Clinical trials: in Italy
Obesity, Sarcopenic Obesity
Effects of Obesity on Physical Abilities and Daily Living Activities in Elderly Adults
Obesity is a significant health problem whose prevalence has tripled worldwide in the last fifty years, also involving older people.
- Trial name
- CAPFISOBEANZ (NCT07614464)
- Testing
- Fitness tests and questionnaires
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Meningitis
A Phase 3 Study to Assess the Immune Response and Safety of rMenB+OMV NZ in Primed Healthy Participants (10 to 20 Years Old)
The main purpose of this study was to evaluate the immune response and safety of a booster dose of the meningococcal group B vaccine, rMenB+OMV NZ (also known as Bexsero), in adolescents and young adults aged 10 to 20 years.
- Trial name
- NCT06995430
- Testing
- rMenB+OMV NZ vaccine
- Where
- 17 sites in Finland, Italy and 2 more
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Migraine
Study of the Glymphatic System in Migraine
This study aimed to investigate the role of the glymphatic system in the initiation of migraine attacks, using non-invasive magnetic resonance imaging techniques and a validated model of migraine induction by nitroglycerin…
- Trial name
- NCT05907655
- Testing
- Nitroglycerin 0.3 MG, MRI, Blood sampling
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Anorexia Nervosa
Posture and Spinal Mobility in Anorexia Nervosa
The primary objective of the study is to compare the results of the postural and mobility analysis obtained with the use of the Idiag M360 instrument in adult women with anorexia nervosa and in a control group represented by…
- Trial name
- SPINALAN (NCT06800924)
- Testing
- Postural and mobility analysis
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Periodontal Disease
Thermosensitive Hyaluronic Gel With Octenidine as an Adjunctive to Subgingival Instrumentation
This will be a spontaneous, postmarketing trial with a medical device (MD), split-mouth, nationwide multicenter study (coordinator center: Periodontal Unit, Dental Clinic, DIBINEM, Bologna University, Italy, with satellite center…
- Trial name
- PX-2025 (NCT07725913)
- Testing
- Use of px gel
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Motor Disorders, Neuromuscular Diseases
Usability of the FTEXES Wearable Textile Platform for Functional Electrical Stimulation and EMG
FTEXES (Functionalized TEXtiles for Electrical Stimulation) is a wearable platform based on sensorized garments (Smart Pants and Smart T-shirt) with integrated textile electrodes for surface electromyography (EMG) recording and…
- Conditions
- Motor Disorders, Neuromuscular Diseases, Healthy Volunteers
- Trial name
- FTEXES (NCT07922980)
- Testing
- FTEXES wearable system
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Politecnico di Milano
Pneumococcal Disease
A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants
The purpose of this study is to learn about the safety of a new pneumococcal vaccine and how the new pneumococcal vaccine helps to fight against germs that can cause pneumonia (lung infections), meningitis (brain infections), and…
- Trial name
- NCT07573462
- Testing
- PG4, 20-valent pneumococcal conjugate vaccine (20vPnC)
- Where
- 91 sites in United States, Argentina and 9 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Pfizer
Functional Recovery, Motor Rehabilitation
Cervical tsDCS on Stroke Patients
The present project aims to evaluate the facilitatory modulation of motor responses of the limb upper limb by tsDCS in patients with arm/hand hyposthenia after cerebral ischemia to verify the possible therapeutic benefits that…
- Trial name
- AMPLI-MOV (NCT06826274)
- Testing
- tDCS
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Anorexia Nervosa
Orexin Gene in Anorexia Nervosa
The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate…
- Trial name
- ORESSANNE (NCT06800898)
- Testing
- Blood samples and Questionnaires
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Cardiovascular Risk, Genetic Cardiovascular Risk
Novel Risk Prediction Approaches for the Primary Prevention of Cardiovascular Diseases in Italy: the CVRISK-IT Trial (CVRISK-IT)
The CVRISK-IT study aims to evaluate the health benefit of measuring genetic and imaging risk information in men and women considered at 'low-to-moderate' or 'high' risk of developing cardiovascular diseases (CVD) in a randomized…
- Trial name
- CVRISK-IT (NCT06832644)
- Testing
- Lifestyle Management
- Where
- 17 sites in Italy
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Dementias, Neurodegenerative Dementia
In-depth Analysis of Cholesterol Metabolism and Related Biomarkers in the Pathogenesis and Progression of the Disease in Neurodegenerative Dementias
The aim of the study is to evaluate the role of cholesterol in the pathogenesis of neurodegenerative dementias. Hypercholesterolemia is a known risk factor for Alzheimer disease (AD), and oxysterols, the principal cholesterol…
- Trial name
- RF-2021-123742 (NCT07207486)
- Where
- 2 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Parkinson Disease, Alexithymia
Visuospatial and Affective Abilities in Parkinson Disease
The aim of the study is to investigate whether prismatic adaptation (PA) and virtual prismatic adaptation (VPA), a non-invasive neuromodulation technique, that involves the use of lenses that deviate the visual field, can…
- Conditions
- Parkinson Disease, Alexithymia, Visuospatial/Perceptual Abilities
- Trial name
- NCT06341829
- Testing
- Prismatic adaptation, Schirmer test
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Ehlers-Danlos Syndrome
Registry of Ehlers-Danlos Syndrome
RED is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains…
- Trial name
- RED (NCT04133272)
- Where
- Italy
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Luca Sangiorgi
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Plantar Fasciitis, Chronic
Sensitivity and Tests for Evaluation of Plantar Fasciopathy
Plantar fasciopathy (PF), one of the leading causes of foot pain, affects up to one in ten individuals in their lifetime. Characterized by pain and structural alterations at the proximal insertion of the plantar fascia on the…
- Trial name
- STEP (NCT07567807)
- Testing
- Gastroc Sign, Tenderness at the Medial Calcaneal Tuberosity, Silfverskiöld Test
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Developmental Dyslexia, Reading Problem
Personalization of Visual Characters and Text-to-Speech (TTS) to Support Learning in Students With Reading Difficulties
Previous research has shown the importance of font type, size and spacing to facilitate text reading in dyslexia. A special automatized procedure was designed to select the most favorable parameters for both text visualization…
- Trial name
- NCT06947512
- Testing
- Seleggo Test
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Preterm Birth, Parent-Child Relations
Biological Underpinnings of Socio-emotional Regulation in Preterm Infants and Healthy Controls
Preterm infants (PT) often need to spend their first weeks of life in the Neonatal Intensive Care Unit (NICU) where they are exposed to several adverse conditions.
- Conditions
- Preterm Birth, Parent-Child Relations, Epigenetics
- Trial name
- NCT05253924
- Testing
- DNA methylation of target genes, EEG acquisition
- Where
- Italy
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Developmental Dyslexia, Developmental Language Disorder
Dynamic Assessment of the Risk for Language and Reading Disorders in Monolingual and Multilingual Children
The project represents the completion of a part of the recently concluded European project MultiMind, in which a computer platform called MuLiMi was developed and validated.
- Trial name
- NCT06937255
- Testing
- computerized Dynamic Assessment
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Obese Patients, Obese Patients With Bariatric Surgery
Bariatric Surgery and Gut Microbiota Changes Over Time
The goal of this observational study is to learn how bariatric surgery affects gut bacteria and gut-related metabolic products over time in adults with obesity.
- Conditions
- Obese Patients, Obese Patients With Bariatric Surgery, Gut Microbiota, Healthy Participants
- Trial name
- RYGB-MICROGUT (NCT07381140)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Gingival Graft, Recession, Gingival
i-PRF-Based Bioactive Matrix vs. Connective Tissue Graft in the Treatment of Gingival Recessions
This study aims to evaluate the efficacy of a novel bioactive matrix, consisting of an equine collagen core soaked in i-PRF and wrapped in L-PRF, used in combination with a coronally advanced flap as an alternative to the…
- Conditions
- Gingival Graft, Recession, Gingival, Platelet Rich Fibrin
- Trial name
- NCT07918326
- Testing
- Coronally advanced flap and i-PRF based bioactive matrix, Coronally advanced flap and subepithelial connective tissue graft
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
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