Clinical trials: in India
Endoscopic Variceal Band Ligation
Comparison of Rabeprazole and Vonoprazan in the Prevention of Post-endoscopic Variceal Ligation Ulcer in Patients With Cirrhosis
The study aims to to evaluate Vonoprazan effectiveness in prevention of post endoscopic variceal ligation (EVL) ulcer and its related bleed in comparison to Rabeprazole.
- Trial name
- NCT07608536
- Testing
- Vonoprazan, Rabeprazol
- Where
- India
- Volunteers
- 300 people
- Sponsor
- King George's Medical University
Relapsing Multiple Sclerosis
Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS
The purpose of this study is to collect long-term safety, tolerability, effectiveness and health outcomes data in eligible subjects who have participated in a Novartis ofatumumab clinical MS study.
- Trial name
- ALITHIOS (NCT03650114)
- Testing
- Ofatumumab, Tetanus toxoid (TT) containing vaccine (Td, Tdap), 13-valent pneumococcal conjugate vaccine (13-PCV)
- Where
- 295 sites in United States, Argentina and 35 more
- Volunteers
- 1,882 people
- Sponsor
- Novartis Pharmaceuticals
Periodontitis
Validation of Hindi Version Oral Health Impact Profile for Periodontitis
Translation of OHIP-CP questionnaire in Hindi language will be done. Patients recruited will undergo clinical examination and recording of periodontal parameters (Pocket probing Depth and Clinical Attachment Loss) will be…
- Trial name
- NCT07303491
- Testing
- OHIP-P-HIN Questionnaire
- Where
- India
- Volunteers
- 196 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Solid Tumours
A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test
WAYFIND-R is a registry that aims to capture high-quality real-world data linking next-generation sequencing, treatments and outcomes from cancer patients diagnosed with a solid tumour.
- Trial name
- NCT04529122
- Where
- 136 sites in Argentina, Austria and 30 more
- Volunteers
- 7,864 people
- Sponsor
- Hoffmann-La Roche
Physiology Education, Simulation-Based Learning
AI-Assisted Adaptive Simulation in Physiology Education
This randomized controlled trial evaluated whether an AI-assisted, rule-based adaptive screen-based simulation module could improve physiology learning outcomes among undergraduate health science students compared with…
- Conditions
- Physiology Education, Simulation-Based Learning, v, Artificial Intelligence in Education
- Trial name
- PBL (NCT07608315)
- Testing
- AI-Assisted Algorithm-Supported Adaptive Simulation, Conventional Physiology Instruction
- Where
- India
- Volunteers
- 672 people, healthy volunteers welcome
- Sponsor
- Saveetha University
Tooth Mobility, Periodontitis
Impact of MINST With and Without Splinting in Periodontitis Patients With Mobile Anterior Teeth
The goal of this clinical trial is to evaluate impact of Minimally Invasive Non-Surgical Therapy (MINST) with and without splinting on clinical periodontal parameters and Oral Health Related Quality of Life (OHRQoL) in…
- Trial name
- NCT06436729
- Testing
- Splinting, MINST alone
- Where
- India
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Gingival Recession
Comparison of Root Coverage Outcomes by NORD Flap Versus Subepithelial Connective Tissue Graft in RT1 Gingival Recession
Management of GR in the initial stages (when there is no inter proximal attachment and bone loss involved) has better clinical outcomes and reduces the chances of further progression of recession.
- Trial name
- Recession type (NCT05844254)
- Testing
- novel overlapping rotated double (NORD) flap
- Where
- India
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Oral Health Quality of Life (OHQoL) Was Assessed
Responsiveness of Hindi Version of Oral Health Impact Profile for Periodontitis (OHIP-P-HIN)
The distribution- and anchor-based methods will be used to estimate the Minimal Important Difference (MID) of the OHIP-P-HIN. Two established distribution-based approaches, the standardized effect size (ES) and standardized…
- Trial name
- NCT07304596
- Testing
- Non Surgical Periodontal Therapy
- Where
- India
- Volunteers
- 106 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Allostatic Load, Periodontitis, Chronic
Impact of Periodontal Inflammation on Allostatic Load
Periodontitis is a prevalent global health issue that contributes to systemic inflammation and is closely linked to stress as a risk factor. Both conditions have been investigated for bidirectional relationship.
- Trial name
- NCT06978712
- Testing
- Sub-gingival instrumentation
- Where
- India
- Volunteers
- 112 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Acute Myocardial Infarction (AMI)
Dexrazoxane to Protect Against Hemorrhagic STEMI
This Phase Ila trial evaluates whether the intravenous administration of Dexrazoxane can reduce permanent heart muscle damage in patients undergoing standard stent procedures (PCI) for a severe heart attack (STEMI).
- Trial name
- SHIELD-MI (NCT07502521)
- Testing
- Dexrazoxane, Normal Saline
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Rohan Dharmakumar
Neoplasms, Head and Neck
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
The goal of this study is to assess the safety and effectiveness of Dostarlimab compared to Placebo in adult participants with Head and Neck Squamous Cell Carcinoma (HNSCC)
- Trial name
- JADE (NCT06256588)
- Testing
- Dostarlimab
- Where
- 277 sites in United States, Argentina and 29 more
- Volunteers
- 864 people
- Sponsor
- GlaxoSmithKline
Procrastination
Procrastination in Seeking Dental Care
Patients fulfilling the eligibility criteria will be enrolled in the study will be given online survey to fill questionnaire. Questionnaire will be provided to the patient which include the questions about following parameters…
- Trial name
- NCT07306780
- Testing
- Irrational Procrastination Scale (IPS), Oral Health Self Efficacy Scale (OHSES)
- Where
- India
- Volunteers
- 196 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Depression, Depressive Disorder
Improving Outcomes in Depression in Primary Care in a Low Resource Setting
The OptimizeD study aims to improve outcomes in depression in primary care in India. This study will randomize 1500 patients with moderate to severe depression to either psychotherapy based on behavioral activation called the…
- Trial name
- OptimizeD (NCT05944926)
- Testing
- Healthy Activity Program (HAP), Antidepressant medication (fluoxetine)
- Where
- India
- Volunteers
- 1,500 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Complicated Urinary Tract Infection, Acute Pyelonephritis
Study of Cefepime-zidebactam (FEP-ZID) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)
This is a Phase 3, randomized, double-blind, multicenter, non-inferiority study to evaluate the efficacy, safety, and tolerability of FEP-ZID vs. meropenem in the treatment of hospitalized adults with cUTI or AP.
- Trial name
- NCT04979806
- Testing
- Cefepime-zidebactam (FEP-ZID), Meropenem
- Where
- 48 sites in United States, Bulgaria and 7 more
- Volunteers
- 530 people
- Sponsor
- Wockhardt
Decompensated Liver Cirrhosis
Effect of Single vs Repeated Cycles of a Combination of Granulocyte Colony Stimulating Factor and Darbepoetin vs Standard Medical Treatment on Immunometabolic Profile in Patient With Early Decompensated Cirrhosis.
Exogenous growth factor-mobilized bone marrow (BM) stem cells(G-CSF) and DARBEPOETIN use have shown a differential response in the management of decompensated cirrhosis (DC) with improved survival, CTP and MELD scores.
- Trial name
- NCT07002827
- Testing
- Darbepoetin, G-CSF, Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Personality Type, Leadership Style
Personality Type, Leadership Style and Training Needs Among Nurses
Personality traits and leadership styles among nurses influence professional behaviour, communication, clinical decision-making, teamwork, and quality of patient care.
- Conditions
- Personality Type, Leadership Style, Training Status
- Trial name
- NCT07603830
- Where
- India
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Sri Ramachandra Institute of Higher Education and Research
Ischemic Stroke, Stroke
Gravity Stent-Retriever System For Reperfusion Of Large Vessel Occlusion Stroke Trial
The study aims to evaluate the safety and efficacy of the Supernova stent retriever device, developed by Gravity Medical Technology, for treating acute ischemic stroke.
- Conditions
- Ischemic Stroke, Stroke, Cerebrovascular Disorders, Brain Diseases
- Trial name
- GRASSROOT (NCT06249776)
- Testing
- Supernova revascularization device
- Where
- 11 sites in India, Iran and 1 more
- Volunteers
- 55 people
- Sponsor
- Gravity Medical Technology, INC
Mucormycosis; Pulmonary (Etiology)
Amphotericin Versus Posaconazole for Pulmonary Mucormycosis
Pulmonary mucormycosis is a serious illness with high morbidity and mortality (approximately 57%). Surgery and antifungal therapy are central in the management of mucormycosis.
- Trial name
- NCT05468372
- Testing
- Posaconazole 600 mg followed by posaconazole 300 mg once daily, Liposomal Amphotericin B
- Where
- India
- Volunteers
- 82 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Rheumatoid Arthritis
An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis
The main purpose of this study is to evaluate the efficacy and safety of LY3871801 in adult participants with active moderately-to-severe rheumatoid arthritis (RA).
- Trial name
- NCT05848258
- Testing
- LY3871801
- Where
- 54 sites in United States, Argentina and 8 more
- Volunteers
- 164 people
- Sponsor
- Eli Lilly and Company
Follicular Lymphoma
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
The study is designed as a multicenter, randomized, open label Phase 3 study to compare the efficacy and safety of golcadomide in combination with rituximab vs investigator's choice in participants with relapsed/refractory…
- Trial name
- NCT06911502
- Testing
- Golcadomide, Rituximab, Lenalidomide
- Where
- 160 sites in United States, Australia and 19 more
- Volunteers
- 400 people
- Sponsor
- Celgene
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