Clinical trials: Azithromycin
Child Mortality
Improving Care Through Azithromycin Research for Infants in Africa
Infectious diseases are among the most common causes of mortality in the over 2.5 million children under 5 years of age (U5) who died in 2018 in sub-Saharan Africa (SSA).
- Trial name
- ICARIA (NCT04235816)
- Testing
- Azithromycin
- Where
- Sierra Leone
- Volunteers
- 20,560 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Trachoma
Enhancing the A in SAFE for Trachoma
This study will assess the cost and feasibility of two strategies of enhanced Mass Drug Administration (MDA) of Zithromax to treat trachoma in the Republic of South Sudan.
- Trial name
- NCT05634759
- Testing
- Azithromycin for Routine Community-wide MDA, Two Additional Rounds of Azithromycin for Children, Azithromycin for Second Community-wide MDA
- Where
- South Sudan
- Volunteers
- 34,630 people, healthy volunteers welcome
- Sponsor
- Emory University
Bacterial Infections, Eye Infections
Study of AzaSite Versus Vigamox Concentrations in the Conjunctiva and Aqueous Humor in Subjects Undergoing Routine Cataract Surgery
The purpose of this study is to evaluate the drug concentrations in the conjunctiva and aqueous humor of AzaSite™ compared to Vigamox® in subjects undergoing routine cataract surgery
- Conditions
- Bacterial Infections, Eye Infections, Cataract Extraction
- Trial name
- NCT00575380
- Testing
- AzaSite Eye Drops, Vigamox Eye Drops
- Where
- 13 sites in United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Helminth Infection
Intestinal Microbiome Post-Azythromycin/Albendazole Treatment
Molecular testing of the gut microbiome and enteric pathogens is rapidly moving beyond targeted PCR testing to next generation sequencing techniques.
- Trial name
- NCT03032042
- Testing
- Azithromycin, Albendazole, Delayed treatment
- Where
- Ethiopia
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Asthma, COPD
Anti-viral Effects of Azithromycin in Patients With Asthma and COPD
The purpose of this study is to investigate the anti-viral effects of low-dose AZM treatment in patients with asthma and COPD with an exacerbation history.
- Conditions
- Asthma, COPD, Exacerbation Copd, Asthma; Eosinophilic
- Trial name
- AZIMUNE (NCT04319705)
- Testing
- Azithromycin
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Trachoma
Sanitation, Water, and Instruction in Face-washing for Trachoma I/II
SWIFT I is a series of 3 cluster-randomized trials designed to assess several alternative strategies for trachoma control in communities that have been treated with many years of mass azithromycin distributions.
- Trial name
- SWIFT I/II (NCT02754583)
- Testing
- Water, sanitation, and hygiene (WASH) intervention, Standard of care WASH intervention, Azithromycin
- Where
- Ethiopia
- Volunteers
- 47,605 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trachoma
Azithromycin Reduction to Reach Elimination of Trachoma B
The investigators propose a randomized controlled trial of discontinuation versus continuation of annual mass azithromycin distribution in hypoendemic communities of Maniema, DRC.
- Trial name
- ARRET (NCT06289647)
- Testing
- Azithromycin
- Where
- Democratic Republic of the Congo
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Periodontal Diseases, Antibiotics
Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
Periodontitits is a bacteria induced inflammatory disease that destroys the supporting tissues of the tooth and leads to tooth loss.
- Conditions
- Periodontal Diseases, Antibiotics, Pharmacokinetics
- Trial name
- AMA (NCT04669717)
- Testing
- 3/d 500 mg Amoxicilline Sandoz plus 500 mg Flagyl for 7 days, 3/d 500 mg Amoxicilline Sandoz plus 500 mg Flagyl for 3 days, 1/d 500 mg Azithromycine Pfizer for 3 days
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Chlamydia Trachomatis Infection
Genital CT Treatment to Pregnant Women to Prevent Adverse Pregnancy Outcomes: A Pilot RCT
This study aims to identify the relationship between genital C. trachomatis and adverse pregnancy outcomes, and investigate whether screening and treatment of genital C.
- Trial name
- RCT (NCT03862495)
- Testing
- C. trachomatis and N. gonorrhoeae, Azithromycin, Partner notification and treatment
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Child Mortality
REACH2: Implementation Research on Bi-Annual Mass Distribution of Azithromycin to Children 1-11 Months in Côte d'Ivoire
REACH2 is a three-year implementation research study designed to examine the implementation through a mass drug administration platform of bi-annual single-dose azithromycin to reduce child mortality among children ages 1 to 11…
- Trial name
- REACH (NCT05016895)
- Testing
- Single-dose azithromycin
- Where
- Côte d’Ivoire
- Volunteers
- 767,535 people, healthy volunteers welcome
- Sponsor
- FHI 360
Malaria
Gut and Azithromycin Mechanisms in Infants and Children II
Childhood mortality is decreasing worldwide. However, many sub-Saharan countries still have high children under 5 mortality rates.
- Trial name
- GAMINII (NCT04315272)
- Testing
- Azithromycin
- Where
- Burkina Faso
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Low Birthweight, Preterm Birth
Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia
The ENAT study will test the impact of packages of antenatal interventions to enhance maternal nutrition and manage pregnancy infections on the outcomes of infant birth size, gestational length, and infant growth in the first 6…
- Conditions
- Low Birthweight, Preterm Birth, Maternal; Malnutrition, Affecting Fetus, Sexually Transmitted Diseases
- Trial name
- ENAT (NCT04171388)
- Testing
- Azithromycin 500 mg, Multiple Micronutrient or Fortified Balanced Energy Protein Supplement, Enhanced Infection Management Package (EIMP)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sexually Transmitted Infections, Schistosoma Haematobium
Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar
A cross-sectional study of urogenital schistosomiasis and sexually transmitted infections (STI) prevalence and associated morbidity in a rural community in Madagascar.
- Trial name
- FGS/MGS/STI (NCT00713999)
- Testing
- Treatment with anti-STI and anti-schistosoma regimens
- Where
- Madagascar
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gonococcal Infection
Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)
This is a Phase 1, interventional, non-randomized, experimental infection model study in healthy adult males (N=up to 25) between the ages of 18-35 at study enrollment.
- Trial name
- NCT04870138
- Testing
- Azithromycin, Ceftriaxone, Ciprofloxacin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Eye Infections, Bacterial
Ocular Tolerance, Safety and Ocular Pharmacokinetics After 1 Drop of T1225 0.5, 1.0, 1.5% in 48 Healthy Volunteers
To compare the ocular tolerance, the safety and the ocular pharmacokinetics of 3 concentrations (0.5% - 1.0% - 1.5%) and the vehicle of T1225 after one drop instillation
- Trial name
- NCT00357292
- Testing
- Azithromycin (T1225)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laboratoires Thea
Infections
Comparative Bioavailability Study of Azithromycin 200mg/5mL Suspension Following a 600mg Dose Under Fed Conditions
The purpose of this study is to demonstrate the bioequivalence of Azithromycin 200mg/5mL oral suspension.
- Trial name
- NCT00875966
- Testing
- Azithromycin for Oral Suspension 200mg/5mL Eon Pharma, LLC, Zithromax (azithromycin for oral suspension) 200mg/5mL Pfizer
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sandoz
Maternal Death, Maternal Infections Affecting Fetus or Newborn
Azithromycin-Prevention in Labor Use Study (A-PLUS)
Maternal and neonatal infections are among the most frequent causes of maternal and neonatal deaths, and current antibiotic strategies have not been effective in preventing many of these deaths.
- Conditions
- Maternal Death, Maternal Infections Affecting Fetus or Newborn, Neonatal SEPSIS, Maternal Sepsis During Labor
- Trial name
- NCT03871491
- Testing
- Azithromycin
- Where
- 8 sites in Bangladesh, Democratic Republic of the Congo and 5 more
- Volunteers
- 58,747 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health