Clinical trials: Sertraline
Substance Use Disorders, Substance Dependence
Correlation of Genetic Variations With Clinical Response in Substance Use Disorder
This research outcomes can be summarized as follows: 1. Pharmacogenomic analysis of Substance Use Disorder (SUD) and medications used for the treatment of SUD. 2.
- Trial name
- NCT05833399
- Testing
- Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Healthy
Bioequivalence Study of Sertraline Hydrochloride Tablets 100 mg Under Fasting Conditions
The objective of this study was to compare and evaluate the single-dose oral bioavailability of the test formulation of Sertraline Hydrochloride 100 mg tablets (Dr.
- Trial name
- NCT01267396
- Testing
- Sertraline
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Healthy
Bioequivalence Study of Sertraline Hydrochloride Tablets 100 mg in Fed Conditions
The objective of this study was to compare and evaluate the single-dose oral bioavailability of the test formulation of Sertraline Hydrochloride 100 mg tablets (Dr.
- Trial name
- NCT01267383
- Testing
- Sertraline
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Depression, Continuous Antidepressant Abuse
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients
First, the investigators examined the functional relevance of serotonin transporter polymorphisms by quantifying the activity of serotonin transporter in blood platelets of genotyped healthy volunteers and patients with major…
- Conditions
- Depression, Continuous Antidepressant Abuse, Adverse Reaction to Drug
- Trial name
- NCT01237275
- Testing
- SSRI treated group
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Major Depressive Disorder
Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder
Study hypothesis: psychotherapy and SSRI treatment effect in different brain way: psychotherapy in "up to down" way and SSRI in "down to up" way.
- Trial name
- NCT01460212
- Testing
- SSRI antidepressants, Cognitive-Behavior Therapy
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Major Depressive Disorder
The Study of Mindfulness-based Cognitive Therapy and Major Depressive Disorder
The primary objective of the study is to evaluate the clinical curative effect of mindfulness-based cognitive therapy(MBCT) for major depressive disorder(MDD).
- Trial name
- NCT03558256
- Testing
- Mindfulness-based Cognitive Therapy, Medication
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Stereotyped Behavior, Mental Retardation
Phase II Study of Stereotypes and Mental Retardation: Neurobiological Basis
OBJECTIVES: I. Determine differences between persons with repetitive behavior disorders and matched controls on measures of motor control relevant to basal ganglia pathophysiology. II.
- Trial name
- NCT00004300
- Testing
- bromocriptine, sertraline hydrochloride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Major Depression, Treatment
fMRI Study of Treatment Changes in Major Depression
The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional antidepressants do, and in comparison to healthy…
- Trial name
- NCT01027559
- Testing
- Sertraline, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Perinatal Depression, Perinatal Anxiety
Cognitive Behavioral Couple Therapy for Perinatal Distress
The hypotheses of the study are There will be differences in perceived perinatal distress, dyadic coping strategies, social support, domains of quality of life, and well-being in couples at Pre- and Post-Test levels during the…
- Trial name
- NCT06001021
- Testing
- Psychopharmacological Intervention, Cognitive Behavioral Couple Therapy, Combination of Psychopharmacological Intervention and CBCT
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Sameera Shafiq
Healthy
A Relative Bioavailability Study of Sertraline HCl 100 mg Tablets Under Fasting Conditions
To compare the rate of absorption and oral bioavailability of a test formulation of Sertraline 100 mg tablets manufactured by Purepac Pharmaceutical Company to an equivalent oral dose of the commercially available reference…
- Trial name
- NCT00864344
- Testing
- Sertraline HCl 100 mg tablets, single dose, Zoloft® 100 mg tablets, single dose
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Depression
Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients
The purpose of this study is to determine whether alteration of signal transduction components after antidepressant targeting, predict antidepressant responsiveness in advance before the appearance of the drug effects until 4~6…
- Trial name
- NCT01352572
- Testing
- antidepressant response, antidepressant non-response
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Depression
Bioequivalency Study of Sertraline Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Sertraline Tablets, 100 mg, to Zoloft® Tablets, 100 mg (Pfizer) under fed conditions using a single-dose, 2-treatment, 2-period, crossover design.
- Trial name
- NCT00601588
- Testing
- Sertraline
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Major Depressive Disorder
Magnetic Resonance Imaging Study of Geriatric Depression
The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression.
- Trial name
- NCT00245557
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Generalized Anxiety Disorder
Electroacupuncture for Generalized Anxiety Disorder: Clinical Efficacy and Neuroimaging Mechanisms
This study aims to evaluate the clinical efficacy and safety of electroacupuncture (EA) as an adjunctive treatment for generalized anxiety disorder (GAD).
- Trial name
- NCT07392645
- Testing
- Electroacupuncture (EA), Medication
- Where
- China
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Lishu Gao
Healthy, Major Depressive Disorder (MDD)
Neurobiological and Genomic Predictors of Relapse in Depression
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters.
- Trial name
- MDD (NCT07328373)
- Testing
- Antidepressant Medications
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Arikan
Depression
Sertraline for the Prevention of Recurrent Postpartum Depression
This study will determine the effectiveness of taking sertraline within 24 hours of giving birth in preventing a recurrence of postpartum depression.
- Trial name
- NCT00276900
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy
Sertraline Hydrochloride 100 mg Tablets, Fed
The objective of this study is to compare the rate and extent of absorption of sertraline hydrochloride 100 mg tablets (test) versus Zoloft® (reference) administered as 1 x 100 mg tablet under fed conditions.
- Trial name
- NCT00836667
- Testing
- Zoloft® 100 mg Tablets, Sertraline hydrochloride 100 mg Tablets
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Internalizing Psychopathologies (IPs) Depression and Anxiety
Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
Internalizing psychopathologies (IPs) involving depression and anxiety are among the most prevalent, costly and disabling illnesses.
- Trial name
- NCT01903447
- Testing
- SSRI, CBT
- Where
- United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Obesity
Safety & Tolerability of a Combination of Antidepressant and Peptic Ulcer Drug in Overweight Healthy Subjects
The hypothesis of this study is that up to 150 mg of sertraline and up to 3 mg of telenzepine will be safe, tolerable, and have the effect of suppressing appetite, when taken in combination daily by mouth by healthy, overweight…
- Trial name
- NCT01155531
- Testing
- Sertraline plus Telenzepine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Theracos
Obsessive - Compulsive Disorder
Effect of a Family-Based CBT Self-Help Intervention for Adolescents With OCD
The goal of this clinical trial is to learn if self-help book can be used to treat obsessive-compulsive disorder (OCD) in adolescents aged 10 to 17.
- Trial name
- NCT06942494
- Testing
- conventional medical treatment (TAU), Family-Based Self-help Book for Adolescents with Obsessive-Compulsive Disorder
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center