Clinical trials: in Kazakhstan
Metastatic Breast Cancer
HER2-positive Metastatic Breast Cancer in Kazakhstan
Planned study population consists of approximately 240 adult patients with HER2-positive mBC receiving anti-HER2 therapy in 12 oncological centers (in each center it is expected to recruit about 20 patients) in different regions…
- Trial name
- NCT07593196
- Where
- 12 sites in Kazakhstan
- Volunteers
- 240 people
- Sponsor
- AstraZeneca
Healthy Volunteers, Leukocyte Fluorescence Profiling in Whole Blood
AI-Assisted Fluorescence Microscopy of Leukocytes in Fresh Whole Blood
The goal of this observational study is to learn whether a microscope-based method with artificial intelligence (AI) can detect and classify white blood cells in fresh, unstained blood and measure the color of fluorescent light…
- Trial name
- NAO-WBC-YOLO-0 (NCT07862231)
- Testing
- AI-Assisted bright-field and fluorescence microscopy, Romanowsky-Giemsa stained blood smear (reference)
- Where
- Kazakhstan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- MIPO Clinic
Obliterans, Arteriosclerosis, Peripheral Arterial Disease
Combined Treatment for Non-Healing Wounds in Chronic Lower Extremity Arterial Disease: A Comparative Study
Endovascular interventions, such as balloon angioplasty and stenting, are commonly used for PAD due to their proven safety and effectiveness. However, traditional treatments for chronic non-healing wounds are often insufficient.
- Conditions
- Obliterans, Arteriosclerosis, Peripheral Arterial Disease, Diabetic Foot
- Trial name
- NCT06724276
- Testing
- balloon angioplasty and stenting of lower extremity vessels + fibroblasts, balloon angioplasty and stenting of lower extremity vessels
- Where
- Kazakhstan
- Volunteers
- 116 people
- Sponsor
- Tulip Medicine
Hypertension, Cardiovascular Diseases (CVD)
VITAL: Real-World Evaluation of Amlodipine/Valsartan.
The goal of this observational study is to evaluate the effectiveness, safety, and treatment adherence of a fixed-dose combination of amlodipine and valsartan in adults with grade 2-3 hypertension in real-world clinical practice…
- Trial name
- VITAL (NCT07847970)
- Testing
- Amlodipine / Valsartan
- Where
- 18 sites in Kazakhstan
- Volunteers
- 216 people
- Sponsor
- VIVA PHARM LLP
Obesity, Severe Obesity
Prospective Study of an Explainable AI Tool to Support Biliopancreatic Limb Selection in One-Anastomosis Gastric Bypass
This prospective observational cohort study will develop and externally validate a human-supervised, explainable artificial-intelligence decision-support model for analysing factors associated with biliopancreatic limb length…
- Conditions
- Obesity, Severe Obesity, Metabolic Disease
- Trial name
- JI-AI-OAGB (NCT07818317)
- Testing
- One-anastomosis gastric bypass with observed biliopancreatic limb length
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Description of SLE Activity in Patients in Routine Practice in the Republic of Kazakhstan, Description of the Course of SLE in Patients in the Republic of Kazakhstan
Multicenter, Observational, Descriptive Study of the Diagnosis, Course and Treatment of Patients With SLE in Routine Practice in Kazakhstan: a Registry Study With Retrospective and Prospective Components.
Multicenter, observational, descriptive study of the diagnosis, course and treatment of patients with SLE in routine practice in Kazakhstan: a registry study with retrospective and prospective components.
- Conditions
- Description of SLE Activity in Patients in Routine Practice in the Republic of Kazakhstan, Description of the Course of SLE in Patients in the Republic of Kazakhstan, Description of Methods and Approaches to the Treatment of Patients With SLE in the Republic of Kazakhstan
- Trial name
- NCT06899633
- Where
- 12 sites in Kazakhstan
- Volunteers
- 509 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2, Autoimmune Diabetes
Metabolic and Immunoinflammatory Profiles in Adults With Newly Diagnosed Diabetes
The goal of this observational study is to better understand how diabetes develops in adults at the time of diagnosis. The study focuses on adults with newly diagnosed diabetes in the Kazakh population.
- Trial name
- AD-HET-KZ (NCT07522502)
- Where
- Kazakhstan
- Volunteers
- 240 people
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Type 2 Diabetes, Hypertension
iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases
To provide real world data on patient characteristics, disease management, healthcare utilization, and outcomes in patients with type 2 diabetes, Hypertension, Heart failure and/or Chronic kidney diseases
- Conditions
- Type 2 Diabetes, Hypertension, Chronic Kidney Disease, Heart Failure
- Trial name
- iCaReMe (NCT03549754)
- Where
- 76 sites in Brazil, Chile and 18 more
- Volunteers
- 35,000 people
- Sponsor
- AstraZeneca
Systemic Lupus Erythematosus (SLE)
INTERSTELLAR - International Study Evaluating Lupus Outcomes After Anifrolumab Real World Use
INTERSTELLAR study will generate critical prospective real-world evidence on the benefits of adding Anifrolumab to standard of care treatment for SLE in routine clinical practice, to inform physicians, payers and patients.
- Trial name
- INTERSTELLAR (NCT06314282)
- Where
- 32 sites in Argentina, China and 10 more
- Volunteers
- 200 people
- Sponsor
- AstraZeneca
Morbid Obesity, Obesity
TSBL-Based Versus BMI-Based Biliopancreatic Limb Length in One-Anastomosis Gastric Bypass
This study compares two surgical techniques used during one-anastomosis gastric bypass (OAGB) surgery for patients with severe obesity.
- Trial name
- TSBL-OAGB (NCT07796503)
- Testing
- TSBL-based biliopancreatic limb length determination, BMI-based biliopancreatic limb length determination
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- National Scientific Center of Surgery named after A.N.Syzganov
Rate of CKD Diagnosis in Patients With AH and CKD Markers, Demographic and Clinical Characteristics for Those Patients
Prospective Observational Multicenter Study of Patients With AH and CKD Markers in Kazakhstan (PROGRESS-CKD)
Multicenter, non-interventional PRospective Observational study with retrospective analysis to describe the rate of CKD diaGnosis in patients with aRtErial hypErtenSion and CKD markerS in Kazakhstan
- Conditions
- Rate of CKD Diagnosis in Patients With AH and CKD Markers, Demographic and Clinical Characteristics for Those Patients, Routine Therapy Before and After the Diagnosis of CKD
- Trial name
- D1843R00359 (NCT06744335)
- Where
- 28 sites in Kazakhstan
- Volunteers
- 1,283 people
- Sponsor
- AstraZeneca
Cervical Cancer Screening
Cervical Cancer Screening Via Self-sampling
Prevention of cervical cancer is one of the priority areas of the Comprehensive Plan to Combat Cancer in the Republic of Kazakhstan for 2023-2027.
- Trial name
- NCT07111819
- Testing
- Self-sampling acceptance
- Where
- Kazakhstan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Nazarbayev University
Brest Cancer
Creation and Implementation a Method for Breast Reconstruction After Radical Surgery Using Decellularized Xenomatrix in Combination With Lymphovenous Anastomosis in Breast Cancer.
In 2020, more than 31,000 new cancer cases were reported in Kazakhstan, with breast cancer being the most common type, accounting for more than 4,200 new cases.
- Trial name
- NCT07782801
- Testing
- Radical mastectomy with axillary lymph node dissection, Immediate implant-based breast reconstruction, Acellular xenogeneic matrix (AXM)
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- National Research Oncology and Transplantology Center, Kazakhstan
Type 2 Diabetes Mellitus (T2DM), Obesity (Disorder)
Digital Dietary Intervention for Patients Receiving GLP-1 Receptor Agonist Therapy
The goal of this clinical trial is to learn whether adding the NutriSteppe digital dietary intervention to routine medical care improves metabolic health in adults aged 21 to 65 years with type 2 diabetes mellitus, obesity, or…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Obesity (Disorder), Overweight, Metabolic Syndrome
- Trial name
- NutriSteppe (NCT07728669)
- Testing
- NutriSteppe Digital Dietary Intervention
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Academy of Nutrition
Advanced Heart Failure
CorWave LVAS FIH Study
The study is a prospective, multi-center, non-randomized trial to evaluate the safety and effectiveness of the CorWave LVAS for the treatment of advanced heart failure patients.
- Trial name
- NCT06907017
- Testing
- LVAS
- Where
- 3 sites in Australia, Kazakhstan
- Volunteers
- 20 people
- Sponsor
- CorWave
Depression - Major Depressive Disorder
Painhunting Therapy Versus Cognitive Behavioural Therapy for Event-Related Depression
This randomized, active-comparator pilot trial will compare Painhunting Therapy with manualized Cognitive Behavioural Therapy (CBT) in adults with event-related depressive symptoms.
- Trial name
- PH-CBT (NCT07738146)
- Testing
- Painhunting Therapy, Cognitive Behavioural Therapy (CBT)
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Painhunting LLP
Healthy Volunteers
Vestibular Perception Gates Autonomic Responses to Sinusoidal Galvanic Vestibular Stimulation
Brief Summary This randomized, double-blind, sham-controlled clinical trial is designed to investigate whether repeated sinusoidal galvanic vestibular stimulation (GVS) influences cardiac autonomic regulation in healthy adults…
- Trial name
- GVS-HRV (NCT07715227)
- Testing
- Galvanic Vestibular Stimulation (GVS) using BrainPatch device
- Where
- 2 sites in Kazakhstan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Al-Farabi Kazakh National University
Healthy Volunteers (HV), Skin Irritation
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers for Future Surgical Wound Use
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-MELSAFE (NCT07707986)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
Researchers are looking for a better way to treat women with, or at high risk for developing hormone-receptor positive breast cancer, who have vasomotor symptoms (VMS), a condition of having hot flashes caused by anti-cancer…
- Trial name
- OASIS-4 (NCT05587296)
- Testing
- Elinzanetant (BAY3427080)
- Where
- 102 sites in Austria, Belgium and 14 more
- Volunteers
- 474 people
- Sponsor
- Bayer
Rhinitis Allergic
PollenVax Subcutaneous Immunotherapy for Mugwort Pollen-Induced Allergic Rhinitis
This study evaluates the effectiveness and safety of PollenVax, a subcutaneous allergen immunotherapy (SCIT) drug developed for the treatment of allergic rhinitis and asthma caused by mugwort (Artemisia vulgaris) pollen.
- Trial name
- NCT07563439
- Testing
- Recombinant Artemisia vulgaris allergen Art v 1 with Montanide ISA-51 adjuvant
- Where
- Kazakhstan
- Volunteers
- 138 people
- Sponsor
- Kazakh National Agrarian University