Clinical trials: active, in Laos
Scabies; Itch, Scabies
Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study)
This is an open label prospective pharmacokinetic single arm study in Laos PDR. This study will be embedded within a cluster-randomized controlled trial of interventions to address childhood undernutrition (SUANHOAM Trial…
- Trial name
- ITCHY (NCT05500326)
- Testing
- Ivermectin Tablets
- Where
- 5 sites in Laos
- Volunteers
- 120 people
- Sponsor
- Murdoch Childrens Research Institute
Infectious Disease, Therapeutics
Rickettsia Clearance Study
Murine typhus is a disease caused by Rickettisa typhi, an obligate intracellular bacterium transmitted by rodent fleas. The disease has a worldwide distribution; however the true burden is unknown, related to its non-specific…
- Trial name
- RiCS (NCT05972772)
- Testing
- Doxycyclin, Azithromycin
- Where
- 2 sites in Laos
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit
Plasmodium Vivax Malaria
Southeast Asia Dose Optimization of Tafenoquine
Tafenoquine was recently approved by regulatory authorities in the USA and Australia. Tafenoquine is an alternative radical curative treatment to primaquine acting against the dormant liver stage of Plasmodium vivax (the…
- Trial name
- SEADOT (NCT04704999)
- Testing
- Tafenoquine, Chloroquine, Artemether 20 mg-Lumefantrine 120 mg
- Where
- 6 sites in Cambodia, Indonesia and 3 more
- Volunteers
- 820 people
- Sponsor
- University of Oxford
Melioidosis
Environment, Pathogens, and Host Interactions in Melioidosis
This is a longitudinal, multicentre observational study conducted across three established microbiology units integrated within hospital and community health systems in Thailand, Lao PDR, and Cambodia.
- Trial name
- DeEPH (NCT07345910)
- Where
- 3 sites in Cambodia, Laos and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Opisthorchis Viverrini
Efficacy and Safety of Ascending Doses of Arpraziquantel in Children Infected With Opisthorchis Viverrini
This study aims to assess the efficacy, safety and acceptability of ascending doses of arpraziquantel in children infected with Opisthorchis viverrini.
- Trial name
- ADORA-VI (NCT07262814)
- Testing
- Apraziquantel
- Where
- Laos
- Volunteers
- 125 people
- Sponsor
- Jennifer Keiser
Smoking Cessation, HIV
Smoking Cessation Program for Lao People With HIV
Tobacco use remains the leading modifiable risk factor for preventing cancer globally, particularly among people with HIV (PWH). In Laos, 61-80% of male PWH and 3-10% of female PWH smoke cigarettes.
- Trial name
- I-STOP (NCT07014605)
- Testing
- Smoking Cessation Self Help Guide, Smartphone-delivered Automated Messaging
- Where
- 2 sites in Laos
- Volunteers
- 1,200 people
- Sponsor
- University of Oklahoma
Influenza, Influenza, Human
A Phase 2 Trial Comparing Antiviral Treatments in Early Symptomatic Influenza
This trial will use a previously validated platform, to quantitatively assess antiviral effects in low-risk patients with high viral burdens and uncomplicated influenza, to determine in-vivo antiviral activity.
- Trial name
- AD ASTRA (NCT05648448)
- Testing
- Oseltamivir, Favipiravir, Zanamivir
- Where
- 4 sites in Brazil, Laos and 2 more
- Volunteers
- 3,000 people
- Sponsor
- University of Oxford
COVID-19
Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)
The trial will develop and validate a platform for quantitative assessment of antiviral effects in low-risk patients with high viral burdens and uncomplicated COVID-19 to determine in-vivo antiviral activity.
- Trial name
- PLATCOV (NCT05041907)
- Testing
- Nirmatrelvir/ritonavir (e.g. PAXLOVID™), Nitazoxanide, Molnupiravir and nirmatrelvir/ritonavir (e.g. PAXLOVID™)
- Where
- 7 sites in Brazil, Laos and 3 more
- Volunteers
- 3,800 people
- Sponsor
- University of Oxford
Hypoxemia, Morality
Health Systems and Policy Contexts of Medical Oxygen
This is a mixed-methods program evaluation from a health systems and policy perspective, involving (i) stakeholder analysis, (ii) policy-implementation gap analysis, and (iii) comparative country case studies.
- Conditions
- Hypoxemia, Morality, Pneumonia
- Trial name
- MOXY-HSP (NCT06169514)
- Testing
- No intervention
- Where
- 6 sites in Cambodia, Laos and 4 more
- Volunteers
- 1 people
- Sponsor
- Murdoch Childrens Research Institute
Acute Febrile Illness
Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia
This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged >28 days residing in rural areas in Laos, Myanmar, Thailand, the…
- Trial name
- SEACTN-WP-B (NCT04629053)
- Where
- 4 sites in Bangladesh, Laos and 1 more
- Volunteers
- 7,200 people
- Sponsor
- University of Oxford
Cigarette Smoking
Mobile Health Technology for Personalized Tobacco Cessation Support in Laos
In Lao People's Democratic Republic (Lao PDR), 51% of adult men and 7% of adult women smoke tobacco. The development and evaluation of sustainable tobacco cessation interventions suitable for widespread adoption in nations such…
- Trial name
- SupportLaos (NCT05233228)
- Testing
- Nicotine patch, Self-help materials (to support smoking cessation), Smartphone-based automated treatment for smoking cessation
- Where
- 2 sites in Laos
- Volunteers
- 500 people
- Sponsor
- University of Oklahoma
Respiratory Syncytial Virus, Respiratory Syncytial Virus, Human
Assessing Antiviral Treatments in Early Symptomatic RSV
This trial will use a previously validated platform, to quantitatively assess antiviral effects in low-risk patients with high viral burdens and uncomplicated Respiratory Syncytial Virus (RSV), to determine in-vivo antiviral…
- Trial name
- ARSYNAL-FC (NCT06488300)
- Testing
- Ribavirin, Molnupiravir, Favipiravir
- Where
- 2 sites in Laos, Thailand
- Volunteers
- 1,000 people
- Sponsor
- University of Oxford
Hepatitis B, Pregnancy
Antiviral Prophylaxis and Infant Vaccination to Prevent Perinatal Hepatitis B Infection
Most new hepatitis B virus (HBV) infections are acquired perinatally. In this study, pregnant women with HBsAg and HBeAg will receive tenofovir disoproxil fumarate during the last trimester of pregnancy and for two months…
- Trial name
- NCT03343431
- Testing
- Anti-HBV antiviral prophylaxis
- Where
- 20 sites in Laos, Thailand
- Volunteers
- 504 people
- Sponsor
- Institut de Recherche pour le Developpement
Healthy, Adolescents
Integration to Improve Adolescent Health and HPV Vaccination in Laos
The goal of this study is to find out if adding HPV vaccination to adolescent health services works to increase HPV vaccine uptake in 10-13-year-old girls in Laos.
- Conditions
- Healthy, Adolescents, Integrated, Community-Health Systems, HPV Vaccines
- Trial name
- NCT06650956
- Testing
- Integrated HPV and SRH Service Package, Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant
- Where
- Laos
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Health Poverty Action
Pregnant Women, Lactating Mother
Can Village Health Volunteers/Workers Working As Male-Female Pairs Improve the Use of Postnatal Care Services in the Lao People's Democratic Republic
The study aims to assess the effectiveness of male-female VHV/Ws working in pairs on women's uptake of second PNC visits in rural Sepone, Lao PDR.
- Trial name
- NCT06654505
- Testing
- Paired Community Health Workers
- Where
- Laos
- Volunteers
- 302 people
- Sponsor
- University of the Ryukyus