Clinical trials: sponsored by Unity Health Toronto
HIV, Human Immunodeficiency Virus
PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5
Canada continues to see an unrelenting stream of new HIV diagnoses, with a disproportionate burden among gay, bisexual, and other MSM in major centers such as Toronto.
- Trial name
- PREP-5 (NCT02149888)
- Testing
- Tenofovir/emtricitabine
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Early Detection of Cancer, Cancer
Comparing Methods of Recall for Cancer Screening in Primary Care: a Pragmatic Clinical Trial
This randomized trial aims to understand how effective a reminder letter is compared to a reminder phone call in improving breast, cervical and colorectal cancer screening rates and reducing screening disparities.
- Conditions
- Early Detection of Cancer, Cancer, Socioeconomic Status
- Trial name
- NCT02457143
- Testing
- Letter, Phone call
- Where
- Canada
- Volunteers
- 5,270 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Overweight
Effectiveness and Safety of Salba on Weight Loss in Overweight Individuals With Type 2 Diabetes
Canadian statistics indicate that the incidence of obesity is increasing and that the occurrence of diabetes in obese individuals is 5-fold greater than those with a healthy weight, making weight control in this population…
- Conditions
- Diabetes Mellitus, Overweight, Obesity
- Trial name
- LOSS (NCT01403571)
- Testing
- Salba (Salvia hispanica L.), Oat-based Control
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Blood Pressure
Effect of High-carbohydrate or High-monounsaturated Fat on Blood Pressure: Meta-analysis of Randomized Clinical Trials
High saturated fat acids diets are associated with elevated blood pressure which is associated with cardiovascular morbidity and mortality.
- Trial name
- CHO-MUFA (NCT02626325)
- Testing
- High-carbohydrate or High-monounsaturated fat diets
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes
A Computer-Based Simulation of DKA Management
A 2-by-2 factorial cluster randomized controlled trial was performed to: 1) Compare the effects of supervised (coached) versus unsupervised (no coach) administration of the DKA simulator on trainees' knowledge of DKA management…
- Trial name
- DKA (NCT02799563)
- Testing
- Coach, Preselected number of cases, Coach, Self-selected number of cases, No coach, Preselected number of cases
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Healthy
Comparison of Dietary Fats on Vascular Parameters
The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels.
- Trial name
- COIL (NCT01876394)
- Testing
- Coconut Oil, Canola Oil, Grapeseed Oil
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Blood Pressure
Effect of Ginseng on Blood Pressure
To determine the effect of ginseng on blood pressure control.
- Trial name
- NCT01913210
- Testing
- Ginseng
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Blood Pressure
Effects of Soluble Fiber on Blood Pressure: A Meta-analysis of Randomly-controlled Trials
The present study conducted a meta-analysis of 22 randomly controlled trials to assess the effects of soluble fiber intake on blood pressure in human subjects.
- Trial name
- NCT02670967
- Testing
- Soluble Fibre
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hyperglycemia, Postprandial
Effect of Salba & Flax on Postprandial Glycemia and Subjective Satiety
The purpose of this study is to determine whether drinks containing Salvia hispanica L (Salba) or Flax lower postprandial blood glucose levels and improve appetite in healthy individuals.
- Trial name
- NCT02621307
- Testing
- Salba, Flax, Control
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Screening for Partner Violence
Computer-assisted Screening for Intimate Partner Violence in Family Practice
This study tested the effectiveness of computer-assisted screening for identifying patients at risk of intimate partner violence (IPV) in a Canadian family practice.
- Trial name
- NCT00385034
- Testing
- Interactive computer based health-risk survey before doctor's visit
- Where
- Canada
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Congestive Heart Failure
Improvement of Patients With Chronic Heart Failure Using NT-proBNP
This will be a multicentre Phase IV study in which patients with chronic HF who are managed and followed by HF/heart functions clinics will be followed over a period of two years.
- Trial name
- EXIMPROVECHF (NCT00601679)
- Testing
- NT-proBNP guided care
- Where
- 2 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Pituitary Neoplasms, Prolactinoma
Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools
The purpose of this research study is to determine the utility of educational materials designed to inform patients of their pituitary condition, in an effort to assist the patients, families, and staff deal with pituitary…
- Conditions
- Pituitary Neoplasms, Prolactinoma, ACTH-Secreting Pituitary Adenoma, Gigantism
- Trial name
- NCT01775332
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Surgical Technical Skill, Technical Errors in Surgery
Comprehensive Surgical Coaching
Simulation in surgical skills training is widely accepted as a necessary step to improve surgical training outside the operating room. Simulation predominately focuses on teaching a specific task or procedure.
- Trial name
- NCT01875679
- Testing
- Comprehensive Surgical Coaching, Conventional Surgical Training
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Pregnancy, Maternal Nutrition
Effects of Maternal Folate and Folic Acid Supplementation on DNA Methylation in the Newborn Infant
An overwhelming body of evidence of the protective effect of folic acid supplementation on neural tube defect affected pregnancies led to mandatory folic acid fortification in Canada in 1998.
- Conditions
- Pregnancy, Maternal Nutrition, Fetal Health, Epigenetics
- Trial name
- NCT02244684
- Where
- Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Healthy
Standardized Comparison of Triage in EMS
The objective of this study is to evaluate the reliability and validity of acuity estimates by paramedics employing the Canadian Triage Acuity Scale (CTAS) in the out of hospital setting.
- Trial name
- NCT00468780
- Where
- 2 sites in Canada
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Obesity
Effects of Viscous Fibre Containing Foods on Satiety (Gel Form)
The purpose of this study is to assess whether low caloric, low energy density, konjac food products are effective in appetite regulation when administered as caloric replacements.
- Trial name
- NCT02134938
- Testing
- Konjac Glucomannan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Arterial Stiffness, Blood Pressure
Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure
The purpose of the study is to evaluate the acute effect of a standardized extract of KRG (Rg3-KRG) consisting of 30% total ginsenosides, including 10% Rg3 ginsenoside on arterial stiffness and blood pressure, as measured by the…
- Trial name
- KRAB (NCT01951443)
- Testing
- Ginseng, Wheat Bran
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Healthy
Acute Effect of Nitrate From Natural Dietary Sources on Arterial Stiffness and Blood Pressures in Healthy Individuals
The purpose of this study is to evaluate the acute effect of a meal high in dietary nitrates on aortic augmentation index, brachial and aortic blood pressures, and subendocardial viability ration (SEVR).
- Trial name
- DNAB (NCT01604993)
- Testing
- Spinach soup, Asparagus soup
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases
Effect of Flax, Poppy, Sesame & Salba on Postprandial Blood Glucose Response, Vascular, Appetite & Sensory Parameters
Consumption of whole grains has been heavily endorsed by both government and major health agencies, as evidenced in Health Canada's Food Guide, the US Department of Agriculture's Food Pyramid, and the Heart and Stroke…
- Trial name
- NCT01579656
- Testing
- Salba, Poppy, Flaxseed
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Healthy
Effects of Mode of Administration of Soluble Fibre Blend on Glycemia, Appetite & Sensory Parameters
Soluble, viscous fibre has been established as an effective dietary component for lowering postprandial glycemia and promoting satiety.
- Trial name
- FI-FORM (NCT01657058)
- Testing
- Soluble viscous fibre blend powder in hydrophobic matrix, Soluble viscous fibre blend in pre hydrated form, No soluble viscous fibre blend
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto