Clinical trials: sponsored by University Hospital, Tours
Alzheimer Disease
Identification of Diagnosis Biomarkers in the Tears of Alzheimer's Disease Patients: The COG-EYE Pilot Study
The diagnosis of Alzheimer's disease (AD) relies on the detection of protein biomarkers, particularly in cerebrospinal fluid (e.g., Aβ and phosphorylated Tau) or through brain imaging.
- Trial name
- COG-EYE (NCT06661564)
- Testing
- Basal tear collection for the analysis of metabo-lipidomic profiles and concentrations of protein biomarkers (Tau, phosphorylated Tau, Aβ 1-40, and Aβ 1-42), Collection of a blood sample (5 mL) for blood biomarkers analysis
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Autism Spectrum Disorder
Social Information Processing in Children: an ocUlo-pupillometric Tool for Standard Evaluation
The goal of this observational study is to identify behavioral and physiological markers of social alterations in Autism Spectrum Disorders compared to Typically Developping peers.
- Trial name
- SIRCUS (NCT05596331)
- Testing
- eye-tracker
- Where
- France
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Cervical Ripening, Unfavorable Cervix
Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening
Twenty-two percent of deliveries in France are induced. In cases where labor is induced and cervix is unfavorable, cervical ripening prior oxytocin administration is advised in order to reduce the risk of cesarean delivery.
- Trial name
- OPIC (NCT04949633)
- Testing
- Prostaglandins, Oxytocin
- Where
- 14 sites in France
- Volunteers
- 1,494 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
X-Ray
Method for bAdge-dosi Monitoring of X-ray Exposure Values in Operating Theatre Surgery
Surgical procedures involving X-rays in the operating room have increased in recent years, thereby increasing the exposure of operating room staff to ionizing radiation.
- Trial name
- MAVERIC (NCT06659939)
- Testing
- Badge-dosi
- Where
- 4 sites in France
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Communication, Personality
Channels of Communication & Brain Functioning: Pilot fMRI Study
Communication is a social process involving individuals exchanging messages. It is usual to observe different reactions according to the manner of communication, the manner in which such information is exchanged.
- Trial name
- COCACE (NCT04533126)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Acute Ischemic Stroke
Ultrasound for Acute Field Triage of Stroke
Acute ischemic stroke (AIS) is responsible for considerable morbidity and mortality worldwide and has serious medico-economic and psychosocial consequences.
- Trial name
- USTRAFAST (NCT05845203)
- Testing
- perform a simultaneous bilateral DTC acquisition of 20 seconds per hemisphere
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Nasal Disease
Collection of Primary Human
Treatment and prevention of respiratory infections are of great interest in many medical areas. Create a physical device covered by primary human nasal cells could be very usefull in order to analyse delivery and efficiency of…
- Trial name
- BIONOSE (NCT06407102)
- Testing
- Collection of nasal cells during programme surgery
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Neurodevelopmental Disorders
Individual Neurophysiological Sensory Profiles in People With and Without Neurodevelopmental Disorders
The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of…
- Trial name
- SensAUry (NCT07542977)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Alzheimer's Disease (AD)
Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study
Alzheimer's disease (AD) is a neurodegenerative disorder affecting almost 6% of the world's population over the age of 65. This disease, in its most typical sporadic form, is characterized by an episodic memory impairment linked…
- Trial name
- PINK-AD (NCT04570761)
- Testing
- Dreem headband
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Liver Steatosis
Fibroscan® Medical Device, Assessment for Non Invasive Diagnosis of Liver Steatosis
Hypothesis of this study is the existence of a relation between parameters measured by FibroScan® FS 502 according to our non invasive method and liver steatosis condition.
- Trial name
- TRANSTEATOSE (NCT02575625)
- Testing
- Fibroscan, Blood test for biological assessment of liver function, MRI
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Autism Spectrum Disorder, Bipolar Disorder
Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder (REMBAU)
The objective of this study is to identify the specific characteristics of Autism Spectrum Disorder (ASD) in emotional response profiles and shared with Bipolar Disorder (BD) characteristics.
- Trial name
- REMBAU (NCT02423499)
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Systemic Lupus Erythematosus, Physiopathology
Study of Neonatal IgG Fc Receptor Expression in Natural Killer T Cells Expressing an Invariant T Receptor : Implication in the Pathophysiology of Systemic Lupus
This study evaluates the variation of expression of the neonatal Fc receptor (FcRn) in Natural Killer T Cells Expressing an Invariant T Receptor (iNKT) and monocytes along with the surface expression of Fc gamma type II receptor…
- Trial name
- FiNKLUPUS (NCT05859191)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Obesity (Disorder)
Role of the Environment in Pediatric Obesity
Childhood obesity is a particular concern in developed countries such as the United States, the United Kingdom, Canada, and certain European countries.
- Trial name
- REOP (NCT07545174)
- Testing
- Blood test, Urine sample, Hair sample
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Dental Consultation
Atlas of Ultrasound Imaging of the Oral Cavity: Characterization and Description of Anatomical Structures
Ultrasound imaging is a non-invasive and non-ionizing technique widely used for the evaluation of soft tissues in many medical specialties.
- Trial name
- ATLAS-US (NCT07463534)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Lung Cancer (NSCLC), Lung Cancer (Non-Small Cell)
Immune Response to Immunotherapy in Lung Cancer: Study of Sputum and Blood Samples
Lung cancer is the leading cause of cancer-related death worldwide, with nearly 2.48 million cases and 1.8 million deaths in 2022.
- Trial name
- RICEPS-2 (NCT07163507)
- Testing
- Blood sample, sputum sample
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Behavior
The Effects of Mindfulness Meditation on Brain Metabolism in the Limbic Regions Studied by Magnetic Resonance Spectroscopy
Stress reduction methods based on mindfulness meditation have been experiencing significant growth in various fields of society over the past twenty years.
- Trial name
- MEMOREM (NCT05710250)
- Testing
- 6-week MBSR program, 6-week muscular relaxation program
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Autism, Fragile-X Syndrome (FXS)
Glutaminergic Transmission in Autism : Molecular Imaging Exploration
Glutamatergic transmission exploration using PET (Positron Emission Tomography) imaging in autism compared to Fragile-X Syndrome ( FXS) and Healthy Volunteers
- Conditions
- Autism, Fragile-X Syndrome (FXS), Healthy Volunteers
- Trial name
- TANGAU (NCT02719951)
- Testing
- [18F]FPEB PET imaging, Biological samples, MRI
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Neurological Diseases
In Vivo and ex Vivo Validation of MR Tractography of Brain White Matter Tracts - FIBRATLAS II-III
White matter tracts connect cortical areas to other parts of the cortex, to basal ganglia and to the brain stem and spinal cord. These tracts form the internal part of the brain and transmit the nervous impulses.
- Trial name
- FIBRATLAS (NCT02455284)
- Testing
- MRI
- Where
- 7 sites in France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Depressive Symptoms, Depressive Disorder, Major
Olfactory Training and Emotional State
During the past three decades, researchers have paid particular attention to the study of olfactory disorders in depression. Recent studies have shown that depression is characterized by a change in olfactory and emotional…
- Trial name
- ENOLFEA (NCT03605524)
- Testing
- Sensory training
- Where
- 3 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
redOx Metabolism
Analyses of Bone Marrow and Blood Samples From Healthy Volunteers: Focus on the redOx Metabolism
Oxidative stress is defined by an excess of reactive oxygen species (reactive oxygen species or ROS) in cells. ROS are essential to cell life (proliferation, differentiation), including kinase activity via inhibition of…
- Trial name
- HEALTHOX (NCT02789839)
- Testing
- Blood test, Medullar test
- Where
- France
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours