Clinical trials: sponsored by University of Iowa
Electronic Cigarette Use, Endothelial Dysfunction
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007.
- Conditions
- Electronic Cigarette Use, Endothelial Dysfunction, Inflammation
- Trial name
- NCT06489249
- Testing
- Salsalate 750 MG Oral Tablet [DISALCID]
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Endothelial Function
Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation
The increase in skin blood flow in response to rapid local heating of the skin (i.e., cutaneous vasodilation) is commonly used to assess nitric oxide (NO)-dependent dilation and overall microvascular function.
- Trial name
- CAP NOVA (NCT06499844)
- Testing
- Acetylcholine
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
- Trial name
- INC-6602 (NCT01193088)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Healthy, Ankle Foot Orthosis (AFO)
Reliability of Force Measurement Within the Carbon Fiber Orthosis Proximal Cuff
The primary purpose of this research study is to determine if forces within carbon fiber custom dynamic orthoses (CDOs) can be reliability assessed using Loadpad and Loadsol force measuring sensors (Novel GMBH, St. Paul, MN).
- Conditions
- Healthy, Ankle Foot Orthosis (AFO), Peripheral Neuropathy
- Trial name
- CuffForce (NCT06127264)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Healthy
Pharmacokinetics of Transdermal Metronidazole
This is a crossover pharmacokinetic clinical study in healthy volunteers to compare metronidazole delivery through skin when a gel or cream metronidazole product is applied to skin treated with a micropatch.
- Trial name
- NCT05929794
- Testing
- Metronidazole 0.75% Topical Gel, Metronidazole 0.75% Topical Cream, Transdermal water loss measurement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Quality of Life, IVF
CALM IVF (Creating Affiliations, Learning, and Mindfulness for In Vitro Fertilization Patients)
The investigators have designed a psychoeducational group curriculum specifically for new in vitro fertilization (IVF) patients (both male and female) to improve their treatment knowledge, to allow them to engage more in their…
- Conditions
- Quality of Life, IVF, Patient Satisfaction, Patient Engagement
- Trial name
- NCT04048772
- Testing
- CALM IVF, Standard of Care
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Gingival Recession
Dimensional Changes: Randomized Clinical Trial
The goal of this clinical trial is to evaluate the dimensional changes in the short and long-term in patients with thin gum tissues who have gum grafts placed on either denuded bone or gum grafts placed on a bone with some…
- Trial name
- NCT05684068
- Testing
- Gum Graft Placed on Denuded Bone, Gum Graft Placed on Split Thickness Periosteal Bed Preparation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Abdominal Abscess
Antibiotic Irrigations for Intra-Abdominal Drains
Intra-abdominal abscesses are pus-filled pouches in the abdominal cavity. Current standard of care includes drain placement in the abscess cavity to reach source control as well as administration of systemic antibiotics.
- Trial name
- AID (NCT03476941)
- Testing
- Gentamicin Sulfate Inj 20mg/2ml vial for injection, Clindamycin phosphate 6 mg/1ml for injection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Tooth Loss
Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®
The purpose of this study is to clinically, radiographically and histologically evaluate the healing sequence of post-extraction sockets grafted with Bio-Oss Collagen® at 3, 6 and 9 months following tooth extraction in…
- Trial name
- NCT03659617
- Testing
- xenograft (BioOss Collagen)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Autism Disorders and Maternal Stress, Development Delay
Perinatal Autism Genetics and Epigenetics Study
The University of Iowa's Center for Disabilities and Development is researching how pregnancy, early childhood experiences, and genetic factors influence child development, with a focus on autism spectrum disorder (ASD).
- Conditions
- Autism Disorders and Maternal Stress, Development Delay, Prenatal Stress, Social Behavior
- Trial name
- PAGES (NCT07738003)
- Testing
- Change in child's DNA methylation, Perinatal stress, Early social experience
- Where
- United States
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Caries,Dental
Birth to Three - Cavity Free
Early childhood caries (ECC) is a potentially painful and debilitating disease, which represents a significant public health problem among young children.
- Trial name
- BTCF (NCT05756413)
- Testing
- Self-determination theory
- Where
- 16 sites in United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Aquagenic Wrinkling of Palms, Carrier State
Aquagenic Wrinkling Prediction
The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status.
- Trial name
- NCT06831110
- Testing
- Aquagenic Wrinkling
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Pregestational Diabetes
Does the Use of Continuous Glucose Monitoring (CGM) in the Immediate Postpartum Period in Women With Pregestational Diabetes Admitted to the Hospital Decrease Hypoglycemic Episodes
This study will examine whether continuous glucose monitoring in patients hospitalized in the immediate postpartum period is more effective than traditional point of care glucose testing in identifying patients with hypoglycemia.
- Trial name
- NCT06141941
- Testing
- CGM
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Arthritis Shoulder Glenohumoral Joint, Rotator Cuff Tear Arthropathy
Telerehabilitation After Shoulder Arthroplasty
The use of reverse total shoulder arthroplasty (RSA) has increased dramatically in the United States in recent years. The importance of postoperative physical therapy in the setting of anatomic total shoulder is well understood…
- Conditions
- Arthritis Shoulder Glenohumoral Joint, Rotator Cuff Tear Arthropathy, Arthropathy Shoulder
- Trial name
- NCT05499728
- Testing
- Telerehabilitation; physical therapy via telecommunication device (i.e. online video conferencing)
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Ankle Fractures, Post-traumatic Osteoarthritis
Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. Research suggests that ankle arthritis develops after ankle fracture, in part, due to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP-FPA2 (NCT04562896)
- Testing
- Custom Carbon Fiber Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Healthy, Lower Limb Injury
Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics
Carbon fiber custom dynamic orthoses (CDOs) consist of a proximal cuff that wraps around the leg just below the knee, a posterior carbon fiber strut that stores and returns energy during gait, and a carbon fiber foot plate that…
- Conditions
- Healthy, Lower Limb Injury, Post-Traumatic Osteoarthritis
- Trial name
- AFOCUFF (NCT05456295)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Physical Inactivity
Cognitive Control to Boost Physical Activity Adherence
This trial is designed to develop and test the efficacy of cognitive training strategies to improve self-regulatory capacities for middle-aged adults to adopt and sustain a physically active lifestyle.
- Trial name
- BOOST (NCT06338774)
- Testing
- Cognitive training, Exercise
- Where
- 2 sites in United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Edentulous Jaw, Edentulous Mouth
Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Older removable denture wearing adults suffer from a complex set of oral health challenges, with relatively few solutions identified at this time.
- Trial name
- NCT05441527
- Testing
- MI Paste, then, Biotene Dry Mouth Gel, Biotene Dry Mouth Gel, then, MI Paste
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Tooth Extraction, Immediate Implant Placement
Ultrasound-based Imaging to Detect Early Changes of Hard and Soft Tissue Around Immediately Placed Implants With or Without Soft Tissue Augmentation
Mid-facial recession following immediate implant placement (IIP) in the place of a tooth poses a significant challenge for clinicians to treat.
- Trial name
- NCT05330702
- Testing
- Xenogeneic Volume-Stable Collagen Matrix (VCMX) graft No Intervention: No Soft Tissue Augmentation, Tuberosity Connective Tissue Graft (CTG)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Iowa