Clinical trials: Best Practice
Schizophrenia
Cognitive Enhancement Therapy for Early-Stage Schizophrenia
This study will determine the effectiveness of cognitive enhancement therapy (CET) in treating cognitive abnormalities in people experiencing the early stages of schizophrenia.
- Trial name
- NCT00167362
- Testing
- Cognitive enhancement therapy (CET), Enriched supportive therapy (EST)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Alcohol Use Disorder (AUD)
The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study
A phase II randomized, double-blind, placebo-controlled clinical trial (RCT) to evaluate the ability of zonisamide (ZON) to decrease alcohol use among treatment-seeking adults with an alcohol use disorder (AUD).
- Trial name
- NCT05134857
- Testing
- Zonisamide
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Washington State University
Newborn; Infection
Deploying POKE Within Intermountain Healthcare
To assess the impact of POKE on babies, the investigators will longitudinally track outcomes before and after implementation at Intermountain Healthcare's five NICUs.
- Trial name
- POKE (NCT03688607)
- Testing
- There will not be an intervention, rather the investigators will deploy best practices and track POKEs within the healthcare system to evaluate clinical and operational outcomes.
- Where
- United States
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Cardiovascular Reactivity to Stress
Effects of Yoga on Heart Rate and Heart Rate Variability Responses to Stress
Introduction: Yoga has been shown to reduce stress and have benefits for a number of stress-related disorders. However, the effects of an acute bout of yoga practice on cardiac autonomic response to and recovery from stress…
- Trial name
- NCT04897230
- Testing
- Hatha Yoga, Video Watching
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hematologic Malignancies
Digital Health Intervention for Self-Management and Telemonitoring in Chimeric Antigen Receptor (CAR-T) Therapy
The overall purpose of this randomized control trial (RCT) is to determine the clinical effect of a multilevel, RPM-enhanced intervention during and after completion of outpatient CAR-T therapy in 190 patients and their family…
- Trial name
- NCT07186192
- Testing
- Educational Intervention, Health Telemonitoring, Questionnaire Administration
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Carcinoma
Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Groups
This clinical trial implements research strategies to increase colorectal cancer (CRC) screening rates among low income and ethnic minority groups.
- Trial name
- NCT06090643
- Testing
- Best Practice, Consultation, Educational Intervention
- Where
- United States
- Volunteers
- 9,745 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Diabetes Mellitus, Cardiovascular Disease
SPREAD-NET: PRactices Enabling Adapting and Disseminating in the Safety NET
The investigators propose to compare the effectiveness of 3 strategies (low, medium, high intensity) at supporting CHCs' implementation of the ALL Initiative (an intervention shown to reduce patients' cardiovascular disease (CVD)…
- Trial name
- SPREAD-NET (NCT02325531)
- Testing
- Low support, Medium support, High support
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Hepatitis C, HepatoCellular Carcinoma
STOP HCC: Mailed HCV Treatment Outreach Program for HCC Prevention
Aim 1: The investigators will conduct a randomized controlled trial comparing two strategies to promote HCV screening, follow-up testing, and treatment among baby-boomers (i.e.
- Trial name
- NCT03706742
- Testing
- Mailed outreach
- Where
- United States
- Volunteers
- 12,386 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8
A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer
This clinical trial compares the use of a shared decision-making communication tool during a clinical encounter to standard care for improving the quality of the shared decision-making process among patients with non-small cell…
- Conditions
- Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT06122064
- Testing
- Best Practice, Communication Intervention, Electronic Health Record Review
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pulpotomized Primary Molars
Clinical Outcomes of Digital vs Prefab Crowns for Pulpotomized Primary Molars
NuSmile Zirconia crowns: Prefabricated pediatric Zirconia crowns offer an excellent alternative to full-coverage crowns when restoring deciduous teeth with a sizeable carious defect.
- Trial name
- NCT06733909
- Testing
- Restoration of Pulpotomized Primary Molars using NuSmile Zirconia crowns, Restoration of Pulpotomized Primary Molars using BioFlx crowns, Restoration of Pulpotomized Primary Molars using Digital VITA ENAMIC crowns (CAD/CAM blanks)
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Tobacco Use Disorder, Smoking Cessation
Development of a mHealth Intervention for Ambivalent Smokers
The current pilot study will assess the feasibility and acceptability of a novel mHealth app designed for people who are ambivalent about quitting smoking.
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Motivation, Behavior, Smoking
- Trial name
- NCT04560868
- Testing
- Control mHealth program, Experimental mHealth program, Nicotine patch
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Child, Child Development
Influence of Different Physical Education Pedagogical Approaches on the Health and Development of 5-6 Year Old Children
The Skill Acquisition Methods underpinning Pedagogy for LEarning in Physical Education (SAMPLE-PE) project aims to investigate the influence of different pedagogical approaches to teaching and learning in physical education (PE)…
- Conditions
- Child, Child Development, Health Behavior, Physical Activity
- Trial name
- SAMPLE-PE (NCT03551366)
- Testing
- Linear, Nonlinear
- Where
- United Kingdom
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Chronic Disease
A Mobile Intervention Merging Yoga and Self-Management Skills
Chronic disease self-management interventions and meditative movement approaches (.e.g., yoga) can independently improve depressive symptoms.
- Trial name
- MYSkillsMobile (NCT04758312)
- Testing
- MY-Skills Mobile
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
POTS - Postural Orthostatic Tachycardia Syndrome
Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?
Postural tachycardia syndrome (POTS) is a common and disabling disorder among adolescents. No epidemiologic data exist to support the often cited 0.5 to 2% prevalence.
- Trial name
- NCT06616363
- Testing
- Questionnaires to be competed, Provide list of medication and lifetime events, Use phone App to record new life events
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Stress (Psychology), Inflamation
A Mindfulness-Based Intervention to Reduce Stress Through the Cultivation of Loving-Kindness, Compassion, Joy, and Equanimity in Healthcare Professionals
Nearly 50% of the adult workforce experience adverse psychological symptoms (e.g., stress, depression, burnout, etc.) stemming from workplace stressors, with healthcare workers experiencing rates as high as 80%.
- Conditions
- Stress (Psychology), Inflamation, Psychosocial Functioning
- Trial name
- FIERCE (NCT07283744)
- Testing
- Building Emotional Strength Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV Infections
ETE Interventions in the Dental Setting
The purpose of this study is to use information technology (IT) to support the delivery of HIV prevention and care best practices in the dental care setting to meet the Department of Health and Human Services (DHHS) Ending the…
- Trial name
- NCT05584501
- Testing
- Care Navigator, Health Information Supported Ending the HIV Epidemic (ETE) Activities in Dental Setting
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Columbia University
Bicycling, Knowledge
Study to Improve Adolescent Bicycling Safety
This cluster randomized controlled trial will evaluate a community-based bicycle safety education program with and without an in-person parent training component.
- Conditions
- Bicycling, Knowledge, Adolescent, Self Efficacy
- Trial name
- NCT05265689
- Testing
- Bike Club, Bike Club Plus
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Cara J. Hamann
Parenting Practices, Co-parenting Practices
The Good Start Matters - Parenting Program
Early childhood is an important period where the family can support the development and maintenance of healthy eating and active behaviors to prevent or reduce childhood obesity.
- Conditions
- Parenting Practices, Co-parenting Practices, Child Eating and Dietary Behaviors, Child Physical Activity/active Play/outdoor Play
- Trial name
- NCT05802160
- Testing
- Good Start Matters - Parenting intervention
- Where
- Canada
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Uterine Cervical Neoplasms
Conducting Outreach to Improve Cervical Cancer Screening Rates Among Underscreened Patients
The purpose of this project is to determine whether outreach to HIV-negative patients who are overdue for a Pap smear at a New England urban community health center can increase cervical cancer screening rates.
- Trial name
- NCT02427399
- Testing
- Letter and informational sheet, Email, Phone
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Burnout, Professionals, Wellness, Psychological
Development and Validation of Single-Session Digital Self-Guided Intervention to Prevent Burnout & Improve Wellness
This study develops and evaluates a self-guided digital single-session mental health intervention designed to reduce workplace burnout and enhance psychological well-being among employed Canadian adults.
- Trial name
- NCT07583420
- Testing
- Single-Session Intervention to Prevent Burnout & Enhance Psychological Wellness, Creative Writing
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Saint Mary's University (Canada)