Clinical trials: open to volunteers, in Lithuania
Hematologic Malignancy
Early Detection and Screening of Hematological Malignancies - SANGUINE
This is a multicenter, open-label, non-interventional controlled study to identify and characterize the epigenetic signatures for a set of hematological malignancies: Multiple myeloma (MM), pre-MM conditions [smoldering MM (SMM)…
- Trial name
- SANGUINE (NCT05735704)
- Testing
- Blood sampling for HemaChip screening/diagnostic testing
- Where
- 4 sites in Czechia, Greece and 2 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- JaxBio Ltd
C3 Glomerulopathy (C3G), Healthy Adult Participants
A Clinical Trial to Test the Safety, Tolerability, and How the Body Processes CPV-104 in Healthy People and Patients With C3-Glomerulopathy
This study is the first time the new medicine CPV-104 is being tested in people. CPV-104 is designed to regulate the complement system, which can be overactive in diseases such as C3 glomerulopathy (C3G), an ultra-rare kidney…
- Trial name
- Essential One (NCT07483827)
- Testing
- CPV-104
- Where
- 17 sites in Austria, Belgium and 10 more
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- eleva GmbH
Ovarian Cancer
Innovative Ovarian Cancer Biomarker Assays
Ovarian cancer is often diagnosed at a later stage because early symptoms can be mild or non-specific. Earlier detection of ovarian cancer could improve treatment options and outcomes.
- Trial name
- DISARM CSB (NCT07693894)
- Testing
- Investigational ovarian cancer biomarker assays
- Where
- 7 sites in Czechia, Greece and 3 more
- Volunteers
- 2,080 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Ovarian Cancer
CanRisk-Based Ovarian Cancer Risk Assessment Versus Standard Practice (DISARM CSA)
The purpose of this study is to improve how the risk of developing ovarian cancer is assessed in people who may be at increased risk of ovarian cancer due to their family history or genetic background.
- Trial name
- DISARM CSA (NCT07809659)
- Testing
- CanRisk, Standard clinical risk assessment
- Where
- 6 sites in Czechia, Greece and 2 more
- Volunteers
- 2,130 people, healthy volunteers welcome
- Sponsor
- Instituto Portugues Oncologia de Lisboa Francisco Gentil
Dental Implant Macrodesign, Dental Implant Surface Treatment
Effect of Implant Macro-Design and Surface Treatment on Insertion Torque and Early Implant Stability Quotient (ISQ)
This prospective, randomized pilot clinical trial will evaluate the effect of dental implant macro-design and surface treatment on insertion torque values (ITV) and early implant stability quotient (ISQ) trajectories in healed…
- Conditions
- Dental Implant Macrodesign, Dental Implant Surface Treatment, Dental Implant Primary Stability, Dental Implant Secondary Stability
- Trial name
- NCT07744776
- Testing
- Chairside implant surface treatment with Plasma X Motion device, SLA implant surface, Straumann BLT implant macro design
- Where
- Lithuania
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dantu implantologijos centras
Mental Health, Well-being
A Mentalization Based Prevention Program to Foster Well-Being and Mental Health in Pre-Adolescent Children and Their Families
The FLOW project involves the implementation and rigorous evaluation of an evidence-based, multi-level mentalization prevention program targeting social and psychological determinants of well-being in four European countries…
- Trial name
- FLOW (NCT07494929)
- Testing
- Lighthouse Program, Mentalization Based Skills Training, Lighthouse program parenting guidebook
- Where
- 4 sites in Germany, Lithuania and 2 more
- Volunteers
- 15,200 people, healthy volunteers welcome
- Sponsor
- Svenja Taubner
Perimenopause, Menopause
CARAMEL Observational Study
CARAMEL is a project funded by the European Commission under the Horizon Europe programme. Its aim is to develop a personalized prevention approach based on state-of-the-art artificial intelligence models for cardiovascular risk…
- Conditions
- Perimenopause, Menopause, Cardiovascular (CV) Risk, Women (Between 30 to 60 Years Old)
- Trial name
- CARAMEL-OS (NCT07695376)
- Where
- 6 sites in Colombia, Croatia and 3 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute
Breast Cancer Prevention
MELIORA Virtual Coach Intervention for Breast Cancer Prevention
Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide, with early-onset cases increasing due to genetic and lifestyle factors.
- Trial name
- MELIORA (NCT07200427)
- Testing
- MELIORA Virtual Coach Intervention, Control (generic advice)
- Where
- 7 sites in Greece, Lithuania and 2 more
- Volunteers
- 2,080 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Chickenpox
A Study on the Safety of an Investigational Chickenpox Vaccine, When Given to Healthy Children, 12 to 15 Months of Age
The purpose of this study is to assess how well-tolerated GSK's investigational varicella vaccine (VNS Vaccine) is, in comparison to an already approved varicella vaccine (VV) known as Varivax.
- Trial name
- NCT06693895
- Testing
- Investigational varicella vaccine, Marketed varicella vaccine, Measles, mumps, and rubella vaccine
- Where
- 46 sites in United States, Bulgaria and 6 more
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Kidney Failure, Chronic, Peritoneal Dialysis Complication
International (Pediatric) Peritoneal Biobank
Within few years the peritoneal membrane of adult peritoneal dialysis (PD) patients undergoes substantial morphological transformation, including progressive fibrosis, vasculopathy and neoangiogenesis.
- Conditions
- Kidney Failure, Chronic, Peritoneal Dialysis Complication, Transplantation, Healthy
- Trial name
- NCT01893710
- Testing
- biopsy sampling
- Where
- 26 sites in United States, Austria and 13 more
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Joint Hypermobility
Characteristics of the Functional State of the Musculoskeletal System, Body Awareness, and Quality of Life in Individuals With Joint Hypermobility, Their Associations, and Guidelines for Intervention.
The goal of this observational study is to learn about the characteristics of the functional state of the musculoskeletal system, body awareness, and quality of life in individuals with joint hypermobility, their associations…
- Trial name
- NCT07476976
- Testing
- No intervention
- Where
- Lithuania
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Questionnaires, Validation
Adaptation and Validity of the Lithuanian Version of the Baecke Physical Activity Questionnaire
The aim of this study is to adapt the Baecke Questionnaire of Habitual Physical Activity for use in Lithuania. Individuals who meet the following criteria may participate in this study: Adults aged 18 years or older.
- Trial name
- NCT07402889
- Testing
- No Interventions
- Where
- Lithuania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ernesta Aukštuolytė
Pelvic Floor Dysfunction, Postpartum Care
Comparison of Outpatient Rehabilitation Versus Self-training for the Treatment and Prevention of Postpartum Pelvic Floor Dysfunction
The main goal of this study to compare self-training postpartum and training with a specialist support (physiotherapist and physical medicine and rehabilitation doctor) effect on pelvic floor dysfunction prevention and treatment…
- Conditions
- Pelvic Floor Dysfunction, Postpartum Care, Postpartum Comfort, Female Urinary Incontinence and Pelvic Organ Prolapse
- Trial name
- DDDPREV (NCT07426770)
- Testing
- Rehabilitation postpartum, Self-training
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Cancer Diagnosis
Digital Solutions for bEtter cAre
The target population includes cancer patients, caregivers, family members, healthcare providers and mental health specialists, who will be the primary end-users of the Althea platform.
- Trial name
- ALTHEA (NCT07416513)
- Testing
- Patients, survivors, caregivers, family members and healthcare professionals
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Breast Cancer Prevention
MELIORA Data Collection Campaigns
To support the development of the MELIORA digital app for the MELIORA main intervention, an initial pilot study (Data Collection Campaign, DCC) is being conducted with the three target participant groups: healthy women at…
- Trial name
- DCC (NCT07190066)
- Testing
- Data Collection campaign
- Where
- 7 sites in Greece, Lithuania and 2 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Healthy Adults
The Effect of Different Physical Activity Strategy on Cognitive Efficiency and Mental Fatigue Resistance
The main aim of this biomedical study is to determine the effect of moderate-intensity aerobic exercise, before and after an 8-hour workday and a combined work model, on the performance and efficiency of cognitive functions…
- Trial name
- NCT07130825
- Testing
- 8 hours simulated mental workday, Moderate intensity aerobic activity, Combined work model
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Prostate Cancer
Prostate Cancer Awareness and Initiative for Screening in the European Union
PRAISE-U was initiated on the 1st of April 2023 and is set to last for three years. This collaborative effort involves 25 institutions across 12 countries, all driven by a shared objective: to rationalize prostate cancer…
- Trial name
- PRAISE-U (NCT06424275)
- Testing
- Risk-based screening algorithm
- Where
- 5 sites in Ireland, Lithuania and 2 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- European Association of Urology Research Foundation
Obese Adolescents, Mental Health
Co-creating School Community Intervention Program on Physical Activity to Increase Health Equity in Children and Adolescents
The goal of this observational and interventional study is to understand whether environmental and behavioral interventions can improve physical activity and health outcomes in children aged 12-16 years attending VDU Atžalynas…
- Trial name
- Connection (NCT07120516)
- Where
- Lithuania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sandra Andrusaityte
Complication of Surgical Procedure, Infections
Pathogenesis of Postoperative Infections and Biomarkers for Early Diagnosis of it
Infections remain a prevalent complication after major abdominal surgery. The common belief that most surgical site infections (SSIs) following elective surgery with modern antiseptic techniques are due to intraoperative…
- Trial name
- NCT06513598
- Testing
- Major visceral surgery for gastrointestinal cancer
- Where
- 2 sites in Lithuania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Healthy
Effect of a 16-day Hot and Cold Acclimation on Adaptive Responses and Health-related Indicators
There are no previous studies of the effects of a combination of whole-body immersions in hot and cold baths on adaptive responses and health-related markers.
- Trial name
- NCT06346639
- Testing
- 16-day hot and cold acclimation
- Where
- Lithuania
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University