Clinical trials: Paracetamol
Acetaminophen Toxicity
A Randomized, Single-blind, Parallel Group and Multiple - Dose Design Study
To investigate and compare the possible response of Panadol® and SafeTynadol® formulations in healthy volunteers.
- Trial name
- NCT03451487
- Testing
- Panadol®, SafeTynadol®
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sinew Pharma Inc.
Acute Pain
A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy
The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of VX-993 in treating acute pain after a bunionectomy.
- Trial name
- NCT06619847
- Testing
- VX-993, HB/APAP
- Where
- 14 sites in United States
- Volunteers
- 367 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Analgesia
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Phase 3b, open-label single-arm study in which all subjects receive HTX-011 as part of a scheduled non-opioid MMA regimen.
- Trial name
- NCT03974932
- Testing
- HTX-011, Ibuprofen, Acetaminophen
- Where
- 6 sites in United States
- Volunteers
- 116 people
- Sponsor
- Heron Therapeutics
Pain, Postoperative Pain
A Comparative Study of JNS013 in Participants With Post-Tooth-Extraction Pain
The purpose of this study is to evaluate the efficacy and safety of JNS013 with single oral dose administration in participants with pain after tooth-extraction of mandibular impacted wisdom tooth.
- Trial name
- NCT00737048
- Testing
- Tramadol Hydrochloride, Acetaminophen, Tramadol plus Acetaminophen
- Where
- 11 sites in Japan
- Volunteers
- 328 people
- Sponsor
- Janssen Pharmaceutical K.K.
Healthy Subjects
Evaluation of Apraglutide on Gastric Emptying
The primary objective is to assess the effect of apraglutide on gastric emptying of liquids in healthy subjects, as measured by the PK of acetaminophen mixed with a liquid meal.
- Trial name
- NCT05995704
- Testing
- Apraglutide, Acetaminophen
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VectivBio AG
Post Operative Pain
Maxigesic IV Phase 3 Bunionectomy Study
The purpose of the study is to determine the clinical efficacy and safety of Maxigesic IV, acetaminophen IV, Ibuprofen IV versus placebo IV for the treatment of acute postoperative pain after bunionectomy
- Trial name
- NCT02689063
- Testing
- Maxigesic IV, IV Acetaminophen, IV Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 276 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Healthy Volunteer
At What Time Therapeutic Plasma Concentrations of Paracetamol Are Achieved in Two Marketed Formulations
This will be a single centre, open label, randomised, two-way crossover study in healthy volunteers under semi-fed conditions. Two formulations of paracetamol, are being tested in this study to establish at what time point a…
- Trial name
- NCT01551836
- Testing
- Paracetamol formulation 1, Paracetamol formulation 2
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Pain, Bunionectomy
A Clinical Trial of GRT7040 in Adults With Acute Pain Following Bunionectomy
This is a Phase 2 clinical trial of GRT7040, currently being developed for the treatment of moderate-to-severe acute pain. The primary purpose of this trial is to assess efficacy and safety of GRT7040 compared with placebo in…
- Trial name
- NCT07807644
- Testing
- GRT7040, Hydrocodone bitartrate/ acetaminophen (HB/APAP)
- Volunteers
- 400 people
- Sponsor
- Grünenthal GmbH
Infections, Streptococcal
Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A
The purpose of this trial is to assess if the rate of febrile reactions following the co-administration of a booster dose of pneumococcal conjugate vaccines with standard infant vaccines is lowered when paracetamol is given…
- Trial name
- NCT00496015
- Testing
- Pneumococcal conjugate vaccine GSK1024850A., Infanrix hexa., Meningococcal vaccine GSK134612.
- Where
- 10 sites in Czechia
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Postoperative Pain
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
- Trial name
- NCT00092313
- Testing
- MK0966, rofecoxib, Comparator: oxycodone and acetaminophen
- Volunteers
- 271 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain
A 12-Week Efficacy Study of Paracetamol 1000mg Sustained-release Tablets in Patients With Osteoarthritis
The purpose of the study is to determine whether paracetamol 1000 mg sustained-release (SR) tablets administered orally, twice daily are effective and safe in the treatment of patients with osteoarthritis of the knee or hip.
- Trial name
- NCT02311881
- Testing
- Paracetamol 1000 mg SR tablets, Paracetamol 665 mg SR tablets
- Where
- 56 sites in United States
- Volunteers
- 960 people
- Sponsor
- GlaxoSmithKline
Respiratory Tract Infections
To Test Bioequivalence Between Two Formulations of Paracetamol/Phenylephrine
This study is designed to assess bioequivalence between two paracetamol/ phenylephrine combination products.
- Trial name
- NCT01112462
- Testing
- Paracetamol 500 mg/Phenylephrine 5 mg tablets, Paracetamol 1000 mg/Phenylephrine 10 mg sachet
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McNeil AB
DiGeorge Anomaly, Complete DiGeorge Anomaly
Phase I/II Thymus Transplantation With Immunosuppression #950
The study purpose is to determine if cultured thymus tissue implantation (CTTI) (previously described as transplantation) with tailored immunosuppression based on the recipient's pre-implantation T cell population is a safe and…
- Conditions
- DiGeorge Anomaly, Complete DiGeorge Anomaly, Complete Atypical DiGeorge Anomaly, Complete DiGeorge Syndrome
- Trial name
- #950 (NCT00579527)
- Testing
- Cultured Thymus Tissue for Implantation (CTTI), Cultured Thymus Tissue Implantation and Parental Parathyroid Transplantation, Blood Draw
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Healthy
Effects of Oxybutynin Topical Gel on Gastric Emptying
This study explores the effect of oxybutynin topical gel on gastric emptying
- Trial name
- NCT00926926
- Testing
- Oxybutynin Chloride Gel
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Watson Pharmaceuticals
Healthy
Bioequivalnce Study of Loratadine / Pseudoephedrine Sulfate 10/ 240 mg Extended-Release Tablets Under Fasting Conditions
The objective of this study was to compare the single-dose relative bioavailability of Ranbaxy and Schering (Claritin-D® 24 hour) Loratadine 10mg /Pseudoephedrine Sulfate 240 mg Extended-Release Tablets, in a fully replicated…
- Trial name
- NCT00837915
- Testing
- Loratadine 10mg /Pseudoephedrine Sulfate 240 mg Extended-Release Tablets
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Osteoarthritis
Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly
The primary objective is to compare buprenorphine transdermal delivery system (BTDS) with standard- treatment in subjects with osteoarthritis (OA).
- Trial name
- NCT00324038
- Testing
- Buprenorphine, Codeine paracetamol
- Where
- United Kingdom
- Volunteers
- 219 people
- Sponsor
- Napp Pharmaceuticals Limited
Cesarean Section; Dehiscence
To Study and Evaluate the Effectiveness of Treatment by Percutaneous Electrical NeuroStimulation (PENS) for Post-operative Pain in Cesarean Section Patients Using Primary Relief v 2.0
To study and evaluate the Effectiveness of Treatment by Percutaneous Electrical NeuroStimulation (PENS) for post-operative pain in Cesarean Section patients using First Relief
- Trial name
- POPS (NCT03829774)
- Testing
- Primary Relief v 2.0, Paracetamol
- Where
- India
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- DyAnsys, Inc.
Migraine Disorders, Heart Disease
Telcagepant (MK-0974) Treatment of Migraine in Participants With Stable Vascular Disease (MK-0974-034)
The purpose of this study is to evaluate the safety and efficacy of telcagepant in the treatment of acute migraine in participants with stable vascular disease.
- Conditions
- Migraine Disorders, Heart Disease, Cerebrovascular Accident, TIA (Transient Ischemic Attack)
- Trial name
- NCT00662818
- Testing
- Telcagepant, Acetaminophen/Paracetamol
- Volunteers
- 165 people
- Sponsor
- Merck Sharp & Dohme LLC
Pemphigus
Long-Term Extension Study of Ofatumumab in Subjects With Pemphigus Vulgaris
This study is designed as a multi-country, multicenter, open label extension to Phase III trial OPV116910. The primary objective is to provide continued treatment with ofatumumab subcutaneous (SC) for eligible subjects who…
- Trial name
- NCT02613910
- Testing
- Ofatumumab, Acetaminophen/paracetamol, Antihistamine (cetirizine or equivalent)
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Pain
A Study to Compare Two Paracetamol Formulations.
A pharmacokinetic study investigating the rate and extent of absorption of paracetamol and an adjuvant from two different paracetamol formulations.
- Trial name
- NCT01592227
- Testing
- Marketed paracetamol, Experimental paracetamol formulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline