treatment, is an effective treatment option for cervical cancer.
- Trial name
- NCT07585929
- Testing
- Stereotactic Body Radiotherapy Boost to Involved Pelvic Lymph Nodes, Standard Arm: Simultaneous Integrated Boost to involved pelvic node
- Where
- 3 sites in India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences
Hypertension
A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2
GZL2 is an independent study conducted under the GZPL master protocol. GZL2 study will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.
- Trial name
- NCT06952530
- Testing
- Orforglipron
- Where
- 99 sites in United States, Argentina and 9 more
- Volunteers
- 487 people
- Sponsor
- Eli Lilly and Company
Knowledge, Attitude
Knowledge, Attitude, Practice Survey
This study aimed to assess the knowledge, attitude, and practice(KAP) towards infection-control guidelines among undergraduate and postgraduate dental students in Haryana, and to evaluate the incidence of needlestick/sharp…
- Conditions
- Knowledge, Attitude, Practice
- Trial name
- NCT07614750
- Testing
- Questionnaire
- Where
- India
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Hypertension
A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
The GZPL master protocol will support 2 independent studies, J2A-MC-GZL1 (GZL1) and J2A-MC-GZL2 (GZL2). The purpose of this study is to create a framework to evaluate the safety and efficacy of orforglipron for the treatment of…
- Trial name
- NCT06948422
- Testing
- Orforglipron
- Where
- 100 sites in United States, Argentina and 9 more
- Volunteers
- 974 people
- Sponsor
- Eli Lilly and Company
Periodontitis With Low Oral Hygiene-related Self-efficacy
Evaluation of Behaviour Intervention on Adherence and Periodontal Outcomes
Periodontitis is a chronic inflammatory disease in which long-term treatment success depends greatly on patients' adherence to oral hygiene practices and periodontal therapy.
- Trial name
- NCT07614737
- Testing
- Behavioural intervention, Conventional oral hygiene instructions
- Where
- India
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Jaundice, Neonatal, Neonatal Diseases and Abnormalities
Evaluation of Bili-ruler, a Low-cost, Plastic Icterometer for Community-based Screening of Jaundice in Newborns
Newborn jaundice, or accumulation of bilirubin molecules in blood, affects 60-80% of newborns and, in severe cases, places newborns at risk of brain damage and death.
- Conditions
- Jaundice, Neonatal, Neonatal Diseases and Abnormalities, Neonatal Hyperbilirubinemia, Screening Tool
- Trial name
- NCT06687746
- Testing
- Bili-ruler
- Where
- 5 sites in India, Kenya and 2 more
- Volunteers
- 4,060 people, healthy volunteers welcome
- Sponsor
- George Washington University
Diabete Type 2
Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
Methodology Patient with diabetes 2 with informed consent -convenience sampling over a one year period.The tooth isolated with a rubber dam and the correct disinfection procedures will be used.
- Trial name
- NCT07549373
- Testing
- 940 nm diode laser, apple cider vinegar, Gymnema Sylvestre
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Sharda University
Pulpitis - Irreversible
Effect of Alcohol Consumption on the Success Rates
This prospective, randomized, double-blind clinical trial will be carried out Conservative Dentistry, Faculty of Dentistry, Jamia Millia Islamia.
- Trial name
- NCT06201871
- Testing
- Lidocaine Hydrochloride
- Where
- India
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Jamia Millia Islamia
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