Clinical trials: in Sri Lanka
Non-Alcoholic Fatty Liver Disease
Motivational Interviewing in the Management of Non Alcoholic Fatty Liver Disease
The goal of this study is to assess if motivational counselling works to reduce the weight in participants with Non Alcoholic Fatty Liver Disease (NAFLD).
- Trial name
- NCT06348628
- Testing
- Motivational Interview
- Where
- Sri Lanka
- Volunteers
- 231 people
- Sponsor
- Madunil Anuk Niriella
SARS-CoV-2 Infection
Nitric Oxide Nasal Spray (NONS) as Prevention for Treatment of Individuals at Risk of Exposure to COVID-19 Infection
A multicenter, randomized, double-blinded, placebo-controlled, phase 3 clinical efficacy study evaluating nitric oxide nasal spray (NONS) as prevention for treatment of individuals at risk of exposure to COVID-19 infection.
- Trial name
- NCT05109611
- Testing
- Nitric Oxide, Nasal spray with isotonic saline
- Where
- 6 sites in Canada, Sri Lanka
- Volunteers
- 1,389 people, healthy volunteers welcome
- Sponsor
- Sanotize Research and Development corp.
Arbovirus Infections
Spatial Repellents for Aedes-borne Virus Control in Sri Lanka
The primary objective of the study is to demonstrate and quantify the protective efficacy (PE) of a single SR product, in reducing DENV infection and active Aedes-borne virus (ABV) disease in human cohorts.
- Trial name
- AEGIS ABV (NCT05452447)
- Testing
- Transfluthrin
- Where
- 2 sites in Sri Lanka
- Volunteers
- 6,949 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Intracerebral Haemorrhage (ICH), Hypertension
Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial
An investigator initiated and conducted, multicentre, international, double-blinded, placebo-controlled, parallel-group, randomised controlled trial to determine the effect of more intensive blood pressure control provided by a…
- Trial name
- TRIDENT (NCT02699645)
- Testing
- telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg
- Where
- 58 sites in Australia, Brazil and 8 more
- Volunteers
- 1,671 people
- Sponsor
- The George Institute
Female Infertility, Oocyte Competence
Adipose Stem Cell Mitochondria Supplementation to Oocytes (ASCENT)
The purpose of this study is to investigate the potential of autologous adipose stem cell (ASC) mitochondrial transfer (ASCENT) to oocytes along with intracytoplasmic sperm injection (ICSI)as a means of enhancing embryo…
- Conditions
- Female Infertility, Oocyte Competence, Mitochondria, Recurent Implantation Failures
- Trial name
- NCT07066267
- Testing
- Experimental
- Where
- Sri Lanka
- Volunteers
- 20 people
- Sponsor
- Sunkaky Medical Cooperation
Hypertension
Efficacy and Safety of GMRx2 Compared to Dual Combinations for the Treatment of Hypertension
Recent hypertension guidelines recommend combination therapy as initial treatment for many or most patients. Several trials suggest triple low-dose combination therapy may be highly effective in terms of achieving blood pressure…
- Trial name
- GMRx2_ACT (NCT04518293)
- Testing
- Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg, telmisartan 40 mg/amlodipine 5 mg/indapamide 2.5 mg, Telmisartan 20 mg/amlodipine 2.5 mg
- Where
- 89 sites in United States, Australia and 5 more
- Volunteers
- 1,385 people
- Sponsor
- George Medicines PTY Limited
Hypertension
Efficacy and Safety of GMRx2 Compared to Placebo for the Treatment of Hypertension
Recent hypertension guidelines recommend combination therapy as initial treatment for many or most patients. Several trials suggest triple low-dose combination therapy may be highly effective in terms of achieving blood pressure…
- Trial name
- GMRx2_PCT (NCT04518306)
- Testing
- Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg, Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg
- Where
- 47 sites in United States, Australia and 3 more
- Volunteers
- 755 people
- Sponsor
- George Medicines PTY Limited
Chronic Obstructive Pulmonary Disease, Cardiovascular Diseases
Preventing Adverse Cardiac Events in COPD
A double-blind, randomised controlled trial in participants with COPD to assess the efficacy of proactive treatment of cardiac risk in people with COPD.
- Trial name
- PACE in COPD (NCT03917914)
- Testing
- Bisoprolol
- Where
- 24 sites in Australia, India and 2 more
- Volunteers
- 280 people
- Sponsor
- The George Institute
Heart Failure With Reduced Ejection Fraction
Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy in Sri Lanka
The primary objective of this trial is to see if the research team can successfully recruit participants and carry out study related procedures in Sri Lanka.
- Trial name
- NCT06831864
- Testing
- HFrEF Polypill, Comparator Arm
- Where
- 2 sites in Sri Lanka
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Treating Paroxysmal Nocturnal Haemoglobinuria Patients With rVA576
rVA576 for patients with Paroxysmal Nocturnal Hemoglobinuria (PNH).
- Trial name
- CAPSTONE (NCT03588026)
- Testing
- rVA576, Standard of care (SOC)
- Where
- 3 sites in Kazakhstan, Lithuania and 1 more
- Volunteers
- 9 people
- Sponsor
- AKARI Therapeutics
Spasms, Infantile, Prednisolone
Clinical Trial on 7-day Followed by Maintenance Therapy for 10 Weeks vs. 14-day and no Maintenance Course of Prednisolone for the Treatment of Infantile Epileptic Spasms Syndrome (IESS)
The goal of this clinical trial is to learn if short courses (7 days) of oral prednisolone are as effective as longer courses (14 days) in treating Infantile Epileptic Spasms Syndrome (IESS) in infants.
- Trial name
- SLISS (NCT06838559)
- Testing
- Short-Duration Oral Prednisolone with Extended Tapering, Standard Oral Prednisolone Regimen with Tapering
- Where
- 7 sites in Sri Lanka
- Volunteers
- 182 people
- Sponsor
- University of Colombo
Hypertension
Control of Blood Pressure and Risk Attenuation-rural Bangladesh, Pakistan, Sri Lanka, Feasibility Study
High blood pressure (BP) is the leading attributable risk for cardiovascular disease (CVD). In rural South Asia, hypertension remains to be a significant public health issue with sub-optimal rates of case finding and management.
- Trial name
- COBRA-BPS (NCT02341651)
- Testing
- Multicomponent intervention
- Where
- 3 sites in Bangladesh, Pakistan and 1 more
- Volunteers
- 453 people
- Sponsor
- Duke-NUS Graduate Medical School
Neck Pain
Comparing Efficacy of Dry Needling Combined with Passive Stretching and Muscle Energy Technique on Myofascial Trigger Points
The goal of this clinical trial is to assess and compare the efficacy of dry needling (minimally invasive treatment by using a tiny needle) combined with two types of stretching techniques in patients with neck pain for more than…
- Trial name
- NCT06780904
- Testing
- Dry Needling
- Where
- Sri Lanka
- Volunteers
- 46 people
- Sponsor
- University of Peradeniya
Type 2 Diabetes
SGLT2 Inhibitors As First Line Therapy to Prevent Renal Decline in Type 2 Diabetes
The aim of the trial is to evaluate the effects of the SGLT2 inhibitor, dapagliflozin, compared to metformin on annual decline in eGFR when used as first line therapy in people with Type 2 Diabetes.
- Trial name
- START (NCT05345327)
- Testing
- Dapagliflozin, Metformin
- Where
- 8 sites in Australia, Sri Lanka
- Volunteers
- 994 people
- Sponsor
- The George Institute
Systemic Lupus Erythematosus
Validation of the Lupus Low Disease Activity State (LLDAS) in the Asia Pacific Region
Lupus Low Disease Activity State (LLDAS) study is an international, multi-centre prospective study, developed by the Asia Pacific Lupus Collaboration (APLC) to investigate whether the attainment of LLDAS is associated with…
- Trial name
- APLCLLDAS (NCT03138941)
- Where
- 20 sites in Australia, China and 9 more
- Volunteers
- 5,000 people
- Sponsor
- Monash University
Oral Cancer, Palliative Supportive Care
Early Palliative Care For Patients With Oral Cancer in Sri Lanka
The goal of this quasi experimental study is to develop and assess the effectiveness of an early palliative care intervention in patients with oral cancer in Sri Lanka.
- Conditions
- Oral Cancer, Palliative Supportive Care, Psychological Distress, Quality of Life of Patients
- Trial name
- NCT06726317
- Testing
- Early palliative care integration
- Where
- 4 sites in Sri Lanka
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Colombo
Oral Cancer, Health Education, Community
Testing and Comparing the Impacts of Mhealth-Based and Web-Based Education on Oral Cancer
Introduction: Oral cancer is a malignant neoplastic disease affecting the lip, oral cavity (mouth) and/or the oropharynx. Despite the intense and diverse public health interventions on oral cancer prevention, the global…
- Conditions
- Oral Cancer, Health Education, Community, Digital Intervention, MHealth Application
- Trial name
- NCT06711848
- Testing
- A web-based educational intervention on oral cancer, A mobile health app-based educational intervention on oral cancer
- Where
- 5 sites in India, Nigeria and 2 more
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Rwanda
Crohn's Disease
Filgotinib in Long-Term Extension Study of Adults With Crohn's Disease
The primary objective of this study is to observe the long-term safety of filgotinib in adults who have completed or met protocol specified efficacy discontinuation criteria in a prior filgotinib treatment study in Crohn's…
- Trial name
- DIVERSITY LTE (NCT02914600)
- Testing
- Filgotinib
- Where
- 486 sites in United States, Argentina and 38 more
- Volunteers
- 1,188 people
- Sponsor
- Lakefront Biotherapeutics NV
Depression Moderate, Depression Mild
A Pilot Study Comparing the Efficacy of Traditional Buddhist Mindfulness Training Versus Secular Mindfulness-based Cognitive Therapy for Patients Having Residual Depressive Symptoms
This interventional study is conducted with the goal of comparing the efficacy of traditional Buddhist mindfulness training versus secular mindfulness based cognitive therapy among patients with depressive disorders.
- Trial name
- NCT06456931
- Testing
- Traditional Buddhist mindfulness, secular mindfulness based cognitive therapy
- Where
- Sri Lanka
- Volunteers
- 60 people
- Sponsor
- Anuradha Baminiwatta
Upper Back Pain
Comparison of Thoracic Mobility Exercise Versus Manual Release Technique in Minimizing Upper Back Pain
Methodology: study aims to evaluate the effectiveness of thoracic mobility exercise and manual release technique in terms of pain intensity, thoracic mobility, muscle strength and improving disability.
- Trial name
- NCT06340542
- Testing
- Thoracic Mobility exercises, Manual Release technique
- Where
- Sri Lanka
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Dhaka