Clinical trials: Methotrexate
Ectopic Pregnancy
Medical Treatment in Ectopic Tubal Pregnancy
Ectopic pregnancy (EP) is estimated to be responsible for approximately 20% of all pregnancy-related mortality and 46% early pregnancy mortality.1 Hemodynamically stable women with EP are frequently managed with methotrexate…
- Trial name
- NCT05208034
- Testing
- Methotrexate
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nishtar Medical University
Vitiligo - Evaluation of Methotrexate Iontophoresis and Topical Methotrexate Gel as Localized Treatment Approache
Methotrexate Iontophoresis Versus Methotrexate 1% Gel on Depigmentation in Vitiligo Patients
Vitiligo is a common autoimmune depigmenting disorder characterized by selective destruction of melanocytes. Methotrexate (MTX) has shown potential in stabilizing disease activity and promoting repigmentation; however, systemic…
- Trial name
- NCT07208890
- Testing
- Methotrexate Iontophoresis/a low-intensity electric current
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Hyperhidrosis, Iontophore
Methotrexate Iontophoresis Versus Coal Tar Ointement in the Treatment of Primary Palmer Hyper Hidrosis
The purpose of the study is to compare the therapeutic effect of methotrexate iontophoresis versus coal tar ointment on the the treatment of primary palmer hyperhidrosis?
- Trial name
- NCT05875285
- Testing
- Iontophoresis with methotrexate, Iontophoresis with coal tar ointement
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy Volunteers
Study to Investigate Safety, Tolerability, Pharmacokinetics, and Drug-drug Interaction of Multiple Oral Doses of BAY1830839 in Healthy Male Participants
The aim of this study is to investigate safety, tolerability and pharmacokinetics of increasing repeated oral doses of BAY1830839 in healthy male participants including the investigation of any potential drug-drug interactions of…
- Trial name
- NCT03965728
- Testing
- BAY1830839, Midazolam, Methotrexate
- Where
- Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Bayer
Acute Lymphoblastic Leukemia
Vitamin D and Methotrexate Adverse Effects
Since methotrexate toxicity represents a major problem in patients treating with cancer and there are few studies about the role of vitamin D in the pathogenesis of this toxicity, so the aim of the present study is investigation…
- Trial name
- NCT04488237
- Testing
- Vitamin D
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation
This phase II trial studies how well 3 different drug combinations prevent graft versus host disease (GVHD) after donor stem cell transplant.
- Conditions
- Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Trial name
- NCT03602898
- Testing
- Anti-Thymocyte Globulin, Busulfan, Cyclophosphamide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Rheumatoid Arthritis
Baricitinib, Methotrexate as Monotherapy or Combination in the Treatment of Rheumatoid Arthritis - an Open Label Randomized Clinical Trial
The goal of this open-label randomized clinical trial is to assess the efficacy of baricitinib 2 mg in comparison to methotrexate 25 mg as monotherapy followed by baricitinib 4 mg in comparison to methotrexate 10 mg and…
- Trial name
- NCT05827497
- Testing
- Baricitinib 2 MG, Methotrexate 25mg
- Where
- Bangladesh
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Inflammation, Aging
Inflammation Control For Elders: ICE Study
This study will be the first to test whether a selected anti-inflammatory agent, methotrexate, reduces inflammation in a human body, improve cognitive and physical function, and reduce pain levels in older adults at risk for…
- Trial name
- ICE (NCT02079948)
- Testing
- Methotrexate + Folic Acid, Functional MRI Experimental Tasks, Muscle Biopsy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Inflammation
Food Effect, Oral & Intravenous Pharmacokinetics and Absolute Bioavailability of BAY1834845 Including Drug-drug Interaction With Methotrexate
This study is planned to explore the effect of food on the oral pharmacokinetics, the intravenous pharmacokinetics and the absolute bioavailability of BAY1834845.
- Trial name
- NCT03244462
- Testing
- BAY1834845, Methotrexate
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bayer
Ectopic Pregnancy
Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment.
Ectopic Pregnancy is an entity in which a fertilized ovum is implanted outside its normal place, is considered a public health problem worldwide and is one of the main causes of maternal mortality in the first trimester.
- Trial name
- EENCBE (NCT05136274)
- Testing
- Medical treatment
- Where
- Angola
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- EDGREM Investimentos
Clostridium Difficile, Inflammatory Bowel Diseases
Seroprevalence of Anti-bodies Against Clostridium Difficile Toxins and Prevalence of Asymptomatic Carriage of Clostridium Difficile in IBD Patients.
The objective of this study to evaluate the seroprevalence of anti-bodies against C. difficile toxins A and B and the asymptomatic carriage of C.
- Trial name
- NCT03889808
- Testing
- Determination of serum anti-toxin Abs for C. difficile
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Anal Squamous Intraepithelial Lesion (ASIL), HPV DNA
Anal Dysplasia in Patients With Inflammatory Bowel Disease and Healthy Controls
This study is designed to establish the prevalence of anal squamous intraepithelial lesion (ASIL) in patients with inflammatory bowel disease (IBD) and healthy controls.
- Trial name
- ADIBD (NCT01860963)
- Testing
- Anal Pap smear and HPV DNA testing
- Where
- United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Stanford University
Premature Endothelial Dysfunction, Rheumatoid Arthritis
Exploratory Trial to Evaluate Premature Endothelial Dysfunction in Early Rheumatoid Arthritis(RA)Compared to Patients With Established RA, and Normal Subjects
Premature Endothelial Dysfunction is present in patients with early rheumatoid arthritis.
- Conditions
- Premature Endothelial Dysfunction, Rheumatoid Arthritis, Healthy
- Trial name
- NCT01499732
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Orrin M Troum, M.D. and Medical Associates
Healthy Volunteer
Effect of Food, Rabeprazole, Methotrexate and Formulation on the Pharmacokinetics (PK) of GDC-0853 and the Effect of GDC-0853 on the PK of Methotrexate in Healthy Subjects
This study is a Phase I, single center, randomized (Parts 1 and 2 only), open-label, 3 part study. Parts 1 and 2 are 2-way crossover, with 1-fixed sequence, 3-period designs to investigate the effect of formulation, food and…
- Trial name
- QCL117578 (NCT02699710)
- Testing
- Folic Acid, GDC-0853, Methotrexate
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Juvenile Idiopathic Arthritis
The Efficacy of Influenza Vaccine Program in Children With Juvenile Idiopathic Arthritis. A Single Centre Results From Hungary
The aim of our study is to compare the immune function of patient treated with DMARD (methotrexate), or tumor necrosis factor (TNF)-alpha inhibitor (adalimumab) to healthy children. The study consists of three parts.
- Trial name
- NCT03833271
- Testing
- Influenza vaccine, Immune function
- Where
- Hungary
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Systemic Lupus Erythematosus
Biomarkers of Lupus Disease: Serial Biomarker Sampling in Patients With Active Systemic Lupus Erythematosus (SLE)
Hypothesis: A reason for repeated disappointing outcomes of clinical trials testing targeted immune biologics for lupus may be the heterogeneity of the disease, exacerbated by the variable effects on immune homeostasis of the…
- Trial name
- BOLD (NCT00987831)
- Testing
- Group B SLE one blood donation, Blood drawing only Group C, Group A SLE prospective study
- Where
- 2 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Psoriasis Vulgaris
Informative Value of Determining the Level of NF-κB Translocation in Lymphocyte Populations in Children With Psoriasis
This study is the first to quantify the level of NF-kB translocation in lymphocyte populations in children and adolescents with psoriasis of varying severity.
- Trial name
- NCT04989296
- Testing
- Peripheral blood samples were obtained following the standard procedures.
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Children's Health, Russian Federation
Primary Vitreoretinal Lymphoma
Construction of Diagnosis and Treatment System for Primary Vitreoretinal Lymphoma
This study intends to apply for the establishment of research beds, establish a Chinese PVRL research cohort, and carry out a to achieve the following research objectives: The goal of this prospective observational study is to…
- Trial name
- NCT05950490
- Testing
- Intravitreal injection of methotrexate
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Inflammatory Disease, Crohn Disease
Monitoring of Inflammatory Conditions
People with inflammatory diseases treated with immune-suppressing medication are recommended to have regular blood-tests to monitor for potential side-effects of this treatment on their blood count, liver and kidneys.
- Conditions
- Inflammatory Disease, Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis
- Trial name
- NCT05458531
- Testing
- Questionnaire, Semi-structured interview
- Where
- United Kingdom
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- University of Nottingham