Clinical trials: Experimental
Healthy Participants
An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab
The purpose of this study is to compare the pharmacokinetic (PK) exposures of a single subcutaneous (SC) dose of tozorakimab administered using AI or APFS in healthy participants.
- Trial name
- NCT06908577
- Testing
- Tozorakimab, Autoinjector (AI) Device, Accessorised Prefilled Syringe (APFS) Device
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers
The Purpose of the Study is to Evaluate the Safety, Tolerability and Pharmacokinetics of Single-ascending and Multiple-ascending Doses of GIM-407
This study is for the evaluation of the safety, tolerability, PK, PD, and biomarker activity of GIM-407 in healthy volunteers in the absence of any disease-related or potentially confounding factors.
- Trial name
- NCT06536101
- Testing
- GIM-407
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Georgiamune Inc
Musculoskeletal Pain, Musculoskeletal Injury
Surgeon Core-strengthening Program as a Modifier for Exertion Associated With Vaginal Surgery
Work-related musculoskeletal pain and injury is a growing concern in surgery. Vaginal surgery has unique ergonomic risks, but no studies have addressed the potential for an exercise regimen to reduce physical strain by vaginal…
- Trial name
- SCORE (NCT06525701)
- Testing
- Execise Group, Control Group
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loyola University
Temporomandibular Joint Disorders
Application of the Visualization of Treatment Objective (VTO) Analyses in Fabricating Anterior Repositioning Splints
This study conducted a randomized controlled clinical trial to evaluate the effect of the the therapeutic position of the anterior repositioning splint determined by VTO analyse compared with traditional method for the treatment…
- Trial name
- NCT05362201
- Testing
- therapeutic position of the anterior repositioning splints
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Healthy Volunteers
A PET Study Following a Single Oral Dose of ITI-333 in Healthy Subjects
This is an open-label, single-dose study of up to 4 dose levels of ITI-333 in healthy male and female subjects. Each cohort will enroll 6 subjects.
- Trial name
- NCT05470101
- Testing
- ITI-333
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Intra-Cellular Therapies, Inc.
Adiposity, Insulin Sensitivity
Metabolic Adaptations to High-fat Diet
The purpose of this study is to understand how the body's response after a meal is influenced by insulin and sugar in the blood.
- Conditions
- Adiposity, Insulin Sensitivity, Impaired Glucose Tolerance, Metabolic Disturbance
- Trial name
- MetFlexHFD (NCT06537401)
- Testing
- Hypercaloric, High Fat Diet
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- George Washington University
Labor Pain, Yoga
Nada Yoga Music Therapy for Pain and Anxiety in Labor
This study was designed as a randomized controlled trial. Based on the power analysis (Cohen's d = 0.80, α = 0.05, power = 80%), a total of 52 pregnant women were included, with 26 participants in the intervention group and 26 in…
- Conditions
- Labor Pain, Yoga, Music Therapy
- Trial name
- NCT07392112
- Testing
- Nada Yoga music therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sinop University
Sedentary Lifestyle, Physical Activity
Applying Mobile Persuasive Technologies to Increase Physical Activity in Women
The primary purpose of this study is to assess the efficacy of the mobile phone-based physical activity intervention on increasing physical activity compared to the control group.
- Trial name
- NCT01280812
- Testing
- Mobile phone based physical activity intervention with maintenance plus, Mobile phone based physical activity intervention with maintenance regular, Control (pedometer only)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy
Estriol and Trimegestone Dose-response Trial With Single Dose Application of Vaginal Rings
This clinical trial is performed as proof of pharmacological action investigation by demonstration of ovulation inhibition (dose-response study) under treatment with three Test vaginal rings releasing varying doses of estriol…
- Trial name
- NCT03343912
- Testing
- Estriol 0.400 mg/day and Trimegestone 0.06 mg/day, Estriol 0.300 mg/day and Trimegestone 0.12 mg/day, Estriol 0.200 mg/day and Trimegestone 0.18 mg/day
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Healthy
Bioavailability of Telmisartan/Amlodipine Fixed Dose Combination in Healthy Male and Female Volunteers
Study to investigate the effect of food intake on the bioavailability of a fixed dose combination of 80 mg telmisartan / 10 mg amlodipine following a high fat breakfast
- Trial name
- NCT02259777
- Testing
- Telmisartan/Amlodipine, high fat, high caloric meal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Safety, Tolerability and Pharmacokinetics of Eptinezumab in Healthy Chinese Subjects
The purpose of the study is to investigate how the body absorbs and get rid of eptinezumab when given directly into a vein in Chinese subjects.
- Trial name
- NCT05045781
- Testing
- Eptinezumab
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Healthy Volunteers
Safety, Tolerability, and Pharmacokinetics of Multiple-Dose TAK-058 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of multiple doses of TAK-058 in healthy non-elderly and elderly participants.
- Trial name
- NCT02389881
- Testing
- TAK-058
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Takeda
Hiv
Positive Deviance to Improve Retention in HIV Care HIV Care in South Africa
The goal of this pilot trial is to test the effectiveness of a newly developed multicomponent clinic-level intervention for improving retention in HIV care among people living with HIV in South Africa.
- Trial name
- NCT06157281
- Testing
- Connect
- Where
- South Africa
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- RAND
Healthy
Pilot Study on the Effect of a XOS95 on the Human Gut Microbiome
The purpose of this clinical trial is to assess the efficacy of a novel prebiotic, XOS95, at two different dosages, in comparison to a placebo by assessing shifts in microbial populations after 8 weeks of supplementation…
- Trial name
- NCT03074019
- Testing
- Xylooligosaccacharide, Maltodextrin
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Prenexus Health
Hearing Loss
Clinical Trial Evaluating Outcomes of Self-Fit and Professionally Fit Hearing Aids
Approximately 48 million people in the United States have hearing loss or hearing difficulties in noisy environments. Whisper.ai Inc has previously brought to market a commercial hearing aid system that reduces background noise…
- Trial name
- NCT05527730
- Testing
- Comparison of PRO-FIT or SELF-FIT fitting
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Whisper.ai
Surgery
Immersive Care - Virtual Reality(VR) 360 Pediatric Surgery Preparation.
Context: This study is part of the larger Immersive Care project which (in short) seeks the connection between technology and care by conducting feasibility studies with promising technological interventions tailored to care.
- Trial name
- NCT04658030
- Testing
- VR 360 video surgery preparation, Care as usual
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Thomas More University of Applied Sciences
Respiratory Distress Syndrome, Newborn
LISA Catheter With Marked vs. Unmarked Tip in Extremely Low Birth Weight Infants With RDS
This is an unblinded, randomized, controlled, crossover (AB/BA) trial of surfactant treatment with LISA catheter with a marked tip vs.
- Trial name
- NCT05399628
- Testing
- Surfactant administration with less invasive surfactant administration (LISA) marked tip catheter, Surfactant administration with less invasive surfactant administration (LISA) unmarked tip catheter
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Cardiovascular Disease
Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines
The purpose of this study is to confirm the protective effect and mechanism of anthocyanins on hyperuricemia patients with Cardiovascular disease.
- Trial name
- NCT02797028
- Testing
- Anthocyanidins capsule, Allopurinol
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Healthy Participants
A Study to Assess the Relative Bioavailability of Brensocatib Pediatric Oral Solution to Oral Tablets in Healthy Participants
The primary purpose of this study is to determine the relative bioavailability of brensocatib between the pediatric oral solution and oral tablets in healthy participants.
- Trial name
- INS1007 (NCT06344728)
- Testing
- Brensocatib Oral Solution, Brensocatib Oral Tablet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Healthy
A Study of LY3537031 in Healthy Participants
The main purpose of this study is to evaluate the safety and tolerability of LY3537031 in healthy participants. The blood tests will be performed to check how much LY3537031 gets into the bloodstream, how long the body takes to…
- Trial name
- NCT04648865
- Testing
- LY3537031
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
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