Clinical trials: sponsored by Alcon Research
Dry Eye
Systane® Ultra Preservative Free Lubricant Eye Drops
The purpose of this post-market clinical follow-up (PMCF) study is to assess the performance and safety of Systane Ultra Preservative-Free (PF) in subjects experiencing dry eye symptoms (Group 1) and contact lens (CL) wearers…
- Trial name
- NCT05902364
- Testing
- Systane Ultra PF lubricant eye drops
- Where
- 4 sites in Canada, New Zealand
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye Disease
Evaluation of the Safety and Tolerability of Ocular Lubricants
The purpose of this study is to evaluate the safety and tolerability of three new artificial tear formulations in subjects with moderate dry eye disease.
- Trial name
- NCT06571656
- Testing
- FID123359 test formulation, FID123360 test formulation, FID123361 test formulation
- Where
- 5 sites in Australia
- Volunteers
- 73 people
- Sponsor
- Alcon Research
Refractive Errors
Air Optix Plus HydraGlyde Multifocal Daily/Extended Wear Contact Lenses
The purpose of this Post-Market Clinical Follow-Up (PMCF) study is to assess long term performance and safety of Air Optix plus HydraGlyde Multifocal soft contact lenses in a real-world setting when worn as daily wear or extended…
- Trial name
- NCT05886894
- Testing
- Lotrafilcon B multifocal soft contact lenses, Comfilcon A multifocal soft contact lenses
- Where
- 8 sites in United States
- Volunteers
- 351 people
- Sponsor
- Alcon Research
Aphakia
A Real-World Evidence (RWE) Long-Term Follow-Up Study to Assess Outcomes of Alcon Monofocal Intraocular Lenses
The purpose of this post-market clinical follow-up (PMCF) study is to describe the long-term safety and performance of AcrySof Single-Piece and AcrySof Multi-Piece monofocal intraocular lenses (IOLs).
- Trial name
- NCT05799950
- Testing
- AcrySof single-piece IOL, AcrySof multi-piece IOL
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 138 people
- Sponsor
- Alcon Research
Refractive Errors
Air Optix Extended Wear Contact Lenses
The purpose of this Post-Market Clinical Follow-Up (PMCF) study is to assess long term performance and safety of Air Optix Aqua Sphere, Air Optix plus HydraGlyde Sphere, and Air Optix plus HydraGlyde Toric soft contact lenses in…
- Trial name
- NCT05886881
- Testing
- Lotrafilcon B spherical soft contact lenses, Lotrafilcon B spherical soft contact lenses with comfort additive, Lotrafilcon B toric soft contact lenses with comfort additive
- Where
- 4 sites in United States
- Volunteers
- 505 people
- Sponsor
- Alcon Research
Ametropia, Myopia
Post-market Clinical Follow-up Study of Alcon TOTAL30® Contact Lenses (Lehfilcon A)
The purpose of this Post-Market Clinical Follow-Up (PMCF) study is to continuously assess the visual performance and safety of TOTAL30 Sphere and TOTAL30 for Astigmatism contact lenses in a real-world setting across a broad…
- Conditions
- Ametropia, Myopia, Hyperopia, Astigmatism
- Trial name
- NCT06408649
- Testing
- Lehfilcon A spherical contact lenses, Lehfilcon A toric contact lenses
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Alcon Research
Myopia, Hyperopia
DAILIES TOTAL1® Soft Contact Lenses - Post-Market Clinical Follow-up Study
The purpose of this study is to continuously assess the visual performance and safety of DAILIES TOTAL1 soft contact lenses in a real world setting and broader patient base through routine clinical practices.
- Conditions
- Myopia, Hyperopia, Presbyopia, Astigmatism
- Trial name
- NCT06483113
- Testing
- Delefilcon A spherical soft contact lenses, Delefilcon A toric soft contact lenses, Delefilcon A multifocal soft contact lenses
- Where
- 12 sites in United States
- Volunteers
- 192 people
- Sponsor
- Alcon Research
Refractive Errors
Post-market Clinical Follow-up Study of Alcon PRECISION1™ Spherical and PRECISION1™ for Astigmatism Soft Contact Lenses
The purpose of this study is to assess long term performance and safety of verofilcon A soft contact lenses in a real-world setting in a population of 7 years or older having at least 1 year of verofilcon A (sphere or toric)…
- Trial name
- NCT06462456
- Testing
- Verofilcon A spherical soft contact lenses, Verofilcon A toric soft contact lenses
- Where
- 12 sites in United States
- Volunteers
- 140 people
- Sponsor
- Alcon Research
Vitreoretinal Disease With or Without Cataracts
Next Generation Cataract and Vitreoretinal Surgery Study
The purpose of this study is to obtain device-specific safety and performance clinical data to support marketability in Europe and to collect formal user feedback.
- Trial name
- NCT06165744
- Testing
- UNITY Vitreoretinal Cataract System, Posterior segment surgery in the operating room with or without simultaneous cataract surgery
- Where
- 5 sites in Australia
- Volunteers
- 120 people
- Sponsor
- Alcon Research
Cosmetic Appearance
Lotrafilcon B Plano Cosmetic Contact Lenses Study
The purpose of this study is to gather long-term performance and safety data on AIR OPTIX™ COLORS (lotrafilcon B) plano cosmetic contact lenses in subjects 12 years of age and older.
- Trial name
- NCT06493383
- Testing
- Lotrafilcon B plano cosmetic contact lenses
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alcon Research
Cosmetic Appearance
Cosmetic Contact Lenses Post-Market Clinical Follow-up Study
The purpose of this post-market study is to gather long term performance and safety data on FreshLook® One-day Colors cosmetic contact lenses and DAILIES FreshLook® ILLUMINATE cosmetic contact lenses in participants 12 years of…
- Trial name
- NCT06517316
- Testing
- Nelfilcon A plano cosmetic contact lenses
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alcon Research
Cataract
Next Generation Cataract Surgery Study
The purpose of this study is to obtain device-specific safety and performance clinical data to support marketability in Europe and to collect user preference data.
- Trial name
- NCT06071104
- Testing
- Anterior segment ophthalmic surgery, UNITY VCS
- Where
- 4 sites in United States
- Volunteers
- 121 people
- Sponsor
- Alcon Research
Ametropia, Astigmatism
Comparison of Clinical Performance of Two Monthly Replacement Toric Soft Contact Lenses
The purpose of this study is to assess the clinical performance of TOTAL30 for Astigmatism (T30fA) soft contact lenses with Biofinity Toric soft contact lenses.
- Trial name
- NCT06165627
- Testing
- Lehfilcon A toric contact lenses, Comfilcon A toric contact lenses, CLEAR CARE
- Where
- 5 sites in United States
- Volunteers
- 67 people
- Sponsor
- Alcon Research
Myopia
WaveLight® EX500 Excimer Laser System for the Correction of Myopia Using InnovEyes™ in Conjunction With InnovEyes™ Sightmap
The purpose of this study is to evaluate the safety and effectiveness of the WaveLight EX500 excimer laser system for the correction of myopia with and without astigmatism using InnovEyes in conjunction with InnovEyes sightmap.
- Trial name
- NCT04219891
- Testing
- WaveLight EX500 excimer laser system with InnovEyes sightmap, LASIK, InnovEyes sightmap
- Where
- 9 sites in United States
- Volunteers
- 272 people
- Sponsor
- Alcon Research
Dry Eye
Systane® Complete Preservative Free Lubricant Eye Drops
The purpose of this post-market clinical follow-up (PMCF) study is to assess the performance and safety of Systane Complete Preservative Free (PF) lubricant eye drops in subjects experiencing dry eye symptoms.
- Trial name
- NCT05932225
- Testing
- Propylene glycol solution/drops
- Where
- 4 sites in Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye Disease
Evaluation of Reflex Tear Production
The purpose of this study is to evaluate reflex tear production following cotton swab nasal stimulation in subjects with dry eye disease (DED).
- Trial name
- NCT06565624
- Testing
- Cotton Swab Nasal Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Neovascular Age-Related Macular Degeneration, Choroidal Neovascularization
Efficacy and Safety of RTH258 Versus Aflibercept - Study 2
The purpose of this study is to compare brolucizumab (RTH258) ophthalmic solution for intravitreal (IVT) injection (6 mg) to aflibercept ophthalmic solution for IVT injection (2 mg) in subjects with untreated active choroidal…
- Trial name
- HARRIER (NCT02434328)
- Testing
- Brolucizumab ophthalmic solution, Aflibercept ophthalmic solution
- Volunteers
- 1,048 people
- Sponsor
- Alcon Research
Neovascular Age-Related Macular Degeneration, Choroidal Neovascularization
Efficacy and Safety of RTH258 Versus Aflibercept - Study 1
The purpose of this study is to compare brolucizumab (RTH258) ophthalmic solution for intravitreal (IVT) injection at two dosage levels (3 mg and 6 mg) to aflibercept ophthalmic solution for IVT injection (2 mg) in subjects with…
- Trial name
- HAWK (NCT02307682)
- Testing
- Brolucizumab ophthalmic solution, Aflibercept ophthalmic solution
- Where
- United States
- Volunteers
- 1,775 people
- Sponsor
- Alcon Research
Open Angle Glaucoma, Primary Open Angle Glaucoma
Safety and Effectiveness of the Hydrus Microstent
The purpose of this study is to assess the safety and effectiveness of the Hydrus Microstent for lowering intraocular pressure (IOP) in pseudophakic patients with open-angle glaucoma for whom IOP is not sufficiently controlled on…
- Conditions
- Open Angle Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigmentary Glaucoma
- Trial name
- FRONTIER (NCT05198297)
- Testing
- Hydrus Microstent, Ophthalmic surgery
- Where
- 5 sites in United States
- Volunteers
- 33 people
- Sponsor
- Alcon Research
Refractive Errors
Contralateral Study of WaveLight® Femtosecond Laser Devices for Corneal Flap Creation
The purpose of this study is to assess the WaveLight Ultraviolet Femtosecond Laser System, Model 1026 (UV fs-Laser) corneal flap creation accuracy as compared to the already marketed WaveLight FS200 Infrared Femtosecond Laser…
- Trial name
- NCT06021353
- Testing
- UV fs-Laser, IR fs-Laser, LASIK
- Where
- Australia
- Volunteers
- 47 people
- Sponsor
- Alcon Research