Clinical trials: sponsored by Duke University
Hypoxemia, Desaturation of Blood
Alternate Methodology of Pulse Oximeter Validation
This study will determine if the replacement of the measured arterial blood oxygen saturation with expired (end-tidal) oxygen value is an acceptable method to calculate the accuracy of pulse oximeters.
- Trial name
- NCT03628560
- Testing
- RespirAct Step-Wise Normocapnia desaturation sequence, RespirAct Slope Normocapnia desaturation sequence, RespirAct Step-Wise Hypocapnia desaturation sequence
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Duke University
Age-Related Macular Degeneration
AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark…
- Trial name
- NCT06619405
- Testing
- Streetlab VR
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Digestion Rate
Food DNA Digestion
This pilot study investigates the digestion rate of naturally occurring food DNA through the human digestive tract by detecting residual food DNA in stool samples.
- Trial name
- Anna Bauer (NCT06687226)
- Testing
- Reconstitutable food powder
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Develop and Test Robotically Assisted Imaging System for the Front of the Eye
Robotic OCT for ER Anterior Eye Exams
The purpose of this study is to develop and test a robotically assisted imaging system for the front of the eye with a goal of helping eye care through the emergency department.
- Trial name
- NCT06566339
- Testing
- Robotically Aligned Eye Imaging System
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes (DM)
Studies of Insulin and Glucagon Action in the Liver
This study examines how glucagon works to regulate glucose metabolism, based on new findings that suggest glucagon signaling in the liver has more than one role, and that these multiple roles can be opposing in nature.
- Trial name
- SIGNAL (NCT07300982)
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Retinal Disease, Glaucoma
Optimize Pediatric OCT Imaging
Handheld optical coherence tomography (OCT) has become an important imaging modality to evaluate the pediatric retina. The objective of this pilot study is to compare a new contact OCT system (Theia Imaging) with an…
- Conditions
- Retinal Disease, Glaucoma, Optic Nerve Diseases
- Trial name
- NCT06139523
- Testing
- Investigational contact OCT system, Investigational noncontact OCT system:
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain, Dementia, Mild
Pain With Dementia
The purpose of the study is to develop a caregiver-assisted pain coping skills training program for older adults who have pain and mild to moderate dementia and are living at home with a family caregiver.
- Conditions
- Pain, Dementia, Mild, Dementia, Moderate
- Trial name
- PWD (NCT06854718)
- Testing
- Caregiver-Assisted Pain Coping Skills Training (CG-PCST)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV
PrEP (Pre-exposure Prophylaxis) Stigma and Women Ethnodrama Pilot Phase
The investigators will pilot test an ethnodrama intervention designed to transform community member beliefs about and foster support of young cisgender women (YCW) using Pre-exposure Prophylaxis (PrEP).
- Trial name
- NCT07225894
- Testing
- Ethnodrama Intervention
- Where
- Kenya
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV
PrEP (Pre-exposure Prophylaxis) Stigma and Women Ethnodrama Pre-Test Phase
The investigators will develop and pre-test an ethnodrama intervention designed to transform community member beliefs about and foster support of young cisgender women (YCW) using PrEP.
- Trial name
- NCT06501885
- Testing
- Ethnodrama Intervention
- Where
- Kenya
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
Influenza
Immunogenicity of Influenza Vaccinations
This study is a randomized immunogenicity study in an enrolled cohort with active surveillance for influenza-like illness (ILI).
- Trial name
- NCT06518577
- Testing
- Flucelvax® (ccIIV3), Flublok® (RIV3)
- Where
- 7 sites in United States
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV Infection
MAPS PrEP Van Study
For this study the investigators aim to see if giving participants an oral HIV prevention medication on a medical van, is a good option of care for individuals who inject drugs and/or are sexually active and therefore at a higher…
- Trial name
- MAPS PrEP (NCT06908252)
- Testing
- Pre-Exposure Prophylaxis (PrEP)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Duke University
Obstructive Pulmonary Disease, Restrictive Pulmonary Disease
Lung Health and the Microbiome Among Adults in Botswana: the Go-hema Cohort
Chronic respiratory diseases like chronic obstructive pulmonary disease (COPD) are responsible for millions of deaths each year, the majority of which occur in low- and middle-income countries (LMICs).
- Trial name
- NCT07699614
- Where
- Botswana
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Duke University
Cannabis
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
The growing legalization of cannabis across the U.S. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (CUD).
- Trial name
- iCURE (NCT05401929)
- Testing
- iTBS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Motivation, Memory
MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants
The purpose of this research study is to understand how healthy individuals self-regulate motivation by observing brain activity using magnetic resonance imaging (MRI).
- Conditions
- Motivation, Memory, Self-regulation
- Trial name
- NCT05929898
- Testing
- Ventral tegmental area of dopaminergic midbrain (VTA) fMRI neurofeedback
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Duke University
Preexposure Prophylaxis, HIV Infections
Start the Conversation: Evaluating Implementation of a Multi-level PrEP Initiative for Black Cisgender Women in Nola
The study objectives are to: Evaluate implementation outcomes from piloting the Start the Conversation Initiative Assess initial indicators of clinical effectiveness among patients engaged in the Start the Conversation Initiative…
- Trial name
- NCT05909176
- Testing
- GYN Residency Training, Social Media Campaign
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Duke University
Sleep, Psychiatric Health
Sustainable Habits for Encouraging Even Teen Sleep
This study will examine the feasibility, acceptability, and effectiveness of two digital sleep interventions in improving sleep regularity and psychiatric health during a critical period of adolescence.
- Trial name
- SHEETS (NCT05378373)
- Testing
- Garmin, Pattern Health App
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Duke University
Acute Pain, Postoperative Pain
Study of QL Analgesic Response and Extent
A total of 14-18 healthy volunteers will be included. There will be three different procedure days, separated by at least one week. On each visit, the subjects will receive a QL block, according to the randomization process.
- Conditions
- Acute Pain, Postoperative Pain, Regional Anesthesia Block
- Trial name
- SQUARE (NCT07566312)
- Testing
- Quadratus Lumborum with 1.5% Lidocaine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain, Injection Site Reaction
Safety of Pediatric COVID-19 Vaccination
This is a prospective, observational study. During the study, children and adolescents (ages ≥ 5 to < 16) will be followed post administration of mRNA COVID-19 vaccines.
- Conditions
- Pain, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05157191
- Testing
- Observational
- Where
- 5 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Duke University
Spatial Neglect
Dosing and Deployment Trial: A Home-based Optokinetic Treatment
Several interventions exist for remediation of spatial neglect, but they have mixed evidence. Optokinetic stimulation is a bottom-up intervention; in other words, it is a stimulus-driven process, with Level A (strongest)…
- Trial name
- NCT07519317
- Testing
- Optokinetic stimulation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Duke University
Cardiorespiratory Fitness
Calibre vs. COSMED
This study evaluates agreement between the Calibre device and the COSMED Quark CPET system for measurement of cardiorespiratory fitness parameters during maximal exercise testing in adults aged 18-55 years.
- Trial name
- NCT07596108
- Testing
- COSMED Quark CPET metabolic cart, Calibre Biometrics
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University