Clinical trials: in India
Lung Cancer, Peripheral Vascular Diseases
Peripheral Vascular Disease as a Clinical Trigger for Opportunistic Lung Cancer Screening Referral: An Implementation Study
The study aims to determine whether patients with peripheral vascular disease who attend the vascular clinics are eligible for lung cancer screening.
- Conditions
- Lung Cancer, Peripheral Vascular Diseases, Ankle Brachial Index, Low Dose Computed Tomography
- Trial name
- PVD-Lungs (NCT07598279)
- Testing
- Observational - low dose computed tomography scan, Experimental - low dose computed tomography scan
- Where
- India
- Volunteers
- 355 people
- Sponsor
- International Agency for Research on Cancer
Glucocorticoid Induced Hyperglycemia
Comparing the Safety and Efficacy of Insulin GLARGINE and DEGLUDEC in Glucocorticoid Induced HYPERGLYCEMIA in Hospitalized Patients".
Glucocorticoids (GC) represent therapeutic agents of great importance in the treatment and prophylaxis of multiple inflammatory and non-inflammatory conditions.
- Trial name
- NCT07599891
- Testing
- Degludec insulin, Glargine insulin
- Where
- India
- Volunteers
- 79 people
- Sponsor
- Max Healthcare Insititute Limited
Intrahepatic Cholestasis of Pregnancy, Genetic Mutation
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population
Intrahepatic cholestasis of pregnancy (ICP) is a disorder characterized by itching, elevated fasting serum bile acids ≥10μmol/L (and elevated serum transaminases), with increased risks of perinatal complications, including…
- Conditions
- Intrahepatic Cholestasis of Pregnancy, Genetic Mutation, Health Related Quality of Life
- Trial name
- ICP (NCT05691036)
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Glioma
BIO-SHORT: Hypofractionated RT for Poor-Prognosis GBM
High grade gliomas, particularly glioblastoma, are among the most aggressive brain tumors and are associated with poor outcomes despite standard treatment.
- Trial name
- BIO-SHORT (NCT07338539)
- Testing
- Standard radiotherapy using hypofractionated RT, Experimental Arm Intervention
- Where
- India
- Volunteers
- 108 people
- Sponsor
- Tata Memorial Centre
Lung Cancer
Indian Lung Screening Trial
The GLOBOCAN 2022 report for India, suggests lung cancer as the second most frequent cancer in males, with a case count at 58,970 forming 8.5% of the entire cancer burden for males in India.
- Trial name
- ILST (NCT07590440)
- Testing
- Low dose CT
- Where
- India
- Volunteers
- 1,716 people
- Sponsor
- All India Institute of Medical Sciences
Cirrhosis, Microplastics
Microplastics, Cirrhosis and Portal Hypertension
Cirrhosis and portal hypertension are associated with an hyperdynamic circulation and hepatic inflammation, leading to complications like ascites, variceal bleeding, acute kidney injury, and higher infection risk.
- Conditions
- Cirrhosis, Microplastics, Portal Hypertension Related to Cirrhosis, Nanoplastics
- Trial name
- NCT07280390
- Testing
- Assessment of microplastics in tissue
- Where
- 2 sites in India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Myasthenia Gravis
Myasthenia Gravis Inebilizumab Trial
Randomized, double-blind, placebo-controlled, Phase 3, parallel-group study with optional open-label extension.
- Trial name
- MINT (NCT04524273)
- Testing
- inebilizumab
- Where
- 104 sites in United States, Argentina and 17 more
- Volunteers
- 238 people
- Sponsor
- Amgen
Breast Cancer
A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)
This is a Phase III, randomised, open-label, 2 arm, multicentre, international study assessing the efficacy and safety of Dato-DXd compared with ICC in participants with locally recurrent inoperable or metastatic TNBC who are not…
- Trial name
- NCT05374512
- Testing
- Dato-DXd, Paclitaxel, Nab-paclitaxel
- Where
- 228 sites in United States, Argentina and 21 more
- Volunteers
- 644 people
- Sponsor
- AstraZeneca
Gestational Diabetes Mellitus (GDM), Pregnancy Induced Hypertension (PIH)
mHealth Integrated Model of Hypertension, Diabetes and Antenatal Care in India and Nepal
Our research aims to address a critical gap in the provision of quality antenatal care (ANC) in India and Nepal, by developing and evaluating an intervention comprising of a tablet-based electronic decision support system (EDSS).
- Conditions
- Gestational Diabetes Mellitus (GDM), Pregnancy Induced Hypertension (PIH), Anemia
- Trial name
- NCT03700034
- Testing
- mHealth Integrated Model of Antenatal Care
- Where
- 6 sites in India, Nepal
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation of India
Multiple Sclerosis
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
The purpose of this randomized, double-blind, placebo-controlled, parallel group study is to determine the efficacy of frexalimab in delaying the disability progression and the safety up to 36 months double-blind administration…
- Trial name
- FREVIVA (NCT06141486)
- Testing
- Frexalimab, MRI contrast-enhancing agents
- Where
- 311 sites in United States, Argentina and 25 more
- Volunteers
- 943 people
- Sponsor
- Sanofi
Dry Socket
Impact of Treatment With ALVEOGYL in Patients With Post-extraction Dry Socket
Alveogyl (Septodont, Saint-Maur-des-Fossés - France) is a Medical Device used as dressing in case of dry socket. ALVE study is a clinical investigation measuring Alveogyl performance and safety in patients with post-extraction…
- Trial name
- NCT05536115
- Testing
- Alveogyl
- Where
- 16 sites in France, India
- Volunteers
- 120 people
- Sponsor
- Septodont
Multiple Sclerosis (MS)
Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis
Efficacy and safety of ofatumumab and siponimod compared to fingolimod in pediatric patients with multiple sclerosis
- Trial name
- NEOS (NCT04926818)
- Testing
- Fingolimod, Ofatumumab, Siponimod
- Where
- 51 sites in United States, Argentina and 23 more
- Volunteers
- 129 people
- Sponsor
- Novartis Pharmaceuticals
Cirrhotic Cardiomyopathy, Empagliflozin
DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis
1. This proposed double-blind placebo controlled randomized controlled trial incorporates recent advances in management of heart failure and portal hypertension using the SGLT-2 inhibitor i.e. EMPAGLIFLOZIN.
- Conditions
- Cirrhotic Cardiomyopathy, Empagliflozin, Cardiometabolic Risk Factors, Cirrhosis
- Trial name
- DICE (NCT07322237)
- Testing
- Empagliflozin + Carvedilol, Carvedilol
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Attention Difficulties
Effectiveness of Mindful Attention Awareness Breathing on Attention and Wellbeing Among Undergraduate Students
Mindfulness-based interventions, particularly breathing techniques, have shown promise in enhancing cognitive and emotional outcomes.
- Trial name
- MAAB (NCT07497022)
- Testing
- Mindful attention awareness breathing
- Where
- India
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Sri Ramachandra Institute of Higher Education and Research
Cataract, Refractive Errors
Strengthening Community- to- Hospital Eye Care Pathways From Boko Eye Care Center in Rural Assam
This operational research project aims to strengthen continuity of eye care delivery between community screening and hospital-based treatment in rural Assam by redesigning referral pathways from the Boko Eye Care Center (ECC) to…
- Trial name
- NCT07333248
- Testing
- Experimental: Integrated Referral and Engagement Model
- Where
- India
- Volunteers
- 2,000 people
- Sponsor
- Seva Canada Society
Non-urgent Emergencies, Emergency Department Visits
Non Urgent Visit to Emergency Department
The use of ED by patients with non-urgent conditions has largely been seen in many hospitals. However, in general, half of the patients who visit the ED are non-urgent conditions.
- Trial name
- NCT07588204
- Where
- India
- Volunteers
- 29,856 people
- Sponsor
- Sri Ramachandra Institute of Higher Education and Research
Acute Breast Abscess
Comparison of Standard Incision and Drainage Versus Percutaneous Suction Drainage in the Management of Acute Breast Abscess
This prospective interventional study compares the effectiveness of standard incision and drainage versus percutaneous suction drain placement in the management of acute pyogenic breast abscess.
- Trial name
- I&D VS PSD (NCT07588412)
- Testing
- Incision and Drainage, Percutaneous Suction Drain
- Where
- India
- Volunteers
- 80 people
- Sponsor
- GSVM Medical College
Ulcerative Colitis
A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to evaluate the efficacy and safety of mirikizumab as maintenance therapy in participants who completed as clinical responders in the prior 12-week induction study LUCENT-1 (NCT03518086).
- Trial name
- LUCENT 2 (NCT03524092)
- Testing
- Mirikizumab SC, Mirikizumab IV
- Where
- 385 sites in United States, Argentina and 32 more
- Volunteers
- 1,328 people
- Sponsor
- Eli Lilly and Company
Osteoporotic Fractures, Osteoporosis
The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures
This is an international multicenter prospective observational study. Patients with radiologically confirmed, symptomatic, single- or multilevel contiguous TL (from T1 to L5) fractures as a result of primary osteoporosis will be…
- Trial name
- NCT07027306
- Testing
- Posterior stabilization (pedicle screws)
- Where
- 15 sites in United States, Argentina and 12 more
- Volunteers
- 648 people
- Sponsor
- AO Foundation, AO Spine
MASLD, Chronic Kidney Diseases
Safety and Efficacy of Finerenone in Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD/NAFLD) Related Cirrhosis Patients With Ascites in Prevention of Chronic Kidney Disease.
Renal dysfunction is a frequent and clinically important complication in cirrhosis, and MASLD/NAFLD is associated with increased risk of incident CKD; however, finerenone has not been specifically studied in MASLD-cirrhosis…
- Trial name
- NCT07585526
- Testing
- Finerenone, Spironolactone, Standard Medical Treatment
- Where
- India
- Volunteers
- 160 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
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