Clinical trials: Transcranial Direct Current Stimulation
Alzheimer Disease, Working Memory
Induction and Stabilization of Gamma Oscillations With 40 Hz External Brain Stimulation
The goal of the present studies is to develop and validate novel stimulation protocols for the entrainment of gamma oscillations, which are associated with many cognitive functions and critically involved in cognitive impairment…
- Conditions
- Alzheimer Disease, Working Memory, EEG Brain Oscillations
- Trial name
- NCT06680154
- Testing
- Transcranial alternating current stimulation, Theta burst stimulation
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Orthorexia Nervosa
Effects of tDCS on Cognitive Flexibility and EEG Oscillations in Orthorexia Nervosa
Orthorexia Nervosa (ON); is a condition characterized by individuals being overly focused on healthy eating habits, constantly checking and classifying the foods they will consume.
- Trial name
- NCT07141979
- Testing
- Active tDCS
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Pain Management
BreEStim and tDCS for Neuropathic Pain Management - Healthy Subjects
This study looks at the effect of combined breathing-controlled electrical stimulation (BreEStim) and transcranial direct current stimulation (tDCS) on neuropathic pain after spinal cord injury, amputation, or brain injury.
- Trial name
- NCT03302780
- Testing
- BreEStim, tDCS active
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission
Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This 7-year randomized controlled trial will compare the efficacy of non-invasive brain stimulation (trans-cranial Direct Current Stimulation - tDCS) combined with cognitive remediation (CR) versus sham ("placebo") tDCS combined…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission
- Trial name
- PACt-MD (NCT02386670)
- Testing
- tDCS + CR
- Where
- 5 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Stuttering, Developmental, Aphasia, Primary Progressive
Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech
Persistent developmental stuttering affects more than three million people in the United States, and it can have profound adverse effects on quality of life.
- Trial name
- NCT05437159
- Testing
- Learning of non-native phoneme combinations: 6 training sessions, Learning of non-native phoneme combinations: 1 training session, Learning of novel multisyllabic nonwords
- Where
- 3 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Anxiety State
A Functional Magnetic Resonance Imaging Investigation of Transcranial Direct Current Stimulation
This study evaluates the effect of frontal cortex transcranial direct current stimulation (tDCS) on the neural correlates of threat processing in healthy volunteers with a high level of trait anxiety.
- Trial name
- NCT03623815
- Testing
- transcranial direct current stimulation
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Logopenic Progressive Aphasia, Primary Progressive Aphasia
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
AD afflicts over 5.5. million Americans and is one of the most expensive diseases worldwide. In AD the variant in which language functions are most affected are referred to as 'logopenic variant Primary Progressive Aphasia'…
- Trial name
- NCT03887481
- Testing
- High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Effect of Electrical Stimulation (DC Polarization) to the Brain on Memory
This study will test the effect of direct current (DC) brain polarization (the application of a very weak electrical current to the brain) on learning and memory.
- Trial name
- NCT00471107
- Testing
- DC brain polarization
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebral Palsy, Perinatal Stroke
Single-session tDCS in Cerebral Palsy
The goal of this study is to characterize individual responses to a single application of transcranial direct current stimulation (tDCS) in children with unilateral cerebral palsy (UCP), and to test which electrode configuration…
- Conditions
- Cerebral Palsy, Perinatal Stroke, Periventricular Leukomalacia
- Trial name
- NCT03635775
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenia, Psychosis
Enhancement of Treatment of Delusions in Schizophrenia Through Neuromodulation
The proposed study aims to use a form of neuromodulation, known as transcranial alternating current stimulation (tACS), to improve the effectiveness of the metacognitive training (MCT) program for treatment of delusions in…
- Conditions
- Schizophrenia, Psychosis, Delusions
- Trial name
- tACS (NCT03062553)
- Testing
- Metacognitive Training (MCT), transcranial alternating current stimulation (tACS)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Psychosis, Schizophrenia
Targeting Individual Alpha Frequencies to Enhance Perceptual Timing
This is a single-blind randomized within-subject crossover design study that will be conducted in 2 phases. In Phase 1, up to 50 participants, after signing informed consent and determining eligibility, will undergo a baseline…
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT04856657
- Testing
- Transcranial alternating current stimulation
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain
High Definition Transcranial Direct Current Stimulation Motor Cortex Versus Insula
Brain stimulation is a technique that can alter cortical function and thus be suitable for treating pain. This is especially when pain is chronic and associated with functional and even structural reorganization of the central…
- Trial name
- NCT03216707
- Testing
- HD tDCS active motor cortex, HD tDCS active insula cortex, Capsaicin cream
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Stroke
Brain Stimulation-aided Stroke Rehabilitation: Neural Mechanisms of Recovery
The purpose of this study is to investigate whether benefits of training the affected hand in patients with stroke can be improved by combining training with a painless, noninvasive technique called Transcranial Direct Current…
- Trial name
- NCT01539096
- Testing
- tDCS: noninvasive brain stimulation, Constraint induced movement therapy (CIMT)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Stress Related Disorder, Anxiety
Modulation of Fear Extinction Processes Using Transcranial Electrical Stimulation
The aim of this study is to examine the effects of transcranial electrical stimulation on processes associated with fear extinction in healthy humans.
- Trial name
- NCT02723188
- Testing
- DC stimulation (1.5 milliampere, 20 minutes), AC stimulation (1.5 milliampere,1.5 Hertz frequency)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Cognitive Change
Decision Making in Video Games
The purpose of this study is to determine whether anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex induces approach motivation, and whether anodal tDCS applied to the right…
- Trial name
- NCT03869489
- Testing
- Anodal left dorsolateral prefrontal cortex tDCS stimulation, Anodal right dorsolateral prefrontal cortex tDCS stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Stroke, Aphasia
Enhance of Language Learning With Neurostimulation
The purpose of this study is to test the effect of transcranial direct current stimulation over the motor cortex of the language dominant hemisphere on language learning in healthy subjects and stroke patients with aphasia.
- Conditions
- Stroke, Aphasia, Aging
- Trial name
- NCT00854893
- Testing
- transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Parkinson's Disease
The Effects of Multi-focal tDCS on Motor-cognitive Dysfunctions in Parkinson's Disease
The current RCT aims to establish the therapeutic potential of tDCS for freezing of gait (FOG) and motor-cognitive dysfunctions in PD.
- Trial name
- NCT02656316
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Working Memory Deficits
Transcranial Direct Current Stimulation (tDCS) on Working Memory in College Going Students
Working memory deficiencies, might make it difficult for students to recall instructions, complete complex activities, and grasp and follow directions solving a math problem or writing a sentence.
- Trial name
- NCT05737498
- Testing
- Transcranial direct current stimulation (tDCS)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
no Condition Being Studied; tDCS Only in Healthy Subjects
Using tDCS to Enhance Learning of a New Walking Pattern
The ability to change walking patterns is important for daily tasks such as stepping over an obstacle. This change of walking pattern can occur in a strategic manner, i.e., consciously making one step longer or shorter.
- Trial name
- NCT03582904
- Testing
- tDCS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Delaware
Healthy
Modulating Speech Perception With Current Stimulation
This study aims to further develop tACS as a tool to improve speech perception, by manipulation of brain-speech synchronisation ("entrainment"), thereby transforming a promising approach into a technique that can benefit to…
- Trial name
- SPEECHSTIM (NCT05446350)
- Testing
- transcranial alternating current stimulation (tACS), electroencephalography (EEG), brain imaging (fMRI)
- Where
- France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse