Clinical trials: in Kenya
Sickle Cell Disease
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
The purpose of this study is to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of osivelotor.
- Trial name
- NCT05431088
- Testing
- Osivelotor
- Where
- 80 sites in United States, Brazil and 5 more
- Volunteers
- 389 people
- Sponsor
- Pfizer
Human Papillomavirus Infection
Evaluating Clearance of High-Risk HPV and Safety After Administration of ABI-2280 Vaginal Inserts
This is a blinded study to assess safety, tolerability, and efficacy of ABI-2280 vaginal inserts in participants diagnosed with persistent cervical hrHPV infection.
- Trial name
- NCT06491446
- Testing
- ABI-2280
- Where
- 24 sites in Australia, Kenya and 2 more
- Volunteers
- 141 people
- Sponsor
- Antiva Biosciences
Malaria in Pregnancy, Pregnancy Related
MiMBa Pregnancy Registry
The MiMBa (Malaria in Mothers and Babies) Pregnancy Registry aims to generate robust evidence on the safety of a range of antimalarials when used in pregnancy, particularly in the first trimester.
- Conditions
- Malaria in Pregnancy, Pregnancy Related, Congenital Anomaly
- Trial name
- NCT04825782
- Where
- 2 sites in Burkina Faso, Kenya
- Volunteers
- 15,391 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Chronic Obstructive Pulmonary Disease
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to assess the long-term safety and to explore the efficacy of astegolimab in participants with chronic obstructive pulmonary disease (COPD) who have completed the 52-week placebo-controlled treatment…
- Trial name
- NCT05878769
- Testing
- Astegolimab
- Where
- 481 sites in United States, Argentina and 38 more
- Volunteers
- 2,000 people
- Sponsor
- Hoffmann-La Roche
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
BPH Global Registry
Benign prostatic hyperplasia (BPH) is one of the most common performed surgical procedures in urology. Over the past few decades there have been an increasing development of newer surgical treatment options.
- Trial name
- NCT05543200
- Where
- 30 sites in United States, Canada and 19 more
- Volunteers
- 7,500 people
- Sponsor
- Société Internationale d'Urologie
Cervical Cancer, HPV
mSaada: A Mobile Health Tool
In the R21 phase of this project, investigators will: (1) work with key stakeholders and local and international developers to finalize the mSaada platform, building on the existing prototype to add patient and specimen tracking…
- Conditions
- Cervical Cancer, HPV, mHealth
- Trial name
- NCT05848557
- Testing
- mSaada
- Where
- Kenya
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Hiv, Transmission Vertical
Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV
Mentor Mothers (MMs) are peer supporters who help pregnant and postpartum women living with HIV (WLHIV) as they receive prevention of mother-to-child transmission of HIV (PMTCT) services in resource-limited settings like Kenya.
- Conditions
- Hiv, Transmission Vertical, Viremia, Adherence, Treatment
- Trial name
- PIE-eMMs (NCT06999928)
- Testing
- Enhanced Mentor Mother Strategy
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
Intimate Partner Violence (IPV), Climate Change
Smartphone Climate Adaptation and IPV Intervention for Women in Informal Settlements in Kenya
This study is testing a smartphone-delivered program to help women living in informal settlements in Kenya manage intimate partner violence (IPV) and stress related to extreme weather events.
- Conditions
- Intimate Partner Violence (IPV), Climate Change, Stress (Psychology)
- Trial name
- NCT07492368
- Testing
- Event-Triggered WINGS-Based EMI, Single-Session Mobile WINGS
- Where
- Kenya
- Volunteers
- 272 people
- Sponsor
- Africa Institute of Mental and Brain Health (AFRIMEB)
Shigellosis
Study to Expand Safety and Immunogenicity Data With Shigella Bioconjugate Vaccine (Shigella4V2) in 9-month-old Infants.
In this study, the second-generation tetravalent bioconjugate candidate vaccine Shigella4V2 will be tested to confirm data on its safety and immunogenicity in infants and to identify the best dose of Shigella4V2 in 9-month-old…
- Trial name
- S4V02 (NCT06523231)
- Testing
- Shigella4V2, MenACWY
- Where
- Kenya
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
IPV, HIV
Tu'Washindi RCT: Adolescent Girls in Kenya Taking Control of Their Health
This study will test the effectiveness of a youth-designed multilevel intervention, Tu'Washindi, to increase PrEP use and reduce intimate partner violence (IPV) among Kenyan AGYW and to identify implementation challenges and…
- Conditions
- IPV, HIV, PrEP
- Trial name
- NCT05599581
- Testing
- Tu'Washindi
- Where
- 2 sites in Kenya
- Volunteers
- 1,562 people, healthy volunteers welcome
- Sponsor
- RTI International
Malaria, Severe Malaria
Monoclonal Antibodies in Children With Severe Anaemia or Severe Malaria to Prevent Malaria After Hospital Discharge
Background and rationale: Hospitalised children with severe anaemia remain at high risk of dying or requiring hospital readmission for at least 6 months after discharge.
- Conditions
- Malaria, Severe Malaria, Severe Anaemia, Post Discharge
- Trial name
- L9LS-pd (NCT07082205)
- Testing
- Antimalarial monoclonal antibodies, Dihydroartemisinin - Piperaquine (DP)
- Where
- 2 sites in Kenya
- Volunteers
- 398 people
- Sponsor
- Liverpool School of Tropical Medicine
Autism
Expanding Autism Diagnostic Biomarkers to Kenya
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures.
- Trial name
- KinleyET (NCT06685822)
- Testing
- Eyelink Portable Duo
- Where
- Kenya
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV
PrEP (Pre-exposure Prophylaxis) Stigma and Women Ethnodrama Pilot Phase
The investigators will pilot test an ethnodrama intervention designed to transform community member beliefs about and foster support of young cisgender women (YCW) using Pre-exposure Prophylaxis (PrEP).
- Trial name
- NCT07225894
- Testing
- Ethnodrama Intervention
- Where
- Kenya
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Duke University
Undernutrition, Healthy
Iron Absorption From Lipid-Based Nutrient Supplements
The overall objective of this study is to determine dietary iron absorption from lipid-based nutrient supplements (LNS) in apparently healthy and undernourished children.
- Trial name
- NCT06870201
- Testing
- Lipid-Based Nutrient Supplement
- Where
- Kenya
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Violence, Domestic, Violence, Sexual
Dissemination and Implementation of a Web-based Relationship Safety App, myPlanKenya, for Women at Risk for Intimate Partner Violence in Nairobi, Kenya
This effectiveness-implementation hybrid-3 study evaluates dissemination, implementation, and effectiveness of myPlanKenya. myPlanKenya will be disseminated through formal and informal sectors.
- Conditions
- Violence, Domestic, Violence, Sexual, Violence, Gender-Based
- Trial name
- myPlanKenya (NCT05609786)
- Testing
- Personalized safety planning tool
- Where
- Kenya
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV Infections
Long-term Follow-up of Long-acting Cabotegravir (CAB LA) for PrEP (Pre-exposure Prophylaxis) in Participants at Risk of Acquiring HIV (Human Immunodeficiency Virus)
The purpose of this study is long-term evaluation of long-acting injectable cabotegravir (CAB LA) for HIV pre-exposure prophylaxis (PrEP) in eligible participants who have completed DAIDS (Division of AIDS) sponsored studies HPTN…
- Trial name
- PALISADE (NCT06134362)
- Testing
- CAB LA
- Where
- 33 sites in Argentina, Botswana and 10 more
- Volunteers
- 2,996 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV, Tobacco Use
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, Kenya
People with HIV (PWH) smoke tobacco cigarettes and drink alcohol at higher rates than the general population, both in the US and internationally, including low- and middle-income countries.
- Conditions
- HIV, Tobacco Use, Alcohol Use Disorder
- Trial name
- NCT06790342
- Testing
- Cystine, Positively Smoke Free, Standard of Care
- Where
- 2 sites in Kenya
- Volunteers
- 300 people
- Sponsor
- University of Chicago
Epilepsy
Bridging the Treatment Gap by Expanding Access to Care for People With Epilepsy in Kenya (BEACON)
This cluster randomized trial aims to learn about the effectiveness of task-sharing supported by an epilepsy medical records system (EMRS) (hereafter referred to as BEACON) with patient-tracking data in improving treatment…
- Trial name
- BEACON (NCT06623994)
- Testing
- Task sharing with Epilepsy Medical Record Systems
- Where
- Kenya
- Volunteers
- 650 people
- Sponsor
- University of Virginia
HIV
PrEP (Pre-exposure Prophylaxis) Stigma and Women Ethnodrama Pre-Test Phase
The investigators will develop and pre-test an ethnodrama intervention designed to transform community member beliefs about and foster support of young cisgender women (YCW) using PrEP.
- Trial name
- NCT06501885
- Testing
- Ethnodrama Intervention
- Where
- Kenya
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV Infections
Safety and Virologic Effect of a Human Monoclonal Antibody (VRC01) Administered Intravenously to Adults During Early Acute HIV Infection
This study will evaluate the safety and virologic effect of an experimental human monoclonal antibody (mAb), VRC-HIVMAB060-00-AB (VRC01), alone or in combination with antiretroviral therapy (ART), in adults during early acute HIV…
- Trial name
- NCT02591420
- Testing
- VRC01, Antiretroviral therapy (ART) (regimen will vary within countries and by patient)
- Where
- 5 sites in Kenya, Tanzania and 2 more
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)