Clinical trials: Pemetrexed
Direct Pulp Capping in Primary Teeth
DPC in Primary Molars.
To evaluate clinical and radiographical outcomes of direct pulp capping using calcium hydroxide (CH), mineral trioxide aggregate (MTA), and premedicated direct pulp capping (PDPC) with formocresol (FC) in primary teeth.
- Trial name
- NCT05222243
- Testing
- Direct pulp capping with calcium hydroxide, Direct pulp capping with MTA, Direct pulp capping with Formocresol
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Deep Caries, Reversible Pulpitis
Similar Outcomes of Vital Pulp Therapy Using Mineral Trioxide Aggregate or Biodentine™
This study aimed to evaluate the clinical performance of White MTA (MTA, Angelus, Londrina, Brazil) and Biodentine™ in pulp capping of cariously exposed mature permanent teeth.
- Conditions
- Deep Caries, Reversible Pulpitis, Irreversible Pulpitis
- Trial name
- NCT03186690
- Testing
- Biodentine, Mineral Trioxide Aggregate
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Lung Cancer, Nonsmall Cell
Pembrolizumab as Neoadjuvant Therapy for Resectable Stage IA3 to IIA Non-Small Cell Lung Cancer (NSCLC)
This is a prospective, randomized, single-site, open-label Phase II trial of neoadjuvant pembrolizumab (3 cycles) followed by surgery, versus concomitant neoadjuvant pembrolizumab with platinum doublet chemotherapy (3 cycles)…
- Trial name
- NCT04638582
- Testing
- Pembrolizumab, Carboplatin, Paclitaxel
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Necrotic Pulp, Single Root Teeth
Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and Swelling
aim of the study will be conducted to compare the effect of MTA fill apex sealer and endo sequence bioceramic sealer in obturation on the intenisty of postoperative pain and the incidence of post operative swelling in patient…
- Trial name
- NCT05419752
- Testing
- bioceramic sealer, MTA, resin sealer
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Exposure
Pulp Capping With Two Different Agents
The purpose of this study is to determine if MTA or calcium hydroxide are more effective as pulp capping agents
- Trial name
- MTA (NCT00812877)
- Testing
- Mineral Trioxide Aggregate, Calcium Hydroxide
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
NSCLC
JS207 Combined With Chemotherapy in Subjects With Stage II-III NSCLC
This is a phase II clinical study to evaluate the safety, tolerability, preliminary efficacy and pharmacokinetics of JS207 (anti-PD-1/VEGF bispecific antibody) combined with platinum-based doublet chemotherapy in subjects with…
- Trial name
- NCT06944470
- Testing
- Paclitaxel + Carboplatin/cisplatin for squamous cell carcinoma and pemetrexed + carboplatin/cisplatin for non-squamous cell carcinoma, surgery, Radiochemotherapy
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Reversible Pulpitis, Extremely Deep Caries
Outcome of Direct Pulp Capping and Partial Pulpotomy in Reversible Pulpitis
AIM: -The aim of the study is to compare the outcome of Direct Pulp Capping and Partial Pulpotomy in mature permanent teeth with Reversible Pulpitis OBJECTIVES: - Primary Objective: to compare the difference in clinical and…
- Trial name
- NCT07300124
- Testing
- Partial Pulpotomy in Reversible Pulpitis, Direct pulp capping with MTA
- Where
- India
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Non-small Cell Lung Cancer Metastatic
Camrelizumab Combination With SBRT and Concurrent Chemotherapy Treated Stage IV Oligometastatic Non-small Cell Lung Cancer
This study evaluated the effectiveness and safety of Camrelizumab combination with SBRT and concurrent chemotherapy treated stage IV oligometastatic non-small cell lung cancer
- Trial name
- IMCORT-2 (NCT05472467)
- Testing
- Camrelizumab, stereotactic body radiation therapy, Chemotherapy
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Non-small Cell Lung Cancer
ALK Tyrosine Kinase Inhibitors in ALK-rearranged Advanced Squamous Cell Carcinoma
This study was to explore the efficacy of ALK-TKI in lung squamous cell carcinoma. Approximately 5% of lung adenocarcinomas have oncogenic fusions of EML-4 and ALK a mutation associated with tumorigenesis and migration.
- Trial name
- ATPase (NCT05014464)
- Testing
- Crizotinib
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hunan Province Tumor Hospital
Pulp Disease, Dental
Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Carious Primary Molars
The study will be self-funded by investigator and carried out on patients from outpatient clinic in Pediatric Dentistry and Public Health Department- Faculty of Dentistry, Cairo University- Egypt.
- Trial name
- NCT03580135
- Testing
- Propolis, Mineral Trioxide Aggregate
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necrosis
Effect Of Different Lining Materials in Stepwise Excavation
Deep carious lesions will encounter the dentist with the challenge of selecting a treatment method that could avoid the pulpal exposure and maintain the pulp vitality.Conventional restorative treatments suggest complete removal…
- Trial name
- NCT01730287
- Testing
- Control, Calcium Hydroxide, Mineral Trioxide Aggregate(MTA)
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azad University of Medical Sciences
EGFRmutant Stage IIIB/C or IV Non-squamous NSCLC
ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma
ETOP 15-19 ABC-lung is an international, multi-centre open-label, randomized phase II trial with two non-comparative parallel arms of atezolizumab plus bevacizumab with carboplatin-paclitaxel (Arm A) or atezolizumab, bevacizumab…
- Trial name
- ABC-lung (NCT04245085)
- Testing
- Atezolizumab, Bevacizumab, Carboplatin
- Where
- 18 sites in Germany, Singapore and 3 more
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- ETOP IBCSG Partners Foundation
Pulp Necrosis, Apexification
Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth
This study was conducted to evaluate the effect of the use of apical matrix, with Mineral Trioxide Aggregate (MTA) or calcium hydroxide Ca(OH)2 Apexification on apical healing and calcific barrier formation of immature teeth with…
- Trial name
- NCT03849222
- Testing
- Apexification, MTA, Ca(OH)2
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Pulp Exposure, Dental
Pulpotomy Technique Preserving Vitality of Traumatized Anterior Permanent Immature Teeth
Aim of the study: To compare the clinical and radiographic outcomes of mineral trioxide aggregate (MTA) and Biodentine as vital pulp therapy materials (pulpotomy) preserving the vitality of traumatized immature anterior permanent…
- Trial name
- NCT03838068
- Testing
- Biodentine, mineral trioxide aggregate, cervical pulpotomy
- Where
- Egypt
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gihan M Abuelniel ,PhD
Reversible Pulpitis, Deep Carious Lesions
Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions
AIM: To compare the efficacy of a Novel calcium silicate doped treated dentin matrix and Mineral Trioxide aggregate as biomaterials for miniature pulpotomy.
- Trial name
- hTDM (NCT07302438)
- Testing
- Calcium Silicate doped treated dentin matrix for miniature pulpotomy (CaSi+hTDM MP)., Mineral Trioxide Aggregate (MTA) for Miniature Pulpotomy
- Where
- 2 sites in India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Non-small Cell Lung Cancer(NSCLC)
the"Fuzheng" Therapy of TCM to Improve the Survival Quality of Early-stage NSCLC by Intervening the CTCs
Metastasis is the leading cause of death in patients with lung cancer, and circulating tumor cells(CTCs) play a key role in the process of distant metastasis.
- Trial name
- CTC-TCM-FZ (NCT02603003)
- Testing
- JinFuKang, Cisplatin, Pemetrexed
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Mesothelioma
Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma
Objectives: The investigators will test whether combination of chemoimmunotherapy or dual agent immunotherapy alone improves efficacy for patients with MPM.
- Trial name
- NCT05932199
- Testing
- Durvalumab / tremelimumab, Platinum cisplatin or carboplatin and pemetrexed chemotherapy plus durvalumab/tremelimumab
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Root Perforation at the Bifurcation Area
Evaluation for Healing of Iatrogenic Perforation After Repair With Different Materials
The goal of this clinical trial is to evaluate healing potentiality of MTA and bioceramics materials as a root perforation repair material.
- Trial name
- NCT06976411
- Testing
- MTA, Bioceramic putty
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mohamed Salah Elwakeel
Non-Small Cell Carcinoma of Lung, Gut Microbiomes
Microbiota in Neoadjuvant Chemoimmunotherapy for NSCLC
Locally advanced lung cancer (LALC) has poor prognosis despite multimodal therapies. Neoadjuvant chemoimmunotherapy is now standard for resectable stage II-IIIB NSCLC, but patient responses vary.
- Conditions
- Non-Small Cell Carcinoma of Lung, Gut Microbiomes, Neoadjuvant Chemoimmunotherapy
- Trial name
- NCT07752589
- Testing
- Neoadjuvant chemoimmunotherapy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Dentin Bridge, Pulpitis
Partial Pulpotomy on Caries Free Human Teeth
The purpose of this study is to compare the human pulp response to partial pulpotomy using White ProRoot MTA or iRoot BP in the terms of dentinal bridge formation and inflammation.
- Trial name
- NCT01420718
- Testing
- MTA, iRoot BP
- Where
- Iran
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj