Clinical trials: sponsored by University Medical Center Groningen
Microtia, Congenital, Auricular Reconstruction
Social Perception of Microtia
Rationale: Microtia is a congenital craniofacial condition characterized by the underdevelopment of the external ear. Children with microtia become aware of their deformity at a young age, and this awareness intensifies in…
- Trial name
- NCT07721805
- Where
- Netherlands
- Volunteers
- 1,271 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
PEM, a Starting Point to Investigate ME/CFS
Exercise is an important contributor to general health and is considered a potential remedy for chronic diseases. This is in strong contrast with the observation that in most myalgic encephalomyelitis (ME/CFS) patients exercise…
- Trial name
- PEM_CFS (NCT07715838)
- Testing
- No intervention is planned
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Depression in Remission
Mechanisms of Change of Positive Interventions in Reducing Vulnerability for Depression
The purpose of this study is to understand the effects of mindfulness and fantasizing in reducing perseverative cognition underlying vulnerability for depression.
- Trial name
- MINDCOG (NCT06145984)
- Testing
- Mindfulness, Positive Fantasizing
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Healthy Participants
Virtual Reality Assisted Schema Therapy
Schema therapy helps people understand which emotional needs were not met during childhood, and how they can take care of those needs now.
- Trial name
- VRAST (NCT07171736)
- Testing
- Virtual Reality chairwork exercise, Imagination exercise
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Education, Professional, Refugees
Empowering Nursing Newcomers Program
In the Netherlands, more and more nurses with an international background, such as refugees and migrants, are starting to work in healthcare.
- Conditions
- Education, Professional, Refugees, Nursing, Migrants
- Trial name
- EMPOWER (NCT07500688)
- Where
- Netherlands
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Adrenal Incidentaloma, Adrenocortical Carcinoma
Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield
Standard diagnostic work-up for adrenal incidentalomas (AI) consists of periodical biochemical analysis and CT-scanning in case the initial work-up does not demonstrate the presence of hormonal hypersecretion or adrenocortical…
- Trial name
- SERENDIPITY (NCT02324647)
- Where
- Netherlands
- Volunteers
- 807 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Palliative Medicine
The MuSt-PC: a Feasibility Study on Intent to Use a Tool With Regard to Symptom Management
A study on the intent to use a tool (MuSt-PC) to manage symptoms of patients in a palliative care trajectory.
- Trial name
- NCT06110624
- Testing
- Survey
- Where
- 2 sites in Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Deep Sedation
Prospective Validation of the Eleveld Model of Propofol for Procedural Sedation in Adults.
The goal of this prospective observational study is to identify effect site concentrations (CET) of propofol using the Eleveld model for different levels of procedural sedation.
- Trial name
- NCT06325033
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Fatigue, Walking, Difficulty
Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS
Transcutaneous Electrical Nerve Stimulation (TENS) is a treatment that could potentially reduce walking problems and fatigue in persons with Multiple Sclerosis.
- Conditions
- Fatigue, Walking, Difficulty, Multiple Sclerosis
- Trial name
- NCT06432686
- Testing
- Transcutaneous Electrical Nerve Stimulation, Movement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Healthy Volunteer Study
Smart Blister Packaging and Mobile Application to Monitor and Support Medication Adherence: a Two-arm Usability Study
Many people struggle to take their medications as prescribed, which can lead to poor health outcomes and increased healthcare costs.
- Trial name
- SMART-BLISTER (NCT07099612)
- Testing
- MEMS® Mobile smartphone application, Cere®Pak smart blister pack
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Testicular Cancer
Health Status and Burden of Late Effects in Very Long-term Testicular Cancer Survivors (STANDBY-study)
Depending on disease stage, testicular cancer (TC) treatment consists of an orchidectomy, alone or followed by radiotherapy (RT) or platinum-based chemotherapy (CT).
- Trial name
- STANDBY (NCT02572934)
- Where
- Netherlands
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Cervical Radiculopathy, Cervical Myelopathy
Quantitative Imaging of Cervical Spinal Structures - the DISC Pilot Study -
The aim of this study is to explore a multi-parametric quantitative MRI approach to measure cervical intervertebral discs, the spinal cord and its nerve roots in healthy participants and patients with cervical degenerative disc…
- Trial name
- DISC (NCT06610175)
- Testing
- Quantitative MRI and anatomical MRI
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Endodontically-Treated Teeth, Endocrown Restoration
Direct Versus Indirect Endocrowns on Endodontically Treated Molars
In this clinical trial the performance of monolithic restorations made of indirect lithium disilicate ceramic and direct resin composite materials on severe structurally compromised endodontically treated molar teeth is…
- Conditions
- Endodontically-Treated Teeth, Endocrown Restoration, Restoration of Posterior Teeth, Composite Resins
- Trial name
- Endocrowns (NCT06934460)
- Testing
- Composite resin, lithium disilicate endocrown
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
HPV Infection, Cervix Cancer
Validation of Artificial Intelligence as Decision Support System in VIA (PRESCRIP-TEC)
The research project is a component of another research project that applies the protocol of the World Health Organization for screening of cervical cancer, with testing of high-risk Human Papilloma Virus (hrHPV) as first…
- Conditions
- HPV Infection, Cervix Cancer, Cervical Dysplasia
- Trial name
- AI-DSS (NCT06452004)
- Testing
- Validation of AI-DSS in Bangladesh, Validation of AI-DSS in Uganda, Validation of AI-DSS in India
- Where
- Uganda
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
PASC Post Acute Sequelae of COVID 19, Long COVID
From Inflammation to Remodelling Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19
Rationale: The diagnosis and pathogenesis of long COVID remains unknown. We have previously shown that [68Ga]FAPI Positron Emission Tomography-Computed Tomography (PET/CT) imaging shows potential for diagnosis and molecular…
- Conditions
- PASC Post Acute Sequelae of COVID 19, Long COVID, Long Covid-19, PASC
- Trial name
- LIBERATE (NCT06911476)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Multiple Sclerosis
The MS-CEBA Study: Determining Cognitive, Energetic, Behavioural and Affective (CEBA) Profiles in Multiple Sclerosis
Multiple Sclerosis (MS) is an invalidating neurological disease known to cause physical symptoms, which usually are the main focus of treatment.
- Trial name
- MS-CEBA (NCT06016309)
- Testing
- There is no intervention.
- Where
- Netherlands
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Melanoma, Non-small Cell Lung Cancer (NSCLC)
Taste and Smell Dysfunction in Patients More Than Two Years After Start of Immune Checkpoint Inhibitor Therapy
Background of the study: Immune checkpoint inhibitors (ICIs) are widely used as treatment for multiple cancer types and the number of patients with longterm disease control after ICIs is increasing.
- Conditions
- Melanoma, Non-small Cell Lung Cancer (NSCLC), Urogenital Cancers
- Trial name
- TasteSPICIER (NCT06495008)
- Testing
- no intervention, only questionnaires, saliva collection and taste/smell tests
- Where
- Netherlands
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Young-onset Dementia
YOD-RiSoCo: Social Cognition and Risk-taking Behaviour in Patients with Young-onset Dementia
The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD).
- Trial name
- YOD-RiSoCo (NCT06286293)
- Testing
- Neuropsychological assessment, driving simulator task
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Sjogren Syndrome, Malignant Tumors
The Feasibility of Multispectral Optoacoustic Tomography in Different Diseases
Optoacoustic imaging is a new and innovative imaging technique that combines the high contrast of optical imaging with the penetration depth and high spatial resolution of ultrasonography using the optoacoustic effect.
- Conditions
- Sjogren Syndrome, Malignant Tumors, Arterial Disease
- Trial name
- FOMO (NCT06740175)
- Testing
- Multispectral optoacoustic tomography
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen