Clinical trials: in Kazakhstan
Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
Researchers are looking for a better way to treat women with, or at high risk for developing hormone-receptor positive breast cancer, who have vasomotor symptoms (VMS), a condition of having hot flashes caused by anti-cancer…
- Trial name
- OASIS-4 (NCT05587296)
- Testing
- Elinzanetant (BAY3427080)
- Where
- 102 sites in Austria, Belgium and 14 more
- Volunteers
- 474 people
- Sponsor
- Bayer
Rhinitis Allergic
Phase I Study of PollenVax in Patients With Mugwort Pollen-Induced Allergic Rhinitis
This Phase I randomized, double-blind, placebo-controlled clinical trial evaluates the safety and tolerability of PollenVax, a novel recombinant allergen-based vaccine for allergen-specific immunotherapy, in adult patients with…
- Trial name
- NCT07317960
- Testing
- PollenVax
- Where
- Kazakhstan
- Volunteers
- 30 people
- Sponsor
- Kazakh National Agrarian University
Rhinitis Allergic
PollenVax Subcutaneous Immunotherapy for Mugwort Pollen-Induced Allergic Rhinitis
This study evaluates the effectiveness and safety of PollenVax, a subcutaneous allergen immunotherapy (SCIT) drug developed for the treatment of allergic rhinitis and asthma caused by mugwort (Artemisia vulgaris) pollen.
- Trial name
- NCT07563439
- Testing
- Recombinant Artemisia vulgaris allergen Art v 1 with Montanide ISA-51 adjuvant
- Where
- Kazakhstan
- Volunteers
- 138 people
- Sponsor
- Kazakh National Agrarian University
Monitoring, Immunologic
Immunosurveillance for Metastatic Colorectal Cancer
The goal of this clinical trial is to learn if adding sodium nucleinate to FOLFOX chemotherapy helps people with metastatic colorectal cancer (colon or rectal cancer that has spread).
- Trial name
- ISMCC (NCT06509880)
- Testing
- Adenorine, FOLFOX regimen
- Where
- Kazakhstan
- Volunteers
- 187 people
- Sponsor
- MIPO Clinic
Loss-Related Depression, Interpersonal Loss
Painhunting Therapy for Event Related Depression
This pilot randomized controlled trial evaluates the efficacy of Painhunting therapy, a brief structured psychotherapy, for adults with depressive symptoms following adverse life events in Kazakhstan.
- Conditions
- Loss-Related Depression, Interpersonal Loss, Complicated Grief
- Trial name
- PH-GRIEF (NCT07490691)
- Testing
- Painhunting Therapy
- Where
- Kazakhstan
- Volunteers
- 84 people
- Sponsor
- Painhunting LLP
Worsening Heart Failure, Congestion
SURE-HF: Urinary Sodium-Guided Diuretic Therapy in Heart Failure
The SURE-HF trial is a pragmatic, multicentre, randomized controlled study evaluating natriuresis-guided optimization of intravenous loop diuretic therapy in patients hospitalized with worsening heart failure (WHF).
- Conditions
- Worsening Heart Failure, Congestion, Heart Failure
- Trial name
- SURE-HF (NCT07631780)
- Testing
- Furosemide, Horiba LAQUAtwin B-722
- Where
- Kazakhstan
- Volunteers
- 260 people
- Sponsor
- Nurgul Ablakimova
Glioblastoma Multiforme, Diffuse Midline Glioma, H3 K27M-Mutant
Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status)
The objective of this pilot study is to evaluate the efficacy of adding S-Gboxin to standard RT/TMZ treatment protocols in patients with glioblastoma multiforme (GBM) or midline glioma (DMG), regardless of their mutation status
- Conditions
- Glioblastoma Multiforme, Diffuse Midline Glioma, H3 K27M-Mutant, Gliosarcoma, Giant Cell Glioblastoma
- Trial name
- NCT06806228
- Testing
- S-Gboxin
- Where
- 3 sites in Georgia, Kazakhstan and 1 more
- Volunteers
- 10 people
- Sponsor
- Petrov, Andrey
Macular Holes
Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques
This study compares ten modern vitreoretinal surgical techniques for full-thickness macular hole repair. Participants will be randomly assigned to one of the surgical approaches during pars plana vitrectomy, using stratified…
- Trial name
- FTMH-10 (NCT07606404)
- Testing
- Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Eye Research Institute
Gymnastics Injury, Motor Learning, Balance
Effects of a 6-Month Gymnastics Program on Somatotype and Motor Performance in Children Across Age Groups
The study adopted a controlled 6-month study design to compare the gymnastics group (n= 56) with the inactive control group (n=88).
- Trial name
- Motor Progress (NCT07614334)
- Testing
- Gymnastic Exercise
- Where
- Kazakhstan
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Hodgkin Lymphoma
PD-1 Inhibitors Maintenance for cHL Post-autoHCT
This phase II study is designed to determine the clinical efficacy of PD-1 inhibitors, administered as maintenance therapy after autologous stem cell transplant (autoHCT), in patients with relapsed or refractory (R/R) classical…
- Trial name
- NCT06812858
- Testing
- Nivolumab, Pembrolizumab
- Where
- 4 sites in Kazakhstan, Russia
- Volunteers
- 83 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Obesity, Morbid
The FundoRingOAGB Versus Non-wrapping (Non-banded) Standard Method of Laparoscopic One Anastomosis Gastric Bypass
Currently, one anastomosis gastric bypass (OAGB) or mini-gastric bypass (MGB) is a common bariatric procedure for treating obesity. Weight gain after surgery is a big problem in bariatric practice.
- Trial name
- FundoRingMGB (NCT04834635)
- Testing
- FundoRingOAGB, OAGB
- Where
- Kazakhstan
- Volunteers
- 1,000 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Myocardial Ischemia, Surgery
Ischaemic PReconditioning In Non Cardiac surgEry
Several randomized trials suggested a cardioprotective beneficial effect (eg reduction in cardiac troponin release) of remote ischemic preconditioning in cardiac surgery.
- Trial name
- PRINCE (NCT02427867)
- Testing
- Remote ischemic preconditioning, no ischemic preconditioning
- Where
- 26 sites in China, Colombia and 7 more
- Volunteers
- 1,217 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Respiratory Distress Syndrome (ARDS)
Pirfenidone to Prevent Fibrosis in Ards.
Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury and a major cause of Intensive Care Unit (ICU) admission worldwide.
- Trial name
- PIONEER (NCT05075161)
- Testing
- Pirfenidone
- Where
- 17 sites in Italy, Kazakhstan
- Volunteers
- 130 people
- Sponsor
- Università Vita-Salute San Raffaele
Type 2 Diabetes Mellitus (T2DM), Obesity & Overweight
The Transit Bipartition With the Use of a Metallic Anastomosis Clip and Circular Fundocorporeal Gastroplication
This study evaluates a new surgical device - the Metallic Anastomotic Clip (MAC) - for performing a laparoscopic bypass gastroenteroanastomosis with entero-enteric anastomosis (transit bipartition / "dual-path" procedure) in…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Obesity & Overweight, Marginal Ulcer (Peptic) or Erosion, Leakage, Anastomotic
- Trial name
- MACBIPARTFCG (NCT07495020)
- Testing
- Laparoscopic transit bipartition with Metallic Anastomotic Clip and Circular Fundocorporeal Gastroplication, Laparoscopic transit bipartition (gastroenteroanastomosis and entero-enteric anastomosis) use the Metallic Anastomotic Clip and with sleeve gastrectomy, laparoscopic duodenal transit bipartition using the Metallic Anastomotic Clip with circular fundocorporeal gastroplication without gastrectomy
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Obesity & Overweight
Effect of a High-Protein Diet With Meal Replacements on Weight Loss
The goal of this clinical trial is to learn if a structured high-protein diet with meal replacements can help with weight loss in adults with overweight or obesity.
- Trial name
- NCT07547722
- Testing
- Meal Replacement and Dietary Supplementation, Calorie-Restricted Diet
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Kazakh Academy of Nutrition
Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count <50,000/μL).
- Conditions
- Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
- Trial name
- PACIFICA (NCT03165734)
- Testing
- Pacritinib, Physician's Choice medications
- Where
- 207 sites in United States, Australia and 22 more
- Volunteers
- 407 people
- Sponsor
- Swedish Orphan Biovitrum
Erectile Dysfunction
A Prospective Comparative Study of Autologous Bone Marrow-Derived and Adipose Tissue-Derived Mesenchymal Stem Cells Versus Platelet-Rich Plasma and Standard Therapy in Patients With Organic Erectile Dysfunction
Erectile dysfunction (ED) is a common condition characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual activity.
- Trial name
- NCT07544537
- Testing
- Autologous Bone marrow-derived Mesenchymal Stem Cells (BMSC), Autologous Platelet-Rich Plasma (4 mL), Autologous Platelet-Rich Plasma (6 mL)
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- National Scientific Medical Center, Kazakhstan
Uveitic Macular Edema
Vamikibart in Participants With Uveitic Macular Edema
This study will assess the efficacy and safety of vamikibart in participants with uveitic macular edema.
- Trial name
- Sandcat (NCT05642325)
- Testing
- Vamikibart
- Where
- 94 sites in United States, Argentina and 17 more
- Volunteers
- 256 people
- Sponsor
- Hoffmann-La Roche
Vibration, Respiratory Complications
The Course of Acute Respiratory Failure in Geriatric Patients With Hip Fracture Using Different Modes of a Vibroacoustic Device for the Lungs
A medical professional trained in the procedure and use of the device will conduct the vibroacoustic therapy session. He will also take blood samples.
- Trial name
- NCT07517497
- Testing
- Vibrolung
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Astana Medical University
Pancreatogenic Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM)
Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes
The goal of this observational study is to better understand how the pancreas works in adults with type 2 diabetes. The study focuses on both hormone production (endocrine function) and digestive function (exocrine function) of…
- Conditions
- Pancreatogenic Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Exocrine Pancreatic Insufficiency (EPI)
- Trial name
- T3cDM-AKT (NCT07512934)
- Where
- Kazakhstan
- Volunteers
- 310 people
- Sponsor
- West Kazakhstan Marat Ospanov Medical University