Clinical trials: Prednisone
Disorder Related to Renal Transplantation
Efficacy of Certican® in Combination With Myfortic® in Renal
The primary objective is to demonstrate the superiority of everolimus plus Myfortic® plus corticosteroids following CNI withdrawal at week 16 compared to tacrolimus plus Myfortic® plus corticosteroids as measured by the change in…
- Trial name
- HUSJ1 (NCT01399242)
- Testing
- Certican
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Universitário São José
Atherosclerosis, Dyslipidemias
The Effect of Prednisone on Atherogenesis as Studied in the Macrophage Foam Cell Formation Model System.
Glucocorticoids (GCs) are a class of endogenous steroid hormones produced by the adrenal glands and controlled by the hypothalamic-pituitary-adrenal axis (HPA).
- Conditions
- Atherosclerosis, Dyslipidemias, Diabetes
- Trial name
- NCT03367663
- Testing
- Prednisone 20 Mg, Prednisone 40 Mg
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Prof. Tony hayek MD
Adrenal Gland Hypofunction
Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Suppression of the adrenal function is a common, potentially dangerous and unpredictable consequence of short term high dose glucocorticoid treatment. Identification of patients at risk would be of high clinical importance.
- Trial name
- NCT00975078
- Testing
- adrenal insufficiency testing, prednisone
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Asthma
Dexamethasone Versus Prednisone for Asthma Treatment in the Pediatric Inpatient Population; a Feasibility Study
Current corticosteroid regimens for children hospitalized with asthma typically include a 5-day course of prednisone or prednisolone. However, these medications taste poorly and are associated with vomiting and poor compliance.
- Trial name
- NCT03133897
- Testing
- Dexamethasone, Prednisone
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Hepatic Impairment, Healthy Participants
A Study to Evaluate Opevesostat (MK-5684) in Male Participants With Moderate Hepatic Impairment (MK-5684-009)
Researchers have designed a study medicine called opevesostat as a new way to treat prostate cancer. The purpose of this study is to learn what happens to opevesostat in a person's body over time (a pharmacokinetic [PK] study).
- Trial name
- NCT06860243
- Testing
- Opevesostat, Prednisone, Fludrocortisone acetate
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Delayed Type Hypersensitivity
Characterization of the Molecular Mechanisms Involved in Delayed-Type Hypersensitivity Reactions to House Dust Mite, Diphencyprone, Nickel, and Tuberculin Purified Protein Derivative in Healthy Volunteers
This study will be conducted in 2 cohorts. In Cohort A, approximately 40 subjects will participate in a single-center, open-label, non-randomized, parallel-group trial to investigate the molecular mechanisms involved in…
- Trial name
- NCT03625219
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Innovaderm Research Inc.
Airway Inflammation
Woodsmoke Particulate + Prednisone
Deployment of military personnel has been associated with increased respiratory illness likely due, in part, to inhalation of unusual particulate matter (PM), such as from burn pits.
- Trial name
- Smokisone (NCT03861390)
- Testing
- 60 mg Prednisone
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hemophilia A
Trial of Rituximab Versus Oral Cyclophosphamide to Eradicate or Suppress Autoimmune Anti-Factor VIII Antibodies in Acquired Hemophilia A
The purpose of this study is to evaluate the rate of response when administering rituximab to suppress or eliminate the anti-body in a patient's blood that inhibits the effectiveness of their factor replacement product compared…
- Trial name
- NCT00306670
- Testing
- Rituxan, prednisone
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Healthy
Single Dose Study Of PF-04308515 And Prednisone On Carbohydrate
This study will investigate the effect of a single dose of PF-04308515 or prednisone on calculated measures of glucose tolerance and insulin resistance by using a modified oral glucose tolerance test.
- Trial name
- NCT01199029
- Testing
- PF-04308515, Prednisone
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Thyroid Diseases
An Assessment of Aspirin Plus Prednisone Treatment for Euthyroid Women With Thyroid Autoimmunity
Thyroid autoimmunity(TAI) per se have adverse effect on pregnancy outcomes，and aspirin and prednisone were used frequently in antithyroid antibodies(ATA) positive infertile women in clinical practice, but the impact of these…
- Trial name
- NCT04943146
- Testing
- Prednisone 10 MG+aspirin 100MG
- Where
- 2 sites in China
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepatic Impairment
A Single Dose Evaluation of the Effects of Moderate Hepatic Impairment on Deflazacort Pharmacokinetics
This is a non-randomized, open-label, single-dose study to compare the PK of 21-desacetyl-DFZ and, if data permits, deflazacort in 8 subjects with moderate hepatic impairment (based on the Child Pugh classification, Grade B) to…
- Trial name
- NCT02286609
- Testing
- Deflazacort
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PTC Therapeutics
Healthy
Single and Multiple Ascending Dose Study of CORT125329 in Healthy Participants
The purpose of this study is to evaluate the dose-related safety, tolerability, pharmacokinetics (PK) and pharmacological effects (PD) of CORT125329 after single and multiple ascending oral doses of CORT125329 lipid capsule…
- Trial name
- NCT04672512
- Testing
- CORT125329 lipid capsule formulation, Prednisone
- Where
- United Kingdom
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Systemic Lupus Erythematosus (SLE) or Cutaneous Lupus Erythematosus
A Phase 1/2a Study of DB-2304 in Healthy Adults and SLE/CLE Participants
A Phase 1/2a Study of DB-2304 in Healthy Participants and Participants with Systemic Lupus Erythematosus or Cutaneous Lupus Erythematosus
- Trial name
- NCT06625671
- Testing
- DB-2304, Prednisone
- Where
- 7 sites in United States, Australia
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- DualityBio Inc.
Rheumatoid Arthritis
Study of LFD-200 in Healthy Adults and Adults With Moderate to Severe Rheumatoid Arthritis
This is a double-blind, randomized, placebo- and active-controlled study investigating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of subcutaneous (SC) doses of LFD-200.
- Trial name
- NCT07207954
- Testing
- LFD-200, Oral Prednisone
- Where
- 10 sites in Australia, Georgia and 3 more
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Lifordi Immunotherapeutics, Inc.
Rheumatoid Arthritis, Healthy Controls
Subunit Vaccine Against Herpes Zoster in RA Patients Treated With JAK-inhibitors (VACCIMIL-ZOSTER)
Background. A new subunit vaccine against herpes zoster (HZ) has recently been approved for vaccination of adults i in Sweden. This vaccine (Shingrix) elicits a strong cellular and humoral immune response in healthy adults…
- Trial name
- NCT03886038
- Testing
- Shingrix
- Where
- Sweden
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Region Skane
ITP, Croticosteroid Therapy
Therapy of Adults Affected by Idiopathic Thrombocytopenic Purpura With Dexamethasone
In this prospective, randomized, controlled clinical trial investigators' aim was to compare the efficacy and the adverse effect of 3 therapy cycles of HD-DXM versus conventional treatment with PDN for untreated adult patients…
- Trial name
- NCT02914054
- Testing
- High dose Dexamethasone pulses, Prednisone
- Where
- Iran
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Healthy
CORT125281 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)
This initial Phase I study will evaluate the dose-related safety and tolerability pharmacokinetics (PK) of CORT125281, and CORT125324 (active metabolite), and pharmacodynamics (PD) after single and multiple ascending oral doses…
- Trial name
- NCT03335956
- Testing
- CORT125281, 40mg, fasted, Prednisone 25mg, fasted, Pioglitazone 15mg Tablet
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Chronic Sinusitis, Rhinosinusitis
Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study
This is a study to evaluate the cause of chronic sinus disease. Oral steroids have long been used in the treatment of inflammatory conditions including chronic sinusitis, asthma, and arthritis.
- Conditions
- Chronic Sinusitis, Rhinosinusitis, Nasal Polyps
- Trial name
- NCT00841802
- Testing
- Prednisone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Healthy Adults
The Dose Response of Prednisone on Biochemical and Clinical Makers in Adult Healthy Volunteers
The purpose of this study is to further access the utility of biochemical and clinical biomarkers for glucocorticoid-mediated anti-inflammatory effects and safety endpoints against which dissociated agonists of the glucocorticoid…
- Trial name
- NCT02767089
- Testing
- Prednisone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
First-in-human Study in Healthy Subjects
This initial Phase I study will evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending doses of CORT118335, the effect of concomitant administration with food on exposure to CORT118335, and…
- Trial name
- NCT03315338
- Testing
- CORT118335, 25 mg, Prednisone Oral Tablet, Glucose
- Where
- United Kingdom
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics