Clinical trials: Fentanyl, open to volunteers
Thyroidectomy, Oxidative Stress
Opioid-Free Versus Opioid-Based Anesthesia in Thyroid Surgery
This study will compare opioid-free anesthesia and opioid-based anesthesia in adult euthyroid patients undergoing elective thyroidectomy.
- Conditions
- Thyroidectomy, Oxidative Stress, Anesthesia
- Trial name
- OFA-OBA (NCT07864155)
- Testing
- Fentanyl (IV), Dexmedetomidine and lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Fentanyl Overdose, Fentanyl Poisoning
A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and efficacy of CS-1103 (1,000 mg), given by intravenous (IV) infusion in healthy participants in the presence of a clinically relevant dose of…
- Trial name
- NCT07459166
- Testing
- Naloxone Hydrochloride, Fentanyl, Sterile Saline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Clear Scientific, Inc.
Postoperative Pain
Intraperitoneal Ketamine Versus Fentanyl as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is the standard surgical treatment for gallbladder stones; however, the origin of pain after LC is multifactorial and complex in nature.
- Trial name
- NCT07670052
- Testing
- Fentanyl, Ketamine
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain Following Knee Arthroplasty, Total Knee Arthroplasty
Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty
This prospective randomized controlled study aims to evaluate the effect of ultrasound-guided Biceps Femoris Short Head (BiFeS) block combined with adductor canal block on postoperative opioid consumption and pain control in…
- Trial name
- BiFeS Adductor (NCT07577869)
- Testing
- Procedure: Biceps Femoris Short Head Block, Procedure: Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ömer Kayar
Analgesia, Emergencies
Nebulized Fentanyl in Healthy Volunteers
Pain constitutes the predominant motive prompting individuals to seek emergency medical attention, accounting for 80% of admissions to emergency departments.
- Trial name
- AEROfen (NCT06281951)
- Testing
- Fentanyl - Inhalation by facial nebulization, Fentanyl - Nebulisation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Breakthrough Pain
PIEB Compared With CEI on Breakthrough Pain in Nulliparous Women
The goal of this randomized controlled trial is to examine the impact of programmed intermittent bolus epidural analgesia technique on the incidence of breakthrough pain during labor in nulliparous women compared to continuous…
- Trial name
- NCT06494280
- Testing
- programmed intermittent Bolus epidural analgesia, continuous epidural infusion
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Breakthrough Pain
Programmed Intermittent Epidural Bolus Compared With Continuous Infusion in Multiparous Women
The goal of this randomized controlled trial is to examine the impact of programmed intermittent bolus epidural analgesia technique on the incidence of breakthrough pain during labor in multiparous women compared to continuous…
- Trial name
- NCT06580327
- Testing
- programmed intermittent Bolus epidural analgesia, continuous epidural infusion
- Where
- Israel
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Laryngoscopy, Hemodynamic Changes
Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy
Participants will undergo routine pre-operative evaluation. An intravenous line will be placed in the recovery area. On arrival in the operating room, standard monitoring (blood pressure, heart rate, oxygen saturation, ECG…
- Trial name
- NCT07435337
- Testing
- Nalbuphine, Fentanyl
- Where
- Pakistan
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Institute of Cardiology
Labour Analgesia
Spinal Analgesia in Labour Pain
To evaluate the efficacy and safety of dexmedetomidine as an adjuvant to bupivacain and fentanyl in spinal Analgesia to decreases pain during normal labour
- Trial name
- NCT07332130
- Testing
- injecting dexmedetomidine, injecting mixture of bupivacaine fentanyl
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Minia University Hospital
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Spinal Anesthesia, Postoperative Complications
D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary Retention
This study aims to compare two medications, dexmedetomidine and fentanyl, when used alongside a commonly used spinal anesthetic called bupivacaine in patients undergoing lower limb surgery.
- Conditions
- Spinal Anesthesia, Postoperative Complications, Dexmedetomidine, Fentanyl
- Trial name
- D-FAB-POUR (NCT07117565)
- Testing
- Intervention 1: Intrathecal Dexmedetomidine with Bupivacaine, Intervention 2: Intrathecal Fentanyl with Bupivacaine
- Where
- Nepal
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Vaginal Delivery, Normal Labor
Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor
the goal of this randomized control trial is to compare the effect of adding fentanyl v.s dexmedetomidine to bupivacaine in single shot spinal analgesia in achievement of analgesia by decreasing visual analogue scale, onset and…
- Trial name
- SSSA (NCT06823349)
- Testing
- Dexmedetomidine, fentanyl, Saline 0.9%
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jehan George Sadek
Regional Anaesthesia, Cesarean Section
Dose-response Study of Spinally Administered Ropivacaine for Caesarean Section in Tall Parturients
The main goal is to determine the optimum dose of ropivacaine, a local anaesthetic, that provides regional anaesthesia with no or minimum adverse effects (i.e.
- Trial name
- NCT03936790
- Testing
- Ropivacaine, Fentanyl
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paraskevi Matsota
Post Operative Pain, Acute
Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia
Pregabalin is a structural analogue of gamma amino butyric acid (GABA). It binds to presynaptic alpha-2-delta subunit of voltage gated calcium channels in the brain and the spinal cord.
- Trial name
- NCT05150795
- Testing
- Pregabalin 150mg, Fentanyl 100 micrograms ampoule
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Pain, Acute
Effectiveness of Fentanyl-Added TAP Block in Laparoscopic Cholecystectomy
The aim of this study is to evaluate the effectiveness of adding fentanyl to the TAP block in laparoscopic cholecystectomy cases.
- Trial name
- NCT06778668
- Testing
- TAP block with bupivacaine only, TAP block with bupivacaine and fentanyl
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Uludag University
Analgesia, Postoperative
Comparison Between Fentanyl and Dexmedetomidine As Adjuvant to Bupivacaine in Combined IPACK and Adductor Canal Block for Postoperative Analgesia After Knee Surgeries
This study will be undertaken to compare the analgesic effects of of fentanyl versus dexmedetomidine as adjuvant to bupivacaine in combined IPACK and ACB for pain management after total knee arthroplasty.
- Trial name
- NCT06759116
- Testing
- Control group, Fentanyl group, Dexmedetomidine group
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Laparoscopic Cholecystectomy
Comparison Between Dexmedetomidine and Fentanyl As an Adjuvant to Bupivacaine in the Paravertebral Nerve Block in Laparoscopic Cholecystectomy for Postoperative Analgesia: Randomized Comparative Clinical Trial.
Laparoscopic cholecystectomy is one of the most common surgeries today, cause it has many advantages over open cholecystectomy. Although these advantages pain remains a big problem after laparoscopic cholecystectomy which causes…
- Trial name
- NCT06752629
- Testing
- Bupivacaine and Dexmedetomidine, Bupivacaine and Fentanyl
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Analgesia
Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve (PECS) Block
In 2012 Blanco et al. [1] described the ultrasound technique for Pectoral nerve (PECS) block as a new, less invasive regional analgesic technique for breast surgeries.
- Trial name
- NCT06636578
- Testing
- dexmedetomidine, ropivacaine, fentanyl
- Where
- 2 sites in Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fayoum University