Clinical trials: sponsored by University Hospital, Clermont-Ferrand
Metabolic Syndrome, Vascular Compliance
Orange Juice, Hesperidin and Their Role in Vascular Health Benefit
Although epidemiological studies have associated the consumption of sugary beverages with adverse health effects, experimental studies have demonstrated that the metabolic response of the human body to fruit juice as compared to…
- Conditions
- Metabolic Syndrome, Vascular Compliance, Predisposition to Cardiovascular Disease
- Trial name
- HESPER-HEALTH (NCT04731987)
- Testing
- Beverage consumption
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Nausea and Vomiting
Prevalence of Hyperemesis Gravidarum
Nausea and vomiting during pregnancy represent one of the most common symptoms of pregnancy, affecting 35 to 91% of women. Most often, the symptoms are mild, without impairment of quality of life and disappear at the end of the…
- Trial name
- PHyperEG1 (NCT06415084)
- Where
- France
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Migraine
Suppressive Functions of Regulatory T Cells in Migraine
Migraine is a frequent, disabling condition, of great social and economical impact worldwide. This condition is more frequent in women and subjects with autoimmune and/or inflammatory diseases.
- Trial name
- SIIM-reg (NCT07067112)
- Testing
- Blood sampling, questionnaire and phone call
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy Women
Endothelial Function in Healthy Volunteers
The aim of this study is to measure FMD (flow-mediated dilation) in healthy volunteers aged over 50 in order to establish reference values for women aged over 50.
- Trial name
- NormFMD (NCT07837076)
- Testing
- Measurement of endothelial function using FMD
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Psychosocial Risk Factors
PSYCHosocial Risk Factors of AThletes, Evaluation of a Questionnaire Constructed by CHATGPT
The goal of this observational study was to assess themes generated by ChatGPT to help organize psychosocial risk factors in professional sport.
- Trial name
- PsyChAt (NCT07862855)
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Physical Activity and Sedentary Behavior
Validation of a Short Physical Activity Questionnaire (Work and Leisure)
Validated physical activity questionnaires are often long and time-consuming, particularly when assessing both leisure-time and occupational physical activity and sedentary behavior.
- Trial name
- Actiwork (NCT07844265)
- Testing
- ACTIWORK questionnaire, Recent Physical Activity Questionnaire (RPAQ), REPEAS questionnaire
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity & Overweight
Childhood Obesity Risk Markers (MARIOBE)
Metabolic diseases, including childhood obesity, represent a major public health challenge. Studies in mice have identified transcriptomic markers in adipose tissue capable of predicting a predisposition to obesity prior to any…
- Trial name
- MARIOBE (NCT07831291)
- Testing
- early transcriptomic markers
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Kidney Injury, Transient Acute Renal Failure
Impact of the Characteristics of Acute Renal Failure in Intensive Care on the Long-term Renal Prognosis: Prospective Multicenter Cohort Study
The purpose of this study is to assess the impact of Acute Kidney Injury (AKI) characteristics on long-term renal prognosis in Intensive Care Unit (ICU) patients.
- Conditions
- Acute Kidney Injury, Transient Acute Renal Failure, Persistent Acute Renal Failure
- Trial name
- MAKI (NCT05247502)
- Testing
- Data observation
- Where
- 2 sites in France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pregnant Woman
Physical Activity and Sedentary Behavior During Pregnancy
Our main objective is to evaluate the intervention that best enables women's adherence to physical activity (PA). Our hypothesis is that identifying types of interventions suitable for pregnant women (in-person PA sessions…
- Trial name
- PREGMOUV (NCT06585085)
- Testing
- In person PA sessions, Interactive videoconference PA sessions, In person and by videoconference (mixed format) PA sessions.
- Where
- France
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Sedentary Behavior, Occupational Stress
Effects of a Sedentary Behaviors at Work on Health in Emergency Medical Dispatchers and CODIS Operators (SECODIS)
The purpose of the study is to study changes in sedentary behavior following a behavioral intervention (sit-and-stand desk, and cycloergometer)
- Trial name
- SECODIS (NCT05931406)
- Testing
- Control, Sit-and-stand desk, Cycloergometer
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Concussion, Brain
Diffusion Tensor Brain MRI in the Detection of Structural Abnormality of the White Substance in Concussion
Concussions in sports are a major public health problem because of their frequency, and are often underdiagnosed because of an unspecific clinical picture or sometimes masked by the concussion itself.
- Trial name
- COMMOTION (NCT06144359)
- Testing
- specific MRI Acquisition (Diffusion Tensor Imaging) at 3T
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Fibrous Dysplasia of Bone, McCune Albright Syndrome
PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study
Fibrous dysplasia of bone (FD) / McCune-Albright syndrome (MAS) is a rare congenital bone disorder affecting one or multiple bones, caused by a mosaic somatic mutation of the GNAS gene.
- Trial name
- PAINDYS (NCT07476768)
- Testing
- Visit 1 at the center
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
Paracetamol and Pharmacogenetic
Recent works has emphasized that the mechanism of action of paracetamol analgesic depend on its metabolism in the body, since a breakdown product of paracetamol, the AM404 is now considered the analgesic metabolite of paracetamol…
- Trial name
- NCT01520792
- Testing
- Paracetamol (drug)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetes, Hearing Problems
Screening and Characterization of Hearing Disorders in Diabetic Persons
Diabetes is now the most common chronic disease, affecting nearly 6% of the population in Western populations. Diabetic neuropathy is a priori the most common and the most common specific complications of diabetes.
- Trial name
- DeCaTAuDiab (NCT03437135)
- Testing
- Glasgow Hearing Status Inventory questionnaire
- Where
- France
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Neuropathic Pain
Adrenocorticotropic Axis and Neuropathic Pain
Chronic pain is often associated with a chronic stress and HHSG axis plays a pivotal role in maintaining homeostasis. The literature reports that pain in patients treated with opioids, significant changes are taking place in this…
- Trial name
- HORMONES (NCT01543425)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Visual Deficiency, Congenital Blindness
VISIODOL: Validation of the VISIODOL® Scale
The aim of this study is to validate the VISIODOL® scale for screening of pain in people with visual impairment.
- Conditions
- Visual Deficiency, Congenital Blindness, Acquired Blindness
- Trial name
- VISIODOL (NCT03968991)
- Testing
- VISIODOL® (Diagnostic tool)
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Normal Weight Adults, Adults With Obesity
Validation of a French-version of the Leeds Food Preference Questionnaire in Normal Weight and Patients With Obesity
While Food reward is an important component of the appetite control to consider, there is actually no tool that has been developed in French to perform its evaluation.
- Trial name
- LFPQ-F (NCT04041830)
- Testing
- Visit 1, Visit 2
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Metabolic Syndrome, Hypertriglyceridemia
Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers (ProVegOmics)
The dietary shift from animal to plant protein sources is one of the key aspects of the nutritional transition towards more sustainable food system and diets.
- Conditions
- Metabolic Syndrome, Hypertriglyceridemia, Fasting Blood Sugar Above Normal, Lower Than Standard HDL-cholesterol Level
- Trial name
- ProVegOmics (NCT04236518)
- Testing
- Diets with either predominantly animal protein sources., Diets with predominantly plant protein sources
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pediatric Obesity
Appetite Response to Exercise- Versus Mixed (Exercise + Dietary Restriction)-Induced Energy Deficit in Adolescents With Obesity
The aim of the present study is to compare the effect of iso-energetic energy deficits induced by energy restriction alone or exercise + dietary restriction (Mixed deficit) on energy intake and appetite feelings in adolescents…
- Trial name
- IDEX2 (NCT04734639)
- Testing
- CON . control condition without exercise / rest condition, Def-Mixed. Condition with a mixed energy deficit induced by exercise + dietary restriction., Def-EI. Condition with an energy-restriction energy deficit
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
Acetaminophen's Antinociceptive Effect When Associated With N-Acetylcysteneine
Acetaminophen is one of the most widely used analgesic in the world, recommended for the symptomatic treatment of fever and pain.
- Trial name
- PANACE (NCT02206178)
- Testing
- N-acetylcysteine combination with acetaminophen
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand