Clinical trials: in Kyrgyzstan
Achalasia Cardia, GERD-HRQL Scale
Compare the Quality of Life of Patients With Achalasia Cardia (AC) After Laparoscopic and Open Esophagocardiomyotomy.
Study design. A randomized, prospective design study with retrospective data addition was conducted at two medical institutions between December 2017 and July 2025.
- Conditions
- Achalasia Cardia, GERD-HRQL Scale, Eckardt Scale
- Trial name
- GERD-HRQL (NCT07177222)
- Testing
- laparoscopic esophagocardiomyotomy, open surgery
- Where
- Kyrgyzstan
- Volunteers
- 38 people
- Sponsor
- Osh State University
High Altitude Effects, High Altitude Hypoxia
HighCycle Study: Acetazolamide, High Altitude and Plasma Volume
Each year, millions of people living at low altitude (< 1,000 m) travel to high altitude (≥ 2,500 m) for work, tourism, or sports activities.
- Conditions
- High Altitude Effects, High Altitude Hypoxia, Acute Mountain Sickness (AMS), Plasma Volume
- Trial name
- NCT07118462
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Varicose Veins
Vacuum-assisted Laser Ablation (VALA) for Treatment of Large Saphenous Veins
Endovenous thermal ablation (EVTA), including radiofrequency ablation (RFA) and endovenous laser ablation (EVLA), is considered the main method for the treatment of symptomatic truncal vein reflux.
- Trial name
- NCT06971068
- Testing
- Procedure: EVLA, Procedure: VALA
- Where
- 9 sites in Belarus, Kyrgyzstan and 2 more
- Volunteers
- 184 people
- Sponsor
- Center Of Phlebology
Opioid-use Disorder, HIV Infections
Project MATLINK: Development and Evaluation of a Screening, Brief Intervention, & Referral to Treatment (SBIRT) Program for Opioid Dependent Prisoners and Probationers Transitioning to the Community
The purpose of this study is to evaluate the efficacy a Screening, Brief Intervention, and Referral to Treatment (SBIRT) program for linking opioid dependent individuals currently incarcerated or in probation in Moldova…
- Conditions
- Opioid-use Disorder, HIV Infections, Tuberculosis, Hepatitis C
- Trial name
- MATLINK (NCT04947475)
- Testing
- SBIRT
- Where
- 3 sites in Kyrgyzstan, Moldova and 1 more
- Volunteers
- 835 people
- Sponsor
- Yale University
HIV
Exploring the Feasibility of a Peer-Driven Intervention to Improve HIV Prevention Among Prisoners Who Inject Drugs
The purpose of this study is to develop, conduct, and assess the feasibility of a) a pilot peer-driven intervention (PDI) to reduce HIV risk and increase the uptake of primary HIV prevention services (i.e.
- Trial name
- NCT05786027
- Testing
- PDI
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- Yale University
Cardiovascular Diseases, Risk Factor, Cardiovascular
Prospective Urban Rural Epidemiology Study
To examine the impact of health determinants at the individual (e.g. health related behaviors) and societal level (e.g. environmental factors, health related policy, quality of health systems) on health outcomes (e.g.
- Conditions
- Cardiovascular Diseases, Risk Factor, Cardiovascular, Health Behavior, Environmental Exposure
- Trial name
- PURE (NCT03225586)
- Where
- 34 sites in Argentina, Bangladesh and 23 more
- Volunteers
- 200,000 people
- Sponsor
- Population Health Research Institute
Antibiotic Resistance, Respiratory Tract Infections
CRP for Respiratory Diagnosis in Kyrgyz Pediatric Practice
Rationale: Overuse of antibiotics globally is leading to increasing rates of antibiotic resistance and may lead to a 'post-antibiotic' era.
- Conditions
- Antibiotic Resistance, Respiratory Tract Infections, Pediatric Infectious Disease, CRP
- Trial name
- COORDINATE (NCT05195866)
- Testing
- CRP POCT (C-reactive protein point of care test)
- Where
- Kyrgyzstan
- Volunteers
- 1,204 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Altitude Hypoxia
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude.
Randomized, placebo controlled trial evaluating efficacy of acetazolamide on right heart function at rest in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03540914
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease, Altitude Sickness
Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate efficacy of acetazolamide in preventing overt altitude-related adverse health effects (ARAHE) in lowlanders with chronic obstructive pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Altitude Sickness, Altitude Hypoxia
- Trial name
- NCT04913389
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Early Signs of Altitude Illness in Patients With COPD
This study evaluates whether structured self-monitoring (SSM) by a symptom checklist in combination with a pulse oximeter worn at the wrist allows lowlanders with COPD to accurately identify whether or not they will experience an…
- Trial name
- NCT03957759
- Testing
- Structured self-monitoring during an altitude ascent and stay at high altitude
- Where
- Kyrgyzstan
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Altitude Hypoxia
Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating efficacy of acetazolamide on right heart function during exercise in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03537924
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Right Heart Function, Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the effect of acetazolamide on right heart function at rest in lowlanders with chronic obstructive pulmonary disease (COPD) traveling to high…
- Conditions
- Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness
- Trial name
- NCT04915365
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Altitude Hypoxia
Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on lung water content by ultrasound in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03539367
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Rheumatic Heart Disease
INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority
This program is a comprehensive evaluation of rheumatic valvular heart disease (RVHD), Atrial fibrillation (AF)/flutter and stroke.
- Trial name
- INVICTUS-VKA (NCT02832544)
- Testing
- Rivaroxaban (20 mg), Vitamin K antagonists (VKA)
- Where
- 139 sites in Botswana, Brazil and 23 more
- Volunteers
- 4,565 people
- Sponsor
- Population Health Research Institute
Hypoxia Altitude Simulation Test, High Altitude
Hypoxia-altitude Testing to Predict Altitude Related Adverse Health Effects in Chronic Obstructive Pulmonary Disease (COPD) Patients
The predictive value of the hypoxia altitude simulation test (HAST) or other baseline values to predict altitude-related adverse health effects (ARAHE) is not established.
- Trial name
- NCT04915378
- Testing
- hypoxia altitude simulation test (HAST) at 760m, High Altitude (3100m)
- Where
- Kyrgyzstan
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Tuberculosis, Multidrug-Resistant
Expand New Drugs for TB [endTB]
This observational study will examine the safety and efficacy of bedaquiline and delamanid used (individually, not together) in routine, multidrug regimens for treatment of MDR-TB.
- Trial name
- NCT03259269
- Testing
- This is a non-intervention observational study
- Where
- 16 sites in Armenia, Bangladesh and 12 more
- Volunteers
- 2,804 people
- Sponsor
- Partners in Health
Tuberculosis, MDR
FS-1 Drug for Treatment of Multiple Drug-resistant Tuberculosis
Drug-resistant tuberculosis is becoming a major problem for the whole humanity, and development of new Anti-TB drugs is of great importance.
- Trial name
- FS-1 (NCT02607449)
- Testing
- FS-1
- Where
- 6 sites in Kazakhstan, Kyrgyzstan
- Volunteers
- 344 people
- Sponsor
- Scientific Center for Anti-infectious Drugs, Kazakhstan
CHF
Effects of Remote Monitoring of Patients With Heart Failure Based on Smartphone Application
CHF is a most wild-spread and prognostically poor outcome most of cardiovascular and other disease. Despite of significant progress in treatment of CHF for the last years, death from this pathology stayed very high, reaching 60%…
- Trial name
- ERICA-HF (NCT04591964)
- Testing
- mobile application "M-Cardio" based on android
- Where
- Kyrgyzstan
- Volunteers
- 300 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Low Back Pain, Recurrent
Treatment and Companion Diagnostics of Lower Back Pain Using SCENAR and Passive Medical Radiometry (MWR)
Evaluation of the effectiveness of treatment of nonspecific pain in the lower back (LBP) is currently largely based on the patient's subjective feelings.
- Trial name
- SCENAR/MWR (NCT05223946)
- Testing
- Microwave Radiometry, SCENAR-CHENS-01, Traditional Combination Therapy
- Where
- 2 sites in Kyrgyzstan
- Volunteers
- 55 people
- Sponsor
- Kyrgyz State Medical Academy
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Lung Water Content by Ultrasound in Patients With Respiratory Disease at Altitude
This trial will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on lung water content by ultrasound at acute altitude exposure in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT03540901
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 112 people
- Sponsor
- University of Zurich