Clinical trials: sponsored by Asan Medical Center
Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
Trial of Neoadjuvant Durvalumab Plus Docetaxel, Oxaliplatin, S-1 Followed by Surgery and Adjuvant Durvalumab Plus S-1 Chemotherapy in Potentially Resectable MMR Proficient Gastric or Gastroesophageal Junction Adenocarcinoma
Neoadjuvant durvalumab (MEDI4736) plus docetaxel, oxaliplatin, S-1 (DOS) followed by surgery and adjuvant durvalumab plus S-1 chemotherapy in potentially resectable MMR proficient (pMMR) gastric or gastroesophageal junction (GEJ)…
- Trial name
- NCT04221555
- Testing
- Docetaxel, Oxaliplatin, S-1 and Durvalumab, Durvalumab and Tremelimumab
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Dermal Fillers
Pivotal Study to Evaluate the Efficacy and Safety of Injection With LASBEAU Strong in Correction of Nasolabial Folds
Background: Nonsurgical injectable treatments have become popular for aesthetic purposes. In recent years, cross-linked hyaluronic acid (HA) fillers containing lidocaine have been used to correct the nasolabial folds.
- Trial name
- NCT06310863
- Testing
- LASBEAU Strong or Restylane Lyft injection as hyaluronic acid fillers
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Sclerotherapy, Endometrioma
Two-session Catheter-directed Sclerotherapy Using Ethanol for Endometrioma
The goal of this clinical trial is to evaluate the safety and clinical outcomes of two-session catheter-directed sclerotherapy (CDS) with 96% ethanol in patients with endometrioma.
- Trial name
- NCT06274086
- Testing
- Two-session catheter-directed sclerotherapy
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Enhanced Recovery After Surgery, Mortality
Impact of Anesthesia-related Enhanced Recovery After Surgery Components on Mortality After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD), one of the most complex and invasive abdominal surgeries, is associated with long length of stay (LOS) and high morbidity and mortality rates.
- Trial name
- NCT06256133
- Testing
- Enhanced Recovery After Surgery protocol
- Where
- South Korea
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Chronic Obstructive Pulmonary Disease
A Study About Association Between Microbiome, Metabolome and Clinical Characteristics in COPD Patients
The goal of this observational registry study is to compare characteristics of gut and sputum microbiome and metabolome among COPD patients with significant smoking history, COPD patients without significant smoking history and…
- Trial name
- NCT06101459
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Functional Recovery, Laparoscopy
Comparison of Functional Recovery Between Laparoscopic and Open Pancreaticoduodenectomy
Laparoscopic surgery has not changed much in safety compared with open surgery through many existing studies, and has become a procedure to help patients' recovery.
- Conditions
- Functional Recovery, Laparoscopy, Periampullary Cancer
- Trial name
- NCT03870698
- Testing
- Laparoscopic group
- Where
- South Korea
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreatic Cancer, Adult, Margin, Tumor-Free
Usefulness of the Artery First Approach in Pancreatic Cancer Surgery
This study is aimed to evaluate difference of the 2 year recurrence free survival after pancreaticoduodenectomy for pancreatic cancer between artery-first approach and conventional procedure groups.
- Conditions
- Pancreatic Cancer, Adult, Margin, Tumor-Free, Surgery Site Fistula, Recurrence Tumor
- Trial name
- NCT04136522
- Testing
- conventional pancreaticoduodenectomy, total mesopancreas excision including superior mesenteric artery first approach
- Where
- South Korea
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreaticoduodenectomy, Delayed Gastric Emptying
Comparison Between Pylorus-resecting and Preserving Pancreaticoduodenectomy on Delayed Gastric Emptying and Nutrition
Pylorus preserving pancreaticoduodenectomy has been standard procedure for periampullary benign and malignant disease. Delayed gastric emptying is one of most common complications after the procedure.
- Conditions
- Pancreaticoduodenectomy, Delayed Gastric Emptying, Nutrition
- Trial name
- NCT05314244
- Testing
- Pylorus resecting pancreaticoduodenectomy
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Healthy Volunteer, Alzheimer Disease
Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain
The overall goal of this imaging trial is to evaluate [18F]PI-2620, a tau targeted positron emission computed tomography radioligand, in individuals with tauopathies and healthy volunteers (HV).
- Conditions
- Healthy Volunteer, Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease
- Trial name
- NCT03510572
- Testing
- [18F]PI-2620
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreatic Tumor
Effect of Thrombin-containing Collagen-based Hemostatic Matrix
Under the hypothesis that collagen-based hemostatic agents improve the suppression of leakage of hemostatic pancreatic fluid at the surgical site during surgery, thrombin-containing collagen-based hemostatic agents are applied in…
- Trial name
- TCM (NCT04357483)
- Testing
- flowable thrombin containing collagen hemostat matrix, thrombin coated L-dopa contained collagen patch
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pulmonary Disease, Chronic Obstructive, Microbiota
Analysis of the Microbiome in the Healthy Smokers and COPD Patients
This study is to build a microbiome cohort by collecting sputum and fecal samples every few months for three years from healthy smokers and chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT04336423
- Testing
- Obtain samples from sputum and feces
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Acute Myelogenous Leukemia
Randomized Study of Haploidentical Hct and Subsequent Donor nk Cell Infusion in High-risk AML and MDS
This is a single center, open label, random comparison phase 2b study. The primary objective of this study is, by random comparison, to assess the anti-leukemia effect of allogeneic, donor-derived natural killer (NK) cells…
- Trial name
- DNKI-4 (NCT02477787)
- Testing
- allogeneic, donor-derived NK cells
- Where
- South Korea
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Chronic Interstitial Cystitis
The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome (Pilot Study)
This study is to evaluate the efficacy of urine biomarker in patients with interstitial cystitis/painful bladder syndrome
- Trial name
- NCT02331472
- Where
- 2 sites in South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Attention Deficit Disorder With Hyperactivity
Identification of Neuropsychological, Genetic and Neuroimaging Markers and Treatment Response Predictors of ADHD
The objective of this study is to identification of neuropsychological, genetic and neuroimaging markers and treatment response predictors of attention-deficit/hyperactivity disorder (ADHD).
- Trial name
- NCT02430896
- Testing
- Methylphenidate (MPH), Atomoxetine
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Interstitial Cystitis
The Efficacy of Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome
The purpose of this study is to evaluate efficacy of biomarker in patient with interstitial cystitis/painful bladder syndrome
- Trial name
- NCT01985880
- Where
- 2 sites in South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pulmonary Disease, Chronic Obstructive, Emphysema or COPD
The Microbiome of Sputum, Urine and Feces in Healthy Persons and Chronic Obstructive Pulmonary Disease (COPD) Patients
Extensive studies suggest composition of microbiome of respiratory samples or lung tissues in COPD patients is different from the composition of healthy smokers.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Emphysema or COPD, Microbiota
- Trial name
- COPD (NCT03755505)
- Testing
- obtain samples from sputum, feces and urine
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreatic Neoplasms
Evaluation of Killing Activity of Expanded Natural Killer Cells From Blood in Patients With Pancreatic Cancer
Pancreatic cancer, one of the deadliest epithelial malignancies, has a 5-year survival rate of only about 8%. The mortality rate has decreased slightly, but the incidence rate has been steadily increasing, and it is predicted to…
- Trial name
- NCT03665571
- Testing
- Receptor specific activation method
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Cervical Cancer
Significance of Fluorescence Colposcopy With Autofluorescence Imaging for Cervical Cancer
Clinical Trial to access Significance of fluorescence colposcopy with autofluorescence imaging for the screening of cervical cancer
- Trial name
- NCT01854983
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Parkinson's Disease
Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor Patients
The purpose of this study is to determine whether F-18 FPCIT is effective and safe radiopharmaceutical for the objective diagnosis of Parkinson's disease.
- Trial name
- FPCIT (NCT00468078)
- Testing
- PET/CT, F-18 FPCIT
- Where
- South Korea
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Depression
A Genotype Stratification Study for Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Male Subjects
A total of 24 healthy Korean male subjects will receive a single oral dose of amitriptyline, 25 mg. Subjects will be enrolled in this study based on their cytochrome P450 2D6 and cytochrome P450 2C19 genotypes, and serial blood…
- Trial name
- NCT02519400
- Testing
- Amitriptyline
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center