Clinical trials: sponsored by Genentech, Inc.
Healthy Volunteers
A Study to Investigate the Bioequivalence of Two Different Forms of Entrectinib (Forms A and C) Under Fasted Conditions in Healthy Subjects
This study aims to demonstrate similarities between two different forms of entrectinib (A and C) when administered under fasted conditions in healthy subjects.
- Trial name
- NCT03796013
- Testing
- Entrectinib Form A, Entrectinib Form C
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteer
Effect of Food, Rabeprazole, Methotrexate and Formulation on the Pharmacokinetics (PK) of GDC-0853 and the Effect of GDC-0853 on the PK of Methotrexate in Healthy Subjects
This study is a Phase I, single center, randomized (Parts 1 and 2 only), open-label, 3 part study. Parts 1 and 2 are 2-way crossover, with 1-fixed sequence, 3-period designs to investigate the effect of formulation, food and…
- Trial name
- QCL117578 (NCT02699710)
- Testing
- Folic Acid, GDC-0853, Methotrexate
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteers
A Study to Investigate the Relative Bioavailability of Entrectinib Capsule Formulations F1 and F06 Under Fed Conditions in Healthy Participants
This study aims to investigate the relative bioavailability, safety, and tolerability of entrectinib capsule formulations F1 and F06 under fed conditions in healthy adult male and female participants.
- Trial name
- NCT03796260
- Testing
- Entrectinib Test Formulation (F1), Entrectinib Reference Formulation (F06)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteer
A Study to Determine the Safety, Tolerability, and Pharmacokinetics of GDC-0310 in Healthy Volunteers
The purpose of this study is to evaluate the safety and tolerability of single and multiple orally ascending doses of GDC-0310 administered in healthy participants as 4 parts including Part 1- a single dose (SD) part using a…
- Trial name
- NCT02742779
- Testing
- GDC-0310
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Alzheimer's Disease
Longitudinal Evaluation of [18F]GTP1 as a PET Radioligand for Imaging Tau in the Brain of Participants With Alzheimer's Disease Compared to Healthy Participants
This is an open-label, longitudinal observational study evaluating the imaging characteristics of the tau positron-emission tomography (PET) radioligand [18F] Genentech Tau Probe 1 (GTP1) in the brain of participants with…
- Trial name
- NCT02640092
- Testing
- [18F]GTP1
- Where
- 16 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Hepatic Insufficiency
A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants
This is a Phase 1 study evaluating the pharmacokinetics, tolerability and safety of a single dose of ipatasertib in participants with mild, moderate or severe hepatic impairment compared to healthy participants.
- Trial name
- NCT03341884
- Testing
- Ipatasertib
- Where
- 3 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteers
A Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of Single and Multiple Ascending Doses of GDC-0334 and the Effect of Food on the Pharmacokinetics of GDC-0334 in Healthy Adult Participants
This is a randomized, double-blind, placebo-controlled, single-center, three-part study designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamic effects of single and multiple ascending doses of…
- Trial name
- NCT03381144
- Testing
- GDC-0334
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteer
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MHAB5553A in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, single-ascending dose study in healthy volunteers to investigate the safety, tolerability, and pharmacokinetics (PK) of MHAB5553A.
- Trial name
- NCT02528903
- Testing
- MHAB5553A
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Participants
A Drug-Drug Interaction Study Between GDC-0853 and Midazolam, Itraconazole, Rosuvastatin, and Simvastatin
The purpose of this study is to assess the potential for a drug interaction between GDC-0853 and midazolam, itraconazole, rosuvastatin, and simvastatin.
- Trial name
- NCT03174041
- Testing
- Midazolam, GDC-0853, Midazolam and GDC-0853
- Where
- 3 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteers
A Study to Investigate the Effect of Formulation, Food, and Rabeprazole on the Pharmacokinetics (PK) of GDC-0853 in Healthy Participants
The purpose of this study is to evaluate the PK of GDC-0853 following changes to formulation and in the presence or absence of food, the proton pump inhibitor (rabeprazole), or both.
- Trial name
- NCT03290703
- Testing
- GDC-0853, Rabeprazole
- Where
- United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteers
A Study to Compare Pharmacokinetics (PK) of Etrolizumab Administered Subcutaneously by a Prefilled Syringe With Needle Safety Device (PFS-NSD) or an Auto-injector (AI)
This is a randomized, 2-part, 2-arm, open-label, parallel-group, multi-center study to compare the PK of etrolizumab administered subcutaneously by an AI (test device) or a PFS-NSD (reference device) in healthy participants.
- Trial name
- NCT02996019
- Testing
- Etrolizumab, Auto-Injector (AI), Prefilled Syringe With Needle Safety Device (PFS-NSD)
- Where
- 4 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Mild Atopic Asthma
A Study to Investigate the Safety, Pharmacokinetics, and Immunogenicity of BITS7201A in Healthy Volunteers and Participants With Mild Atopic Asthma
This randomized, observer-blinded, placebo-controlled, single and multiple ascending-dose study will be conducted in two parts to evaluate the safety, pharmacokinetics, and immunogenicity of BITS7201A.
- Trial name
- NCT02748642
- Testing
- BITS7201A
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Insulin Resistance
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of BFKB8488A in Otherwise Healthy Overweight and Obese Participants With Likely Insulin Resistance
This study will evaluate the safety and tolerability profile of BFKB8488A following subcutaneous (SC) administration in overweight and obese participants (body mass index [BMI] greater than [>] 27 to less than or equal to [</=]…
- Trial name
- NCT02593331
- Testing
- BFKB8488A
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteer
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, single-ascending dose study in healthy volunteers, enrolled at a single site in the United States to investigate the safety, tolerability, and pharmacokinetics of…
- Trial name
- NCT02596399
- Testing
- DSTA4637S
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteer
A Study to Assess the Relative Bioavailability And Food Effect of a Tablet Formulation of GDC-0276 in Healthy Participants
This open-label, randomized, 4-way crossover study in healthy participants will determine the relative bioavailability of the tablet formulation relative to the capsule formulation and the effect of a high-fat and low-fat meal on…
- Trial name
- NCT02856152
- Testing
- GDC-0276 capsule, GDC-0276 tablets
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteer
Study to Investigate the Effect of Formulation and Food on the Pharmacokinetics of GDC-0810
This is a phase 1, randomized, open-label, single center, crossover study to investigate the effect of formulation and food on the pharmacokinetics of GDC-0810 in female healthy participants of non-childbearing potential.
- Trial name
- NCT02722018
- Testing
- GDC-0810 Phase II Tablet, GDC-0810 Phase III Prototype Tablet
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteers
A Study of Relative Bioavailability and Food Effect Study of Cobimetinib in Healthy Participants
This study will be an open-label, randomized, 3-way, 6-sequence crossover study in healthy participants for determining the relative bioavailability of the tablet formulation to the capsule formulation and the effect of food on…
- Trial name
- NCT01249131
- Testing
- Cobimetinib
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Alzheimer's Disease
A Study of RO7105705 in Healthy Participants and Participants With Mild-to-Moderate Alzheimer's Disease
This is a Phase I, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, pharmacokinetics, and preliminary activity of RO7105705 in two participant populations: healthy participants and…
- Trial name
- NCT02820896
- Testing
- RO7105705
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy
A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential
This is an open-label, Phase I, single-center, single-dose administration study to determine the absolute bioavailability, clearance, and volume of distribution of GDC-0449 (Part A) and to determine the routes of excretion and…
- Trial name
- NCT00991718
- Testing
- GDC-0449 oral capsules (non-labeled), GDC-0449 IV injection (labeled), CDC-0449 oral suspension (labeled)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteer
A Study of the Safety, Tolerability, Pharmacokinetics, and Bioavailability of IV and SC MABT5102A in Healthy Volunteers
This Phase I, single-dose, randomized, parallel-group, open-label study will evaluate the safety, tolerability, and pharmacokinetics of MABT5102A following subcutaneous (SC) and intravenous (IV) administration in healthy…
- Trial name
- NCT00997919
- Testing
- MABT5102A
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.