Clinical trials: in Mozambique
Breast Neoplasm Malignant Primary
A Prospective Cohort With Patient Navigation as an Intervention for Breast Cancer Patients
The objective of this observational study is to introduce a patient navigation system within the breast cancer unit at Hospital Central de Maputo (MOZ) and gather data to assess the efficacy of patient navigation in enhancing…
- Trial name
- NAVIMOZ (NCT06257888)
- Testing
- patient navigation
- Where
- Mozambique
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Renato Cagnacci Neto
HIV-1-infection
Ndovu RCT: Investing the Optimal Management of Dolutegravir Resistance
This clinical trial will address the gap in published data on the effect of dolutegravir (DTG)-associated drug-resistant mutations on viral suppression among people remaining on DTG-based antiretroviral therapy.
- Trial name
- NCT06747507
- Testing
- Dolutegravir Pill, Darunavir+Ritonavir
- Where
- 9 sites in Kenya, Lesotho and 2 more
- Volunteers
- 392 people
- Sponsor
- University of Nairobi
HIV Disease Progression
Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
A double blinded, placebo-controlled, multicenter trial to evaluate effectiveness of azithromycin prophylaxis on mortality in advanced HIV.
- Trial name
- REVIVE (NCT05580666)
- Testing
- Azithromycin Oral Tablet
- Where
- 52 sites in Côte d’Ivoire, Ethiopia and 9 more
- Volunteers
- 8,000 people
- Sponsor
- Population Health Research Institute
Acute Malaria
Phase IIa Proof of Concept Study of M5717-Pyronaridine in Adults and Adolescents With Acute Uncomplicated Plasmodium Falciparum Malaria (CAPTURE 1)
The purpose of this study was to evaluate the safety, efficacy, and pharmacokinetic of the combination M5717 plus pyronaridine in participants with acute uncomplicated Plasmodium falciparum malaria.
- Trial name
- NCT05689047
- Testing
- M5717 330 mg, M5717 500 mg, M5717 660 mg
- Where
- 5 sites in Burkina Faso, Gabon and 2 more
- Volunteers
- 38 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Malaria
In Vivo Efficacy of Artemether-Lumefantrine, Amodiaquine-Artesunate, Dihydroartemisinin-Piperaquine, and Pironaridine-Artesunate in Mozambique
This is a classical in vivo clinical trial, following World Health organization's recommendations, ran as a multisite study within Mozambique trying to assess the efficacy and safety in 5 sites of the four oral ACTS…
- Trial name
- MEFI_IV (NCT05343312)
- Testing
- AL (Coartem), AS-AQ (Carsucam), DHP
- Where
- 5 sites in Mozambique
- Volunteers
- 870 people
- Sponsor
- Centro de Investigacao em Saude de Manhica
HIV/AIDS, Tuberculosis
Choice Architecture Based TB Preventive Therapy Prescribing
Background: Clinical guidelines and policies often fail to achieve high levels of delivery of intended clinical interventions. The difference in what investigators know works and what is actually delivered at the clinic-level to…
- Trial name
- CAT (NCT04466293)
- Testing
- Choice Architecture
- Where
- 3 sites in Malawi, Mozambique and 1 more
- Volunteers
- 57 people
- Sponsor
- Johns Hopkins University
Device Related Infection, Device Malfunction
Project My Heart Your Heart: Pacemaker Reuse
Lack of access to pacemakers is a major challenge to the provision of cardiovascular health care in Low and Middle Income Countries (LMIC).
- Conditions
- Device Related Infection, Device Malfunction, Bradycardia
- Trial name
- MHYH (NCT04016870)
- Testing
- Reconditioned Pacemaker, New Pacemaker
- Where
- 8 sites in Kenya, Mexico and 5 more
- Volunteers
- 370 people
- Sponsor
- University of Michigan
Tuberculosis
A Pan-TB Regimen Targeting Host and Microbe
This project will develop the first regimen meeting WHO criteria for a pan-TB indication, ie, not requiring knowledge of RIF susceptibility.
- Trial name
- panTB-HM (NCT05686356)
- Testing
- Sutezolid, N-acetyl cysteine, Pretomanid
- Where
- 8 sites in Mozambique, South Africa and 1 more
- Volunteers
- 352 people
- Sponsor
- The Aurum Institute NPC
Hypertension, Diabetes Mellitus
Implementation of the COmmunity HEalth System InnovatiON Project in Low- and Middle- Income Countries
The COHESION-I project will evaluate the effects of the co-creation intervention (2016 to 2019) and the co-design intervention (2023 to 2024) on improving (a) health system responsiveness, and (b) patient satisfaction, at the…
- Conditions
- Hypertension, Diabetes Mellitus, Neglected Tropical Diseases
- Trial name
- COHESION-I (NCT06989502)
- Testing
- Co-creation (2016 to 2019) + Co-design (2023 to 2024), Co-design only (2023 to 2024)
- Where
- 3 sites in Mozambique, Nepal and 1 more
- Volunteers
- 2,094 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
Infective Endocarditis
Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study
Introduction. Comprehensive data on infective endocarditis in developing countries are scarce. Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis…
- Trial name
- EndoDev (NCT02128139)
- Where
- 6 sites in Fiji, Laos and 3 more
- Volunteers
- 300 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
HIV, HIV Antiretroviral Therapy (ART) Adherence
Selection of Resistant Mutations to Dolutegravir in PLWH Treated in Mozambique
The HIV infection not fully controlled, despite being under antiretroviral treatment, could make virus resistance against the antiretroviral treatments, making hardest the well control of HIV infection.
- Trial name
- REDOCH (NCT06607588)
- Testing
- Not applicable- observational study
- Where
- Mozambique
- Volunteers
- 200 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Malaria (Uncomplicated)
Efficacy of Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Under 12 Years at Four Sentinel Sites in Mozambique
This is a classical in vivo clinical trial, following World Health organization's recommendations, ran as a multisite study within Mozambique trying to assess the efficacy and safety in four sites of artemether-lumefantrine (AL)…
- Trial name
- NCT06970600
- Testing
- Artemether-lumefantrine (Coartem)
- Where
- 4 sites in Mozambique
- Volunteers
- 352 people
- Sponsor
- Centro de Investigacao em Saude de Manhica
Tuberculosis, Diagnoses Disease
TB-CAPT CORE Truenat Trial
A cluster randomized controlled trial to evaluate the effect of placing Truenat platform/TB assays at primary health care clinics combined with rapid communication of results on time to treatment initiation of microbiologically…
- Trial name
- NCT04568954
- Testing
- Truenat TB platform/TB assays
- Where
- 4 sites in Mozambique, Tanzania
- Volunteers
- 3,987 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Tuberculosis, HIV Coinfection
TB-CAPT EXULTANT - HIV
The overall aim of this study is to assess the potential of an expanded TB testing strategy to increase the number of HIV-positive patients with microbiologically diagnosed TB who are started on treatment in adult wards of…
- Conditions
- Tuberculosis, HIV Coinfection, Diagnoses Disease
- Trial name
- NCT04568967
- Testing
- Concentrated urine with Xpert Ultra, Stool with Xpert Ultra
- Where
- 4 sites in Mozambique, Tanzania
- Volunteers
- 1,172 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
STEMI, Remote Ischaemic Conditioning
Remote Ischaemic Conditioning in STEMI Patients in AFRICA
The RIC-AFRICA trial is a multi-centre, sham-controlled, randomised controlled trial (RCT) involving 1400 ST-segment elevation myocardial infarction (STEMI) patients presenting within ≤ 24 hours of myocardial infarction (MI)…
- Conditions
- STEMI, Remote Ischaemic Conditioning, Myocardial Reperfusion Injury
- Trial name
- RIC-AFRICA (NCT04813159)
- Testing
- Remote Ischaemic Conditioning (RIC)
- Where
- 20 sites in Kenya, Mozambique and 4 more
- Volunteers
- 1,400 people
- Sponsor
- University of Cape Town
Malaria
Evaluation of IR3535 as a Spatial Repellent for Malaria Control.
Mozambique contributes with 5% of global malaria cases, and despite control efforts the Sofala province continues to experience a high burden of malaria.
- Trial name
- REPELMALARIA (NCT04419766)
- Testing
- IR3535 (3-(N-acetyl-N-butyl) aminopropionic acid ethyl ester) house spraying
- Where
- Mozambique
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Malaria
Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA)
The BOHEMIA program consists of a combination of studies organized around a central community prevention mass drug administration protocol and four sub-studies (i.e.; social science, entomology, health economics, and…
- Trial name
- BOHEMIA (NCT04966702)
- Testing
- Albendazole Pill, Ivermectin Pill, Ivermectin Injectable Product
- Where
- 2 sites in Kenya, Mozambique
- Volunteers
- 48,145 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
COVID-19
Characterising Transmission of SARS-CoV-2 in a Peri-urban Population in Mozambique
A population-based COVID19 surveillance in a household cohort will be set-up using an existing Household demographic surveillance system (HDSS).
- Trial name
- AfriCoVER (NCT04442165)
- Where
- Mozambique
- Volunteers
- 6,049 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Anemia
Evaluating of the Impact of Micronutrient Interventions Among Adolescents in Mozambique
This purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status and the impact of a nutrition curriculum on diet diversity and anemia knowledge…
- Trial name
- NCT06815315
- Testing
- Multiple micronutrient supplementation, Iron Folic Acid Supplementation, Adolescent Nutrition Curriculum
- Where
- Mozambique
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- World Vision US
Tuberculosis
Predicting the Future: Incipient Tuberculosis
The investigators will study, prospectively, if contacts (household or close contacts) of tuberculosis (TB) patients with high C-reactive protein (CRP), low hemoglobin (Hb) levels, and a positive Xpert Host Response (HR)…
- Trial name
- PreFIT (NCT04825327)
- Where
- 3 sites in Mozambique, South Africa and 1 more
- Volunteers
- 3,016 people
- Sponsor
- Amsterdam Institute for Global Health and Development