Clinical trials: Buprenorphine
Healthy
Study to Assess the PK Profile of NanoBUP Capsules Relative to Suboxone
Phase 1 study to determine the pharmacokinetic profile of NanoBUP Capsules to Suboxone.
- Trial name
- NCT01260675
- Testing
- Buprenorphine HCl/Naloxone HCl
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- NanoSHIFT LLC
Heroin Dependence
Pharmacogenomics Study of Sleep Disturbance and Neurocognitive Impairments in the Opioid Addicts
Opioid abuse is a complex problem, which not only impacts on addicts' physical and psychological health individually, but also threats the society.
- Trial name
- NCT01668706
- Where
- 5 sites in Taiwan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Smoking Cessation
A Pilot Text Messaging Intervention to Reduce Smoking in Office-based Buprenorphine and Inpatient Detoxification Patients
The primary purpose of this study is to understand the feasibility of a text messaging intervention developed by the National Cancer Institute, known as Smokefreetxt, to improve smoking cessation among opiate and/or alcohol…
- Trial name
- NCT02665208
- Testing
- Treatment As Usual (TAU), Nicotine Replacement Therapies, Text Message Intervention (TMI)
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Opioid-Related Disorders
Effects of Buprenorphine/Naloxone Administered in Different Ways For Treating Opioid Dependence
Buprenorphine is a treatment for opioid dependence. Naloxone is given in addition to buprenorphine in order to limit the abuse potential that is commonly associated with buprenorphine.
- Trial name
- NCT00134914
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder
Buprenorphine for Individuals in Jail
This study is an open label randomized controlled trial of extended-release buprenorphine (BRIXADI, XR-B) vs. sublingual buprenorphine (SL-B) in a large metropolitan jail.
- Trial name
- NCT06306443
- Testing
- extended-release buprenorphine (XR-B)
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Healthy
Effects of Voriconazole on the Pharmacokinetics and Pharmacodynamics of Oral Buprenorphine: A Two-phase Cross-over Study in Healthy Subjects
Variability in drug response can be due to either pharmacokinetic or pharmacodynamic factors. The reasons why people differ in pharmacokinetics or pharmacodynamics are manifold and include, e.g., genetic factors, diseases, age…
- Trial name
- NCT01466803
- Testing
- Vorikonazole
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Opioid Dependence
XRB vs. SLB in Jail and at Re-entry: Pilot, Proof of Concept
This is a pilot proof-of-concept randomized controlled trial, open-label and unblinded, examining the feasibility and acceptability of Buprenorphine extended-release vs.
- Trial name
- NCT03604159
- Testing
- Buprenorphine Extended Release, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Opioid Use
Buprenorphine for Probationers and Parolees: Bridging the Gap Into Treatment
This five-year study will evaluate the effectiveness of the administration of buprenorphine bridge treatment (BBT) to probationers and parolees compared to treatment as usual (TAU), which consists of referral to a community…
- Trial name
- NCT03616236
- Testing
- Buprenorphine/Naloxone, Treatment as usual
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Opioid Use Disorder
Oral Buprenorphine as a Novel Low-dose Induction Strategy for Opioid Use Disorder
This is a human laboratory-based, randomized, cross-over study in which buprenorphine will be administered to healthy volunteers (n=22) in 3 separate inpatient 2-night visits, at least 1 week apart.
- Trial name
- NCT06086275
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy
Buprenorphine Disposition and Cyclosporine
The determine the effect of cyclosporine on buprenorphine disposition
- Trial name
- NCT01648270
- Testing
- buprenorphine
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HIV Infections, Opioid Use Disorder
NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings
The investigators plan to conduct an R61/33 hybrid type 2 implementation-effectiveness trial that includes 1) a one-year exploratory R61 phase that will enable the development of the intervention protocol needed for the R33 trial…
- Conditions
- HIV Infections, Opioid Use Disorder, Incarceration; Lens
- Trial name
- NOTRE (NCT06854029)
- Testing
- Cabotegravir Injection, Cabotegravir Pill, Buprenorphine injection
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid Dependence, Substance-Related Disorders
Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14
The purpose of this study is the safety and efficacy of Buprenorphine/Naloxone in the treatment of opioid dependence. A compassionate use study.
- Trial name
- NCT00015340
- Testing
- Buprenorphine/naloxone
- Where
- 5 sites in United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy Volunteers
Pharmacokinetics and Pharmacodynamics of Buprenorphine in Healthy Volunteers
The purpose of this study is to determine the amount of buprenorphine and its metabolites in blood and urine after administration of 0.6 mg buprenorphine in healthy volunteers.
- Trial name
- NCT00347815
- Testing
- Buprenorphine
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Danish University of Pharmaceutical Sciences
Chronic Pain
The Effects of Water Temperature on the Cold Pressor Test
This current study is intended to be completed under the umbrella of the current GHUCCTS IRB- approved study "Opioid-Induced Hyperalgesia In Prescription Opioid Abusers: Effects of Pregabalin" (Lyrica study) (PRO00000669).
- Trial name
- NCT03083626
- Testing
- Cold pressor test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Hepatic Failure, Hepatic Impairment
Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects
The objective was to determine if hepatitis C virus (HCV) infection or mild to severe hepatic impairment (Child-Pugh Classes A, B, and C) altered the PK of buprenorphine, norbuprenorphine, or naloxone.
- Conditions
- Hepatic Failure, Hepatic Impairment, Chronic Hepatitis C Infection With Hepatic Coma
- Trial name
- NCT01846455
- Testing
- 2.0mg Buprenorphine/0.5mg Naloxone, Promethazine
- Where
- 3 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.