Clinical trials: open to volunteers, in Sweden
Patient-controlled Admissions, Matched Control Group
Patient-controlled Admissions to Inpatient Care
Patient-controlled admissions refer to the possibility for patients with severe psychiatric conditions to admit themselves to inpatient care.
- Trial name
- NCT04862897
- Testing
- Patient-controlled admissions
- Where
- Sweden
- Volunteers
- 564 people
- Sponsor
- Karolinska Institutet
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART C (NCT05745714)
- Testing
- Ruxolitinib, Venetoclax, Dexamethasone
- Where
- 33 sites in Austria, Belgium and 12 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Metastatic Breast Cancer
Sweden Cancerome Analysis Network - Breast Recurrence (SCAN-B-rec)
Prospective multicenter observational study to assess molecular drivers of metastatic breast cancer and disease evolution upon therapeutic pressure.
- Trial name
- NCT03758976
- Testing
- Biopsies, blood
- Where
- 2 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Lund University Hospital
Lung Transplant Failure and Rejection, Lung Transplant Infection
Liquid biopsiEs fOr luNg AllogRaft Damage classificatiOn - LEONARDO
LTx has the shortest survival of all solid organ transplants. The complex and time-demanding diagnostics of allograft dysfunction are a significant reason for this.
- Trial name
- LEONARDO (NCT06679257)
- Testing
- cell-free dNA
- Where
- Sweden
- Volunteers
- 146 people
- Sponsor
- Jesper Magnusson
Pulmonary Atresia With Intact Ventricular Septum, Congenital Heart Disease
Prognostic Model of Postnatal Circulation in Pulmonary Atresia-critical Stenosis With Intact Ventricular Septum
Pulmonary atresia (PA)/critical stenosis (CS) with intact ventricular septum (PA/CS-IVS) is a rare congenital heart disease (CHD), that presents heterogeneously.
- Conditions
- Pulmonary Atresia With Intact Ventricular Septum, Congenital Heart Disease, Fetal Cardiac Disorder
- Trial name
- NCT07095829
- Testing
- No intervention
- Where
- 2 sites in Spain, Sweden
- Volunteers
- 150 people
- Sponsor
- Hospital Universitario 12 de Octubre
Amyotrophic Lateral Sclerosis
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
The objective is to compare the efficacy and safety of masitinib in combination with riluzole versus matched placebo in combination with riluzole for the treatment of Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT03127267
- Testing
- Masitinib (6.0), Riluzole, Masitinib (4.5)
- Where
- 56 sites in United States, Belgium and 15 more
- Volunteers
- 495 people
- Sponsor
- AB Science
Mitral Regurgitation, Mitral Valve Prolapse
Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
Study objectives: To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline…
- Conditions
- Mitral Regurgitation, Mitral Valve Prolapse, Ventricular Tachycardia
- Trial name
- Mitra-VT (NCT06255457)
- Testing
- Mitral valve surgery
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Neuroendocrine Tumors
Systemic Targeted Adaptive RadioTherapy of NeuroEndocrine Tumors.
There are several ways of personalizing PRRT (peptide receptor radionuclide treatment) in NEN (neuroendocrine neoplasia). Nevertheless, the current treatment regimen is not personalized.
- Trial name
- START-NET (NCT05387603)
- Testing
- 177Lu-DOTATOC, Capecitabine
- Where
- 4 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Lund University Hospital
Hospital
Hospital-at-Home Education as Implementation Tool - RCT
To enhance implementation of Hospital-at-home (HaH) in Scandinavia, the Nordic Digital Health \& Education (NorDigHE) project has developed a comprehensive virtual education on HaH for clinical staff.
- Trial name
- HAH-EDUCATION (NCT07166653)
- Testing
- HaH education
- Where
- 3 sites in Denmark, Norway and 1 more
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Contraception, Intrauterine Device
Structured Contraceptive Counseling During Pregnancy
Unintended pregnancy is common among women of fertile age, and also among those who have recently given birth. A Swedish study has shown that about 7.7% experience a new pregnancy, and that 2.5% will have an abortion between…
- Conditions
- Contraception, Intrauterine Device, Contraceptive Implant, Long-acting Reversible Contraception
- Trial name
- NCT05550064
- Testing
- Structured contraceptive counseling
- Where
- 4 sites in Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Dalarna University
Rheumatoid Arthritis (RA)
Treatment With Auricular Vagus Nerve Stimulation in Rheumatoid Arthritis - the TRAVAGA Study
Purpose and aim The overall aim is to investigate efficacy and safety of a newly developed non-invasive auricular investigational device that electrically stimulates the auricular branch of the vagus nerve to activate the…
- Trial name
- TRAVAGA (NCT06779123)
- Testing
- Transauricular vagus nerve stimulation., transauricular vagus nerve non-stimulation
- Where
- 6 sites in Sweden
- Volunteers
- 128 people
- Sponsor
- taVNS AB
Type 1 Diabetes Mellitus
The Skin Barrier in Users of Diabetes Devices
Diabetes technology (insulin pumps and continuous glucose monitoring) have become standard of care in children with type 1 diabetes.
- Trial name
- StenoLin (NCT06856954)
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Jannet Svensson
Pelvic Girdle Pain, Physical Activity
WOMENinMOTION An Intervention Model for Pelvic Girdle Pain
The overall aim is to educate women to handle common pregnancy-related pain experiences to facilitate healthy life-long physical activity habits and prevent chronic pain.
- Trial name
- WIMPGP (NCT07158957)
- Testing
- knowledge, motivation for behavioral change
- Where
- 2 sites in Sweden
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Prostate Cancer Patients
A Digitally Distributed Yoga Intervention in Prostate Cancer Rehabilitation : Protocol for a Randomized Controlled Trial
Prostate cancer and its treatment can affect psychological, physical, and social quality of life. The most common side effects of the disease and treatment are bowel and urinary problems, sexual issues, and reduced quality of…
- Trial name
- Digiyoga-P (NCT07158138)
- Testing
- Digital yoga intervention
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Region Örebro County
Gall Bladder Cancer
Robotic-assisted Contra Open Resection for Suspected or Confirmed Gallbladder Cancer (ROBOCOP)
The Robocop trial is an international multi-centre, single blinded, randomized controlled superiority trial conducted in centres experienced in robotic-assisted liver surgery.
- Trial name
- ROBOCOP (NCT06246448)
- Testing
- Robotic-assisted radical cholecystectomy, Open radical cholecystectomy
- Where
- Sweden
- Volunteers
- 94 people
- Sponsor
- Karolinska University Hospital
Rare Diseases, Genetic Disease
Structural Chromosome Rearrangements and Brain Disorders
The project is focused on the detailed study of structural genomic variants (SVs). Such genetic mutations are in fact alterations in the DNA molecule structure and include copy number variants, inversions and translocations.
- Conditions
- Rare Diseases, Genetic Disease, Chromosome Abnormality
- Trial name
- NCT06072079
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Karolinska Institutet
Heart Failure
Registry BAsed Optimization Of Therapy in Heart Failure
Rationale. Although several pharmacological treatments, namely renin-angiotensin-system inhibitors, sacubitril/valsartan, beta-blockers, mineralocorticoid receptor antagonists and sodium-glucose cotransporter-2 inhibitors…
- Trial name
- REBOOT-HFrEF (NCT07154758)
- Testing
- Screening for need of HFrEF GDMT implementation through SwedeHF
- Where
- 6 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Region Stockholm
Mandibular Reconstruction, Segmental Mandibular Defects
Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection and Drugs-induced Osteonecrosis
Prospective will be collected in a minimum of 300 patients presenting with an acquired segmental mandibular defect ≥ 2 cm secondary to OSSC removal and drugs-induced osteonecrosis, and who require mandibular reconstruction.
- Trial name
- NCT04098146
- Testing
- Surgical Resection and Reconstruction
- Where
- 19 sites in United States, Germany and 6 more
- Volunteers
- 300 people
- Sponsor
- AO Innovation Translation Center
General Surgery, Perioperative Medicine
Preoperative Walking Evaluation and Postoperative Outcome
The hypothesis is that physical activity is associated with a reduced risk of complications and death after surgery. Self-reporting of physical activity is prone to be unreliable.
- Trial name
- PREVENT (NCT06023069)
- Testing
- Number of steps recorded by mobile phone as a proxy for physical activity
- Where
- Sweden
- Volunteers
- 264 people
- Sponsor
- Karolinska Institutet
Diabetes Mellitus
Role of Red Blood Cells in Cardiovascular Disease
The risk of myocardial infarction is dependent on cardiovascular risk factors including type 2 diabetes (T2D) but underlying mechanisms are poorly understood.
- Trial name
- NCT07151222
- Where
- Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
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