Clinical trials: Acetaminophen
Meniscus Disorder, Narcotic Use
Nonopioid Analgesia After Arthroscopic Meniscus Surgery
This is a randomized, single blinded, standard of care controlled clinical trial. This project aims to compare postoperative pain control in patients in two treatment arms of arthroscopic meniscus surgery: a treatment group given…
- Trial name
- NCT03820193
- Testing
- Celecoxib, Hydrocodon/Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Drug Induced Liver Injury
Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by processing it in the liver. During the processing, some of the acetaminophen may bind to proteins in the liver.
- Trial name
- Non-Drinker (NCT00616018)
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Kennon Heard
Acute Dental Pain
Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain
Acute dental pain is one of the most challenging conditions to treat and manage in dental practice. The aim of this study was to compare the efficacy of naproxen sodium + codeine phosphate (550/30 mg) and dexketoprofen trometamol…
- Trial name
- NCT06916234
- Testing
- Dexketoprofen Trometamol + Paracetamol, Naproxen Sodium + Codeine Phosphate
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ibrahim doğru
Headache, Pregnancy Related
Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
This is an open label randomized controlled trial evaluating response to bupivacaine occipital nerve block compared to Tylenol/Caffeine cocktail in treatment of pregnant patients seeking care of headache.
- Conditions
- Headache, Pregnancy Related, Occipital Nerve Block
- Trial name
- NCT03951649
- Testing
- Occipital Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Thumb Basal Joint Osteoarthritis, Postoperative Pain
Journavx to Treat Pain After Thumb Basal Joint Arthroplasty
The purpose of this study is to find out how well suzetrigine, a newly FDA-approved non-opioid pain medication, works to relieve pain after thumb basal joint replacement surgery.
- Conditions
- Thumb Basal Joint Osteoarthritis, Postoperative Pain, Joint Replacement Surgery, Joint Replacement
- Trial name
- NCT07723352
- Testing
- suzetrigine 100mg, Acetaminophen
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Pain, Postoperative, Postoperative Pain, Acute
Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries
This is a double-arm randomized control trial evaluating the impact of preoperative opioid-free analgesia on time to trial of void in ambulatory urogynecologic surgeries.
- Trial name
- NCT06379425
- Testing
- Acetaminophen, Celecoxib, Gabapentin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Anxiety, Pain, Postoperative
Postoperative Effects of Preoperative Anxiety
INTRODUCTION Patients who will have obesity surgery have about %48 psychiatric illnesses like anxiety disorder. Studies which analyze the relationship between preoperative anxiety level and postoperative pain had reported…
- Trial name
- NCT04432558
- Testing
- Spielberger's State-Trait Anxiety Inventory, Visual analog scale, Ramsay's sedation scale, Tramadol, paracetamol, diclofenac sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Baskent University
Pain
IV Acetaminophen for Postoperative Pain Analgesia After Laparoscopic Hysterectomy
The objective of this study is to quantify the change in post-operative pain scores and narcotic requirements in women receiving pre and post-operative IV acetaminophen compared to placebo in women undergoing laparoscopic…
- Trial name
- NCT02400580
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Emotional Pain
Effects of Acetaminophen on Hurt Feelings
The purpose of the study is to investigate whether ingestion of acetaminophen reduces the experience of hurt feelings.
- Trial name
- NCT00561288
- Testing
- acetaminophen, cornstarch
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Low Back Pain
Effect of Intraabdominal Hypopressive Exercises on Postnatal Backache and Functional Disability
The purpose of this study was to evaluate the effectiveness of hypopressive exercise in postpartum females with abnormal hyperlordosis and back pain.
- Trial name
- LBP (NCT06814704)
- Testing
- Hypopressive exercises , hot packs, acetaminophen, progressive strengthening exercises, heat therapy, pharmacological therapy, progressive strengthening exercises
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Healthy
Phase 1 Study of DW-0919 & DW-0920 in Healthy Male Volunteers Under Fasting Condition
The purpose of this study is to evaluate safety and pharmacokinetics of DW-0919 and DW-0920 in healthy male volunteers under fasting condition.
- Trial name
- DW0919-1003 (NCT01606059)
- Testing
- DW-0920, DW-0919
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Healthy
Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco
This study aims to determine whether the hydrocodone and acetaminophen exposures following oral dosing of Vycavert are comparable to those following oral dosing of Norco.
- Trial name
- NCT01456520
- Testing
- Vycavert, Norco
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tendinopathy
Can Amino Acid Supplementation Augment the Anabolic Response in Tendon After Exercise
The goal of this study is to determine if an oral provision of amino acids will enhance exercise-induced increases in markers of Achilles tendon collagen production.
- Trial name
- NCT04067479
- Testing
- Amino Acids
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Purdue University
Opioid-Related Disorders
Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users
To determine the relative abuse potential of VYCAVERT (hydrocodone bitartrate and acetaminophen) compared to GENERIC H/A (hydrocodone bitartrate and acetaminophen) when crushed and administered intranasally to non dependent…
- Trial name
- NCT01759446
- Testing
- Generic H/A taken first, Vycavert taken first, Generic H/A plus i taken first
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Acura Pharmaceuticals Inc.
Acetaminophen-protein Adduct Formation
Acetaminophen-Protein Adduct Resolution
The purpose of this study is to better understand the pharmacokinetics of acetaminophen and further clinical interpretations of laboratory results that confirm the presence of acetaminophen-cys adducts.
- Trial name
- AR (NCT01021410)
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters
This phase II randomized, placebo-controlled trial evaluates whether daily supplementation with broccoli seed and sprout extract (BSSE), also known as Avmacol Extra Strength (ES), enhances the body's natural ability to detoxify…
- Conditions
- Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm, Occupational Malignant Neoplasm
- Trial name
- NCT06009926
- Testing
- Acetaminophen, Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Multimodal Analgesic Approach
IV vs Oral Acetaminophen in Spine Fusion Perioperative Care
The United States is currently experiencing an explosive opioid epidemic. In 2014 alone, 28,647 Americans died from an opioid associated overdose; the annual death toll has increased by over 300% since 2000.
- Trial name
- NCT03020875
- Testing
- Ofirmev, Per Os Acetaminophen
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
To Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion
The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion
The last couple of years it has been shown that bile acids not only acts as simple emulsifiers of fat, but constitutes a complex metabolic integrator which not only have an influence on fat digestion and lipid metabolism, but…
- Trial name
- NCT01656057
- Testing
- Acetaminophen, Metformin, Colesevelam
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Filip Krag Knop
Photorefractive Keratectomy, Myopia
Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control
Photorefractive Keratectomy (PRK) is a commonly performed corneal refractive surgery but has significant post-operative pain. Pain medications after PRK are typically opioid-acetaminophen combinations.
- Conditions
- Photorefractive Keratectomy, Myopia, Hyperopia
- Trial name
- NCT05477875
- Testing
- oral cannabinoid, oral codeine/acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Florida
Respiratory Tract Infections
To Test Bioequivalence Between Two Formulations of Paracetamol/Phenylephrine
This study is designed to assess bioequivalence between two paracetamol/ phenylephrine combination products.
- Trial name
- NCT01112462
- Testing
- Paracetamol 500 mg/Phenylephrine 5 mg tablets, Paracetamol 1000 mg/Phenylephrine 10 mg sachet
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McNeil AB