Clinical trials: in Kazakhstan
Acute Ischemic Stroke
A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well
This study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke).
- Trial name
- TENACITY (NCT07361302)
- Testing
- Tenecteplase, Standard of care treatment
- Where
- 257 sites in Argentina, Australia and 14 more
- Volunteers
- 1,325 people
- Sponsor
- Boehringer Ingelheim
Stroke
Effect of an Electromagnetic Trainer on Gait and Balance Recovery After Stroke
This study aims to evaluate the effectiveness of an electromagnetic trainer in improving lower limb motor function, gait, and balance in patients after cerebral stroke.
- Trial name
- NCT07898657
- Testing
- Electromagnetic trainer, Standard medical rehabilitation
- Where
- 2 sites in Kazakhstan
- Volunteers
- 80 people
- Sponsor
- Karaganda Medical University
Metabolic Dysfunction-Associated Steatotic Liver Disease
Clinical Profile of Patients With MASLD in Kazakhstan and Clinical Effectiveness of Ursosan in Almaty
This study will look at the health characteristics of adults with metabolic dysfunction-associated steatotic liver disease (MASLD) in Kazakhstan.
- Trial name
- NCT07889999
- Where
- 7 sites in Kazakhstan
- Volunteers
- 420 people
- Sponsor
- Kazakh Association of Internal Medicine Specialists
Cataract Congenital, Astigmatism
Toric Intraocular Lens Implantation in Pediatric Cataract
To evaluate the visual and refractive outcomes after an intraocular lens (IOL) implantation in pediatric eyes with cataract and preexisting corneal astigmatism
- Conditions
- Cataract Congenital, Astigmatism, IOL
- Trial name
- TILIPC (NCT06294795)
- Testing
- congenital/pediatric cataract surgery, Non-Toric IOLs, Toric IOLs
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Kazakh Eye Research Institute
Rhegmatogenous Retinal Detachment, Hypotony Ocular
Ocular Hypotony and Refractive Predictability in RRD Surgery
This study evaluates how preoperative ocular hypotony (Goldmann IOP ≤ 7 mmHg) affects refractive predictability, axial length measurements, and visual outcomes in patients undergoing combined phacovitrectomy with silicone oil for…
- Trial name
- HYP-RRD (NCT07283614)
- Testing
- Combined Phacovitrectomy with Intraocular Lens Implantation and Silicone Oil Tamponade, Silicone Oil Removal
- Where
- Kazakhstan
- Volunteers
- 45 people
- Sponsor
- Kazakh Eye Research Institute
Glaucoma
Morphometric Markers of the Effectiveness of Micropulse Cyclophotocoagulation
This prospective study aims to evaluate morphometric markers of treatment response following micropulse transscleral cyclophotocoagulation (MP-CPC) in patients with glaucoma.
- Trial name
- MMEMC (NCT07592923)
- Testing
- MicroPulse transscleral cyclophotocoagulation, Conventional transscleral cyclophotocoagulation
- Where
- Kazakhstan
- Volunteers
- 20 people
- Sponsor
- Kazakh Eye Research Institute
Glaucoma
Tear Interleukin Biomarkers After Glaucoma Treatment
This prospective study aims to evaluate inflammatory biomarkers in tear fluid in patients with glaucoma undergoing micropulse transscleral cyclophotocoagulation (MP-CPC), continuous-wave cyclophotocoagulation (CPC), and…
- Trial name
- TIGT (NCT07592988)
- Testing
- MicroPulse Transscleral Cyclophotocoagulation, Conventional Transscleral Cyclophotocoagulation, Antiglaucoma Surgery
- Where
- Kazakhstan
- Volunteers
- 24 people
- Sponsor
- Kazakh Eye Research Institute
Neonatal Dacryocystitis, Congenital Nasolacrimal Duct Obstruction
Efficacy and Safety of Piclosept in the Complex Treatment of Neonatal Dacryocystitis
This single-center, prospective, randomized, controlled, assessor-blinded study will evaluate the efficacy and safety of Piclosept® ophthalmic solution as an adjunct to standardized lacrimal sac massage in children aged 1 to 12…
- Trial name
- NCT07875517
- Testing
- Picloxidine, Levofloxacin, Standardized lacrimal sac massage
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- Kazakh Eye Research Institute
Opioid Use Disorder
Expanding Medication-Assisted Therapies in Central Asia
Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners, and scaling up opioid agonist therapies (OAT) in this region is the…
- Trial name
- ExMAT CA (NCT05579470)
- Testing
- NIATx
- Where
- 4 sites in United States, Kazakhstan and 2 more
- Volunteers
- 900 people
- Sponsor
- Yale University
Bronchiectasis
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations).
- Trial name
- NCT06872892
- Testing
- BI 1291583
- Where
- 478 sites in United States, Argentina and 44 more
- Volunteers
- 1,755 people
- Sponsor
- Boehringer Ingelheim
Metabolic Dysfunction Associated Steatohepatitis
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
This study is open to adults who are at least 18 years old and have: A confirmed liver disease called non-alcoholic steatohepatitis (NASH) or A confirmed liver disease called metabolic-associated steatohepatitis (MASH) BMI of 27…
- Trial name
- NCT06632457
- Testing
- Survodutide
- Where
- 446 sites in United States, Argentina and 34 more
- Volunteers
- 1,590 people
- Sponsor
- Boehringer Ingelheim
Metabolic Dysfunction Associated Steatohepatitis (MASH), Liver Fibrosis
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
This study is open to adults who are at least 18 years old living with obesity and have: a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic associated steatohepatitis (MASH) and moderate or advanced…
- Trial name
- NCT06632444
- Testing
- Survodutide
- Where
- 531 sites in United States, Argentina and 34 more
- Volunteers
- 1,800 people
- Sponsor
- Boehringer Ingelheim
Carcinoma, Non-Small-Cell Lung
A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer
This randomized, active-controlled, multicenter, open-label, Phase III study is designed to investigate the efficacy and safety of alectinib compared with platinum-based in the adjuvant setting.
- Trial name
- NCT03456076
- Testing
- Alectnib, Cisplatin, Vinorelbine
- Where
- 114 sites in United States, Australia and 25 more
- Volunteers
- 257 people
- Sponsor
- Hoffmann-La Roche
Secondary Immunodeficiency (SID)
A Study of Secondary Immunodeficiencies in Adults With Blood Cancers in Kazakhstan Who Have a Weakened Immune System (K-SIDE Study)
Some people with blood cancers (hematologic malignancies) develop a weakened immune system because of their condition or the medicines used to treat it. This is called a secondary immunodeficiency or SID.
- Trial name
- NCT07868107
- Testing
- No Intervention
- Where
- Kazakhstan
- Volunteers
- 200 people
- Sponsor
- Takeda
Dry Eye Disease (DED)
Evaluation of Ophtholic Ultra for Ocular Surface Protection After Cataract Surgery
Study of the Effectiveness and Safety of Ophtholic Ultra in Preventing and Correcting Ocular Surface Disturbances After Uncomplicated Cataract Surgery This is a single-center, prospective, randomized, controlled, assessor-masked…
- Trial name
- NCT07868965
- Testing
- Ophtholic Ultra, Standard postoperative therapy without lubricating eye drops
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Kazakh Eye Research Institute
Skin Irritation, Healthy Volunteers
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-SAFE-1 (NCT07703969)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Inflammatory Bowel Diseases, Crohn's Disease
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 3 active dose regimens of MORF-057 in adult study participants with moderately to severely active Crohn's…
- Trial name
- GARNET (NCT06226883)
- Testing
- MORF-057
- Where
- 225 sites in United States, Australia and 26 more
- Volunteers
- 385 people
- Sponsor
- Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)
Metastatic Breast Cancer
HER2-positive Metastatic Breast Cancer in Kazakhstan
Planned study population consists of approximately 240 adult patients with HER2-positive mBC receiving anti-HER2 therapy in 12 oncological centers (in each center it is expected to recruit about 20 patients) in different regions…
- Trial name
- NCT07593196
- Where
- 12 sites in Kazakhstan
- Volunteers
- 240 people
- Sponsor
- AstraZeneca
Drug Use, HIV
Digital PrEP Micro-Intervention for PWUD in Kazakhstan
This study is a mixed-methods pilot designed to evaluate the feasibility, acceptability, and appropriateness of a brief digital micro-intervention aimed at reducing stigma-related barriers to pre-exposure prophylaxis (PrEP)…
- Trial name
- NCT07508137
- Testing
- Dgital micro-intervention
- Where
- Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Yale University
Healthy Volunteers, Leukocyte Fluorescence Profiling in Whole Blood
AI-Assisted Fluorescence Microscopy of Leukocytes in Fresh Whole Blood
The goal of this observational study is to learn whether a microscope-based method with artificial intelligence (AI) can detect and classify white blood cells in fresh, unstained blood and measure the color of fluorescent light…
- Trial name
- NAO-WBC-YOLO-0 (NCT07862231)
- Testing
- AI-Assisted bright-field and fluorescence microscopy, Romanowsky-Giemsa stained blood smear (reference)
- Where
- Kazakhstan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- MIPO Clinic