Clinical trials: Hydroxychloroquine
COVID-19
Treatment of COVID-19 Cases and Chemoprophylaxis of Contacts as Prevention
This study is a research project to evaluate the efficacy of hydroxychloroquine for post-exposure prophylaxis and early treatment of Covid-19.
- Trial name
- HCQ4COV19 (NCT04304053)
- Testing
- Treatment and prophylaxis, Standard Public Health measures
- Where
- Spain
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Immunosuppression, Rheumatism
To Demonstrate the Relative Bioavailability of Hydroxychloroquine Sulfate, 200 mg Tablets
To demonstrate the relative bioavailability of hydroxychloroquine sulfate, 200 mg tablets.
- Trial name
- NCT00946790
- Testing
- Hydroxychloroquine Sulfate Tablets, 200 mg (Geneva Pharmaceutical, Inc.), Hydroxychloroquine Sulfate Tablets, 200 mg, Plaquenil (Sanofi Winthrop)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sandoz
Covid19, SARS (Severe Acute Respiratory Syndrome)
Safety and Efficacy of Hydroxychloroquine for the Treatment & Prevention of Coronavirus Disease 2019 (COVID-19) Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Coronavirus Disease 2019 (COVID-19) (previously called 2019-nCOV acute respiratory disease) is caused by SARS-CoV-2, a positive-sense single-stranded RNA virus of the coronavirus family.
- Trial name
- NCT04590274
- Testing
- Hydroxychloroquine, Vitamins and Minerals, Azithromycin
- Volunteers
- healthy volunteers welcome
- Sponsor
- International Brain Research Foundation
Coronavirus, Corona Virus Infection
PATCH 2&3:Prevention & Treatment of COVID-19 (Severe Acute Respiratory Syndrome Coronavirus 2) With Hydroxychloroquine
The proposed hypothesis is that high doses of hydroxychloroquine (HCQ) for at least 2 weeks can be effective antiviral medication both as a treatment in ambulatory patients and prophylaxis/treatment in health care workers because…
- Trial name
- NCT04353037
- Testing
- Group 1 HCQ
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- UnitedHealth Group
Malaria,Falciparum, Anemia in Children
Comparing Chemoprevention Drugs for School-based Malaria Control
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine (IPT-DP).
- Trial name
- NCT05980156
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine pyrimethamine
- Where
- Malawi
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
COVID-19
Hydroxychloroquine and Azithromycin as Prophylaxis for Healthcare Workers Dealing With COVID19 Patients
The main objective of this study is to assess the efficacy of the combination hydroxychloroquine and Azithromycin (HCQ and AZ) in reducing the infection risk among health care professionals in direct contact with COVID-19…
- Trial name
- MOPHYDA (NCT04354597)
- Testing
- HCQ & AZ
- Where
- Jordan
- Volunteers
- healthy volunteers welcome
- Sponsor
- King Hussein Cancer Center
Obesity
Effect of Hydroxychloroquine Sulphate in Healthy Lean Females
The effect of an acute administration of hydroxychloroquine sulphate will be investigated on hedonic food intake, appetite related sensations and gastrointestinal hormone release in healthy female subjects.
- Trial name
- PLAQHV (NCT04005768)
- Testing
- Hydroxychloroquine Sulphate
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
COVID-19
The Safety, Tolerability, and Pharmacokinetics of Inhaled TLC19 in Healthy Volunteers
Phase 1 randomized, vehicle-controlled, blinded study to assess the safety, tolerability, and PK of single ascending doses of inhaled TLC19 in healthy volunteer subjects.
- Trial name
- NCT04697654
- Testing
- TLC19, TLC19 Vehicle
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taiwan Liposome Company
Rheumatoid Arthritis
Montelukast Use in Rheumatoid Arthritis
Montelukast is widely used in patients with asthma. Several preclinical data suggest that it could be repositioned as novel strategy for managing rheumatic patients by decreasing inflammatory mediators.
- Trial name
- NCT05447520
- Testing
- Montelukast, Conventional DMARDs
- Where
- Egypt
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Noha Mansour
Diabetes Type Two
The Influence of Plaquenil/Hydroxychloroquine (HCQ) on Insulin Secretion
Antimalarials such as hydroxychloroquine (HCQ), are among the oldest prescribed drugs still used in clinical practice. Relatively inexpensive and well tolerated, these drugs have been recognized to be effective in autoimmune…
- Trial name
- NCT02910076
- Testing
- Hydroxychloroquine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
SARS-CoV-2
COVID-19 Treatment Using Methylene Blue and Photodynamic Therapy
According to the epidemiological situation worldwide and the number of vaccinations made, there is little success in the fight against COVID-19.
- Trial name
- NCT04933864
- Testing
- Methylene Blue and Photodynamic Therapy
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
COVID-19
Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19
Rationale: Currently there are no approved treatments for COVID-19. In the Dutch treatment protocol guideline (SWAB) designated treatment is supportive care with the option to add chloroquine base (CQ) or hydroxychloroquine…
- Trial name
- ARCHAIC (NCT04362332)
- Testing
- Chloroquine Sulfate, Hydroxychloroquine, Standard supportive care
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Systemic Lupus Erythematosus
Multi-omics Studies on the Efficacy of Telitacicept in Chinese SLE Patients
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with abnormal activation of B lymphocytes, which may result in many adverse consequences and even death if not treated actively.
- Trial name
- NCT05666336
- Testing
- Telitacicept, Hydroxychloroquine, Prednisone
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fen Li
COVID-19
The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial
This COVID-19 pandemic warrants urgent strategies to protect people at high risk of infection, particularly the healthcare workers.
- Trial name
- NCT04364815
- Testing
- Hydroxychloroquine plus standard preventive measures
- Where
- Philippines
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of the Philippines
COVID-19
Austrian CoronaVirus Adaptive Clinical Trial (COVID-19)
The Austrian Coronavirus Adaptive Clinical Trial (ACOVACT) is a randomized, controlled, multicenter, open-label basket trial that aims to compare various antiviral treatments for COVID-19.
- Trial name
- ACOVACT (NCT04351724)
- Testing
- Chloroquine or Hydroxychloroquine, Lopinavir/Ritonavir, Best standard of care
- Where
- 9 sites in Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Meconium Stained, Azithromycin
Efficacy of Azithromycin in MSAF Cases to Improve Maternal and Neonatal Outcomes
Meconium stained amniotic fluid increases the risk of maternal complications (e.g., dystocia, operative delivery, and postpartum endometritis) and neonatal complications (e.g., sepsis, admission to the neonatal intensive care…
- Conditions
- Meconium Stained, Azithromycin, Postpartum Endometritis
- Trial name
- NCT05118984
- Testing
- Azithromycin capsule (Zithromax, Pfizer) (250 mg)
- Where
- 2 sites in Egypt
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pregnancy Related, COVID
Hydroxychloroquine Efficacy and Safety in Preventing SARS-CoV-2 Infection and COVID-19 Disease Severity During Pregnancy and Postpartum
It still unclear how SARS-CoV-2 affects pregnant women and their offspring, as well as which factors may influence obstetrical disease and outcomes, including the timing of maternal viral exposure by gestational age, the effects…
- Conditions
- Pregnancy Related, COVID, Covid-19
- Trial name
- COVID-Preg (NCT04410562)
- Testing
- Hydroxychloroquine
- Where
- 9 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Covid19, Hydroxychloroquine
Rapid Development and Implementation of a Remote ECG-monitored Prospective Randomized Clinical Trial During a Pandemic: Hydroxychloroquine Prophylaxis in COVID-19 Household Contacts
organizing an entirely no in-person contact clinical trial is feasible during a 22 COVID-19 pandemic 23 Remote smartphone 6-lead ECG monitoring is possible even in a group unfamiliar 24 with the technology 25 Hydroxychloroquine…
- Conditions
- Covid19, Hydroxychloroquine, Coronavirus Infection, Transmission
- Trial name
- NCT04652648
- Testing
- Hydroxychloroquine
- Where
- 3 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bryn Mawr Hospital
Hidroxicloroquine Intake
Deep Learning in the Detection and Prediction of Hydroxychloroquine Maculopathy
Hydroxychloroquine retinal toxicity affects a significant number of patients using this medication. Detection of toxicity is difficult in the early stages of the disease and depends on the subjectivity of the clinician who reads…
- Trial name
- PLAQUINAI (NCT06839443)
- Testing
- Retinopathy group, Control group
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar de Lisboa Central
Coronavirus Disease 2019 (COVID-19), Post-Exposure Prophylaxis
Hydroxychloroquine Post-Exposure Prophylaxis for Coronavirus Disease (COVID-19) Among Health-Care Workers
Background: The rapid spread and high infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) makes identifying an effective prophylaxis agent highly important.
- Trial name
- NCT04438837
- Testing
- Hydroxychloroquine
- Where
- Israel
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus