Clinical trials: in Morocco
Depression - Major Depressive Disorder
Pharmacogenetic-Guided Antidepressant Treatment in Depression
The purpose of this clinical trial is to evaluate whether using pharmacogenetic testing to guide antidepressant treatment can improve outcomes in adults with major depressive disorder in Morocco.
- Trial name
- PGX-MDD (NCT07480486)
- Testing
- Pharmacogenetic-Guided Treatment, Usual Care
- Where
- Morocco
- Volunteers
- 570 people
- Sponsor
- Mohammed V University in Rabat
Post-induction Hypotension (PIH)
Echocardiography-derived Pre-induction Hemodynamic Phenotypes and Post-induction Hypotension: an Exploratory Clustering Analysis
This study evaluated the occurrence of post-induction hypotension (PIH) in patients undergoing elective surgery under general anesthesia. PIH is a common perioperative complication associated with adverse outcomes.
- Trial name
- NCT07509255
- Where
- Morocco
- Volunteers
- 64 people
- Sponsor
- Avicenna Military Hospital
HELLP Syndrome, Preeclampsia
Analysis of Biological Progression and Regression of HELLP Syndrome in Time
Prospective observational study about progression and regression of biological parameters of HELLP syndrome
- Trial name
- NCT06758960
- Where
- Morocco
- Volunteers
- 72 people
- Sponsor
- CHU Mohammed VI Marrakech
Generalized Pustular Psoriasis
Study to Evaluate the Long-Term Safety and Efficacy of Imsidolimab (ANB019) in the Treatment of Subjects With GPP
This is a Phase 3, long term extension study to evaluate the safety and efficacy of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (GPP).
- Trial name
- GEMINI-2 (NCT05366855)
- Testing
- Double-blind 200 mg imsidolimab, Open-label 200 mg imsidolimab, Standard of Care (SOC)
- Where
- 65 sites in United States, Australia and 13 more
- Volunteers
- 42 people
- Sponsor
- Vanda Pharmaceuticals
Generalized Pustular Psoriasis
Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPP
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (GPP).
- Trial name
- GEMINI-1 (NCT05352893)
- Testing
- 750 mg Imsidolimab, 300 mg Imsidolimab
- Where
- 65 sites in United States, Australia and 13 more
- Volunteers
- 45 people
- Sponsor
- Vanda Pharmaceuticals
Multiple Sclerosis, Primary Progressive
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
This study will evaluate the efficacy and safety of ocrelizumab (Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS), including participants later in their disease course.
- Trial name
- O'HAND (NCT04035005)
- Testing
- Ocrelizumab
- Where
- 155 sites in United States, Australia and 21 more
- Volunteers
- 1,013 people
- Sponsor
- Hoffmann-La Roche
Type 2 Diabetes (T2DM)
Impact of a Nutritional Intervention Based on Moroccan Dietary Habits on the Glycemic Control of Type 2 Diabetics
The goal of this study is to learn if a nutritional intervention adapted to Moroccan dietary habits can improve blood sugar control in adults with Type 2 Diabetes.
- Trial name
- NCT07404280
- Testing
- Moroccan-Adapted Nutritional Plan
- Where
- Morocco
- Volunteers
- 50 people
- Sponsor
- Avicenna Military Hospital
Urinary Incontinence
Posturography Rehabilitation and Pelvic Floor Training on Urinary Incontinence in Women
The goal of this clinical trial is to evaluate whether lumbopelvic postural rehabilitation combined with pelvic floor muscle training (PFMT) is more effective than PFMT alone in women with urinary incontinence.
- Trial name
- NCT07337278
- Testing
- Pelvic Floor Muscle Training, Posturography Rehabilitation
- Where
- Morocco
- Volunteers
- 78 people
- Sponsor
- Mohammed V University in Rabat
Medical Education
Enhancing Teaching Strategies for Newly Recruited Interns: Comparing Massive Open Online Courses, Simulation, and Escape Games
This randomized controlled trial will compare three innovative teaching methods-Massive Open Online Courses (MOOCs), simulation, and escape games-among newly recruited medical interns at Ibn Sina University Hospital in Rabat…
- Trial name
- PEDAGO-INT (NCT07176442)
- Testing
- MOOC (E-Learning), Simulation Training, Educational Escape Game
- Where
- Morocco
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Mohammed V Souissi University
Primary Hyperoxaluria Type 1, End Stage Renal Disease
Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD
The aim of this study is to evaluate DCR-PHXC in participants with PH1 and severe renal impairment, with or without dialysis.
- Trial name
- PHYOX7 (NCT04580420)
- Testing
- DCR-PHXC
- Where
- 18 sites in United States, France and 8 more
- Volunteers
- 28 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Cardiovascular Diseases (CVD)
Study Protocol: 10-Year Follow-Up of Patients Screened for Cardiovascular Risk by the "All With Heart" Association - Development of a Morocco-Specific Risk Score
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and their prevalence is steadily increasing in Morocco.
- Trial name
- NCT07294937
- Where
- 2 sites in Morocco
- Volunteers
- 10,000 people
- Sponsor
- Moroccan Society of Cardiology
Chronic Kidney Disease 5D, Hyperkalemia
Nurse-Led Nutritional Education for Moroccan Dialysis Patients
Why was this study done? Many dialysis centers in Morocco lack dietitians to provide proper, individualized dietary support to patients.
- Conditions
- Chronic Kidney Disease 5D, Hyperkalemia, Hemodialysis
- Trial name
- NCT07277530
- Testing
- Nutritional Education Intervention
- Where
- Morocco
- Volunteers
- 30 people
- Sponsor
- HASSAN 1st university
Oral Hygiene, Toothbrush Contamination
Charcoal Toothbrushes and Bacterial Contamination: a Clinical Trial.
This randomized controlled clinical trial aims to evaluate the antibacterial effectiveness of toothbrushes with charcoal-impregnated bristles compared to conventional toothbrushes without charcoal.
- Conditions
- Oral Hygiene, Toothbrush Contamination, Bacterial Contamination
- Trial name
- NCT07275684
- Testing
- Charcoal-Impregnated Toothbrush, Conventional Toothbrush
- Where
- Morocco
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mohammed V University in Rabat
Environmental Enteric Dysfunction
Indispensable Amino Acids Bioavailability in Children With Environmental Enteropathy Dysfunction (IAA-EED)
In Morocco, large efforts have been made to enhance nutritional status and health conditions of children. Accordingly, stunting was reduced and the prevalence of stunting have decreased from 28,6% in 1987 to 14,9% in 2011.
- Trial name
- IAA-EED (NCT07256028)
- Testing
- Indispensable amino acids supplemntation, Without Indispensable amino acids supplementation
- Where
- Morocco
- Volunteers
- 40 people
- Sponsor
- Morocco's National Centre for Energy, Sciences and Nuclear Techniques
Triple Negative Breast Neoplasms
A Study of the Efficacy and Safety of Atezolizumab Plus Chemotherapy for Patients With Early Relapsing Recurrent Triple-Negative Breast Cancer
This study will evaluate the efficacy and safety of atezolizumab plus chemotherapy compared with placebo plus chemotherapy in patients with inoperable recurrent triple-negative breast cancer (TNBC).
- Trial name
- IMpassion132 (NCT03371017)
- Testing
- Atezolizumab, Gemcitabine, Capecitabine
- Where
- 124 sites in United States, Argentina and 26 more
- Volunteers
- 595 people
- Sponsor
- Hoffmann-La Roche
Acute Coronary Syndromes, Heart Failure
ISGLT2 in Patients Without DM With Acute MI
This study will evaluate the effect of ISGLT2 (Dapagliflozin or Empalgliflozin), administered once daily in addition to standard of care treatments for non-diabetic patients with myocardial infarction (MI) treated with PCI, on…
- Trial name
- ISGTL2-MORMI (NCT06903754)
- Testing
- With ISGLT2
- Where
- Morocco
- Volunteers
- 450 people
- Sponsor
- Mohammed VI University Hospital
Rheumatoid Arthritis
Patient Education and Rheumatoid Arthritis
The goal of this clinical trial is to learn if a culturally adapted patient education program can help people with rheumatoid arthritis (RA) manage their disease and improve their quality of life.
- Trial name
- PE and RA (NCT07170371)
- Testing
- patient education, Usual Care
- Where
- Morocco
- Volunteers
- 88 people
- Sponsor
- Hassan II University
Cesarean Section Complications, Hypotension
Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)
The goal of this clinical trial is to compare norepinephrine and ephedrine in maintaining blood pressure during spinal anaesthesia for elective cesarean delivery.
- Trial name
- INPEACE (NCT06248593)
- Testing
- Continuous infusion of Norepinephrine, Continuous infusion of Phenylephrine
- Where
- 2 sites in Morocco
- Volunteers
- 140 people
- Sponsor
- Hassan II University
Pulmonary Embolism (PE), Snake Envenomation
Pulmonary Embolism Following Viper's Bites: A Case Report
Viper envenomation constitutes a medical emergency predominantly occurring in rural regions, where specific viper species are endemic, with their distribution influenced by climatic variations.
- Trial name
- NCT07009301
- Where
- Morocco
- Volunteers
- 1 people
- Sponsor
- Younes Oujidi
Sickle Cell Disease
A Study of IMR-687 in Subjects With Sickle Cell Disease
A Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease
- Trial name
- NCT04474314
- Testing
- IMR-687
- Where
- 49 sites in United States, Ghana and 11 more
- Volunteers
- 115 people
- Sponsor
- Cardurion Pharmaceuticals, Inc.