Clinical trials: in Sweden
Temporomandibular Joint Disc Displacement, Temporomandibular Joint Disc Displacement, Without Reduction
TMJ Arthroscopy Compared to Arthrocentesis in Disc Displacement Without Reduction
The goal of this clinical trial is to compare the intervention arthroscopic lysis and lavage to the intervention arthrocentesis in treating disabling and painful temporomandibular joint disc displacement without reduction.
- Conditions
- Temporomandibular Joint Disc Displacement, Temporomandibular Joint Disc Displacement, Without Reduction, Temporomandibular Disorders (TMD)
- Trial name
- ACALL (NCT06782178)
- Testing
- Arthroscopic lysis and lavage, Arthrocentesis/Saline
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Temporomandibular Joint Disc Displacement, With Reduction, Temporomandibular Disorders (TMD)
TMJ Arthroscopic Lysis and Lavage Compared to Operative Arthroscopy in Disc Displacement With Reduction.
The goal of this clinical trial is to compare the intervention arthroscopic lysis and lavage to the intervention operative arthroscopy in treating disabling and painful temporomandibular joint disc displacement with reduction.
- Trial name
- ALLOAA (NCT06782191)
- Testing
- Arthroscopic lysis and lavage, Operative arthroscopy
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Karolinska Institutet
Post-COVID Syndrome
Exercise Intolerance in Post-COVID Patients
The post-COVID syndrome poses an unprecedented challenge to modern society, affecting millions of people worldwide. Persistent fatigue and exercise intolerance are among the most common complaints of these subjects.
- Trial name
- EXILE (NCT05445830)
- Testing
- High-Intensity-Interval-Exercise, Moderate-Intensity-Continuous-Exercise, Strength training
- Where
- Sweden
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Muscle-invasive Urothelial Carcinoma
A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)
The original purpose of this study was to evaluate the efficacy of adjuvant treatment with autogene cevumeran plus nivolumab compared with nivolumab in participants with high risk MIUC.
- Trial name
- IMCODE004 (NCT06534983)
- Testing
- Autogene Cevumeran, Nivolumab
- Where
- 43 sites in United States, Argentina and 13 more
- Volunteers
- 62 people
- Sponsor
- Hoffmann-La Roche
Metastatic Breast Cancer
AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.
This program initially aims to recruit 1300 breast cancer patients from a large number of hospitals across Europe. Eligible patients are those who are 18 or older, either female or male, and who have not received more than 1 type…
- Trial name
- AURORA (NCT02102165)
- Testing
- metastatic lesion biopsy
- Where
- 52 sites in Belgium, Germany and 8 more
- Volunteers
- 1,000 people
- Sponsor
- Jules Bordet Institute
Ischemic Stroke, TIA
Atrial Fibrillation Screening Post Ischemic Cerebrovascular Events
Stroke is one of the leading causes behind death and permanent disability in adults. Atrial fibrillation (AF) is the most common clinical arrhythmia and its prevalence is steeply increasing with age.
- Trial name
- AF-SPICE (NCT05134454)
- Testing
- Extended ECG investigation
- Where
- Sweden
- Volunteers
- 3,300 people
- Sponsor
- Karolinska Institutet
Temporomandibular Disorders
Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A
The goal of this clinical trial is to investigate the effect of botulinum toxin on neurons' plasticity in the masseter muscle in humans with and without painful myogenous temporomandibular disorders (TMDM).
- Trial name
- NCT05720065
- Testing
- Botulinum toxin type A, Isotonic saline 0,9%
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Early Childhood Caries (ECC)
Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment
The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for…
- Trial name
- DecodECC (NCT06957509)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Pre-diabetes, Diabetes
OGTT at Home Using CGM vs at the Clinic
This randomized, crossover study evaluates the feasibility and accuracy of a self-administered oral glucose tolerance test (OGTT) at home using continuous glucose monitoring (CGM) compared to a standard clinic-based OGTT.
- Trial name
- OGTT-CGM (NCT06862128)
- Testing
- OGTT at home using CGM, OGTT at the clinic
- Where
- 3 sites in Sweden
- Volunteers
- 70 people
- Sponsor
- Linkoeping University
Lung Cancer, Pulmonary Metastasis
National Register Studies in Thoracic Surgery
The overall project aim is to study risk and outcomes following thoracic surgery by cross-linking high-quality national Swedish health-data registers for population-based investigations of individual level clinically relevant…
- Conditions
- Lung Cancer, Pulmonary Metastasis, Surgery
- Trial name
- NCT03567538
- Testing
- Thoracic surgery
- Where
- Sweden
- Volunteers
- 20,000 people
- Sponsor
- Karolinska University Hospital
Healthy, Gastrointestinal Cancer
Dietary Nitrate and Nitrite Intake and Phosphate Biomarkers and Risk of Chronic Diseases
Nitrate, nitrite, and phosphate (NO3, NO2, P) are at all age stages ubiquitous in our everyday foods, including naturally occurring and as food additives, and in our drinking water.
- Conditions
- Healthy, Gastrointestinal Cancer, Cardiovascular Diseases, Chronic Obstructive Airway Disease
- Trial name
- NCT07746310
- Where
- Sweden
- Volunteers
- 86,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Attention Deficit Disorder With or Without Hyperactivity (ADHD)
Evaluating Effects of Group-based CBT for Emotion Regulation in Adult ADHD
This study will evaluate if a specific treatment for emotion regulation in ADHD, GEARS, effectively reduces symptoms of emotional dysregulation.
- Trial name
- GEARS (NCT07614867)
- Testing
- Group Therapy for Improving Emotional Acceptance and Regulatory Skills in Adults with ADHD (GEARS)
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska Institutet
Oesophageal Cancer, Gastric Cancer (Diagnosis)
REcovery After Cancer Application
The RECapp study is a clinical trial evaluating a digital tool designed to support patients recovering from surgery for oesophageal or stomach cancer. The goal is to reduce symptoms and improve quality of life during recovery.
- Trial name
- RECapp (NCT07642492)
- Testing
- The RECapp platform
- Where
- 7 sites in Sweden
- Volunteers
- 250 people
- Sponsor
- Karolinska Institutet
Myogenic Temporomandibular Joint Disorders, Myofacial Pain
Efficacy of PRP Injections in Reducing Pain for Myogenous TMD Patients
This study aims to evaluate whether intramuscular injections of platelet-rich plasma (PRP) are more effective than isotonic saline in reducing pain and improving jaw function in individuals diagnosed with myogenous…
- Conditions
- Myogenic Temporomandibular Joint Disorders, Myofacial Pain, Masseter Muscle
- Trial name
- NCT07606378
- Testing
- Saline (0.9% NaCl), Platelet rich plasma (PRP)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Depression, Panic Disorder
Evaluating Clinical Routines for ICBT
The overall aim of this study is to test the clinical benefits of an AI-based decision support tool (DST) and to evaluate how the DST affects therapists and their patients with depression, social anxiety, or panic disorder during…
- Conditions
- Depression, Panic Disorder, Social Anxiety Disorder
- Trial name
- NCT05321628
- Testing
- Internet-based Cognitive Behavioural Therapy (iCBT) with Decision Support Tool, Internet-based Cognitive Behavioural Therapy (iCBT)
- Where
- Sweden
- Volunteers
- 401 people
- Sponsor
- Karolinska Institutet
Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
In this study, researchers will learn more about a study drug called BIIB059 (litifilimab) in participants with cutaneous lupus erythematosus (CLE).
- Trial name
- AMETHYST LTE (NCT06044337)
- Testing
- BIIB059 (litifilimab)
- Where
- 104 sites in United States, Argentina and 23 more
- Volunteers
- 306 people
- Sponsor
- Biogen
Amyloidosis, Amyloid Cardiomyopathy
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Transthyretin amyloidosis (ATTR) is a disease where the normally occurring transthyretin (TTR) protein falls apart and forms amyloid, a sticky plaque-like substance that accumulates in different organs in the body and can cause…
- Conditions
- Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Cardiomyopathies
- Trial name
- NCT06563895
- Testing
- Acoramidis
- Where
- 104 sites in United States, Argentina and 22 more
- Volunteers
- 587 people
- Sponsor
- Eidos Therapeutics, a BridgeBio company
Ulcerative Colitis
A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).This study will evaluate how safe and effective risankizumab is…
- Trial name
- REVAMP (NCT06880744)
- Testing
- Risankizumab, Vedolizumab
- Where
- 270 sites in United States, Austria and 29 more
- Volunteers
- 573 people
- Sponsor
- AbbVie
Follicular Lymphoma (FL)
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
Follicular lymphoma (FL) is the second most common B-cell cancer and the most common type of cancer of lymphocytes. Unfortunately, this disease is incurable with conventional treatment and the disease recurs in almost all…
- Trial name
- EPCORE™FL-2 (NCT06191744)
- Testing
- Epcoritamab, Prednisone, Rituximab
- Where
- 266 sites in United States, Australia and 30 more
- Volunteers
- 1,095 people
- Sponsor
- Genmab
Liver Diseases, Alcoholic
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease
The goal of this study is to assess the safety and efficacy of GSK4532990 in participants with alcohol-related liver disease.
- Trial name
- STARLIGHT (NCT06613698)
- Testing
- GSK4532990
- Where
- 140 sites in United States, Argentina and 16 more
- Volunteers
- 393 people
- Sponsor
- GlaxoSmithKline
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