Clinical trials: open to volunteers, in Nepal
Chronic Lung Diseases
Prospective Study on Antimicrobial RESIstance in Chronic Pulmonary DiseasE
This observational, multicentric prospective study aims to understand the prevalence and burden of antimicrobial resistance (AMR) in people with chronic lung diseases (CLD) across the globe, understanding also geographical…
- Trial name
- PRESIDE (NCT07874139)
- Where
- 68 sites in United States, Albania and 31 more
- Volunteers
- 683 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Dengue
Emetine for Viral Outbreaks (a.k.a. EVOLVE Antiviral Initiative)
The goal of this study is to evaluate the efficacy and safety of emetine administered orally for symptomatic patients aged 18-65 years infected with the dengue virus. The main questions it aims to answer are: 1.
- Trial name
- NCT07016321
- Testing
- Emetine Hydrochloride 6mg, Emetine Hydrochloride 12mg
- Where
- 2 sites in United States, Nepal
- Volunteers
- 600 people
- Sponsor
- Johns Hopkins University
Spirometry
The INTERvening for LUNG Health Trial
This research study is being done to find out whether a community health volunteer-delivered, multi-component program can improve lung health for people at risk of chronic respiratory diseases (such as asthma or COPD) in…
- Trial name
- INTERLUNG (NCT07540000)
- Testing
- Community health worker-delivered multi-component respiratory health intervention
- Where
- 2 sites in United States, Nepal
- Volunteers
- 800 people
- Sponsor
- Johns Hopkins University
Lower Respiratory Tract Infection (LRTI), Recurrent Wheezing
Prevent Wheeze Trial
This trial investigates whether a single dose of dexamethasone will prevent recurrent wheezing in children at high-risk for asthma admitted to hospital with a lower respiratory tract infection (LRTI).
- Trial name
- PRE-WHEE (NCT07858773)
- Testing
- Dexamethasone 0.6 mg/kilogram body weight single dose
- Where
- 2 sites in Nepal, South Africa
- Volunteers
- 486 people
- Sponsor
- Norwegian University of Science and Technology
Post-Dural Puncture Headache
Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery
The aim of this study is to examine the effects of altitude (high altitude versus low altitude) on incidence and severity of postural puncture headache (PDPH) following spinal anaesthesia for caesarean delivery.
- Trial name
- NCT05804448
- Where
- 2 sites in Nepal
- Volunteers
- 292 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Suicide, Suicide Prevention
Peer Delivered Youth Suicide Prevention in Nepal
South Asia has the highest suicide rate in the world with important risk profile differences from high-income settings. Investigators will conduct formative research to co-design a package of brief interventions and…
- Trial name
- NCT07680179
- Testing
- Enhanced Usual Care (EUC), Youth-focused, Peer-delivered, Family-engaged Suicide Prevention Package (YPF-SuPP)
- Where
- Nepal
- Volunteers
- 160 people
- Sponsor
- Yale University
Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement
Low INR to Minimize Bleeding With Mechanical Valves Trial
This study evaluates the use of a lower INR target (1.5 to 2.5) in patients with a mechanical bileaflet heart valve in the aortic position.
- Trial name
- LIMIT (NCT03636295)
- Testing
- Warfarin
- Where
- 45 sites in Belgium, Botswana and 16 more
- Volunteers
- 2,625 people
- Sponsor
- Population Health Research Institute
Mental Health
Effectiveness and Implementation of a School-based Mental Well-being Intervention Among Adolescents of Bharatpur, Nepal
The goal of this study is to evaluate the effectiveness and assess the implementation of CROSS-MIND, a school-based mental well-being intervention for adolescents in Nepal. The study uses a Hybrid Type 1 mixed-methods design.
- Trial name
- CROSSMIND_NP (NCT07812168)
- Testing
- CROSS-MIND
- Where
- Nepal
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension, Diabetes
Group-Care for Hypertension and Diabetes Management in Nepal
Hypertension and diabetes represent significant and growing public health challenges in Nepal, particularly in underserved communities.
- Trial name
- GCHD- Nepal (NCT07439380)
- Testing
- Low Intensity Community-Based Group NCD Care, High Intensity Community-Based Group NCD Care
- Where
- Nepal
- Volunteers
- 1,110 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hip Fractures, Myocardial Injury
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
The HIP ATTACK-2 trial is a multicentre, international, parallel group randomized controlled trial to determine whether accelerated surgery for hip fracture in patients with acute myocardial injury is superior to standard care in…
- Trial name
- HIP ATTACK-2 (NCT04743765)
- Testing
- Accelerated medical clearance and surgery
- Where
- 77 sites in United States, Australia and 18 more
- Volunteers
- 1,100 people
- Sponsor
- Population Health Research Institute
Gestational Diabetes, Hypertensive Disorder of Pregnancy
Mobile-based Obstetric Monitoring for Pregnancies Complicated by Hypertension and/or Diabetes (MOM-HD)
Hypertensive disorders during pregnancy (HDP) and gestational diabetes (GDM) are among the leading complications in pregnancy, significantly contributing to global maternal and fetal morbidity and mortality.
- Trial name
- MOM-HD (NCT07243886)
- Testing
- MOM-HD, Standard Care
- Where
- 3 sites in Nepal
- Volunteers
- 864 people
- Sponsor
- Rutgers, The State University of New Jersey
Nurse Led Interventions, Patients on Hemodialysis
Nurse Led Intervention on Self Care Adherence and Quality of Life
Background: Hemodialysis is the most common treatment modality in patients with chronic kidney disease. The majority of people with dialysis have a below-average quality of life.
- Conditions
- Nurse Led Interventions, Patients on Hemodialysis, Self Care, Quality of Life
- Trial name
- Selfcare (NCT07506980)
- Testing
- laptop based education and counselling, Reminder call, distribution of self care booklet having all the content covered in discussion
- Where
- 2 sites in Nepal
- Volunteers
- 112 people
- Sponsor
- Kathmandu University School of Medical Sciences
High Risk Pregnancy
Antenatal High-Risk Pregnancy Intervention Bundle in Rural Nepal
The proposed study will assess and implement a comprehensive antenatal HRP screening and telehealth follow-up program in rural Nepal. The main questions it aims to answer are: 1.
- Trial name
- NCT07717619
- Testing
- High Risk Pregnancy Bundle
- Where
- Nepal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postpartum Preeclampsia
Postpartum Preeclampsia Early Detection and Treatment: Nepal Pilot Study
The goal of this study is to address the significant morbidity associated with preeclampsia diagnosed after delivery. All participants will undergo biomarker evaluation with soluble fms-like tyrosine kinase-1 and placental growth…
- Trial name
- PREDiCT-NPL (NCT07185204)
- Testing
- Early detection and management of postpartum preeclampsia bundle
- Where
- 2 sites in United States, Nepal
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Hypertension, Medication Adherence
Effectiveness and Adoption of the TelTex4BP Intervention Among Adults With Hypertension in Nepal
Despite evidence of preventing cardiovascular disease (CVD) risk through lifestyle changes, many patients with hypertension (HTN) do not comply with this and suffer from CVD and other complications.
- Conditions
- Hypertension, Medication Adherence, Blood Pressure, Cardiovascular Diseases
- Trial name
- TelTex4BP (NCT05979168)
- Testing
- Phone call and text Messages
- Where
- 2 sites in Nepal
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Central Department of Public Health
Anemia
How Precision Diets, Through Gut Bacteria, Affect Anemia in Nepalese Adolescent
This study aims to evaluate whether a food-based nutrition intervention using goat liver can improve anemia among adolescent girls in Kathmandu, Nepal, and compare its effectiveness with the current standard iron and folic acid…
- Trial name
- NCT07661602
- Testing
- Iron folic acid supplement, Goat liver supplementation, Nutrition education on anemia prevention and control
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- Southern Medical University, China
Birth Outcomes
Effect of a Mobile Health Intervention on Birth Outcomes
Globally, neonatal and infant mortality persist as challenging concerns, paralleled by a notable prevalence of low birth weight and preterm birth.
- Trial name
- NCT06431581
- Testing
- mHealth intervention (educational video, SMS and reminder phone call)
- Where
- Nepal
- Volunteers
- 494 people
- Sponsor
- Kathmandu University School of Medical Sciences
Dry Eye Disease (DED)
Randomized Clinical Trial of Artificial Tears With and Without Preservatives in Patients With Dry Eye Disease
Dry Eye Disease (DED) is a common, chronic ocular surface disorder characterized by tear film instability, ocular discomfort, and visual disturbance.
- Trial name
- NCT07635849
- Testing
- Carboxy methyl cellulose, Preservative free Carboxy methyl cellulose
- Where
- Nepal
- Volunteers
- 80 people
- Sponsor
- Pokhara Academy of Health Sciences, Western Regional Hospital
Corneal Ulcer
Follow-up Compliance for Corneal Ulcer Patients With SMS Reminder
Corneal ulcer is defined as the loss of corneal epithelium with underlying stromal infiltration and suppuration, accompanied by signs of inflammation, with or without hypopyon1.
- Trial name
- NCT07377513
- Testing
- SMS reminder
- Where
- Nepal
- Volunteers
- 310 people
- Sponsor
- Seva Canada Society
Chronic Conditions, Multiple, Diseases of the Circulatory System
National Institute for Health and Care Research Global Health Research Centre for Multiple Long-Term Conditions
Multiple Long-Term Conditions (MLTC), defined as the coexistence of two or more chronic conditions, is increasingly prevalent in India.
- Conditions
- Chronic Conditions, Multiple, Diseases of the Circulatory System, Diseases of the Respiratory System, Endocrine, Nutritional and Metabolic Diseases
- Trial name
- NIHR-GHRC MLTC (NCT07582380)
- Testing
- Electronic Decision Support System (EDSS), Assisted Telemedicine, Patient-facing app for self-management, supported by care coordination through Community Champions and Care Coordinators.
- Where
- 120 sites in India, Nepal
- Volunteers
- 3,600 people
- Sponsor
- Centre for Chronic Disease Control, India