Clinical trials: gene expression analysis
Chronic Myeloproliferative Disorders, Fanconi Anemia
Research Study in Healthy Volunteers of Patients With Fanconi Anemia, Myeloproliferative Disorders, or Myeloma
RATIONALE: Analyzing tissue and blood samples from healthy volunteers or patients with Fanconi anemia, myelodysplasia, myeloproliferative disorders, or myeloma in the laboratory may help doctors learn more about the causes of…
- Conditions
- Chronic Myeloproliferative Disorders, Fanconi Anemia, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00900055
- Testing
- microarray analysis, polyacrylamide gel electrophoresis, polymerase chain reaction
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Bronchiolitis Obliterans Syndrome (BOS)
Mechanisms and Targeted Therapy of Airway Basal Cell Dysfunction in Bronchiolitis Obliterans Syndrome
This experimental study aims to investigate the pathogenesis of bronchiolitis obliterans syndrome (BOS) and provide a basis for clinical diagnosis and treatment.
- Trial name
- NCT07018804
- Testing
- Bronchoscopic brushing, Single - cell cloning, Cell function identification
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Haikou Affiliated Hospital of Central South University Xiangya School of Medicine
Pulmonary Arterial Hypertension
BMPR2 Mutations and Iron Metabolism in Pulmonary Arterial Hypertension
Previously characterised PAH patients, including idiopathic, heritable and other forms of group 1 PAH with and without BMPR2 mutation which have already been analysed and are regularly seen in the Center for Pulmonary…
- Trial name
- AMIA (NCT04086537)
- Testing
- hepcidin levels and BMPR2 expression
- Where
- Germany
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Severe Obesity, Type 2 Diabetes Mellitus in Obese
L-Cell Activity in Small Intestine as Biliopancreatic Loop in Obese Patients With DM2 Submitted to RYGBP
Prevalence of Obesity and its association with Diabetes Mellitus 2 (DM2) affect a significant percentage of the world's population with great socioeconomic impact, especially for developing countries.
- Trial name
- NCT05446415
- Testing
- Analyze basal expression incretin for immunolabeling and mRNA expression glucagon-like secretion peptide-1 (GLP-1) and peptide YY (PYY 3-36) incretins by L cells.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Peri-implantitis
Expression of Epithelial-Mesenchymal Transition Associated Markers in Peri-implant Tissues
Peri-implantitis is an inflammation of bacterial etiology characterized by inflammation of mucous membranes and bone loss around the dental implant.
- Trial name
- NCT05832541
- Where
- Iraq
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Metabolic Syndrome, Obesity
Dietary Modulation of Gene Expression and Metabolic Pathways in Glucose Metabolism
Professor Matti Uusitupa, University of Kuopio, Department of Clinical Nutrition (www.uku.fi) Docent Matej Oresic, VTT (www.vtt.fi) Ursula Schwab, PhD, Docent, Marjukka Kolehmainen, PhD, Docent, Leena Pulkkinen, PhD, Docent…
- Conditions
- Metabolic Syndrome, Obesity, Impaired Glucose Tolerance, Impaired Fasting Glucose
- Trial name
- Sysdimet (NCT00573781)
- Testing
- Diet with increased intake of rye bread, berries and fish, Increased intake of whole grain and rye bread, Control diet with decreased intake of rye bread, berries and fish
- Where
- Finland
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Psoriasis, Periodontal Diseases
Interleukin- 17 (IL-17), Bcl-3, and NF-kappa-B Inhibitor Zeta (IκBζ) Expression Levels in the Psoriasis Patients
This study aimed to compare the levels of IL-17 (interleukin- 17), Bcl-3 (B-cell lymphoma 3-encoded protein), and IκBζ (NF-kappa-B inhibitor zeta) in the gingival crevicular fluid of psoriatic and healthy individuals and the…
- Trial name
- NCT06408454
- Testing
- Gingival crevicular fluid collection, periodontal test
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Conjunctivitis, Allergic
OJO-miR: microRNA Expression in Allergic Conjunctivitis.
Allergic conjunctivitis (AC) causes inflammation of the conjunctiva in response to environmental allergens, affecting a significant percentage of the world population and reducing quality of life.
- Trial name
- OJO-miR (NCT07385495)
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Hypoxia, Altitude
Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
- Trial name
- DRU-EMO-K (NCT03823677)
- Testing
- Hypoxia
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Köln
Dietary Habits
A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta
Nuclear factor kappa B (NF-κB) pathway and oxidative stress participate in endothelial dysfunction, which is one of the causes of preeclampsia.
- Trial name
- NCT01667939
- Testing
- Healthy Eating Index (HEI) in supervised pregnancies
- Where
- Mexico
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Materno-Perinatal Hospital of the State of Mexico
Colon Cancer
Screening and Risk Factors of Colon Neoplasia
The investigators propose a screening population-based study to systematically evaluate the accuracy and clinical relevance of sDNA testing as a potential alternative to colonoscopy screening.
- Trial name
- NCT01647776
- Testing
- Stool DNA Test, biopsies of rectal and colon mucosa, Questionnaires
- Where
- United States
- Volunteers
- 3,315 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Infertility
Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women
The aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using Next Generation Sequencing of total RNA.
- Trial name
- NCT02219425
- Testing
- endometrial biopsy
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Giant Cell Arteritis, Polymyalgia Rheumatica
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR).
- Trial name
- GCAIO (NCT06460142)
- Testing
- Aortic/ cardiac magnetic resonance imaging, Vascular ultrasound, Transorbital Ultrasound
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Insulin Sensitivity, Aging
Implication of Metabolic and Genomic Modifications in Elderly Subjects
An increase of longevity and of the number of men and women older than 60 years old is observed in most industrialized countries.
- Trial name
- COMPALICLAMP (NCT00951392)
- Testing
- euglycemic hyperinsulinemic clamp, muscle biopsy, indirect calorimetry
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Prostatic Neoplasms
The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females
Background: Insomnia is associated with difficulty sleeping. The drug zolpidem is widely prescribed for insomnia. Women have reported worse effects from the drug than men.
- Trial name
- NCT03436745
- Testing
- Zolpidem, ECG
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Kidney Cancer
Studying Genes Using Cord Blood and Placenta Samples From Relatively Healthy Newborns and Samples From Younger Patients With Wilms Tumor
RATIONALE: Studying samples of blood and tissue from newborns and from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01576211
- Testing
- DNA methylation analysis, RNA analysis, allele-specific oligonucleotide real-time quantitative polymerase chain reaction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Cardiovascular Disease
Decoding Your Diet (DYD)
Our study will determine if a high quality AHA plant-based diet intervention can promote a genetic signature that is protective against CVD.
- Trial name
- DYD (NCT05904639)
- Testing
- Decoding Your Diet
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Non-melanomatous Skin Cancer, Precancerous Condition
Effect of Solar-Simulated Ultraviolet Radiation on Gene Expression in Unprotected and Sunscreen-Protected Skin of Healthy Adults With Fitzpatrick Skin Type II
RATIONALE: Testing of skin that has been exposed to artificial sunlight may help in understanding the genetic processes involved in the development of skin cancer.
- Trial name
- NCT00099112
- Testing
- microarray analysis, biopsy, evaluation of cancer risk factors
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Periodontal Therapy, miRNA-223
The Effects of Smoking on miRNA-223 Before-After Non-Surgical Periodontal Therapy
Periodontal diseases are one of the most common inflammatory diseases. Periodontal disease results from a complex interplay between the subgingival biofilm and the host immune-inflammatory events that develop in the gingival and…
- Conditions
- Periodontal Therapy, miRNA-223, Periodontitis, Biomarker
- Trial name
- NCT05372965
- Testing
- experimental-periodontitis-mirna-223-gingival tissue-saliva samples, control-clinical healthy mirna-223-gingival tissue-saliva samples
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biruni University
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza