Clinical trials: in Jamaica
Stroke
Exercise For Sub-acute Stroke Patients in Jamaica
Chronic hemiparetic stroke is associated changes in body composition, skeletal muscle and cardiometabolic health; specific changes include paretic limb muscular atrophy, increased intramuscular fat deposition, elevated prevalence…
- Trial name
- JAMMS (NCT01392391)
- Testing
- Task Oriented Exercise Training, Stroke Care "Get with the Guidelines"
- Where
- 2 sites in United States, Jamaica
- Volunteers
- 150 people
- Sponsor
- Baltimore VA Medical Center
Vaso-occlusive Crisis, Sickle Cell Disease
Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC)
The purpose of this study is to evaluate whether MST-188 can reduce the duration of vaso-occlusive crisis (VOC) in subjects with sickle cell disease.
- Trial name
- EPIC (NCT01737814)
- Testing
- Saline, MST-188
- Where
- 72 sites in United States, Belgium and 9 more
- Volunteers
- 388 people
- Sponsor
- Mast Therapeutics, Inc.
Sickle Cell Disease, Cognitive Ability, General
Improving Parental Psychosocial Functioning and Early Developmental Outcomes in Children With Sickle Cell Disease
There are all significant risk factors for poor early cognitive development and, as such, neurocognitive deficits have been demonstrated in pre-school children with sickle cell disease (SCD).
- Conditions
- Sickle Cell Disease, Cognitive Ability, General, Psychological Stress, Parenting
- Trial name
- NCT02394899
- Testing
- Play therapy, Problem solving skills
- Where
- Jamaica
- Volunteers
- 64 people
- Sponsor
- The University of The West Indies
Sickle Cell Anemia
Sparing Conversion to Abnormal TCD (Transcranial Doppler) Elevation (SCATE)
The primary goal of the Phase III SCATE trial is to compare 30 months of alternative therapy (hydroxyurea) to standard care (observation) in children with sickle cell anemia and conditional (170 - 199cm/sec) Transcranial Doppler…
- Trial name
- SCATE (NCT01531387)
- Testing
- Hydroxyurea
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 38 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sickle Cell Disease, Quality of Life
Improving Disease Knowledge in Adolescents With Sickle Cell Disease
Increased knowledge about an illness can increase self-management among those afflicted. In order to facilitate people with sickle cell disease living a longer and healthier life, they should be taught to manage their illness.An…
- Trial name
- KNOW-IT (NCT01945073)
- Testing
- Educational Booklet (BK), Formal Counselling (CB)
- Where
- Jamaica
- Volunteers
- 150 people
- Sponsor
- The University of The West Indies
Inguinal Hernia, Anesthesia, Local
A Trial of Local Anaesthesia Versus Local Anaesthesia and Conscious Sedation for Hernioplasty
The aim of this RCT is to compare patient outcomes of inguinal hernioplasty under Local Anaesthesia alone versus Local Anaesthesia and Conscious Sedation Specific study objectives are to determine the effect of conscious sedation…
- Conditions
- Inguinal Hernia, Anesthesia, Local, Conscious Sedation
- Trial name
- NCT02444260
- Testing
- Midazolam, Intravenous Normal Saline, Bupivocaine
- Where
- Jamaica
- Volunteers
- 180 people
- Sponsor
- The University of The West Indies
Cardiovascular Disease, Dyslipidemia
An Intervention to Improve Management of Dyslipidemia in Primary Care
To assess the effectiveness of a clinical audit and physician based intervention in improving the management of dyslipidemia at Health centres in the Southeast Health Region of Jamaica
- Conditions
- Cardiovascular Disease, Dyslipidemia, Diabetes Melletus, Obesity
- Trial name
- NCT02438943
- Testing
- Audit, Physician Intervention
- Where
- Jamaica
- Volunteers
- 500 people
- Sponsor
- The University of The West Indies
Sickle Cell Disease, Sickle Cell Anemia
Effects of HQK-1001 in Patients With Sickle Cell Disease
The purpose of this study is to evaluate the effects of HQK-1001 on Hb F in subjects with sickle cell disease.
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Sickle Cell Disorders, Hemoglobin S Disease
- Trial name
- NCT01601340
- Testing
- HQK-1001
- Where
- 18 sites in United States, Canada and 3 more
- Volunteers
- 77 people
- Sponsor
- HemaQuest Pharmaceuticals Inc.
Women Wanting Contraceptive Implant for Pregnancy Prevention
A Trial on the Effect of Sino-implant (II) Use on Condom Use Among Women in Kingston, Jamaica
This unblinded, randomized controlled trial (RCT) among women to determine: 1)if unprotected sex as measured prostate-specific antigen (PSA) will be more among women who receive a contraceptive implant immediately at baseline…
- Trial name
- SIS (NCT01684358)
- Testing
- Sino-implant (II)
- Where
- Jamaica
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Small Cell Lung Cancer
Extensive Small Cell Lung Cancer Treatment Using An Investigational Drug Plus Chemotherapy In Chemotherapy-Naive Adults
This study will gather and compare data about the effectiveness and safety of two different treatments for extensive Small Cell Lung Cancer (SCLC) in patients who have not received previous chemotherapy.
- Trial name
- NCT00043927
- Testing
- topotecan/cisplatin, etoposide/cisplatin
- Where
- 176 sites in United States, Austria and 32 more
- Volunteers
- 760 people
- Sponsor
- GlaxoSmithKline
Anemia, Sickle Cell, Sickle Cell Anemia
Safety Study of MP4CO in Adult Sickle Cell Patients
Sickle Cell Anemia is caused by an inherited hemoglobin disorder. Healthy red blood cells are discoid and can deform and move through small blood vessels to carry oxygen to all parts of the body.
- Conditions
- Anemia, Sickle Cell, Sickle Cell Anemia, Sickle Cell Disease, Sickle Cell Disorders
- Trial name
- NCT01356485
- Testing
- MP4CO, Sodium chloride solution
- Where
- 5 sites in France, Jamaica and 2 more
- Volunteers
- 32 people
- Sponsor
- Sangart
Microalbuminuria, Sickle Cell Nephropathy
Efficacy of Antioxidant Therapy Compared With Enalapril in Sickle Nephropathy
The purpose of this study is to determine whether enalapril or antioxidant therapy (N-Acetylcysteine) is effective in reducing microalbuminuria in children with sickle cell disease and and its progression to sickle nephropathy
- Trial name
- NCT01891292
- Testing
- Enalapril, N-Acetylcysteine
- Where
- Jamaica
- Volunteers
- 30 people
- Sponsor
- The University of The West Indies
Sickle Cell Disease, Sickle Cell Anemia
A Study of HQK-1001 in Patients With Sickle Cell Disease
The purpose of this study is to evaluate the safety and tolerability of three dose levels of HQK-1001 administered once daily for 26 weeks in subjects with sickle cell disease.
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Sickle Cell Disorders, Hemoglobin S Disease
- Trial name
- NCT01322269
- Testing
- HQK-1001
- Where
- 16 sites in United States, Canada and 3 more
- Volunteers
- 52 people
- Sponsor
- HemaQuest Pharmaceuticals Inc.
Hemorrhage
Study of the Use of Misoprostol to Decrease Bleeding During a Myomectomy
This study was done to determine if the use of a combination of preoperative rectal misoprostol 400µg used with intraoperative perivascular vasopressin is better than perivascular vasopressin used alone to decrease bleeding at…
- Trial name
- NCT01700478
- Testing
- Misoprostol + vasopressin, Vasopressin
- Where
- Jamaica
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital of the West Indies
Colonoscopy
Effectiveness of Stiffening Wire in Colonoscopy With Pre-Owned Colonoscopes
The study aims to determine whether a proprietary, FDA approved stiffening wire improves the efficiency of colonoscopy (that is, decreases the duration of the procedure) and/or enables complete visualization of the colon in a…
- Trial name
- NCT01115010
- Testing
- Colonoscope stiffening device
- Where
- Jamaica
- Volunteers
- 112 people
- Sponsor
- Cornwall Regional Hospital
Sickle Cell Disease
Phase 1/2 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HQK-1001 Administered Daily in Patients With Sickle Cell Disease
The purpose of this study is to assess the safety and tolerability of HQK-1001 administered for a total of 12 weeks (with one dosing break) in subjects with sickle cell disease.
- Trial name
- NCT00842088
- Testing
- HQK-1001
- Where
- 9 sites in United States, Jamaica
- Volunteers
- 24 people
- Sponsor
- HemaQuest Pharmaceuticals Inc.
Diabetes
Natural History of Pedal Puncture Wounds in Diabetics
There are no evidence (research) based guidelines for treatment of early, closed puncture wounds of the feet in diabetics. Surgeons usually see only the limb- and life-threatening consequences of puncture wounds of the feet in…
- Trial name
- NCT01151891
- Where
- 4 sites in Jamaica
- Volunteers
- 188 people
- Sponsor
- Cornwall Regional Hospital
Human Immunodeficiency Virus (HIV), Acquired Immune Deficiency Syndrome (AIDS)
Impact of Nutrition Intervention on HIV/AIDS Infected Patients
Intervention to investigate the efficacy of a nutritional supplement among ARV-naïve, asymptomatic HIV positive patients with a CD4 count in the range 300-550 cells/ul.
- Trial name
- INI (NCT01171495)
- Testing
- Theragran-M; Ensure Plus, Theragran-M
- Where
- Jamaica
- Volunteers
- 121 people
- Sponsor
- Caribbean Health Research Council
Type 2 Diabetes, Inflammation
Low-Intermediate-Glycemic Index Caribbean Foods Versus High Glycemic Index Foods in Type 2 Diabetes
The purpose of this study is to determine whether low and intermediate GI Caribbean foods are effective in the management of type 2 diabetes.
- Conditions
- Type 2 Diabetes, Inflammation, Cardiovascular Disease
- Trial name
- NCT00818935
- Testing
- Low-Intermediate-Glycemic Index diets, High GI diet
- Where
- Jamaica
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital of the West Indies
Sickle Cell Disease
A Stratified Sickle Event Randomized Trial (ASSERT)
The purpose of this study is to compare the effects of ICA-17043 to placebo with or without hydroxyurea (an oral drug used for treatment of sickle cell disease) in patients with sickle cell disease who have had 2 or more acute…
- Trial name
- ASSERT (NCT00102791)
- Testing
- ICA-17043
- Where
- 49 sites in United States, Brazil and 4 more
- Volunteers
- 297 people
- Sponsor
- Icagen