Clinical trials: Probiotic
Bacterial Vaginosis and Vaginal Candidiasis At Pregnancy
Oral Probiotics for the Treatment and Prevention of Vulvovaginal Infections in Pregnancy - Double-blind, Randomized, Placebo-controlled Study
During pregnancy, bacterial vaginosis (BV), abnormal vaginal flora (AVF) and vulvovaginal candidiasis (VVC) are associated with serious complications and discomfort. Yet, treatment options are limited.
- Trial name
- NCT02795845
- Testing
- Probiotic Capsule containing L. acidophilus, L. Paracasei, L. Rhamnosus, streptococcus thermophilus and Bifidobacterium bifidum
- Where
- 3 sites in Israel
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Moderate Gastrointestinal Discomfort
Investigating the Effectiveness of 2 Different Doses of BIOHM FX Probiotic Blend in Improving Digestive Symptoms
The rationale for this study is to observe the effect of two different doses of a consumer-grade probiotic product called FX Probiotic Blend on digestive symptoms in individuals with moderate gastrointestinal discomfort.
- Trial name
- NCT06782945
- Testing
- BIOHM FX Probiotic Blend
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Biohm Technologies
Mucositis
Use of Probiotics in Oral Health of Patients With Dental Implants
The aim of this study was evaluate the effects of the oral probiotic Lactobacillus reuteri Prodentis upon the peri-implant health of edentulous patients with dental implants and peri-implant mucositis, establishing comparisons…
- Trial name
- NCT01974596
- Testing
- Probiotic tablets of Lactobacillus reuteri
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Influenza
Effect of Drinking Fermented Milk on Immune Response
This blinded randomized controlled trial aims to investigate the effect of drinking fermented milk containing Lactobacillus paracasei (IMULUS) on immune response against influenza.
- Trial name
- NCT02909842
- Testing
- Drinking fermented milk, Seasonal Influenza Vaccine (H1N1, H3N2, PhuB)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Gastrointestinal Health, Immune Health
Effect of Bacillus Subtilis BS50 Supplementation on Gastrointestinal Symptoms in Healthy Adults
The primary objective of this study is to investigate the effect of a novel Bacillus subtilis spore preparation on abdominal bloating, flatulence, and burping in healthy adults.
- Conditions
- Gastrointestinal Health, Immune Health, Cardiovascular Health, Digestive Health
- Trial name
- NCT05004454
- Testing
- Bacillus subtilis BS50 spore preparation, Maltodextrin
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- BIO-CAT Microbials, LLC
Upper Respiratory Symptoms, Mucosal Immunity
Multi-Strain Probiotic Supplementation, Salivary Immunity, and Upper Respiratory Symptoms in Trained Athletes
This completed external pilot study assessed the feasibility of conducting a randomised, double-blind, placebo-controlled trial of four-week multi-strain probiotic supplementation in trained athletes.
- Trial name
- NCT07782983
- Testing
- Multi-Strain Probiotic
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Adverse Effects, Healthy
Effect of Probiotic Intake in Healthy Population
The main objective of this project is to evaluate the absence of adverse gastrointestinal effects following the consumption of a daily probiotic capsule during 15 days.
- Trial name
- PROBIO (NCT07165457)
- Testing
- Probiotic group
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Microbial Colonization
Colonisation of Scalp by Topical Probiotic Micrococcus Luteus Q24
The purpose of this study is to evaluate the skin quality improvement and colonization efficacy following the application of probiotic Micrococcus luteus Q24 (BLIS Q24) to the scalp from a serum format in healthy adults.
- Trial name
- NCT06166979
- Testing
- Active Comparator: Study Group A: Blis Q24 Serum at higher dose, Active Comparator: Study Group B: Blis Q24 Serum at lower dose
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Stress, Psychological, Anxiety
Cognitive and Biological Responses in Stress
The goal of this pilot part of the study (Step 1) is to identify the optimal population of high and low anxiety and stress individuals who will differentially respond to a laboratory stress task as measured by changes in…
- Trial name
- NCT05026333
- Testing
- Cognitive Stress Testing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diarrhea
Probiotics for Prevention of Antibiotic Associated Diarrhea and Clostridium Difficile Associated Disease
The study will evaluate if administration of probiotic Culturelle (Lactobacillus Rhamnosus GG) along with antibiotics can help decrease the occurrence of diarrhea caused by antibiotics as well as Clostridium difficile Diarrhea.
- Trial name
- NCT02076438
- Testing
- Probiotics
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cognitive Change
Improved Cognitive Outcomes Associated With Feihe HMO With DHA/ARA in Infant Formula
The goal of this interventional clinical trial is to test the effectiveness of improving cognitive development in newly born infants fed with Feihe investigational formula product containing HMO, and DHA/ARA.
- Trial name
- NCT06146387
- Testing
- Investigational Formula, Control Formula, Breastfeeding
- Where
- 3 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Heilongjiang Feihe Dairy Co. Ltd.
Healthy
Effects of a Placebo Probiotic on Gut Health and General Well-being in Individuals With Mild Gastrointestinal Symptoms
The present study is aimed at exploring whether positive expectations of receiving a three-week treatment with a probiotic supplement (in fact a placebo) improve symptoms of gastrointestinal distress and promote physical and…
- Trial name
- PlaCIBO (NCT06720558)
- Testing
- Control-no treatment
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Chronic Arsenic Poisoning
Modulation of Anaerobic Gut Bacteria of Arsenicosis Patients by Probiotics
The role of anaerobic bacteria in the pathogenesis of palmer arsenical keratosis is not known. This can be evaluated by administering probiotics.
- Trial name
- NCT01726426
- Testing
- Probiotic
- Where
- Bangladesh
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mental Fatigue, Cognitive Function
Examining the Effects of One-Month Probiotic Treatment on Mental Fatigue
The aim of this study is to demonstrate the effects of 28-days supplementation with a novel probiotic formulation on mental fatigue following a cognitive load in healthy adults.
- Conditions
- Mental Fatigue, Cognitive Function, Mood
- Trial name
- NCT03611478
- Testing
- Probiotic formulation
- Where
- Australia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Swinburne University of Technology
Healthy Lifestyle
Improving Wellbeing Through the Brain-Gut-Microbiota Axis
Well-being is a state defined as the optimal psychological functioning and the experience associated with it, integrating physical and subjective factors.
- Trial name
- IBMA (NCT04823533)
- Where
- Chile
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Vaginal Microbiota, Microbiota
Effect of Hifas Intima Oral on Vaginal Microbiota in Healthy Women
The goal of this clinical trial was to learn whether the vaginal microbiota changed after healthy women aged 18 to 45 years took Hifas Intima, an oral food supplement, for 3 months.
- Conditions
- Vaginal Microbiota, Microbiota, Vaginal Microbiome
- Trial name
- NCT07715058
- Testing
- Hifas INTIMA Oral
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hifas da Terra S.L.
Healthy, Stress, Psychological
Stress & Anxiety Dampening Effects of a Probiotic Supplement Compared to Placebo in Healthy Subjects
The aim of this study is to assess whether a 5 week intake of a probiotic (Lpc-37) can modulate stress and anxiety experienced by healthy subjects during and after an acute stressor compared to placebo.
- Trial name
- NCT03494725
- Testing
- Lpc-37
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Daacro
Gastrointestinal, Overweight , Obesity
A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Impact of CLB101TM️ on Gut Health in Healthy, Overweight Individuals
Anaerostipes caccae CLB101TM️ is a next-generation probiotic isolated from healthy humans. It was shown to be in decreased abundance in people with protein-based food sensitivities/allergies.
- Trial name
- NCT07336615
- Testing
- CLB101™️
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- ClostraBio Inc.
Gingivitis, Orthodontic Appliance Complication
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions.
- Trial name
- NCT04598633
- Testing
- Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Stress, Constipation
The Effects Of Probiotics On Stress Among Healthy Adults From Umm Al-Qura University At Makkah
The goal of this clinical trial is to study the effects of probiotic supplementation on stress levels and bowel habits in healthy Saudi adults for both males and females.
- Conditions
- Stress, Constipation, Anthropometry, Bowel Disease
- Trial name
- NCT06464484
- Testing
- Probiotics (Lactobacillus rhamnosus GG (ATCC 53103)
- Where
- Saudi Arabia
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Umm Al-Qura University
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