Clinical trials: Hydroxychloroquine
Covid19
Efficacy and Safety of Liposomal Lactoferrin in COVID-19 Patients With Mild-to-Moderate Disease and in COVID-19 Asymptomatic Patients
COVID-19 is considered an ongoing international global health problem which already caused 12 million confirmed cases. No specific effective treatment has been identified so far, and available supportive therapies are intended…
- Trial name
- NCT04475120
- Testing
- liposomal lactoferrin, SOC therapy
- Where
- Italy
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Rome Tor Vergata
Prophylaxis, COVID-19
HEalth Care Worker pROphylaxis Against COVID-19: The HERO Trial
This is a double-blinded, randomized placebo-controlled trial to determine if pre-exposure prophylaxis (PrEP) with 400mg hydroxychloroquine (HCQ), taken orally once daily, for health care workers in the hospital reduces…
- Conditions
- Prophylaxis, COVID-19, Health Care Worker, Hydroxychloroquine
- Trial name
- HERO (NCT04352946)
- Testing
- Hydroxychloroquine Pre-Exposure Prophylaxis
- Where
- United States
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- GeoSentinel Foundation
Pregnancy Related, COVID
Hydroxychloroquine Efficacy and Safety in Preventing SARS-CoV-2 Infection and COVID-19 Disease Severity During Pregnancy and Postpartum
It still unclear how SARS-CoV-2 affects pregnant women and their offspring, as well as which factors may influence obstetrical disease and outcomes, including the timing of maternal viral exposure by gestational age, the effects…
- Conditions
- Pregnancy Related, COVID, Covid-19
- Trial name
- COVID-Preg (NCT04410562)
- Testing
- Hydroxychloroquine
- Where
- 9 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Coronavirus Infection, Hydroxychloroquine Adverse Reaction
Safety And Efficacy Of Hydroxychloroquine For At Risk Population (SHARP) Against COVID-19
The Coronavirus Disease 2019 (COVID-19) pandemic has placed tremendous stress on the global economy since its outbreak in December 2019.
- Trial name
- SHARP COVID-19 (NCT04342156)
- Testing
- Hydroxychloroquine Sulfate 200 milligram (mg) Tab
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Meconium Stained, Azithromycin
Efficacy of Azithromycin in MSAF Cases to Improve Maternal and Neonatal Outcomes
Meconium stained amniotic fluid increases the risk of maternal complications (e.g., dystocia, operative delivery, and postpartum endometritis) and neonatal complications (e.g., sepsis, admission to the neonatal intensive care…
- Conditions
- Meconium Stained, Azithromycin, Postpartum Endometritis
- Trial name
- NCT05118984
- Testing
- Azithromycin capsule (Zithromax, Pfizer) (250 mg)
- Where
- 2 sites in Egypt
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
A Study of Nipocalimab With Co-administration of Etanercept or Hydroxychloroquine in Healthy Participants
The primary purpose of this study is to assess the effect of nipocalimab on the pharmacokinetic (PK) of etanercept (Part 1); and to assess the effect of hydroxychloroquine (HCQ) on total serum immunoglobin G (IgG) reduction by…
- Trial name
- NCT04973566
- Testing
- Nipocalimab, Etanercept, Hydroxychloroquine
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
COVID-19
Hydroxychloroquine in the Prevention of COVID-19 Infection in Healthcare Workers
In order to assess the efficacy of hydroxychloroquine treatment weekly for a total of 7 weeks in the prevention of COVID-19 infection, three hundred sixty (360) Healthcare workers with high risk exposure to patients infected with…
- Trial name
- NCT04333225
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Corona Virus Infection
Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers
The objectives of PROVIDE are to: 1. Determine if prophylactic once weekly hydroxychloroquine reduces the incidence of conversion from SARS-2-CoVnasopharyngeal swab negative to positive 2.
- Trial name
- PROVIDE (NCT04371523)
- Testing
- Apo-Hydroxychloroquine
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Malaria,Falciparum, Anemia in Children
Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine (IPT-DP).
- Trial name
- NCT06083688
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine-pyrimethamine-amodiaquine
- Where
- Malawi
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
COVID19, Hydroxychloroquine
Protect: Study With Hydroxychloroquine for Prevention and Early Phase Treatment of Coronavirus Disease (COVID-19)
This is a Italian, superiority, open label cluster-randomised, interventional clinical trial aimed at assessing whether the treatment with Hydroxychloroquine can reduce the percentage of symptomatic subjects compared to…
- Conditions
- COVID19, Hydroxychloroquine, Prophylaxis, Treatment
- Trial name
- PROTECT (NCT04363827)
- Testing
- Hydroxychloroquine
- Where
- Italy
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Aging
Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging Clocks
This study tests whether certain medicines and a skin treatment can slow down or partly reverse the body's aging process. As people age, the activity of their genes changes in predictable ways.
- Trial name
- NCT07888595
- Testing
- Topical anti-aging peptide serum
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Frontiers in Bioscience Research Institute and Aging
Covid19, SARS (Severe Acute Respiratory Syndrome)
Safety and Efficacy of Hydroxychloroquine for the Treatment & Prevention of Coronavirus Disease 2019 (COVID-19) Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Coronavirus Disease 2019 (COVID-19) (previously called 2019-nCOV acute respiratory disease) is caused by SARS-CoV-2, a positive-sense single-stranded RNA virus of the coronavirus family.
- Trial name
- NCT04590274
- Testing
- Hydroxychloroquine, Vitamins and Minerals, Azithromycin
- Volunteers
- healthy volunteers welcome
- Sponsor
- International Brain Research Foundation
COVID-19
Efficacy and Safety of Mucoadhesive Sustained Release, Mucodentol, in Comparison With Hydroxychloroquine to Prevent COVID-19
180 people from the medical staff and high-risk people in Baqiyatallah Hospital, who are in close contact with patients, will enter the study. Participants will be divided into two intervention groups and one control group.
- Trial name
- NCT04466280
- Testing
- Hydroxychloroquine, Mucodentol, Personal protective equipment
- Where
- Iran
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baqiyatallah Medical Sciences University
COVID-19
Hydroxychloroquine and Azithromycin as Prophylaxis for Healthcare Workers Dealing With COVID19 Patients
The main objective of this study is to assess the efficacy of the combination hydroxychloroquine and Azithromycin (HCQ and AZ) in reducing the infection risk among health care professionals in direct contact with COVID-19…
- Trial name
- MOPHYDA (NCT04354597)
- Testing
- HCQ & AZ
- Where
- Jordan
- Volunteers
- healthy volunteers welcome
- Sponsor
- King Hussein Cancer Center
Systemic Lupus Erythematosus
Multi-omics Studies on the Efficacy of Telitacicept in Chinese SLE Patients
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with abnormal activation of B lymphocytes, which may result in many adverse consequences and even death if not treated actively.
- Trial name
- NCT05666336
- Testing
- Telitacicept, Hydroxychloroquine, Prednisone
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fen Li
Sars-CoV2, Infection Viral
HCQ for Primary Prophylaxis Against COVID19 in Health-care Workers
Background: Aim: To demonstrate the efficacy of low-dose hydroxychloroquine as primary prevention in healthcare workers Design, participants and interventions: Prospective, randomized, parallel group, double-blinded, placebo…
- Conditions
- Sars-CoV2, Infection Viral, Healthcare Worker, Prophylaxis
- Trial name
- NCT04336748
- Testing
- Hydroxychloroquine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
COVID-19
Pre-Exposure Prophylaxis With Hydroxychloroquine for High-Risk Healthcare Workers During the COVID-19 Pandemic
The investigators aim to evaluate the efficacy of pre-exposure prophylaxis with hydroxychloroquine in healthcare workers with high-risk of SARS-CoV-2 infection.
- Trial name
- PrEP_COVID (NCT04331834)
- Testing
- Hydroxychloroquine
- Where
- Spain
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
SARS-CoV-2
Hydroxychloroquine to Prevent SARS-CoV-2 Infection/COVID-19
The purpose of this study is to determine whether hydroxychloroquine is an effective prophylactic regimen to prevent SARS-CoV-2 infection among healthcare workers. Participants will be randomized into two parallel groups.
- Trial name
- NCT04414241
- Testing
- Hydroxychloroquine
- Where
- 3 sites in Peru
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
COVID-19
Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19
The HCW Prophylaxis (HCWP) Study, single, open and off label intervention study. Up to 350 participants will be assigned to group that takes HCQ or group that opts to not take study medication.
- Trial name
- NCT04435808
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
COVID-19
Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19
Rationale: Currently there are no approved treatments for COVID-19. In the Dutch treatment protocol guideline (SWAB) designated treatment is supportive care with the option to add chloroquine base (CQ) or hydroxychloroquine…
- Trial name
- ARCHAIC (NCT04362332)
- Testing
- Chloroquine Sulfate, Hydroxychloroquine, Standard supportive care
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht