Clinical trials: Propofol
Hypotensive Anesthesia
Comparison Between Two Drugs (Propofol and Nitroglycerin as a Hypotensive Agents During Endoscopic Sinus Surgery
Background and Objectives: FESS is a common minimally invasive surgery that requires a clear field to be performed well. Hypotensive anesthesia is one of the most common maneuvers performed to help in keeping the field clear.
- Trial name
- prop (NCT04220281)
- Testing
- Propofol, Nitroglycerin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Moderate Sedation, Deep Sedation
Sedation and Neuromediators Concentration
Propofol (Propofol Kabi, Registration number from the State Register of Medicines - 000875) is a widely used intravenous anesthetic.
- Trial name
- NCT04695509
- Testing
- moderate propofol sedation (Bispectral index monitoring 70-90; The Richmond Agitation and Sedation scale (RASS) "-2" - "-3", deep propofol sedation (BIS 60-70, The Richmond Agitation and Sedation scale (RASS) "-4")
- Where
- Russia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Anesthesia, Sedation
A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486
This is a Phase I, single-center, open-label, randomized,two-way crossover, propofol-controlled, two-stage study evaluating the safety and pharmacokinetics/pharmacodynamics of IV maintenance dose after an initial dose and IV…
- Trial name
- NCT03745625
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Hypotension, Anesthesia
Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs
Patient undergoing general anesthesia in elective surgery will be assigned to receive either methohexital or propofol general anesthesia.
- Trial name
- NCT02624050
- Testing
- Methohexital, Propofol
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Lidocaine, Injection Pain
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated With Medium-/Long-chain Triglycerides
Propofol is widely used in general anesthesia induction, but the occurrence of peripheral intravenous pain is relatively high, causing anxiety, fear and other adverse emotions in patients , aggravating the stress response, and…
- Trial name
- NCT04008433
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Digestive System Diseases, Colonoscopy Sedation
Non-anesthesiologist Administered Propofol Sedation for Colonoscopy - a Randomized Clinical Trial
Propofol is the preferred sedation for colonoscopy. There is debate on the safety of the administration of propofol by non-anesthesiologists, despite moderate quality evidence that support its' use.
- Trial name
- NCT02067065
- Testing
- Non-anesthesiologist propofol sedation, Propofol sedation administered by an anesthesiologist, Colonoscopy
- Where
- Portugal
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Hospital Beatriz Ângelo
The Intraoperative Effect of Dexmedetomidine on Cisatracurium Infusion Consumption and Its Recovery Index., Effect of Dexmedetomidine on Sufentanil Consumption.
Study of Cisatracurium and Sufentanil Consumption Using a Closed Loop Computer Control Infusion System
The purpose of this study is to: determine the effect of dexmedetomidine on cisatracurium infusion requirements and sufentanil consumption.
- Conditions
- The Intraoperative Effect of Dexmedetomidine on Cisatracurium Infusion Consumption and Its Recovery Index., Effect of Dexmedetomidine on Sufentanil Consumption., Quantitative Analysis of Cisatracurium Infusion Requirements, Sufentanil Consumption and Recovery Index in Different Age Groups.
- Trial name
- NCT01785446
- Testing
- Effect of dexmedetomidine on cisatracurium and sufentanil consumption, Consumption of cisatracurium and sufentanil in different age groups.
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Anesthesia
Comparative Study of Ultrasound Guided Combined Interscalene and Supraclavicular Brachial Plexus Block Versus General Anesthesia for Brachioaxillary Surgery in Renal Failure Patient
The aim of this study is to evaluate the efficacy of combined supraclavicular and interscalene brachial plexus block in brachio-axillary surgeries in chronic renal failure as a sole anesthetic technique in comparison to general…
- Trial name
- NCT04050891
- Testing
- combined supraclavicular and interscalene block
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Emergence Agitation
Dexmedetomidine and Propofol in the Treatment of Emergence Agitation
1. This clinical research aims to compare the effects of dexmedetomidine and propofol on the treatment of emergence agitation in adult patients after general anesthesia. 2.
- Trial name
- NCT04142840
- Testing
- Dexmedetomidine, Propofol
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Anesthesia
A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation
Hypothesis: A combination of midazolam with dexmedetomidine for sedation during third molar surgery will provide 1) superior patient satisfaction, 2) superior operator satisfaction and 3) no significant hemodynamic or respiratory…
- Trial name
- NCT03255824
- Testing
- Dexmedetomidine and Midazolam, Propofol, Midazolam, and Fentanyl
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Controlled Hypotension for Nasal Surgeries
Comparison of Two Sedative Agents in Terms of Controlled Hypotension
Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention.
- Trial name
- NCT07460050
- Testing
- Propofol, Isoflurane
- Where
- Pakistan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Pain
Sedation and Pain (The Effect of IV Sedation on Pain Perception)
The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).
- Trial name
- NCT00853333
- Testing
- dexmedetomidine, midazolam, propofol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Conscious Sedation
Monitored Anesthesia Care: Dexmedetomidine-Ketamine Versus Dexmedetomidine- Propofol For Chronic Subdural Hematoma
Inadequate sedation and analgesia indicated by intraoperative movements are markers of inadequate MAC during burr-hole surgery for chronic subdural hematoma evacuation especially when general anesthesia poses high risk for the…
- Trial name
- NCT04621526
- Testing
- dexmedetomidine- ketamine, dexmedetomidine- propofol
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Intraocular Pressure, Oncology
Effect of Position and Anesthetic Choice in Intraocular Pressure in Robotic GYN (Gynecologic) Oncology Patients
Steep Trendelenburg positioning and insufflation of the abdominal cavity have shown to increase intra ocular pressure. Different anesthetic techniques can alter intra ocular pressure and a small pilot study showed decrease in…
- Trial name
- NCT04281017
- Testing
- TIVA, Balanced anesthesia
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hemodynamic Responses to Propofol
Hemodynamic Changes After Anesthesia With Propofol: Study of Biomarkers
The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to…
- Trial name
- NCT02442232
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Analgesia
Opioid Free Anesthesia for Laparoscopic Cholecystectomy
The goal of this interventional study is to check the efficacy of Erector Spinae block as Opioid Free Anesthesia for Laparoscopic Cholecystectomy. Laparoscopic Cholecystectomy is a commonly performed day care procedure.
- Trial name
- NCT06202664
- Testing
- Erector Spinae Block, Opioid Analgesic
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Spinal Anesthesia Suitability for Abdominoplasty
Abdominoplasty Under Spinal Anesthesia
100 patients undergoing abdominoplasty under spinal anesthesia. 100 patients undergoing abdominoplasty under general anesthesia
- Trial name
- NCT03810547
- Testing
- Propofol 10 Mg/mL Intravenous Emulsion
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Driving
Accessing the Driving Skills After the Endoscopy of Intravenous Anesthesia by Driving Simulator
The purpose of this study is to assess the driving and cognitive ability of gastrointestinal endoscopy patients at different time points after intravenous anesthesia (propofol for example), and to explore whether the driving and…
- Trial name
- NCT02280148
- Testing
- Endoscopy of Intravenous Anesthesia, Driving Simulator, Propofol
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Rocuronium, Muscle Weakness
General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery
Neuromuscular blocking agents are often used during general anesthesia. Also, general anesthesia may be performed without use of neuromuscular blocking agents.
- Conditions
- Rocuronium, Muscle Weakness, General Anaesthesia
- Trial name
- NCT04760912
- Testing
- Rocuronium, General anesthesia for surgery
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Centre Zagreb
Airway Obstruction, Sedation Complication
Medical Device for Airway Patency During Sedation
OVERALL SYNOPSIS PART A: Systematic evaluation in spontaneously breathing healthy volunteer study participants of cumulative duration of manual measures for airway patency and for mask ventilation with airway device prototype…
- Conditions
- Airway Obstruction, Sedation Complication, Perioperative Complication
- Trial name
- STAIRWAY-2 (NCT06270212)
- Testing
- STAIRWAY, NO DEVICE
- Where
- Sweden
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Stairway Medical AB