Clinical trials: Pemetrexed, completed
Reversible Pulpitis
Direct Pulp Capping Agent on Human Pulp Tissue
This in- vivo study was conducted to evaluate the response of human pulp tissue following direct pulp capping using four different pulp capping agents in premolars scheduled for extraction in patients undergoing orthodontic…
- Trial name
- NCT06435065
- Testing
- Biodentine, Mineral Tri-Oxide Aggregate, THERACAL LC
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- DR SURINDER SACHDEVA
EGFRmutant Stage IIIB/C or IV Non-squamous NSCLC
ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma
ETOP 15-19 ABC-lung is an international, multi-centre open-label, randomized phase II trial with two non-comparative parallel arms of atezolizumab plus bevacizumab with carboplatin-paclitaxel (Arm A) or atezolizumab, bevacizumab…
- Trial name
- ABC-lung (NCT04245085)
- Testing
- Atezolizumab, Bevacizumab, Carboplatin
- Where
- 18 sites in Germany, Singapore and 3 more
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- ETOP IBCSG Partners Foundation
Dental Pulp Disease, Endodontically Treated Teeth
Post Operative Sensitivity of MTA Obturation
The aim of this study was to investigate the difference in postoperative pain caused by different root canal sealers in patients with irreversible pulpitis symptoms and no apical lesions.
- Conditions
- Dental Pulp Disease, Endodontically Treated Teeth, Endodontic Disease
- Trial name
- NCT06795282
- Testing
- MTA
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Vital Pulp Therapy
Vital Pulp Therapy With Different Materials for Young Permanent Teeth
This study will be conducted to: Evaluate clinically and radiographically apexogenesis in immature permanent molars using: 1. Calcium Hydroxide. 2. MTA. 3. Laser. 4. Laser combined with MTA.
- Trial name
- NCT05498337
- Testing
- calcium hydroxide, MTA, Diode Laser
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dentin Bridge
Evaluation of Apexogenesis With Human Treated Dentin Matrix in Young Permanent Molars
Assess the clinical, radiographic, and tomographic outcomes of apexogenesis with human treated dentin matrix in young permanent molars compared to MTA.
- Trial name
- NCT05830695
- Testing
- human treated dentin matrix, Mineral Trioxide Aggregate
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- nora mostafa mohammed abo shanady
Extensively Decayed Primary Molars
Efficacy of Totalfill® and ProRoot MTA® as Pulpotomy Agent in Primary Molars
An experimental prospective double-blind, randomized clinical trial (RCT) with parallel design. To evaluate the outcome of using 2 pulpotomy agents: Totalfill® as study group and mineral trioxide aggregate (MTA®) as a control.
- Trial name
- NCT05149651
- Testing
- Totalfill, MTA
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Ghent
Non-small Cell Lung Cancer, Metastatic Lung Cancer
Emulation of the KEYNOTE-189 Trial Using Electronic Health Records
Investigators are building an empirical evidence base supporting the utility of real-world data through the emulation of randomized controlled trials in the oncology setting.
- Trial name
- NCT05908799
- Testing
- Pembrolizumab + Pemetrexed-Platinum, Pemetrexed-Platinum
- Where
- United States
- Volunteers
- 1,854 people, healthy volunteers welcome
- Sponsor
- Aetion, Inc.
Pulpitis - Irreversible, Tooth Decay
Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth
Of all the various pulpotomy medicaments that have been studied till to date, three agents have been selected for this study to compare their efficacy.
- Trial name
- NCT05266859
- Testing
- Calcium hydroxide, MTA, PRF
- Where
- Pakistan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Liaquat College of Medicine and Dentistry
Direct Pulp Capping in Primary Teeth
DPC in Primary Molars.
To evaluate clinical and radiographical outcomes of direct pulp capping using calcium hydroxide (CH), mineral trioxide aggregate (MTA), and premedicated direct pulp capping (PDPC) with formocresol (FC) in primary teeth.
- Trial name
- NCT05222243
- Testing
- Direct pulp capping with calcium hydroxide, Direct pulp capping with MTA, Direct pulp capping with Formocresol
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Decayed Primary Molars
Partial Versus Complete Pulpotomy Using Three Different Materials in Primary Molars: a Clinical Study
The purposes of the study to compare partial pulpotomy versus complete pulpotomy in primary molars using three different materials (Formocresol, MTA, Theracal LC) .
- Trial name
- NCT05190783
- Testing
- Formocresol, MTA, TheraCal
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pulp Exposure, Dental
Pulpotomy Technique Preserving Vitality of Traumatized Anterior Permanent Immature Teeth
Aim of the study: To compare the clinical and radiographic outcomes of mineral trioxide aggregate (MTA) and Biodentine as vital pulp therapy materials (pulpotomy) preserving the vitality of traumatized immature anterior permanent…
- Trial name
- NCT03838068
- Testing
- Biodentine, mineral trioxide aggregate, cervical pulpotomy
- Where
- Egypt
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gihan M Abuelniel ,PhD
Non-small Cell Lung Cancer(NSCLC)
the"Fuzheng" Therapy of TCM to Improve the Survival Quality of Early-stage NSCLC by Intervening the CTCs
Metastasis is the leading cause of death in patients with lung cancer, and circulating tumor cells(CTCs) play a key role in the process of distant metastasis.
- Trial name
- CTC-TCM-FZ (NCT02603003)
- Testing
- JinFuKang, Cisplatin, Pemetrexed
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Laser, Tooth
Efficacy of Er,Cr:YSGG Laser in Partial Pupotomy
The aim of this study was to compare the efficacy of partial pulpotomy treatment using MTA and Er,Cr:YSGG + MTA in permanent immature molar teeth with deep dentin caries.
- Conditions
- Laser, Tooth, Pulpotomy
- Trial name
- NCT04010929
- Testing
- Partial pulpotomy with laser+MTA, Partial pulpotomy with MTA
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Merve Erkmen Almaz
Apical Periodontitis, Wound Heal
The Effect of MTA and PRF Application in Periapical Lesions
A total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly selected from December 2016-November 2017. Patients were informed about the surgical procedure and signed a consent form.
- Trial name
- NCT03743987
- Testing
- control group, MTA group, PRF group
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Pulp Necrosis, Apexification
Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth
This study was conducted to evaluate the effect of the use of apical matrix, with Mineral Trioxide Aggregate (MTA) or calcium hydroxide Ca(OH)2 Apexification on apical healing and calcific barrier formation of immature teeth with…
- Trial name
- NCT03849222
- Testing
- Apexification, MTA, Ca(OH)2
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Carious Exposure of Pulp
Evaluation of MTA Versus Biodentine as Pulpotomy Agents in Immature First Permanent Molars
Aim of the study: To compare the clinical and radiographic outcomes of mineral trioxide aggregate (MTA) and Biodentine as vital pulp therapy materials (pulpotomy) of cariously exposed vital immature mandibular first permanent…
- Trial name
- NCT03838094
- Testing
- Biodentine, MTA
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gihan M Abuelniel ,PhD
Pulp Necrosis
Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Anterior Teeth
the object of this study is to evaluate clinically and radiographically the effect of using Biodentine and Mineral Trioxide Aggregate as coronal plug materials in revascularization of non-vital immature teeth
- Trial name
- NCT03589560
- Testing
- Biodentine, Mineral Trioxide Aggregate
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Exposure
Pulp Capping With Two Different Agents
The purpose of this study is to determine if MTA or calcium hydroxide are more effective as pulp capping agents
- Trial name
- MTA (NCT00812877)
- Testing
- Mineral Trioxide Aggregate, Calcium Hydroxide
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Dentin Bridge, Pulpitis
Partial Pulpotomy on Caries Free Human Teeth
The purpose of this study is to compare the human pulp response to partial pulpotomy using White ProRoot MTA or iRoot BP in the terms of dentinal bridge formation and inflammation.
- Trial name
- NCT01420718
- Testing
- MTA, iRoot BP
- Where
- Iran
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj