Clinical trials: Blood sampling
Diagnostic Technics, Neurological
Measuring Fluid Flow in the Brain Using Alcohol and MRI in Healthy Participants
Intracranial interstitial fluid (ISF) flow is crucial for adequate clearance of extracellular waste products from the brain parenchyma.
- Trial name
- NCT04608292
- Testing
- Single-voxel MRS, Multi-voxel MRSI, Magnetization Transfer Imaging
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Pre-Eclampsia
First Trimester Screening for Preeclampsia and Intrauterine Growth RestrIction Using Three Dimensional Doppler Angiography
Introduction: Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two major pregnancy complications, related to a chronic utero-placental hypoperfusion.
- Trial name
- SPIRIT (NCT03342014)
- Testing
- Ultrasound, Blood sample collection
- Where
- France
- Volunteers
- 2,159 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Aging Disorder, Age Problem
Health Status and Its Socio-economic Covariates of the Older Population in Poland - the Nationwide PolSenior2 Survey.
The PolSenior2 survey is aimed to characterise health status of old and very-old adults in Poland.
- Conditions
- Aging Disorder, Age Problem, Healthy Aging, Immunity Disorders
- Trial name
- PolSenior2 (NCT04026815)
- Testing
- medical history, blood and urine tests
- Where
- Poland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Healthy Adults
Evaluation of the Ketogenic Potential of Different Diet Supplements
Evaluate the capacity of different dietary supplements to increase ketone production in healthy adults.
- Trial name
- NCT02693106
- Testing
- Control, Leucine, Butyrate -
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cancer
Pilot Study With the Aim to Quantify a Stress Protein in the Blood and in the Urine for the Monitoring and Early Diagnosis of Malignant Solid Tumors
Recent studies shows that extracellular vesicles (named "exosomes") released by cancer cells exhibit at their membrane the stress protein HSP70, contrary to exosomes released by normal cells.
- Trial name
- EXODIAG (NCT02662621)
- Testing
- blood samples, Urine samples
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Georges Francois Leclerc
Hepatitis A
Evaluation of the Long-term Persistence of Hepatitis A Antibodies in Healthy Adults Who Were Vaccinated 21-25 Years Earlier With GlaxoSmithKline (GSK) Biologicals' Hepatitis A Vaccine, Havrix®
The purpose of this study is to assess the long-term persistence of immunity to hepatitis A in adults who were vaccinated 21-25 years earlier with hepatitis A vaccine, Havrix®.
- Trial name
- NCT02124785
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Covid19
Local and General Immune Response After Coronavirus Disease (COVID-19) Vaccination in Volunteers
This study aims to gain more insight in the immunological characteristics and immune response on a local level (the nose) and systemic level (the blood) of healthy people vaccinated with the current available COVID-19 messenger…
- Trial name
- COVACC2 (NCT04996238)
- Testing
- Blood and nasal fluid sampling before and after COVID-19 vaccination
- Where
- Belgium
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Heathy Volunteer, Parkinsonian Syndromes
Ultralow Dose PET Imaging of 18F-FDOPA
The goal of this clinical trial is to evaluate an investigational ultralow dose PET imaging technique for Parkinsonian syndromes, neuroendocrine tumors, and gliomas detection and monitoring.
- Conditions
- Heathy Volunteer, Parkinsonian Syndromes, Neuroendocrine (NE) Tumors, Gliomas
- Trial name
- NCT07542158
- Testing
- 18F-FDOPA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
ST Elevation Myocardial Infarction
SNPs in the DNase 1 Gene Impair Its Activity and Are Increased in a STE-ACS Patient Cohort Compared to Healthy Controls
Neutrophil extracellular traps (NETs) and deoxyribonuclease (DNase) activity determine outcome in ST elevation acute coronary syndrome (STE-ACS). DNase single nucleotide polymorphisms (SNPs) were increased in a japanese cohort.
- Trial name
- NCT02615015
- Testing
- Blood draw
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Precision of Potassium (K) Test in Capillary Whole Blood
Precision Study Measuring Potassium (K) in Capillary Specimens
Assessing precision of i-STAT K test using the IUO i-STAT CG8+ cartridge on the i-STAT 1 Analyzer.
- Trial name
- NCT06291493
- Testing
- Fingerstick blood draw
- Where
- 4 sites in United States, Canada
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Abbott Point of Care
Reference Intervals, Biomarker in Early Diagnosis
Generating Intervals of Reference FFor Early Life Brain Biomarkers.
Highly sensitive immunoassays for the detection of neuro-specific biomarkers are becoming more accessible. Currently, the majority of these biomarkers are detected with the use of labour-intensive and highly skilled wet lab work.
- Conditions
- Reference Intervals, Biomarker in Early Diagnosis, Neonatal
- Trial name
- GIRAFFE (NCT07585149)
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University College Cork
Influenza
Household Transmission of Zoonotic Influenza Viruses in a Cohort of Egyptian Poultry Growers
This study seeks to determine the incidence and transmission of avian influenza viruses in humans exposed to poultry. Enrolled subjects will be selected from five different rural areas (villages) in the Nile delta region in Egypt…
- Trial name
- NCT02459171
- Testing
- Questionnaire, Blood sample, Nasal wash
- Where
- Egypt
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Gestational Diabetes Mellitus (GDM), Oxidative Stress
Impact of Chromium Supplementation on Glucido-lipidic Metabolism, Oxidative Stress and Inflammatory State in Patients with Gestational Diabetes
Our study aims to explore the influence of dietary chromium supplementation in the form of chromium picolinate, at different doses (200 µg and 400 µg per day), on the health of pregnant women with gestational diabetes.
- Conditions
- Gestational Diabetes Mellitus (GDM), Oxidative Stress, Inflammatory Status, Insulin Resistance
- Trial name
- Cr and GDM (NCT06860087)
- Testing
- Oral chromium supplementation during gestational diabetes mellitus through the administration of chromium picolinate tablets (200 µg/d), Dietary Supplement: Oral chromium supplementation during gestational diabetes mellitus through the administration of chromium picolinate tablets (400 µg/d)
- Where
- Algeria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Kasdi Merbah
Pneumonia, Lipopolysaccharides
Effect of Intrapulmonary Recombinant Human Activated Protein C (APC) on Coagulation and Inflammation After Lipopolysaccharide (LPS)
Recombinant human Activated Protein C (rhAPC) has been shown to reduce the mortality of patients with severe sepsis. The biological effects of APC are pleiotropic, and can be roughly divided in anticoagulant and cytoprotective…
- Trial name
- NCT00943267
- Testing
- Drotrecogin alpha, Saline (NaCl 0.9%), Endotoxin
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Anemia, Sickle Cell
Skin and Blood Research Samples From Healthy Volunteers and Patients With Hematologic Diseases
The investigators plan to obtain skin and blood samples from healthy volunteers and patients with a benign, inherited hematologic disease to use for research to use homologous recombination to correct β-globin gene mutations in…
- Trial name
- NCT00840567
- Testing
- Skin biopsy, Blood draw & sample
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy
Prevalence of Renal Failure and Risk Factors in an Unreferred Healthy Population
Blood sample is taken for measurement of serum creatinine, cystatin C, clone V haemoglobin, cholesterol, urine acid, glycemia and CRP. The medical file is gathered.
- Trial name
- NCT00365911
- Testing
- Taking blood sample
- Where
- Belgium
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Acute Lymphoid Leukemia, Acute Myeloid Leukemia in Children
Study of the Medullary Microenvironment in Acute Childhood Leukemia
Acute leukemia (AL) is the most common cancer in children. Despite the optimization of chemotherapy treatments and the development of supportive care, a certain number of LAs relapse and/or progress to death of the child.
- Trial name
- MILA (NCT05792007)
- Testing
- Biological sampling in patients, Biological sampling in control patients
- Where
- 3 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Hypertension, Pulmonary, Pulmonary Arterial Hypertension
Endothelial Function in Patients With Pulmonary Arterial Hypertension
The objectives of the current study are to identify and evaluate new prognostic non-invasive and serological markers in patients with pulmonary hypertension.
- Conditions
- Hypertension, Pulmonary, Pulmonary Arterial Hypertension, Pathophysiology, Genetics
- Trial name
- NCT01317134
- Testing
- EndoPAT measurement, Blood Test
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Failure
A Study Evaluating Biomarkers in Participants With Heart Failure (MK-0000-344)
The aim of this 2-part study is to assess B-type natriuretic peptide (BNP) as well as other circulating and imaging biomarkers in myocardial function.
- Trial name
- NCT02364752
- Testing
- Blood Draw, Loop Diuretic Withdrawal/Salt Load
- Volunteers
- healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Kidney Function Test
Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance
In kidney transplantation, donor selection is based in part on the assessment of the functional capacity of the kidneys. For this purpose, it is recommended to measure the glomerular filtration rate (GFR) by a reference…
- Trial name
- CLIO (NCT05136963)
- Testing
- Iohexol, pharmacokinetics
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
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