Clinical trials: Losartan
Femoroacetabular Impingement
Senolytic Agent Improve the Benefit of Platelet-Rich Plasma and Losartan
The purpose is to explore the possible benefit of administration of Fisetin, (a senolytic agent) to improve the benefit of Platelet-Rich Plasma and losartan for treatment of femoroacetabular impingement and labral tear.
- Trial name
- NCT05025956
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Steadman Philippon Research Institute
Hypertension
Hypertension in Young Adults Trial
This is a pilot randomized controlled trial which will test the effect of 3 different anti-hypertensive agents and 3 different strategies of engaging young adults in home blood pressure monitoring on blood pressure control, with…
- Trial name
- NCT05370599
- Testing
- Anti-hypertensive agent: amlodipine, Anti-hypertensive agent: Chlorthalidone, Anti-hypertensive agent: Losartan
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy Subjects
Clinical Assessment Of Association Pharmacokinetics Atorvastatin + Losartana + Hydrochlorothiazide
The objective of this clinical study, randomized, crossover is to evaluate the pharmacokinetic profile of the polypill (atorvastatin + lorsatana + hydrochlorothiazide) Laboratory Hypermarcas S / A, in relation to drugs Citalor ®…
- Trial name
- NCT01692717
- Testing
- Atorvastatin, Hydrochlorothiazide + Losartan, Hydrochlorothiazide + Losartan + Atorvastatin
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Azidus Brasil
Hypertension
Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)
The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults.
- Trial name
- HIPAC (NCT03354143)
- Testing
- Standard Care, Intensive Treatment
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension
Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome
The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels.
- Trial name
- AMORE (NCT01271374)
- Testing
- amlodipine and olmesartan, losartan and HCTZ
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InVasc Therapeutics, Inc.
Essential Hypertension
Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension
This study is aimed to evaluate the pharmacokinetics and the drug-drug interaction among anti-hypertension drugs-amlodipine, losartan, and hydrochlorothiazide.
- Trial name
- NCT01198249
- Testing
- multiple dose, crossover study between single and concomitant administrations of amlodipine, losartan, and hydrochlorothiazide
- Where
- South Korea
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yonsei University
HIV Infection, HIV Infections
Reversing Tissue Fibrosis to Improve Immune Reconstitution in HIV
This study was designed to test the hypothesis that treatment of HIV infected subjects with losartan, an agent with specific anti-inflammatory and anti-fibrotic actions, will: 1. reverse existing lymphoid tissue fibrosis, 2.
- Trial name
- NCT01852942
- Testing
- Losartan
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Colitis, Ulcerative, Crohn Disease
Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study
The purpose of this study is to evaluate in a step-wise approach the disease drug-drug interaction (DDI) potential for vedolizumab to indirectly affect the exposure of cytochrome P-450 (CYP) substrate drugs by modulating…
- Trial name
- NCT02760615
- Testing
- Caffeine, Losartan, Omeprazole
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Takeda
Obesity, Insulin Resistance
Treating the Endothelium to Restore Insulin Sensitivity
A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
- Trial name
- NCT00402194
- Testing
- Losartan
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hypertension, HIV
Integrating Hypertension Management in DSD for HIV
The goal of this implementation science study is to design evidence based and stakeholder informed implementation strategies to integrate the management of hypertension (HTN) into existing community anti-retro-viral treatment…
- Trial name
- HTN-DSD (NCT06366386)
- Testing
- Screening and treatment of hypertension among PLHIV in DSD models for HIV
- Where
- Uganda
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Healthy
The Effects of Losartan on Attention Control: An Eye-tracking Study
The main aim of the present study is to investigate the effects of orally administered Losartan on bottom-up and top-down attentional control to socio-emotional stimuli by combining a validated saccade/antisaccade eye-tracking…
- Trial name
- NCT06329050
- Testing
- Losartan
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Type 1 Diabetes
Renin Angiotensin System Study (RASS/B-RASS)
To determine if renin angiotensin medications can prevent or delay the onset of diabetic kidney disease.
- Trial name
- NCT00143949
- Testing
- enalapril, losartan
- Where
- 3 sites in Canada
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Michael Mauer, MD
Cytochrome, Pharmacokinetics
Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes
The purpose of this study is to assess whether a cocktail of seven approved drugs (so-called "Basel cocktail") can be used for simultaneous phenotyping of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4.
- Trial name
- NCT01187862
- Testing
- caffeine, efavirenz, losartan, omeprazole, metoprolol, chlorzoxazone and midazolam
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hypertension
Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension
Plasma renin values determine whether volume or vasoconstrictor (renin) factors predominate in elevating blood pressure and are useful in selecting effective antihypertensive therapy.2,3 The researchers hypothesize that: 1.
- Trial name
- Renin (NCT00684489)
- Testing
- clinical hypertension specialist-no specific med. Any anti-hypertension meds., renin guided therapeutics-no specific med. Any anti-hypertensive med.
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy Volunteers
The Effect of Losartan on Emotional Processing in Healthy Volunteers
This experimental medicine study explores whether a single dose of losartan (50mg) versus placebo affects the processing of positive and negative stimuli, using fMRI.
- Trial name
- NCT03434054
- Testing
- Losartan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hypertension, Hyperlipidemia
A Study to Evaluate Pharmacokinetics and Potential Drug Interactions of a Fixed-dose Combination Tablet, HL-040XC, in Healthy Male Subjects
The objective of this study is: To evaluate the pharmacokinetics and safety of an experimental combination tablet containing 20 mg atorvastatin and 50 mg losartan potassium when administered orally as a single dose to healthy…
- Trial name
- NCT01806324
- Testing
- HL040XC, Losartan + Atorvastatin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- HanAll BioPharma Co., Ltd.
Healthy
Losartan and Emotion Processing
The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
- Trial name
- NCT03396523
- Testing
- Losartan
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy
A Randomized, Open-label, Single Dose, Two-way Crossover Clinical Trial to Compare the Safety, Pharmacokinetic Profiles of UI15AML055MT and Amosartan® Tablet 5/50 mg After a Single Oral Administration in Healthy Male Volunteers
A randomized, open-label, single dose, two-way crossover clinical trial to compare the safety, pharmacokinetic profiles of UI15AML055MT and Amosartan® tablet 5/50 mg after a single oral administration in healthy male volunteers
- Trial name
- UI15AML055MT (NCT02166398)
- Testing
- UI15AML055MT, Amosartan 5/50
- Where
- South Korea
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Hypertension
A Study of the Pharmacokinetics and Pharmacodynamics of MK1809 (1809-001)(COMPLETED)
The goal of this study is to identify at least one safe and well tolerated dose of MK1809 that has similar pharmacokinetic qualities as 100 mg losartan.
- Trial name
- NCT01033318
- Testing
- MK1809, Comparator: Losartan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Interaction
Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach
The purpose of this clinical trial is to determine how the supplement oregano affects how the body metabolizes pharmaceutical drugs.
- Trial name
- NCT06693960
- Testing
- Oregano, Drug cocktail
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Washington State University