Clinical trials: sponsored by Children's National Research Institute
Covid19, MIS-C Associated With COVID-19
Pediatric COVID Outcomes Study (PECOS)
This is a multisite prospective observational study to evaluate the clinical sequelae of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the pediatric population, including…
- Conditions
- Covid19, MIS-C Associated With COVID-19, MIS-C Multisystem Inflammatory Syndrome in Children, SARS-CoV2 Infection
- Trial name
- NCT04830852
- Where
- 2 sites in United States
- Volunteers
- 1,097 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Healthy Participants
Pupillary Dilation Reflex in Healthy Volunteers
This a single site, observational study that will examine how the pupil responds to neurostimulation under different conditions in healthy adults.
- Trial name
- NCT07746167
- Testing
- No intervention (observational study)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Chemotherapy-induced Peripheral Neuropathy
Physiologic Measure of VIPN
The purpose of this study is the development of a physiologic endpoint using a novel technology that would provide an objective, easy to use and more sensitive assessment of VIPN in children and adolescents.
- Trial name
- NCT04786977
- Testing
- No Intervention, Observational Study
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Sexually Transmitted Diseases
Health Information Technology to Reduce Disparities in Adolescent Health Outcomes: A Pragmatic Trial
We will compare differences in sexually transmitted infection (STI) detection rates between sexual health survey (SHS)-derived electronic clinical decision support (CDS) versus usual care (e.g.
- Trial name
- NCT04372875
- Testing
- SHS-derived CDS
- Where
- United States
- Volunteers
- 18,500 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Infections, Pain
Augmented Reality For MRI-Guided Interventions
The purpose of this study is to determine feasibility and safety of using an augmented reality system in patients undergoing MRI-Guided needle procedures.
- Conditions
- Infections, Pain, Diagnosis
- Trial name
- NCT06224933
- Testing
- Augmented Reality System
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Perinatal Depression, Perinatal Anxiety
The DC Mother-Infant Behavioral Wellness Program
This randomized controlled study will examine the effectiveness of patient navigation with culturally adapted cognitive-behavioral interventions and peer support groups for low-income Black/of African Descent pregnant women who…
- Conditions
- Perinatal Depression, Perinatal Anxiety, Prenatal Stress
- Trial name
- NCT05345834
- Testing
- Patient Navigation, Adapted Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Zika Virus, Congenital Zika Syndrome
Neurodevelopmental Outcomes in ZIKV-Exposed Children
In this study the investigators will follow the neurodevelopmental outcome of children with in utero ZIKV exposure who do not have microcephaly or severe abnormalities consistent with Congenital Zika Syndrome.
- Conditions
- Zika Virus, Congenital Zika Syndrome, Congenital Infection, Child Development
- Trial name
- NCT04398901
- Testing
- Neurodevelopmental assessments
- Where
- 2 sites in United States, Colombia
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Obesity, Childhood
Acetaminophen Dosing in Obese Adolescents
Although there are numerous studies investigating the pharmacokinetic properties of intravenous acetaminophen in infants and children with normal weight, there are none in the obese pediatric patient .
- Trial name
- NCT03192566
- Testing
- Tylenol
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Adolescent Behavior, Social Stress
Social Navigation for Adolescents in ED
Social determinants of health affect patients throughout the life course. They may be particularly relevant for pediatric emergency department (ED) patients.
- Conditions
- Adolescent Behavior, Social Stress, Emergencies
- Trial name
- NCT03239041
- Testing
- Social navigation team
- Where
- United States
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Paracentesis
Augmented Reality Ultrasound Guidance
Many medical procedures are done with the aid of ultrasound imaging, but they remain difficult to learn and perform. This study will use augmented reality technology for making these procedures potentially more intuitive, easier…
- Trial name
- HoloUS (NCT05964439)
- Testing
- HoloUS app for ultrasound visualization
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Urea Cycle Disorders
Neuroimaging and Neuropsychological Outcomes in Urea Cycle Disorders
In proximal urea cycle disorders (UCD), particularly ornithine transcarbamylase deficiency (OTCD), hyperammonemia (HA) causes increased brain glutamine (Gln) which perturbation is thought to be at the core of the neurological…
- Trial name
- UCD (NCT02935283)
- Testing
- MRI, Behavioral
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Professional Quality of Life
Interventions to Promote Well-being of Nightshift Nursing Team Members
Background: Nightshift health care employees can experience greater likelihood of health threats such as weight gain, hypertension, and sleep disturbances.
- Trial name
- HSWellness (NCT05722249)
- Testing
- Mindfulness and Sleep Hygiene, Phyical activity and Sleep Hygiene
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Concussion, Mild, Concussion, Brain
Acute Concussion and Melatonin
In this study, the investigator plans a randomized trial of melatonin versus placebo post acute pediatric concussion. The investigator hypothesizes that patients with acute concussions managed with melatonin will have improved…
- Conditions
- Concussion, Mild, Concussion, Brain, Pediatric ALL
- Trial name
- NCT04731974
- Testing
- Melatonin 3 MG
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology
Accuracy of the Red Reflex Test in the Pediatric Population
This study is designed to investigate the sensitivity and specificity of the Red Reflex Test (RRT), with and without dilation, for early detection of ocular abnormalities in children and newborns.
- Conditions
- Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology, Optic Nerve Diseases, Retinal Disease
- Trial name
- NCT04125043
- Testing
- Direct ophthalmoscope
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Pediatric ALL, Concussion, Mild
Concussion Active Rehabilitation
In this study, the investigator plans a randomized trial of active rehabilitation and standard care for acute concussion management.
- Conditions
- Pediatric ALL, Concussion, Mild, Concussion, Brain, Concussion, Intermediate
- Trial name
- NCT04248218
- Testing
- Active Rehabilitation Group/Case
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Cardiac Arrhythmia, Syncope
Comparative Study of the Sternal Patch System With a Conventional Holter Recorder
This study will be a comparison of two externally worn recording systems for documentation of cardiac arrhythmias in symptomatic patients or patients at risk for arrhythmia.
- Trial name
- NCT04241692
- Testing
- CarnationTM Ambulatory Monitoring Sternal ECG Patch System, Conventional 24-Hour 7 Lead Holter Monitor Recorder
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Congenital Heart Disease, Cardiovascular Disease
Technical Development for Pediatric Cardiovascular MRI
This study will explore new ways of using magnetic resonance imaging (MRI) to evaluate pediatric patients with cardiovascular disease,congenital heart disease in patients of all ages, fetuses undergoing clinically indicated MR…
- Trial name
- NCT02892136
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Pediatric Car Seat Safety Training
Infant Car Seat Use
Motor vehicle crashes (MVCs) kill more children and young adults than any other single cause in the United States. Proper use of the child safety seat (car seat, or CSS) reduces the risk of death by 71% in infants, and to…
- Trial name
- NCT05252299
- Testing
- Rolling Fresher Group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Congenital Heart Disease, Comorbidities and Coexisting Conditions
Congenital Heart Initiative-Redefining Outcomes and Navigation to Adult Centered Care
Congenital heart defects (CHDs) are a heterogeneous group of rare diseases of varying severity, each diagnosis with its unique set of co-morbidities.
- Trial name
- CHI-RON (NCT05185232)
- Testing
- Impact of gaps in care/loss to healthcare follow-up
- Where
- 16 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute