Clinical trials: Ketamine
Abdominal Pain
Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control
The proposed research will be a single blinded (patient) randomized controlled prospective trial of adult patients receiving treatment for moderate to severe abdominal pain to test the hypothesis that patient satisfaction with…
- Trial name
- NCT04698772
- Testing
- Ketamine, Morphine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Cannula Site Pain
Comparison Between Dexmeditomidine, Midazolam and Ketamine as a Sedative to Help Cannula Insertion in Pediatric Patient
Background and Objectives: Surgery and hospitalization present a very stressful period for children and their parents. The induction of anesthesia and cannula insertion may be the only bad experience a child can remember during…
- Trial name
- NCT04704622
- Testing
- Ketamine, Midazolam, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy Volunteers
A Study to Assess the Pharmacokinetics of Intranasally Administered Esketamine in Healthy Japanese and Caucasian Volunteers
The purpose of this Phase 1 study is to characterize the pharmacokinetic profile (what the body does to the medication) of esketamine when given by the intranasal route (through the nose) to healthy adult Japanese and Caucasian…
- Trial name
- NCT01980303
- Testing
- Esketamine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Pain
Crossover Study to Evaluate the PK Effects of Two Different Wafer Administration Protocols.
The study will look at whether it is preferable to administer two wafers simultaneously or separately.
- Trial name
- NCT02857361
- Testing
- Sublingual ketamine wafers
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- iX Biopharma Ltd.
Allergic Rhinitis
Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal Esketamine
The purpose of this study is to evaluate the effects of allergic rhinitis (group of symptoms affecting the nose) and co-administration of mometasone or oxymetazoline on the pharmacokinetics (explores what the body does to the…
- Trial name
- NCT02154334
- Testing
- Esketamine, Mometasone, Oxymetazoline
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Cognitive Impairment
Characterizing Clinical and Pharmacological Neuroimaging Biomarkers
This study is part of a larger overall study that seeks to characterize clinical and pharmacological neuroimaging biomarkers. The purpose of this registered protocol is understand the effect of emotion on cognitions by…
- Trial name
- NCT03842800
- Testing
- MRI, Ketamine
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Yale University
Suicidal Ideation, Suicide
The Impact of Ketamine on the Reward Circuitry of Suicidal Patients
Every 40 seconds, someone in the world dies by suicide. There is a lack of effective and safe antisuicidal agents for preventing suicide attempts.
- Trial name
- NCT02532153
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome
The purpose of this study is to examine whether neural-derived exosomal miRNAs are differentially expressed that are specific to suicidal ideation or behavior, and which by affecting specific miRNA targets and pathways, are…
- Trial name
- NCT02418195
- Testing
- ketamine
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Coronary Artery Disease, Valve Disease, Heart
Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University
Cardiac surgery is associated with post-operative pain which is one of the major problems and remains one of the most controversial issues.
- Conditions
- Coronary Artery Disease, Valve Disease, Heart, Pain, Acute, Pain, Postoperative
- Trial name
- NCT04223219
- Testing
- Fentanyl, Fentanyl, Propofol, Dexmedetomidine, Ketamine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Headache
Ketamine for Acute Migraine in the Emergency Department
This research study will be a prospective, randomized, double-blind, placebo-controlled trial. Because ketamine has yet to be directly studied as treatment for acute migraine headache in the emergency department, the research…
- Trial name
- NCT02697071
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Acute Pain, Bunion
Study of Wafermine™ for Post-bunionectomy or Abdominoplasty Pain
This study evaluates the safety and effectiveness of Wafermine™ for post-bunionectomy or post-abdominoplasty pain over a 24 hours period.
- Conditions
- Acute Pain, Bunion, Abdominoplasty
- Trial name
- NCT03246971
- Testing
- Wafermine™ 50 mg, Wafermine™ 75 mg, Wafermine™ 25 mg
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- iX Biopharma Ltd.
Major Depressive Disorder
Ketamine in the Treatment of Depression
Depressed patients will be offered experimental treatment with a new, potentially fast-acting antidepressant called ketamine while being scanned by magnetic resonance imaging (MRI) to measure the chemical effect of the drug.
- Trial name
- NCT01558063
- Testing
- Ketamine, Saline, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Columbia University
Emergence Delirium, Anesthesia
Effect of Different Drugs on Emergency Delirium in Preschool Age Patient
Emergence delirium (ED) was first described by Eckenhoff and colleagues in the 1960s and is defined in pediatric anesthesia as 'dissociated state of consciousness in which child is irritable, uncompromising, uncooperative…
- Trial name
- NCT07057193
- Testing
- Dexmedetomidine group (D group), Ketamine group (K group), Midazolam group (M group)
- Where
- Egypt
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Anesthesia
Different Dose of Esketamine Inhibiting Response to Laryngeal Mask Airway Insertion
Objective To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.
- Trial name
- NCT06370130
- Testing
- Esketamine 0.2mg/kg, Esketamine 0.3mg/kg
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Aerospace Center Hospital
Healthy
Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants
N,N-dimethyltryptamine (DMT) is a classical psychedelic with similar effects like LSD or psilocybin. Preliminary evidence from case series and small open-label trials suggests that psychedelics may be promising candidates for the…
- Trial name
- DPS (NCT06180759)
- Testing
- Intravenous infusion of DMT, Intravenous infusion of ketamine
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Bariatrics
Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy
Propofol is one of the most popular anesthetic drugs used for sedation during upper gastrointestinal endoscopies due to its quick onset and quick resolution of symptoms allowing patients to leave the hospital sooner.
- Conditions
- Obesity, Bariatrics, Sleep Apnea Syndromes, Gastric Bypass
- Trial name
- NCT02643979
- Testing
- Ketofol, Propofol, Saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cognitive Dysfunction
N-acetylcysteine and NMDA Antagonist Interactions
This study tests the hypothesis that extrasynaptic mechanisms are critically linked with cognitive effects of NMDA antagonism as evidenced by event-related potentials (ERPs) in healthy humans.
- Trial name
- NCT00611897
- Testing
- N-acetylcysteine and ketamine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
Anesthesia; Reaction
Study of Comparison of the Effectiveness of Three Diagrams for Sedation in Spinal Anesthesia
Objective: To determine the efficacy of sedation schemes to sedation in patients about to undergo spinal anesthesia. Methods: Pilot study, clinical type, randomized, prospective, single-blind, in which the investigators compared…
- Trial name
- NCT02136641
- Testing
- Midazolam, Midazolam+Fentanyl Combination, Midazolam+Ketamine Combination
- Where
- Colombia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad de Cartagena
Obsessive-Compulsive Disorder
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.
- Trial name
- MKET2 (NCT05940324)
- Testing
- Ketamine, Naltrexone Pill
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Stanford University
Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality
The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy
BACKGROUND: Some studies have revealed that intravenous dexmedetomidine and esketamine improve the quality of sleep after surgery.
- Trial name
- NCT06414941
- Testing
- Dexmedetomidine administration, Dexmedetomidine plus low-dose esketamine administration, Dexmedetomidine plus high-dose esketamine administration
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital