Clinical trials: Simvastatin
Hyperlipidemia
Statin Therapy Vs. Therapeutic Lifestyle Changes and Supplements
Randomized trial in a primary prevention population all participants have high LDL cholesterol Group one will take simvastatin 40 mg/day Group Two will make therapeutic lifestyle changes,and take supplements consisting of red…
- Trial name
- NCT00365742
- Testing
- simvastatin, red yeast rice, pharmaceutical grade fish oil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chestnut Hill Health System
Simvastatin, Photodynamic Therapy
Treatment of Intrabony Defects With Simvastatin and Antimicrobial Photodynamic Therapy
Antimicrobial photodynamic therapy (aPDT) is characterized by the association of photosensitizing agents, promoting the generation of reactive oxygen species like free radicals and singlet oxygen, which are cytotoxic to certain…
- Conditions
- Simvastatin, Photodynamic Therapy, Periodontal Diseases
- Trial name
- NCT05031923
- Testing
- SMV and antimicrobial photodynamic therapy, SMV application
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Diabetes Mellitus, Type 2
A Study to Investigate the Interaction of GSK1292263 With Rosuvastatin and Simvastatin in Healthy Subjects
This study is a Phase I, open-label, single-sequence drug interaction study to evaluate the effect of repeated doses of GSK1292263 on the pharmacokinetics of rosuvastatin and simvastatin in healthy adult subjects.
- Trial name
- NCT01101568
- Testing
- Simvastatin, Rosuvastatin, GSK1292263
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Platelet-rich Fibrin, Simvastatin
Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone Changes
ACKGROUND: Simvastatin (SIM), a pharmacological drug used for hypercholesterolemia, has been found to have pleotropic effects on bones. Simvastatin together with the appropriate carrier may decrease bone loss around implants.
- Trial name
- NCT05008068
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Atrial Fibrillation
Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins
The purpose of this study is to determine the effect of statin therapy for prevention of atrial fibrillation (AF) in pacemaker and non-pacemaker patients with paroxysmal atrial fibrillation in the absence of significant coronary…
- Trial name
- PAFRIOSIES (NCT00321802)
- Testing
- Simvastatin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Healthy Volunteers
Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin
The primary objective of this clinical study is to evaluate the effect of repeated oral doses of avacopan (30 mg and 60 mg twice daily approximately 12 hours apart [BID]) given under fed conditions on the PK of a single dose of…
- Trial name
- NCT06207682
- Testing
- Avacopan, Simvastatin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Amgen
Type 2 Diabetes Mellitus
A Drug Interaction Study Between Simvastatin and GSK376501
This study is a 3-period crossover drug interaction study between GSK376501 and simvastatin in healthy adult subjects. This study will examine if repeat doses of GSK376501 affects the pharmacokinetics of simvastatin and if repeat…
- Trial name
- NCT00605449
- Testing
- GSK376501
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Men
LDL Receptor Under Ezetimibe and Simvastatin
The purpose of this study is to investigate the effects of the two lipid -lowering drugs, ezetimibe and simvastatin, on lipid metabolism in humans.
- Trial name
- NCT00317993
- Testing
- ezetimibe, simvastatin, ezetimibe plus simvastatin
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Hypertriglyceridemia
The Effect of Multiple Doses of Epanova® on the Multiple-Dose Pharmacokinetics of Simvastatin in Healthy Normal Subjects
The primary objective is to determine the effect of multiple doses of Epanova® (omega fatty acids) on the pharmacokinetics (PK) of multiple 40 mg doses of simvastatin.
- Trial name
- NCT01486433
- Testing
- Simvastatin, acetylsalicylic acid (ASA), omefas
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Heart Failure
Targeting Sympathetic Overactivity in Heart Failure Patients With Statins
Heart failure (HF) is a leading cause of morbidity and mortality in the United States with the incidence and prevalence of the disease on a continual rise.
- Trial name
- NCT01097785
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Rheumatoid Arthritis
Assess the Pharmacokinetics of Rosuvastatin and Simvastatin When Administered Alone or in Combination With Fostamatinib
A study to Assess the Pharmacokinetics of Rosuvastatin and Simvastatin when administered alone or in combination with Fostamatinib.
- Trial name
- Statin DDI (NCT01725230)
- Testing
- Fostamatinib, Rosuvastatin, Simvastatin
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Atherosclerosis
Effects on Atherosclerosis Regression of Ezetimibe or Ezetimibe Plus Simvastatin; Evaluated by Fluorodeoxyglucose Positron Emission Tomography (FDG-PET)
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.
- Trial name
- NCT00926055
- Testing
- Ezetrol (Ezetimibe), Vytorin (Ezetimibe + Simvastatin)
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Korea University
Healthy Participants
A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy Participants
This study will assess the effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the effect of Erythromycin on AZD5004 in healthy adult male and female participants.
- Trial name
- NCT06948747
- Testing
- AZD5004, Rosuvastatin, Erythromycin
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Periodontitis
Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis
Among the root conditioning materials is the Ethylenediaminetetraacetic acid (EDTA). EDTA exposes the collagen fibers on dentin surfaces and also enhances early cell colonization.
- Trial name
- NCT04044417
- Testing
- currettage, curcumin simvastatin paste, EDTA root conditioning
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy Volunteers
A Study of LY2623091 in Healthy Participants
The first purpose of this study is to evaluate the effect of itraconazole (and possibly diltiazem) on the amount of LY2623091 in the blood stream and how long the body takes to get rid of it.
- Trial name
- NCT02300259
- Testing
- LY2623091, Itraconazole, Simvastatin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Participants
A Pharmacokinetic Interaction Study Between TMC435, Atorvastatin and Simvastatin in Healthy Participants
The purpose of this study is to evaluate effects of steady-state concentrations (constant concentration of medication in the blood) of TMC435 on the single dose pharmacokinetics (what the body does to the medication) of…
- Trial name
- NCT01689623
- Testing
- TMC435, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Chronic Periodontitis
Simvastatin and Metformin in Chronic Periodontitis
This randomized controlled clinical trial compares efficacy of 1.2% simvastatin with 1% metformin in chronic periodontitis subjects.
- Trial name
- NCT02372656
- Testing
- 1% Metformin, 1.2% Simvastatin
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Dyslipidemia
MK0524B Bioequivalence Study (0524B-070)
This study will evaluate: 1. the bioequivalence of simvastatin and simvastatin acid following dose of simvastatin (ZOCOR™) given together with one tablet of MK0524A or as a component of the triple combination tablet MK0524B. 2.
- Trial name
- NCT00943124
- Testing
- MK0524B (ER niacin (+) laropiprant (+) simvastatin), MK0524A (ER niacin + laropiprant), Simvastatin
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Celiac Disease
Study for Identifying Optimal Simvastatin Formulation for Uniform Time to Maximum Plasma Concentration
The inter- and intra-variability in the pharmacokinetic parameters of different formulations and doses of simvastatin in healthy subjects and in subjects with celiac disease in remission will be evaluated.
- Trial name
- NCT01642862
- Testing
- Simvastatin
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Inflammation, Atherosclerosis
Anti-inflammatory Effects of Simvastatin
The purpose of this research study is to determine which of the two ingredients of Vytorin (Simvastatin or Ezetimibe) is responsible for the anti-inflammatory effects of Vytorin
- Conditions
- Inflammation, Atherosclerosis, Hypercholesterolemia
- Trial name
- NCT04638400
- Testing
- Simvastatin 40mg, Ezetimibe 10mg
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- paresh Dandona